上海艾力斯医药科技股份有限公司 2024 年年度股东大会会议资料 二零二五年五月 目 录 | 2024 | 年年度股东大会会议须知 - 2 - | | --- | --- | | 2024 | 年年度股东大会会议议程 - 4 - | | 2024 | 年年度股东大会会议议案 - 5 - | | 议案一：关于公司《2024 | 年年度报告》及其摘要的议案 - 5 - | | 议案二：关于公司《2024 | 年度董事会工作报告》的议案 - 6 - | | 附件一：上海艾力斯医药科技股份有限公司 | 2024 年度董事会工作报告 - 7 - | | 议案三：关于公司《2024 | 年度监事会工作报告》的议案 - 12 - | | 附件二：上海艾力斯医药科技股份有限公司 | 年度监事会工作报告 - 2024 13 - | | 议案四：关于公司《2024 | 年度财务决算报告》的议案 - 16 - | | 附件三：上海艾力斯医药科技股份有限公司 | 2024 年度财务决算报告 - 17 - | | 议案五：关于公司《2024 | 年度独立董事述职报告》的议案 - 24 - | | 附件四：上海艾力斯医药科技股份有限公司 ...

证券研究报告 | 行业简评报告 2025 年 04 月 30 日 内需平稳复苏，新消费急先锋 大消费组"消费的方向"四月观点 研究部/消费品 食饮 陈书慧：白酒龙头平稳开局，食品小额消费看点不断 轻纺 王梓旭：关注拓品类&渠道运营力强的品牌龙头 农业 李秋燕：增配优质低估值猪企，重视粮食安全 风险提示：消费下行风险，消费复苏疲软风险、宏观经济变动风险等 推荐（维持） 行业规模 | | | 占比% | | --- | --- | --- | | 股票家数（只） | 1216 | 23.8 | | 总市值（十亿元） | 16360.1 | 19.6 | | 流通市值（十亿 | 14931.7 | 19.6 | 轻纺 王月：个护大单品红利期 Q1 业绩表现突出，金属包装 Q2 或盈利拐点 向上 家电 史晋星：一季报收官总结，抄底关税错杀+布局新消费 零售 丁浙川：万辰集团 Q1 净利率大超预期，关注鸣鸣很忙上市表现 医药 许菲菲：关税环境下关注创新药及产业链、内需复苏 商社 李秀敏：聚焦内需韧性&文旅复苏，节前关注出行链投资机会 行业简评报告 食饮-陈书慧：白酒龙头平稳开局，食品小额消费看 点不断 行业指数 % 1 ...

Group 1 - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) has seen a strong increase of 1.80%, with notable gains from stocks such as Xiangyu Medical (688626) up 7.27% and Microelectrophysiology (688351) also up 7.27% [1] - The Sci-Tech Biopharmaceutical ETF (588250) rose by 1.78%, marking its third consecutive increase, with the latest price at 1.03 yuan. Over the past month, this ETF has ranked first in its category for growth [1] - The upcoming annual American Society of Clinical Oncology (ASCO) conference is expected to enhance the outlook for innovative drugs, as Chinese experts are set to present at the event, potentially boosting the industry's sentiment [1] Group 2 - Institutions believe that the head-to-head comparison of Kangfang Biopharma's Ivosidenib shows strong positive results, reflecting the company's strength and potentially accelerating competition among similar innovative drugs [2] - The Sci-Tech Biopharmaceutical ETF closely tracks the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index, which includes 50 large-cap companies in biopharmaceuticals and related fields, representing the overall performance of the sector [2] - As of March 31, 2025, the top ten weighted stocks in the Sci-Tech Biopharmaceutical Index account for 51.35% of the index, with companies like United Imaging Healthcare (688271) and BeiGene (688235) among the leaders [2]

Core Viewpoint - The Hong Kong pharmaceutical sector is experiencing a strong upward trend, with significant increases in key stocks and ETFs, driven by favorable policies and innovations in the industry [1][2][4]. Group 1: Market Performance - As of April 30, 2025, the CSI Hong Kong Stock Connect Pharmaceutical and Healthcare Composite Index (930965) rose by 1.05%, with notable increases in stocks such as MicroPort Scientific Corporation-B (02252) up 11.12% and BeiGene (06160) up 5.97% [1]. - The Hong Kong Pharmaceutical ETF (159718) increased by 0.56%, with a recent price of 0.72 HKD, and has seen a 1.56% rise over the past week, ranking among the top in its category [1][2]. - The CSI Pharmaceutical and Medical Device Innovation Index (931484) rose by 0.81%, with stocks like Kelun Pharmaceutical (002422) up 5.83% and East China Pharmaceutical (000963) up 2.70% [4]. Group 2: Trading Activity - The Hong Kong Pharmaceutical ETF recorded a turnover rate of 28.85% during trading, with a total transaction volume of 74.15 million HKD, indicating active market participation [2]. - The ETF's average daily trading volume over the past week was 112 million HKD, and it has seen a significant growth in scale, increasing by 57.33 million HKD this month, leading its category [2]. Group 3: Regulatory and Policy Developments - The Hainan Provincial Government is promoting the rapid clinical use of innovative drugs and medical devices through policy guidance and inter-departmental collaboration, aiming for high-quality development in the biopharmaceutical industry [2]. - The National Medical Products Administration (NMPA) is conducting research to enhance regulatory efficiency and support innovation in drug development, emphasizing the need for comprehensive reforms in drug regulation [2]. Group 4: Investment Opportunities - The current market conditions, including the integration of "Artificial Intelligence +" in medical applications and the emergence of new healthcare business models, present potential investment opportunities in the pharmaceutical sector [2]. - The valuation of the Hong Kong Pharmaceutical ETF, with a price-to-earnings ratio (PE-TTM) of 23.91, is at a historical low, suggesting a favorable entry point for investors [4].

Group 1: 泰恩康 (Tianenkang) - The company has completed the enrollment of 200 subjects for the Phase II clinical trial of CKB ointment, with results expected in July 2025 [1] - The registration application for the domestic production of Hewei Zhengchang Wan has been accepted, and the production line transformation is complete, aiming for approval within the year [1] - Minoxidil lotion has completed pre-listing preparations, with expected revenue recognition in Q2 of this year [1] - The company plans to submit multiple product approvals within the next year, including CKB and injectable paclitaxel polymer micelles [1] Group 2: 环旭电子 (Huanxu Electronics) - The domestic manufacturing ratio has decreased to 60%, with production shifting to Mexico, Poland, and Vietnam [2] - AI accelerator card business is expected to grow by 150%, with capacity expansion in Taiwan and Mexico [2] - The company is focusing on wearable products and SiP modules, with new product lines in Vietnam [2] - Annual capital expenditure (Capex) is projected to be over $200 million [2] Group 3: 艾力斯 (Ailis) - The company is advancing multiple key products, with Golai Resep tablets entering the comprehensive review stage and aiming for inclusion in annual medical insurance negotiations [3] - A new large molecule R&D department has been established, focusing on lung cancer, with plans for IND submission next year [3] - The company plans to continue expanding its marketing team and optimize resource allocation to ensure stable operations [3] - Cash dividends totaling 292.5 million yuan are planned for 2024, with an increase in mid-term dividends expected in the first half of 2025 [3] Group 4: 华阳集团 (Huayang Group) - The automotive electronics business has seen an expanding customer base, with a significant year-on-year increase in new orders [4] - The company has achieved larger display viewing angles for VPD products and is promoting them to multiple automakers [4] - Huayang Group is reducing geopolitical risks by establishing subsidiaries in Thailand and Mexico [4]

Investment Rating - The investment rating for the company is "Buy" [3][8] Core Views - The company has demonstrated strong revenue growth, with a 76.29% year-on-year increase in revenue for 2024, reaching 3.558 billion yuan, and a 47.86% increase in the first quarter of 2025, amounting to 1.098 billion yuan [3][7] - The core product, Furmetin, has maintained high growth, with sales increasing significantly due to its inclusion in the national medical insurance reimbursement list, enhancing patient accessibility [4][8] - The company is actively expanding the indications for Furmetin and has successfully initiated overseas clinical trials, indicating a robust pipeline for future growth [5][6] Financial Performance Summary - In 2024, the company achieved a net profit of 1.430 billion yuan, a year-on-year increase of 121.97%, with a net profit of 410 million yuan in Q1 2025, up 34.13% [3][7] - Research and development expenses for 2024 were 482 million yuan, representing 13.53% of revenue, with a significant increase of 53.81% year-on-year [3] - The company forecasts net profits of 1.778 billion yuan, 2.032 billion yuan, and 2.650 billion yuan for 2025, 2026, and 2027 respectively, with corresponding EPS of 3.95, 4.52, and 5.89 yuan [8][10] Market Position and Product Pipeline - Furmetin has established a leading position in the EGFR-targeted therapy market for lung cancer, with sales growing from 236 million yuan in 2021 to 3.506 billion yuan in 2024 [4] - The company is set to launch the KRAS G12C inhibitor, Goleiras, which has received priority review for its NDA, indicating strong potential for future revenue growth [6][8]

Core Viewpoint - The report highlights the strong growth momentum of Ailis, particularly in the sales of Vomeitin, with significant increases in revenue and net profit exceeding expectations [1][2][3]. Financial Performance - In 2024, Ailis achieved a revenue of 3.558 billion yuan, a year-on-year increase of 76.29%, and a net profit attributable to shareholders of 1.430 billion yuan, up 121.97% [2]. - For Q1 2025, the company reported a revenue of 1.098 billion yuan, a year-on-year increase of 47.86%, and a net profit of 410 million yuan, up 34.13% [3]. - The overall gross margin for 2024 was 95.97%, with a slight decrease of 0.17 percentage points year-on-year, while the operating cash flow net amount was 1.566 billion yuan, an increase of 132.12% [3]. Clinical Development - Ailis is actively exploring the clinical advantages of Vomeitin, with several clinical trials underway for various indications, including first-line treatment for NSCLC with EGFR mutations [4]. - The company has received approvals for multiple clinical trials, including a Phase III trial for Vomeitin in patients with brain metastases [4]. Commercial Strategy - Ailis has a marketing team of over 1,200 people, covering 31 provinces and approximately 4,800 hospitals, enhancing its sales network for Vomeitin and other products [5]. - The company is accelerating the construction of a new production line with an annual capacity of 150 million tablets of Vomeitin, supporting its commercialization efforts [5]. Investment Outlook - Revenue projections for Ailis from 2025 to 2027 are 4.52 billion yuan, 5.38 billion yuan, and 6.12 billion yuan, representing year-on-year growth rates of 27.0%, 19.0%, and 13.7% respectively [6]. - The net profit attributable to shareholders is expected to be 1.59 billion yuan, 1.93 billion yuan, and 2.19 billion yuan for the same period, with corresponding growth rates of 11.4%, 20.9%, and 13.5% [6].

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Views - The company reported a significant increase in revenue and net profit, with 2024 revenue reaching 35.58 billion yuan, up 76.29% year-on-year, and net profit of 14.30 billion yuan, up 121.97% year-on-year [4][5] - The first quarter of 2025 also showed strong performance, with revenue of 10.98 billion yuan, a 47.86% increase year-on-year, and net profit of 4.10 billion yuan, up 34.13% year-on-year [5] - The company is actively expanding its clinical pipeline for its drug, Vumetini, with multiple clinical trials and approvals in progress, indicating a strong focus on lung cancer treatment [6][8] - The company is enhancing its commercialization efficiency and expanding production capacity, with a new production line for Vumetini expected to support sales growth [7][8] - Revenue projections for 2025 to 2027 are 45.2 billion yuan, 53.8 billion yuan, and 61.2 billion yuan, respectively, with corresponding net profits of 15.9 billion yuan, 19.3 billion yuan, and 21.9 billion yuan [8] Financial Summary - In 2024, the company achieved a gross margin of 95.97% and a net profit margin of 40.2% [5][10] - The projected revenue growth rates for 2025, 2026, and 2027 are 27.0%, 19.0%, and 13.7%, respectively [10] - The expected net profit growth rates for the same period are 11.4%, 20.9%, and 13.5% [10] - The company's return on equity (ROE) is projected to be 27.1% in 2024, decreasing to 22.4% by 2027 [10]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" [2] Core Viewpoints - The report anticipates a recovery in the pharmaceutical sector in Q2 2025, with a focus on innovative drugs, AI healthcare, and consumer healthcare [2][17] - The report highlights that 52% of pharmaceutical companies have disclosed their Q1 2025 performance, with 35% showing growth in both revenue and net profit [13][17] - The report suggests that the pharmaceutical sector is expected to experience performance recovery due to the gradual digestion of policy impacts and the revival of both inpatient and outpatient markets [17] Summary by Sections 1. Industry Overview - The pharmaceutical and biotechnology sector's weekly return was 1.16%, ranking 15th among 31 primary sub-industry indices [11] - The medical services sub-sector had the highest weekly increase of 3.38%, while the bioproducts sub-sector saw a decline of 0.93% [11][31] 2. Performance and Valuation of the Pharmaceutical Sector - The pharmaceutical industry index's current PE (TTM) is 26.25 times, which is below the historical average of 31.15 times [21][24] - The report indicates that the pharmaceutical sector's performance over the last month was -2.19%, with a relative performance of 1.51% compared to the CSI 300 index [27] 3. Market Tracking - The report notes that the chemical pharmaceutical sub-sector had the highest one-year increase of 12.82%, while the pharmaceutical commercial sub-sector experienced the largest decline of 14.33% [34] - The report also highlights that the medical services sub-sector had the highest weekly increase of 3.38% [40] 4. Industry and Company Dynamics - The report discusses recent policy developments, including the implementation plan for the digital transformation of the pharmaceutical industry from 2025 to 2030, aiming for comprehensive digital transformation by 2030 [12][49] - It also mentions significant company announcements, such as clinical trial approvals for various innovative drugs [51]

Investment Rating - The report assigns an "Outperform" rating to the company [1][8]. Core Views - The company is expected to achieve net profits attributable to shareholders of 1.77 billion RMB, 2.07 billion RMB, and 2.56 billion RMB for the years 2025, 2026, and 2027, respectively, representing year-on-year growth of 23.6%, 17.3%, and 23.4% [8]. - The projected earnings per share (EPS) for 2025 and 2026 are 3.93 RMB and 4.60 RMB, respectively [8]. - The target price is set at 102.08 RMB, based on a price-to-earnings (PE) ratio of 26 times for 2025 [1][8]. Financial Summary - In 2024, the company achieved revenue of 3.56 billion RMB, a year-on-year increase of 76.29%, and a net profit attributable to shareholders of 1.43 billion RMB, up 121.97% year-on-year [9]. - For Q1 2025, revenue was 1.10 billion RMB, reflecting a 47.86% year-on-year growth, with a net profit of 410 million RMB, up 34.13% year-on-year [9]. - The sales revenue from Fumetinib in 2024 was 3.51 billion RMB, marking a 77.27% increase year-on-year [10]. Research and Development Progress - Fumetinib continues to see volume increases, with multiple indications in clinical stages [10]. - In July 2024, the Phase III clinical trial IND for treating EGFR mutation-positive non-squamous NSCLC with brain metastases was approved [10]. - The Phase III clinical trial IND for Fumetinib versus placebo in EGFR non-classical mutation NSCLC post-surgery was approved in January 2025 [10]. - Goralatib's new drug application for KRAS G12C mutation second-line NSCLC received Priority review status in May 2024 [11].