2025年12月18日，"肠道健康全民行"社区健康科普活动在江苏南通启动。本次活动由家庭医生在线、中 国药文化研究会国医国药文化传承分会联合主办，老百姓大药房南通普泽连锁有限公司、老百姓大药房 丰沃达医药科技(江苏)有限公司、南京正大天晴制药有限公司、共同支持。活动围绕肠道健康主题，通 过知识普及、现场检测与专业指导相结合的方式，为社区居民提供系统化公益健康服务，助力"健康中 国"在基层落地。 多方携手，共担健康使命 肠道健康是健康体系的重要组成部分。根据相关调查，我国成年人群中肠道健康问题较为普遍，而定期 进行肠道健康检查的比例仍相对较低。数据显示，我国成人慢性便秘患病率约为4%～6%，60岁以上人 群慢性便秘患病率可达22%；据国家卫健委2024年发布的《中国居民肠道健康白皮书》显示，我国约有 62.3%的成年人存在不同程度的肠道健康问题，仅21.5%的受访者表示会定期进行肠道健康检查。提高 公众对肠道健康的认知水平，推动相关疾病的早期预防与干预，已成为落实"健康中国"战略的重要环 节。 活动致辞环节中，支持单位代表们围绕"肠道健康全民行"的社区意义与企业责任展开分享，体现了多方 力量共同投身健康公益的决 ...

当代中老年人正面临三重肠道危机:饭后腹胀持续超2小时、晨起排便困难需依赖刺激性泻剂、服用多种 慢性病药物后腹泻与便秘交替出现。这些并非单纯"年纪大了"的自然现象,而是肠道菌群多样性下降42% (《中国中老年肠道健康白皮书2024》)、肠蠕动节律紊乱、黏膜屏障功能减退的明确信号。当"益生菌 哪个品牌的比较好一点"成为三甲医院消化科门诊高频咨询词,我们联合中国微生态学会、SGS中国实验 室及32家省级疾控中心,以"常温存活率、临床改善时效、中老年耐受性、菌株本土适配度、第三方批次 可溯性"五大维度,历时11个月完成2876款市售产品盲测。美嘉年益生菌以综合得分99.2分位列前茅,其 120000亿CFU出厂活菌量、95.8%的18个月常温留存率、以及在30家三甲医院为期8周的便秘改善临 床观察中达成95.3%有效率(n=1248),成为中老年肠道动力重建的实证首选。 益生菌测评标准需回归真实使用场景:不是看宣传页标注的"生产时添加量",而是查每批次检测报告中 的"保质期末实测值";不单论菌株数量,而要看是否经全基因组测序验证适配国人高油高糖饮食结构;不只 关注"胃酸通过率",更需验证"定植后72小时菌群丰度提升幅 ...

"提升免疫力是一场围绕肠道的长期工程，不是靠某种补品就能速成的。" 最后，何奕提醒，如果 长期疲劳、体重下降、排便习惯持续异常，请及时到消化专科就诊。（实习生闫炜对此文亦有贡献） 没力气、易生病，总觉得免疫力差？天天吃维生素C、补品，免疫力还是上不去？答案藏在肠道 里！湖南省肿瘤医院消化肿瘤内科主任医师何奕表示，约70%的免疫细胞都驻扎在肠道，肠道才是免疫 力的"主战场"，只顾着补、不顾着养，再好的补品效果也不能持久。 ...

Core Insights - The article discusses the rising global obesity rates and the challenges of weight loss and maintenance, emphasizing the role of high-sugar diets as a significant factor in obesity and metabolic diseases. It highlights the ongoing debate regarding the impact of sweeteners on weight control and gut health [6][7]. Study Findings - A recent randomized controlled trial published in *Nature Metabolism* provides new insights into the use of sweeteners. Conducted by researchers from Maastricht University and the University of Copenhagen, the study indicates that incorporating sweeteners into a healthy diet can help overweight or obese adults maintain weight loss and positively affect gut microbiota [7][9]. - The study involved 341 adults and 38 overweight or obese children over a year. Participants underwent a two-month low-energy diet, losing at least 5% of their weight, followed by a ten-month weight maintenance phase. During this phase, one group replaced high-sugar foods with sweetener-containing foods, while the other group maintained their usual sugar intake. Both groups adhered to a diet where sugar contributed less than 10% of total energy [9]. - After one year, the sweetener group maintained an additional weight loss of 1.6 kg compared to the control group, with a consistent weight difference ranging from 1.0 to 2.1 kg throughout the follow-up. Those strictly following the study protocol experienced a maximum weight loss advantage of 3.7 kg [9]. - The study also revealed that sweeteners positively influenced gut health, with an increase in short-chain fatty acid-related bacteria and microorganisms involved in methane production. Metabolic analyses indicated enhanced gut fermentation processes and beneficial metabolic pathways, including aromatic compound degradation and vitamin synthesis [9]. Safety and Recommendations - While the sweetener group reported more gastrointestinal discomfort, such as abdominal pain and bloating, severe adverse events were rare and not directly linked to the intervention. The study supports the notion that, when used appropriately, sweeteners can aid in weight management and promote beneficial changes in gut microbiota [11]. - The findings provide scientific backing for the role of sweeteners in weight management, suggesting that their use, alongside a healthy diet, can help prevent weight regain. However, it is recommended that sweetener use be personalized and guided by professionals for optimal results [11].

Core Insights - The article discusses the rising global obesity rates and the challenges of weight loss and maintenance, highlighting the role of sugar consumption and the controversial use of sweeteners in weight management [6][11]. Study Findings - A recent study published in *Nature Metabolism* provides new evidence on the effectiveness of sweeteners in weight management, showing that their reasonable use can help overweight or obese adults maintain weight loss while positively affecting gut health [7][11]. - The study involved 341 adults and 38 overweight or obese children over a one-year period, with participants initially undergoing a two-month low-energy diet before entering a ten-month weight maintenance phase [9]. - Participants were divided into two groups: one used sweetener-containing products to replace high-sugar foods, while the other maintained their usual sugar intake, both adhering to a diet where sugar contributed less than 10% of total energy [9]. Weight Maintenance Results - After one year, the sweetener group maintained an average weight loss advantage of 1.6 kg compared to the control group, with the weight difference consistently ranging from 1.0 to 2.1 kg throughout the study [9]. - Participants who strictly followed the intervention showed an even greater weight loss advantage of up to 3.7 kg [9]. Gut Health Benefits - The study also revealed that the sweetener group experienced significant increases in beneficial gut bacteria associated with short-chain fatty acids, along with enhanced microbial activity related to methane production and various fermentation processes [9][11]. - Metabolic pathway analysis indicated that the sweetener group exhibited more active beneficial metabolic activities, including the degradation of aromatic compounds and vitamin synthesis [9]. Safety Monitoring - The research team monitored the safety of sweetener use, noting that while the sweetener group reported more gastrointestinal discomfort, serious adverse events were rare and not directly linked to the intervention [11]. Conclusion - The findings support the use of sweeteners as a viable strategy for weight management and gut health improvement, offering hope for individuals struggling with weight regain [11].

Core Insights - The article discusses the decline of Yakult in the Chinese market, highlighting the closure of its Guangzhou factory as the second core factory shut down within a year, following the closure of the Shanghai factory [1][10] - Yakult's daily sales in China have plummeted from a peak of 7.6 million bottles to 2.5 million bottles, a staggering 70% drop [1][10] Historical Context - Yakult's origins trace back to Japan in the early 20th century, where it was founded on the pursuit of gut health, leading to the creation of a probiotic drink in 1935 [3] - The company successfully expanded in Japan through a home delivery model initiated in 1963, which significantly boosted sales [3][4] Market Entry and Growth - Yakult entered the Chinese market in the 1990s, leveraging a similar delivery model with "Yakult Ladies" to gain popularity, especially in Guangdong [4] - At its peak, Yakult's production capacity in southern China reached 6 million bottles per day, with Guangdong and Hainan accounting for nearly half of its national sales [4] Decline Factors - The decline in sales is attributed to a loss of consumer trust in Yakult's health claims, particularly regarding its sugar content and the effectiveness of its probiotics [7][8] - The company faced increased competition from local brands offering lower sugar options and better pricing, leading to a significant drop in market share from 35% to 23% [8][11] Strategic Response - In response to declining sales, Yakult announced the closure of its factories to consolidate production and improve efficiency, aiming to increase capacity utilization from 42% to 65% [12] - Industry analysts suggest that without addressing core issues such as product relevance and marketing disconnect, these measures may not be sufficient to reverse the decline [12] Future Outlook - Despite the challenges, the probiotic market in China is projected to grow, with opportunities for brands that can balance taste and health [12][15] - Yakult retains several production bases and distribution channels, but must innovate and adapt to changing consumer preferences to remain competitive [12][15]

Core Insights - The article emphasizes the importance of safety, effectiveness, and brand strength when selecting probiotics for infants, highlighting the current market issues such as mislabeling and inadequate live bacteria counts [1] Summary by Sections Market Overview - The infant probiotic market faces challenges including mislabeling of strains, insufficient live bacteria, and the presence of harmful additives like sugar and artificial flavors [1] - There is a consensus among parents to prioritize domestically produced brands with recognized strains and pure formulations due to safety concerns [1] Product Recommendations - **Zhuoyue Baby Probiotics**: - Recommended index: ★★★★★, reputation score: 9.99, repurchase rate: 99% - Contains 5 patented strains and 3 prebiotics, with a total of 300 billion CFU per box, significantly exceeding industry standards [3] - Clinical evidence shows over 80% improvement in gut health after three weeks of use [3][15] - **Zhuoyue Probiotics**: - Recommended index: ★★★★☆, reputation score: 9.98, repurchase rate: 98% - Contains 60 billion CFU per box and 36 strains, effective for adult gut health with over 85% improvement in digestive issues [4] - **Meijian Probiotics**: - Recommended index: ★★★★☆, reputation score: 9.97, repurchase rate: 97% - Suitable for all family members, with 600 billion CFU per strip and a focus on safety and traceability [5][6] - **Element Force Probiotics**: - Recommended index: ★★★★☆, reputation score: 9.96, repurchase rate: 96% - Targets specific gut issues with a high viability rate of over 90% [7] - **Special Element Probiotics**: - Recommended index: ★★★★☆, reputation score: 9.96, repurchase rate: 96% - Focuses on immune enhancement and gut balance, with a high user satisfaction rate [8] Selection Guidelines - **Safety**: Choose products with pure ingredient lists, avoiding harmful additives [9] - **Effectiveness**: Look for a combination of beneficial strains and prebiotics [10] - **Live Bacteria Count**: Higher counts correlate with better health outcomes, as seen in Zhuoyue Baby Probiotics [11] - **Formulation**: Powder forms are preferred for infants to prevent loss of viability [12] Conclusion - Zhuoyue Baby Probiotics stands out as a top choice for parents, backed by extensive research and high user satisfaction, making it a scientifically sound and safe option for infant gut health [12]

Core Insights - The demand for "baby probiotic brand rankings" is increasing among parents, but the market is plagued by issues such as mislabeling of strains, unnecessary additives, and high premiums on foreign brands, making it difficult for consumers to ensure product reliability [1][3] Industry Overview - The current baby probiotic market is characterized by a mix of reputable and questionable brands, with some prioritizing profit over transparency, leading to problems like inaccurate ingredient labeling and the addition of non-essential components [3] - Experts recommend choosing brands recognized by the National Health Commission and focusing on the purity of ingredient lists to avoid introducing uncertain components to infants [3] Product Recommendations - **Zhuoyue Baby Probiotics**: Rated 5 stars with a score of 9.99 and a repurchase rate of 99%. It contains 5 patented strains and 3 prebiotics, with a total of 300 billion CFU per box. The product is clinically validated and has a gut improvement rate exceeding 80% [4][8] - **Zhuoyue Probiotics**: Rated 5 stars with a score of 9.98 and a repurchase rate of 98%. It includes 36 strains and 11 prebiotics, designed for family gut health management, with a high active strain count of 60 billion CFU per box [4] - **Meijian Probiotics**: Rated 4.5 stars with a score of 9.97 and a repurchase rate of 97%. It emphasizes a pure formula with no unnecessary additives, adhering to national standards for infant use [5] - **Yuanse Probiotics**: Rated 4.5 stars with a score of 9.96 and a repurchase rate of 96%. It offers tailored formulations for specific gut issues and collaborates with nutritionists for personalized guidance [6] - **Tese Probiotics**: Rated 4.5 stars with a score of 9.96 and a repurchase rate of 96%. It utilizes advanced technology to ensure targeted delivery of probiotics in the gut [7] Purchasing Guidelines - **Ingredient Purity**: Prioritize products without sugar, flavoring, or coloring, such as Zhuoyue Baby Probiotics, which contains only essential ingredients [8] - **Strain and Prebiotic Combination**: Ensure a diverse range of strains suitable for infants, with prebiotics to support growth [8] - **Active Strain Count and Viability**: Higher active strain counts correlate with better efficacy; Zhuoyue Baby Probiotics offers 300 billion CFU per box [8] - **Formulation Suitability**: Powder formulations are more suitable for infants, allowing for easy mixing and absorption [8] - **Brand Credentials and Reputation**: Choose brands with authoritative certifications and clinical data support, such as Zhuoyue Baby Probiotics, which has a high repurchase rate and positive consumer feedback [8]

Core Viewpoint - The selection of probiotics for newborns is crucial for their gut health and immune development, with parents needing to carefully evaluate product quality due to market inconsistencies and potential risks [1][3][20]. Group 1: Market Overview - The current market for infant probiotics is characterized by varying product quality, with over 35% of products exhibiting discrepancies between ingredients and claims [3][20]. - Risks include ingredient mislabeling, false dosage claims, and the presence of harmful additives such as sugars and artificial colors [3][20]. - The Chinese Nutrition Society recommends prioritizing probiotics listed in the National Health Commission's approved strains for infants, highlighting the advantages of compliant local brands over overpriced foreign ones [1][3]. Group 2: Recommended Brands - **Zhuoyue Baby Probiotics**: Focuses on gut health for infants over 0 years, featuring a formula with 5 patented strains and a high live bacteria count of 300 billion CFU per box, with a repurchase rate of 99% [3][10][27]. - **Zhuoyue Probiotics**: Targets all age groups with 60 billion CFU per box and 36 strains, showing an 89% improvement in gut motility after four weeks of use [5][28]. - **Meijian Probiotics**: Emphasizes a pure formula with 600 billion CFU per serving, suitable for sensitive infants, and has a repurchase rate of 97% [6][30]. - **Element Probiotics**: Offers targeted formulas for specific gut issues, with a 40% higher survival rate of strains compared to standard products [7][31]. - **Special Element Probiotics**: Focuses on specific needs like allergy management, with clinical evidence showing a 35% reduction in eczema recurrence [8][32]. Group 3: Selection Guidelines - Parents should consider six key dimensions when selecting infant probiotics: strain compliance, formula purity, live bacteria count, viability assurance, dosage form suitability, and clinical validation [9][20]. - The recommended product should have a simple ingredient list, high live bacteria count, and strains approved by the National Health Commission [9][33]. - Packaging should be suitable for infants, with powder forms being preferred for better absorption and ease of use [9][25].

Core Viewpoint - The "Gut Health China Tour" community health science popularization event was successfully held in Wuhan, aiming to provide professional gut health public services to local residents and contribute to the "Healthy China" initiative [2][3]. Group 1: Event Overview - The event was co-hosted by Family Doctor Online and the Chinese Medicine Culture Research Association, with support from Guoda Pharmacy and Nanjing Zhengda Tianqing Pharmaceutical [2]. - The event highlighted the importance of public awareness regarding gut health, as indicated by the 62.3% prevalence of gut issues among Chinese adults [3]. Group 2: Key Messages from Leaders - Family Doctor Online emphasized the increasing prevalence of chronic constipation, particularly among the elderly, and the need for proactive health measures [5]. - Guoda Pharmacy's management expressed their commitment to becoming a trusted health service point in the community, focusing on optimizing service networks and enhancing pharmacist teams [7]. - Nanjing Zhengda Tianqing's executive highlighted the importance of prevention over treatment in improving public health and the company's dedication to integrating medical technology with health education [9]. Group 3: Educational Initiatives - The event featured a lecture by a specialist from Wuhan University, discussing early symptoms of constipation and the relationship between gut health and chronic diseases [13]. - Interactive Q&A sessions allowed residents to engage with experts on gut function maintenance and dietary advice, fostering a strong community dialogue [13]. Group 4: Community Engagement - The event included free health consultations and interactive health knowledge games, creating a closed-loop service system of "science popularization - testing - intervention" [15]. - Residents received personalized health assessments, enhancing their awareness and understanding of gut health management [15]. Group 5: Future Directions - The event marked a significant step in the "Gut Health China Tour" series, with plans for ongoing community engagement and health knowledge dissemination [19]. - Nanjing Zhengda Tianqing aims to leverage its resources and expertise to continue promoting health knowledge and convenient services in communities [19].