Core Viewpoint - The article discusses three assets that have seen significant growth in the first half of 2025: gold, innovative pharmaceuticals, and Pop Mart, highlighting their performance and potential for future investment [1][2]. Group 1: Asset Performance - Gold has increased by approximately 30% over the past six months [1]. - The innovative pharmaceutical index in the A-share market has risen by 20%, while the Hong Kong innovative pharmaceutical index has surged by 50% [1]. - Pop Mart has experienced an extraordinary increase of 220% in the Hong Kong market over the same period [1]. Group 2: Wealth Consensus - The ability of an asset to sustain growth is largely dependent on whether it is recognized as a wealth consensus by society [3]. - Real estate has historically been the strongest wealth consensus over the past 20 years, leading to significant appreciation and investment returns [5]. - Innovative pharmaceuticals are seen as a potential growth sector but lack the broad societal consensus that real estate once had [7]. - Pop Mart does not meet the criteria for wealth consensus, as its appeal is limited to a niche market and lacks widespread understanding and acceptance [8][9]. Group 3: Value Assessment - The article emphasizes the importance of distinguishing between value overshooting and value recovery when assessing asset price movements [14]. - Gold and innovative pharmaceuticals are viewed as undergoing a value recovery process, with gold's price being suppressed historically by the strength of the dollar [16][17]. - The innovative pharmaceutical sector is experiencing upward momentum due to previously low valuations and strong performance exceeding expectations [18][19]. - In contrast, Pop Mart is characterized as experiencing value overshooting, with unsustainable price increases leading to anticipated corrections [20]. Group 4: Investment Recommendations - The article suggests that gold is the most stable asset among the three, with innovative pharmaceuticals following, while Pop Mart is expected to face significant corrections [23][24]. - It is recommended that investors allocate the majority of their funds to stable income-generating assets rather than seeking short-term high returns [25]. - Investors are encouraged to consider gold and high-interest deposit-type assets for more secure investment strategies [26].

近期创新药行情如火如荼，这里到底是为何呢？ 截至 5 月，全球大型跨国药企引进的创新药项目中，42% 来自中国企业，交易总金额超 370 亿美元（接近 2023 年全年水平）。 技术追赶。ASCO大会中国医药公司表现非常的亮眼， 中国药企贡献 73 项口头报告，首次有 11 项入选 "最新突破摘要"（LBA），涵盖肿瘤免疫、ADC 等前沿领域，与跨国药企同台竞 技。 这个抢了大部分海外头部医药公司的风头创新药企业 出海战略的成功不仅带来现金流（如首付 款和里程碑收入），更通过国际多中心临床试验（如 ASCO 会议上 73 项口头报告）提升品 牌影响力，为后续产品出海奠定基础。 其实可以拆分成主要的三个原因： 政策支持。 2024年出台的《全链条支持创新药发展实施方案》为创新药产业构建了覆盖从研 发到商业化的系统性支持体系，尤其突出价格机制、医保支付与商业保险三大核心环节的协同 作用 。 这个简单说就是要保证创新药企业卖药有钱可赚；将创新药进入医保名单的速度加快， 快速通 道进入医保谈判，显著缩短上市后放量周期 。 除此之外， 优先审评审批政策持续推进，如 5 月 29 日单日获批 11 款创新药（含 7 款 ...

政策支持。 2024年出台的《全链条支持创新药发展实施方案》为创新药产业构建了覆盖从研 发到商业化的系统性支持体系，尤其突出价格机制、医保支付与商业保险三大核心环节的协同 作用 。 这个简单说就是要保证创新药企业卖药有钱可赚；将创新药进入医保名单的速度加快， 快速通 道进入医保谈判，显著缩短上市后放量周期 。 近期创新药行情如火如荼，这里到底是为何呢？ 其实可以拆分成主要的三个原因： 截至 5 月，全球大型跨国药企引进的创新药项目中，42% 来自中国企业，交易总金额超 370 亿美元（接近 2023 年全年水平）。 技术追赶。ASCO大会中国医药公司表现非常的亮眼， 中国药企贡献 73 项口头报告，首次有 11 项入选 "最新突破摘要"（LBA），涵盖肿瘤免疫、ADC 等前沿领域，与跨国药企同台竞 技。 这个抢了大部分海外头部医药公司的风头创新药企业 出海战略的成功不仅带来现金流（如首付 款和里程碑收入），更通过国际多中心临床试验（如 ASCO 会议上 73 项口头报告）提升品 牌影响力，为后续产品出海奠定基础。 最后划重点 ： 在政策，流动性，业绩层面边际好转的影响下，造成了从年初到现在创新药 ETF是市场 ...

当前如何看创新药 - 对话汇丰晋信李博康 20250618 摘要 汇丰晋信医疗先锋基金致力于捕捉中国内地和香港医疗先锋主题股票市 场的投资机会，均衡配置 A 股和港股，大约各占 50%。 创新药领域虽短期波动，但整体趋势向好，多家公司开始盈利，商业模 式确定性增强，吸引非医药投资者关注。 美国肿瘤大会期间，多家头部创新药公司在 BD 方面取得超预期成果， 获得海外大公司青睐，展现持续超预期能力。 未来一年以上维度内，医药行业尤其是创新药领域将继续修复并上涨， 国内估值底部稳固，商业确定性增强。 传统药企的重估远未结束，业绩稳健增长，利润增速可达 15-20%以上 且可持续，创新实力及国际化经验尚未被市场充分认可。 当前医药基金主要配置思路包括创新型医药资产、转型中的老牌传统制 药企业和自下而上的阿尔法型个股，均衡配置可有效控制风险并实现收 益最大化。 国产创新药具备"又快又好又便宜"的优势，与海外大型药企的需求形 成完美匹配，BD 合作预计不会很快降速。 Q&A 汇丰晋信医疗先锋基金今年以来的表现如何？ 截至 2025 年 6 月 17 日，汇丰晋信医疗先锋基金今年以来的收益率约为 50%，跑赢业绩基准 40 ...

张韡布局创新药已久。在2023年的季报中，她关注全球NASH、老年痴呆、ADC、减肥药等领域的突破性进展， 判断全球创新有望迎来新周期，于是布局了创新药企业以及传统仿制药公司转型创新药成功的潜在标的。 | Wind代码 | 证券简称 | 2025-01-01到 2025-06-17 | 现任基金经理 | 基金公司 | | --- | --- | --- | --- | --- | | | | 复权单位净值 | | | | | | 相长率(X) | | | | 470888.OF | 汇添富香港优势精选A | 98.66 | 张峰 | 汇漆富基金 | | 022286.OF | 长城医药产业精选A | 75.69 | 梁福睿 | 长城基金 | | 016303.OF | 中信建投北交所精选两年定开A | 74.00 | 冷文鹏 | 中信建投基金 | | 015915.OF | 永赢医药创新智选A | 70.80 | 储可凡,单林 | 永赢基金 | | 020397.OF | 中银港股通医药A | 69.80 | 第宁 | 中银来金 | | 014283.OF | 华夏北交所创新中小企业精选两年定开 | 67.6 ...

Core Insights - The pace of Jiangsu's innovative pharmaceuticals "going global" has significantly accelerated in 2023, with companies like Innovent Biologics, Hengrui Medicine, WuXi Biologics, and Zai Lab achieving international licensing agreements [1][2] - The successful internationalization of these innovative drugs not only benefits global patients but also accelerates the upgrade of Jiangsu's biopharmaceutical industry [1] - By 2024, 20 listed companies in Jiangsu's chemical pharmaceuticals, biological products, and traditional Chinese medicine sectors reported overseas revenues totaling approximately 6.8 billion yuan, accounting for 20% of total revenue [2] Group 1: Key Developments in International Collaborations - Innovent Biologics announced a collaboration with Roche for global development and commercialization rights of a new drug, marking a significant milestone for Chinese innovative drugs in 2025 [1] - WuXi Biologics entered a research service collaboration with a U.S. company, receiving an upfront payment and potential milestone payments totaling up to $925 million [1] - Hengrui Medicine has completed 14 external licensing collaborations, with 9 occurring in the last three years, including partnerships with major international pharmaceutical companies [3] Group 2: Trends and Strategies in Going Global - The mainstream models for Chinese pharmaceutical companies to go global include "self-going," "borrowing a ship," "lightweight approach," and "glorious exit" [4][5] - The "borrowing a ship" model, which involves licensing out drugs to multinational companies, is currently the most prevalent, allowing companies to receive upfront payments and milestone payments without directly participating in overseas operations [5] - The "NewCo" model, where companies establish new overseas entities to manage specific pipelines, has gained traction, providing flexibility and independence in adapting to different international markets [6] Group 3: Challenges in International Expansion - Chinese innovative drug companies face significant challenges in market access, pipeline valuation, global competition, and talent deployment when entering overseas markets [7] - Regulatory hurdles, particularly in the U.S. and EU, complicate the approval processes for clinical trials and drug registrations, posing barriers to entry for Chinese firms [7][8] - Many companies have struggled with patent issues, lacking early international patent strategies, which has hindered their commercialization efforts abroad [8] Group 4: Supportive Policies and Future Outlook - Local governments are actively constructing policy support systems to facilitate the internationalization of Jiangsu's innovative drugs and medical devices [9] - Initiatives include optimizing import and export management for biopharmaceuticals and encouraging participation in global business development activities [9] - Companies are optimistic about the future, with expectations for improved regulatory frameworks and collaborative mechanisms to streamline drug approval processes in key markets [10]

Group 1 - The innovative drug sector has become a focal point in the capital market since 2025, with Hong Kong's innovative drug index showing strong performance, increasing over 60% year-to-date and achieving record trading volumes [1] - Policy incentives and improvements in the industry fundamentals are driving this performance, including accelerated drug approvals and optimization of the medical insurance payment system [2] - The collaboration between domestic companies and international firms, such as the $60.5 billion partnership between 3SBio and Pfizer, highlights the growing international competitiveness of Chinese innovative drugs [2] Group 2 - Despite the long-term positive outlook, short-term volatility risks are present, with some stocks experiencing high price-to-sales ratios and potential profit-taking pressures [3] - The trading congestion in the innovative drug sector reached 3.9% as of June 13, indicating a high level of market activity and potential for significant corrections [3] - Uncertainties in drug development, geopolitical tensions, and currency fluctuations could impact the sector, with risks of clinical trial failures and regulatory changes affecting company valuations [3] Group 3 - The innovative drug index is expected to experience increased differentiation, with leading companies likely to maintain their advantages while weaker firms may lag behind [4] - Investors should focus on performance verification periods and policy developments, such as improvements in the medical insurance payment mechanism and the expansion of the Hong Kong 18A listing [4] - The innovative drug sector is positioned at the intersection of industry cycles and policy benefits, with long-term growth potential driven by international expansion and technological advancements [4]

Group 1 - The Hang Seng Healthcare Index (HSHCI) decreased by 1.12% as of June 18, 2025, with mixed performance among constituent stocks [3] - The top-performing stocks included Sipai Health (00314) up by 8.93%, and Health Road (02587) up by 6.54%, while MicroBrain Science (02172) led the decline at 4.25% [3] - The Hang Seng Healthcare ETF (513060) fell by 0.54%, with a latest price of 0.56 yuan and a turnover rate of 9.23% [3] Group 2 - The 85th American Diabetes Association (ADA) Scientific Sessions will take place from June 20-23, 2025, in Chicago, focusing on GLP-1 agonists as a research hotspot [3] - Chinese pharmaceutical companies are innovating around GLP-1 targets, including long-acting GLP-1 agonists and oral small molecule GLP-1 agonists [3] Group 3 - According to Aijian Securities, there is uncertainty in the US-China competition, but domestic "hard technology" and "strong demand" should be prioritized, particularly in innovative drugs [4] - The Hang Seng Healthcare ETF's latest scale reached 8.055 billion yuan, ranking in the top third among comparable funds [4] Group 4 - As of June 17, 2025, the Hang Seng Healthcare ETF had a one-year Sharpe ratio of 1.91, ranking in the top half among comparable funds [5] - The ETF's management fee is 0.50%, and the custody fee is 0.15% [5] Group 5 - The top ten weighted stocks in the Hang Seng Healthcare Index account for 58.13% of the index, with notable companies including Innovent Biologics (01801) and BeiGene (06160) [6]

Investment Rating - The report rates the pharmaceutical and biotechnology industry as "Outperform" compared to the market [1]. Core Insights - The innovative drug market is expanding, with a notable performance in the pharmaceutical sector, which outperformed the CSI 300 index by 1.40% during the week of June 9-15, 2025 [2][5]. - The driving force behind the current bull market in innovative drugs is the significant improvement in China's pharmaceutical innovation capabilities, with a focus on international collaboration and market expansion [2][10]. - The report emphasizes the importance of focusing on core competitive areas and industry catalysts, particularly in ADC and PD-1 bispecific antibodies, as well as the upcoming ADA 2025 conference showcasing innovative weight-loss drugs [15][18]. Summary by Sections Market Overview - The pharmaceutical sector has shown resilience, with a 1.40% increase, ranking 5th among 31 sectors, while the CSI 300 index decreased by 0.25% [2][5]. - The innovative drug market is experiencing a broad expansion, with significant interest in weight-loss drugs and other innovative therapies [2][10]. Investment Opportunities - The report identifies key areas for investment, including ADC and PD-1 bispecific antibodies, which have potential for international business development (BD) [15][10]. - Companies such as Mawei Biotech, Lepu Biotech, and others are highlighted for their potential in the ADC space, while companies like Zai Lab and Junshi Biosciences are noted for their PD-1 bispecific antibodies [15][10]. - The upcoming ADA 2025 conference is expected to be a significant event for showcasing innovative weight-loss drugs, with companies like Innovent Biologics and Zhenge Biopharma being of particular interest [18][20]. Industry Trends - The report discusses the shift in profit models for Chinese pharmaceutical companies, moving from low-margin raw material exports to high-margin new drug development collaborations with multinational corporations (MNCs) [14][10]. - The report anticipates that the innovative drug market will continue to grow, driven by advancements in research and development capabilities and increasing global recognition of Chinese pharmaceutical innovations [10][16]. Upcoming Events - The 85th ADA Scientific Conference is scheduled for June 20-23, 2025, and is expected to highlight significant advancements in GLP-1 receptor agonists and other innovative therapies [18][20]. - Key data releases from companies like Eli Lilly and others regarding their innovative weight-loss drugs are anticipated during this conference [20][25].

Group 1 - The core viewpoint is that the systematic valuation increase in the innovative drug sector is the biggest catalyst for the return of investment in the pharmaceutical and biotechnology industry, primarily due to the recognition of the business models of Chinese innovative drug companies [1] - Leading companies have entered a profit stage, with their R&D pipelines being transformed into regular income through business development (BD), pushing the innovative pipeline into a systematic valuation phase [1] - The trend of going global is significant, with domestic upfront payments for foreign cooperation and licensing transactions exceeding 2.5 billion USD in 2025, totaling over 50 billion USD, reaching last year's total level [1] Group 2 - Among the global drugs with sales exceeding 5 billion USD, products with patents expiring or nearing expiration before 2030 have sales close to 200 billion USD, creating a substantial patent cliff gap that drives multinational corporations' BD enthusiasm [1] - The industry has reached a turning point, with leading biotech companies starting to profit and officially entering a new stage of business model validation [1] - Technological innovation is driving the industry upward and facilitating outbound BD, with China leading in innovative drug development in areas such as ADC, bispecific and multi-specific antibodies, second-generation IO, and GLP-1, as numerous innovative products begin to yield data [1] Group 3 - The vaccine ETF (code: 159643) tracks the vaccine biotechnology index (code: 980015), which is compiled by China Securities Index Co., Ltd., selecting listed companies involved in vaccine R&D, production, and related biotechnology businesses from the A-share market [1] - The index focuses on the vaccine and biotechnology sectors within the biopharmaceutical industry, reflecting the overall performance of listed companies related to the vaccine industry chain [1]