Core Viewpoint - The Hong Kong medical sector is experiencing a strong upward trend, with the CSI Hong Kong Stock Connect Medical Theme Index showing significant gains, and the Hong Kong medical ETF demonstrating high liquidity and performance [1][5]. Group 1: Market Performance - As of September 5, 2025, the CSI Hong Kong Stock Connect Medical Theme Index (932069) has seen strong increases, with constituent stocks such as Zhaoyan Pharmaceutical, Kanglong Chemical, and Jingtai Holdings rising [1]. - The Hong Kong medical ETF (159366) has increased nearly 2%, with a 30% rise over the past 60 days and an average daily trading volume of 338 million [1]. - The top ten weighted stocks in the CSI Hong Kong Stock Connect Medical Theme Index account for 61.05% of the index, indicating a concentrated performance among leading companies [5]. Group 2: Sector Insights - The CRO/CMO segment is identified as the fastest-growing sub-sector, with a year-on-year growth rate of 12.6%, indicating a recovery from previous challenges [3]. - Chemical pharmaceuticals and CRO/CMO sectors have shown impressive non-GAAP net profit growth rates of 21.1% and 20.9% respectively, significantly outperforming the industry average decline of 13.3% [4]. - The current medical fund holdings are at a low level of 6.9%, suggesting potential for growth in investment allocations within the sector [4]. Group 3: Investment Sentiment - The market sentiment is bolstered by expectations of interest rate cuts from the Federal Reserve, which is favorable for interest-sensitive sectors [3]. - The industry is currently at a historical low in terms of valuation, with a price-to-earnings ratio (TTM) of 31 times, indicating potential for upward movement as innovation drives growth [4].

Group 1 - The pharmaceutical and biotechnology industry shows a trend of marginal improvement in mid-year performance, with segments such as chemical preparations, other biological products, pharmaceutical distribution, offline pharmacies, and medical research outsourcing experiencing revenue growth, particularly strong performance in medical research outsourcing [1] - Innovative drugs and supporting industry chains have demonstrated outstanding performance, with expectations for improved global biopharmaceutical investment and financing driven by anticipated interest rate cuts by the Federal Reserve by Q4 2025, maintaining a positive outlook on innovative drugs, CXO, and upstream life sciences industry chains [1] - The Vaccine ETF (159643) tracks the Vaccine Biotechnology Index (980015), which selects listed companies involved in biological products, life science tools, and services, focusing on vaccine research, production, and related industry chains to reflect the overall performance of listed companies in the biovaccine and related scientific technology fields [1] Group 2 - Investors without stock accounts can consider the Guotai Guozheng Vaccine and Biotechnology ETF Initiated Link A (017185) and Guotai Guozheng Vaccine and Biotechnology ETF Initiated Link C (017186) [1]

Group 1 - The medical sector is active, with the largest medical ETF (512170) reaching a peak price of 0.395 yuan, just 1 cent below the high of 0.396 yuan from September 24 of the previous year [1] - The ETF has seen a trading volume exceeding 720 million yuan, with a premium rate of 0.33% [1][3] - Key stocks in the ETF, including Huatai Medical, United Imaging, and WuXi AppTec, have shown significant gains, with increases of over 6%, 5%, and 4% respectively [2][3] Group 2 - The medical ETF (512170) passively tracks the CSI Medical Index, which has a current PE valuation of 36 times, still below 60% of the time over the past decade [3] - The recent China Medical Device Supervision International Conference emphasized support for high-end medical device innovation, with 52 innovative products approved this year [3] - The biopharmaceutical sector has shown marginal improvement in mid-year performance, with a 2% year-on-year increase in net profit for Q2 2025 [3]

Investment Rating - The report upgrades the revenue growth guidance for the year from 12%-15% to 14%-16% based on the strong performance in the first half of 2025 [5] Core Insights - The company achieved a revenue of 9.953 billion yuan in H1 2025, representing a year-on-year growth of 16.1%. The gross profit reached 4.253 billion yuan, with a gross margin of 42.7%, up by 3.6 percentage points year-on-year [1] - The growth was primarily driven by overseas markets, with North American revenue increasing by 20.1% to 6.018 billion yuan, while revenue from European clients grew by 5.7% to 1.969 billion yuan. However, revenue from Chinese clients declined by 8.5% to 1.297 billion yuan [2][3] - The company signed a record 86 new projects in H1 2025, including 9 "winning molecule" projects, indicating a robust project and order reserve [4][5] Financial Performance Summary - For H1 2025, the company reported a net profit attributable to shareholders of 2.339 billion yuan, a significant increase of 56.0% year-on-year. The adjusted net profit was 2.840 billion yuan, up by 11.6% [1] - The company expects to complete 25 PPQ projects in 2025, contributing to a strong growth foundation [4][5] - The financial projections for 2025-2027 indicate revenues of 21.503 billion yuan, 24.572 billion yuan, and 27.580 billion yuan, respectively, with net profits of 4.405 billion yuan, 5.082 billion yuan, and 5.756 billion yuan [6][7]

Core Insights - The article highlights the significant growth and strategic advancements of the company, Kingsoft, in the context of a rapidly evolving global environment, particularly in the innovative pharmaceutical sector [1][21] - The company has achieved remarkable financial results in the first half of 2025, with a substantial increase in revenue and profit, indicating strong operational resilience and growth potential [2][16] Financial Performance - In the first half of 2025, the company reported a revenue of $518.8 million, representing a year-on-year increase of 81.9% [2] - The gross profit reached $320.6 million, up 140.1% year-on-year, while the adjusted net profit from continuing operations surged to $178 million, a staggering increase of 509.6% [2] - The company’s cash reserves stood at $967 million as of June 30, 2025, providing a solid foundation for future research and development investments [2] Business Segments - **Life Sciences Services and Products**: This segment generated $247.6 million in revenue, a growth of 11.3% year-on-year, with a notable increase in the share of custom protein services [5][6] - **Biopharmaceutical CDMO**: The CDMO business saw a remarkable revenue increase of 511.1% to $246.9 million, driven by advancements in antibody protein drugs and cell gene therapy [10][11] - **Industrial Synthetic Biology Products**: Revenue in this segment reached $28.3 million, growing by 8.4% year-on-year, with strong performance in the enzyme market [13] - **Cell Therapy**: The company’s joint venture, Legend Biotech, reported net sales of approximately $439 million for CARVYKTI, marking a 136% increase, with expectations of reaching operational breakeven by the end of 2025 [14] Strategic Initiatives - The company is focusing on global expansion and automation, with plans to achieve full automation in its four major factories by the end of 2025, enhancing production efficiency and supply chain resilience [6][17] - Kingsoft is leveraging its technological advancements and strategic partnerships to enhance its market position and drive future growth [16][19] Market Outlook - The recovery of the innovative pharmaceutical market is expected to boost demand for CXO services, providing ongoing growth momentum for the company [16] - The company’s management is optimistic about future performance, projecting a revenue growth of 13%-15% for the life sciences business and maintaining a strong outlook for its other segments [18][19]

Core Viewpoint - WuXi AppTec reported strong H1 performance with revenue of 2.701 billion RMB, a year-on-year increase of 62.2%, and net profit of 746 million RMB, up 52.7%, with a net profit margin of 27.6% [1] Group 1: Financial Performance - Revenue for H1 reached 2.701 billion RMB, reflecting a 62.2% year-on-year growth [1] - Net profit increased to 746 million RMB, representing a 52.7% year-on-year growth [1] - Total uncompleted orders rose to 1.329 billion USD, marking a 57.9% year-on-year increase [1] Group 2: Market Drivers - The growth in H1 performance is attributed to the active development of the global antibody-drug conjugates (ADC) and broader bioconjugates market, leading to an increase in both customer and project numbers [1] - The company's solid position as a leading ADC CRDMO service provider has contributed to an increase in market share [1] - Steady progress of projects into later stages has also supported the growth [1] Group 3: Industry Trends - Recent positive developments in the CXO sector have led to the Hang Seng Medical ETF (159892) reaching a new high [1] - The Hong Kong Stock Connect Medical ETF (520510), which focuses on CXO and AI medical concepts, has seen over a 7% increase since its launch on August 7, with trading prices hitting new highs [1] - The sustained performance of leading companies like WuXi AppTec and WuXi Biologics has boosted market confidence in the CXO sector [1]

1. Report Industry Investment Rating - Not provided in the given content 2. Core Viewpoints of the Report - The Hong Kong innovative drug sector's valuation has not reached its peak and is below the 50% quantile. The industry is in a high - prosperity stage with improving performance in innovative drugs and CXO [1][11] - The innovative drug industry is entering a recovery phase in 2025, driven by industry trends, policies, and events. BD licensing of Chinese innovative drugs overseas is booming, indicating international recognition [2] - The Hong Kong Innovative Drug ETF (513120.OF) has advantages such as good liquidity, high - purity composition, and convenient trading, making it a good investment tool [4] 3. Summary by Directory 3.1 Value Analysis - **Valuation Level**: The PE of the China Securities Hong Kong Innovative Drug Index on August 8, 2025, was 45.73, below the 50% quantile (47.42x), indicating that the valuation of the Hong Kong innovative drug sector has not reached its peak [9] - **Performance Improvement**: The performance of innovative drugs (Biotech + Pharma) and CXO is improving. After ten batches of centralized procurement, innovative drug varieties of Pharma companies are becoming the main growth force, and leading biotech companies' products are rapidly expanding. CXO's performance is also rebounding due to the high - prosperity of the innovative drug track [11][13] - **Representative Companies**: Companies like BeiGene, Kelun Botai, and others have strong R & D capabilities, rich pipelines, and successful international cooperation experiences [20][23] - **Comparison between H - shares and A - shares**: H - shares have a larger scale, higher revenue, more listed Biotech companies, and lower valuations than A - shares. The proportion of innovative drugs in H - shares is also higher [36][39] 3.2 Industry Analysis - **Development Stages**: From 2015 - 2025, the innovative drug industry has gone through preliminary exploration (2015 - 2018), capital boom (2019 - 2021), deep adjustment (2022 - 2024), and recovery (2025) stages [2] - **Policy Support**: Policies have evolved from governance system innovation to continuous optimization and national - level support. Domestic policies have accelerated the approval process and improved the commercialization of innovative drugs through measures like optimizing the review and approval process and promoting医保access [2][60] - **Ecosystem Features**: The 18A channel in Hong Kong provides financing for unprofitable biotech companies. Overseas cooperation has led to the re - evaluation of innovative drug companies' valuations, with increasing cooperation between Chinese and international pharmaceutical giants [76][80] - **Internationalization Potential**: China has achieved breakthroughs in the quantity, quality, and technology of innovative drugs. The number of self - developed innovative drugs ranks first globally, the proportion of FIC molecules ranks second, and the gap in drug listing time between China and foreign countries has been significantly shortened [88][90][92] 3.3 ETF Product Introduction - **ETF General Information**: The GF China Securities Hong Kong Innovative Drug ETF was established on July 1, 2022, tracking the China Securities Hong Kong Innovative Drug Index. It has good liquidity, with a fund scale of 16.76 billion yuan as of August 6, 2025, and its daily trading volume has increased significantly [99] - **Features and Advantages**: It has high - purity industry focus and concentration, with the weight of bioproducts and chemical pharmaceuticals in the index reaching 92.5%, and the top ten component stocks' concentration reaching 70.59%. The industry is in a period of intensive realization, and policies provide full - chain support [105][106] - **Configuration Attributes**: It is an efficient tool for investors to allocate to the Hong Kong Biotech track, helping to avoid individual stock R & D risks. It also has medium - to - long - term rotation allocation value, with the index's one - year return ranking first among QDII stock funds and significant south - bound capital inflows [107][108]

Core Viewpoint - The pharmaceutical and biotechnology sectors have seen significant gains recently, driven by supportive policies and strong performance from leading CXO companies, indicating a potential turning point for the sector's earnings [1] Group 1: ETF Performance - The Innovation Drug ETF (517110) rose over 3.2%, the Biopharmaceutical ETF (512290) increased by more than 2.2%, the Medical ETF (159828) gained over 1.3%, and the Vaccine ETF (159643) saw an increase of over 1.0% [1] - The Innovation Drug ETF tracks the SHS Innovation Drug Index (931409), which selects listed companies involved in the research and production of innovative drugs, reflecting the overall performance of companies with research capabilities and growth potential [1] Group 2: Policy and Market Trends - Recent policies, including measures to support the high-quality development of innovative drugs and the 11th batch of centralized procurement notifications, are significant for the pharmaceutical and medical device sectors [1] - The performance of leading CXO companies that have disclosed their earnings has shown a recovery trend, suggesting that the earnings turning point for the sector may be approaching [1] Group 3: Index Descriptions - The Biopharmaceutical ETF (512290) tracks the CS Biomedicine Index (930726), which includes companies in biotechnology, pharmaceuticals, and medical devices, focusing on high-growth and strong R&D capabilities [2] - The Medical ETF (159828) follows the CSI Medical Index (399989), which represents companies in medical devices, services, and biopharmaceuticals, serving as an important benchmark for investment value in the domestic medical industry [2] - The Vaccine ETF (159643) tracks the Vaccine Biotechnology Index (980015), focusing on companies involved in vaccine research, production, and related industries, highlighting significant growth and specialization [2]

Group 1 - The pharmaceutical and biotechnology sector has seen significant growth recently, driven by continuous policy support and the ongoing performance of innovative drugs and CXO companies [1] - The introduction of measures to support the high-quality development of innovative drugs and the 11th batch of centralized procurement notifications are crucial for the pharmaceutical and medical device sectors [1] - WuXi AppTec's net profit attributable to the parent company increased by 101.92% year-on-year, indicating a potential turning point for the sector's performance [1] Group 2 - The medical device sector benefited from optimized centralized procurement rules, with exports of medical instruments and devices increasing by 5.2% year-on-year in June, while imports rose by 9.1% [1] - Policies supporting innovative drugs span the entire chain from research and development to market access and payment, with ongoing progress in the commercial insurance innovative drug catalog [1] - The Guotai ChiNext Medical ETF (159377) tracks the ChiNext Medical Index (399275), which can experience daily fluctuations of up to 20%, reflecting the overall performance of listed companies in the biopharmaceutical, medical device, and healthcare service sectors [1]

Core Insights - The pharmaceutical and biotechnology sector has seen significant growth recently, driven by ongoing trends in innovative drugs and CXO markets [1] - Recent policies, including measures to support high-quality development of innovative drugs and notifications regarding the 11th batch of national drug centralized procurement, are crucial for the pharmaceutical and medical device sectors [1] - CXO leading companies that have disclosed their performance show a positive recovery trend, indicating a potential turning point for the sector's performance [1] Policy Developments - The introduction of the "Several Measures to Support the High-Quality Development of Innovative Drugs" and the notification on the 11th batch of centralized procurement are significant for the pharmaceutical and medical device sectors [1] - The ongoing centralized procurement process is expected to benefit pharmaceutical and medical device companies that adapt to the optimized procurement rules [1] Market Performance - The CXO sector has experienced substantial growth this month, attributed to improved overseas demand and a gradual recovery in orders [1] - The innovative drug policy support window is seen as an opportunity for investors, with a focus on the progress of commercial insurance innovative drug catalog and companies with better-than-expected semi-annual report performances [1] Investment Opportunities - The Guotai Innovation Drug ETF (589720) tracks the Innovation Drug Index (950161), which can fluctuate by up to 20% in a single day [1] - The index focuses on representative new drug research and development companies in the technology innovation field, emphasizing high R&D investment and innovation capabilities [1]