Core Viewpoint - The company Shutaishen (300204.SZ) expects a net profit attributable to shareholders in 2025 to be between -85.33 million and -69.81 million yuan, with a net profit excluding non-recurring gains and losses estimated between -90.56 million and -74.09 million yuan, and operating revenue projected to be between 198.31 million and 242.38 million yuan [1] Group 1 - During the reporting period, the company's production and operational activities were normal, and it actively engaged in various marketing and market exploration efforts, resulting in slight growth in sales revenue and volume of the product Su Tai [1] - The revenue from the product Shutaqing decreased due to external environment and industry policy factors; the company is exploring multiple channels for the Shutaqing product market and focusing on expanding the marketing efforts for polyethylene glycol series products, including "Compound Polyethylene Glycol (3350) Electrolyte Powder (Shusitong)," "Compound Polyethylene Glycol (3350) Electrolyte Oral Solution (Shuyi Qing)," and "Compound Polyethylene Glycol (3350) Electrolyte Vitamin C Powder (Shuchang Qing)" [1] - The company expects non-recurring gains and losses for the year 2025 to be approximately 4.75 million yuan, with specific data to be disclosed in the 2025 annual report [1]

中国经济网北京1月28日讯圣湘生物(688289.SH)今日收报20.67元，跌幅6.56%。该股目前处于破发状 态。 圣湘生物于2020年8月28日在上交所科创板上市，发行数量为4,000万股，无老股转让，发行价格为50.48 元/股，保荐机构(主承销商)为西部证券（002673）股份有限公司，保荐代表人为李锋、邹扬，联席主承 销商为中信证券股份有限公司。 上市首日，圣湘生物盘中创下上市以来最高价155.55元，为该股上市以来最高价。 圣湘生物募集资金总额为201,920.00万元，募集资金净额为186,926.98万元，较原计划多131,268.98万 元。圣湘生物2020年8月24日披露的招股书显示，公司拟募集资金55,658.00万元，计划用于精准智能分 子诊断系统生产基地项目、研发中心升级建设项目、营销网络及信息化升级建设项目。 圣湘生物上市发行费用为1.50亿元，其中西部证券和中信证券获得保荐及承销费用1.28亿元。 圣湘生物2022年5月26日披露2021年年度权益分派实施公告，根据公司2021年年度股东大会审议通过的 《圣湘生物科技股份有限公司关于2021年度利润分配及资本公积转增股本方案的议 ...

中国经济网北京1月28日讯 百奥泰（688177.SH）今日收报23.82元，跌幅3.95%。目前该股处于破 发状态。 百奥泰首次公开发行股票的发行费用总计8940.02万元，其中，支付给保荐机构中金公司、联席主 承销商广发证券、摩根士丹利华鑫证券的承销及保荐费用7783.02万元。 百奥泰于2020年2月21日在上交所科创板上市，发行价格为32.76元/股，发行股份数量为6000万 股，保荐机构为中国国际金融股份有限公司，保荐代表人为谢显明、赵泽宇，广发证券股份有限公司、 摩根士丹利华鑫证券有限责任公司为联席主承销商。 (责任编辑：魏京婷) 上市首日，百奥泰盘中创下上市以来最高价78.00元/股。 百奥泰首次公开发行股票募集资金总额为19.66亿元，扣除发行费用后募集资金净额为18.76亿元。 百奥泰最终募集资金净额较原计划少1.24亿元。百奥泰2020年2月17日发布的招股说明书显示，该公司 计划募集资金20亿元，分别用于药物研发项目、营销网络建设项目、补充营运资金。 ...

Core Viewpoint - The company Baotai expects to reduce its net loss for the fiscal year 2025 compared to the previous year, projecting a net profit attributable to the parent company of between -280 million yuan and -390 million yuan, which represents a reduction in loss of between 120.30 million yuan and 230.30 million yuan [1] Group 1 - The reduction in loss is attributed to the company's market expansion efforts [1] - Sales of Adalimumab and Tocilizumab have increased, contributing to the improved financial outlook [1] - The launch of Ustekinumab in the United States has also positively impacted revenue through licensing and sales growth [1]

Group 1 - The China Securities Regulatory Commission has issued a notice regarding Jiangsu Ruike Biotechnology Co., Ltd.'s application for the conversion of 141,953,489 shares from domestic unlisted to overseas listed shares for trading on the Hong Kong Stock Exchange [1][4][5] - The shareholders involved in this conversion include various investment partnerships and funds, with significant contributions from entities such as Taizhou Yuangong Technology Partnership and Springleaf Investments Pte. Ltd. [4][5] Group 2 - Ruike Biotechnology has recently had its new drug application for the recombinant herpes zoster vaccine REC610 accepted by the National Medical Products Administration, which utilizes the company's self-developed BFA01 adjuvant [3] - Currently, the only other recombinant herpes zoster vaccine available globally is GlaxoSmithKline's Shingrix, indicating a competitive landscape for Ruike's new product [3]

Group 1 - The China Securities Regulatory Commission has issued a notice regarding Jiangsu Ruike Biotechnology Co., Ltd.'s application for the conversion of 141,953,489 shares from domestic unlisted to overseas listed shares for trading on the Hong Kong Stock Exchange [1][4][5] - The shareholders involved in this conversion include various investment partnerships and funds, with significant holdings from entities such as Taizhou Yuangong Technology Partnership and Springleaf Investments Pte. Ltd. [4][5] Group 2 - Ruike Biotechnology has recently had its new drug application for the recombinant herpes zoster vaccine REC610 accepted by the National Medical Products Administration, which utilizes a novel adjuvant BFA01 developed by the company [3] - Currently, the only other recombinant herpes zoster vaccine available globally is GlaxoSmithKline's Shingrix [3]

Core Viewpoint - The stock of Innovent Biologics (01801) rose nearly 3% following the announcement that its drug IBI3003 received Fast Track Designation from the FDA for treating relapsed or refractory multiple myeloma [1] Group 1: Company Developments - Innovent Biologics' IBI3003 is a tri-specific antibody targeting GPRC5D/BCMA/CD3, which is currently undergoing Phase I/II clinical trials in China, Australia, and the United States [1] - The FDA's Fast Track Designation is aimed at patients who have undergone at least four lines of treatment, including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody [1] Group 2: Market Reaction - As of the report, Innovent Biologics' stock price increased by 2.2%, reaching 83.6 HKD, with a trading volume of 204 million HKD [1]

Core Viewpoint - Cinda Biologics (01801) shares rose nearly 3%, currently up 2.2% at HKD 83.6, with a trading volume of HKD 204 million [1] Group 1: Company Developments - Cinda Biologics announced that its anti-GPRC5D/BCMA/CD3 trispecific antibody IBI3003 received Fast Track Designation from the U.S. FDA on January 27, 2026 [1] - The intended indication for IBI3003 is for relapsed or refractory multiple myeloma (R/R MM) patients who have undergone at least four lines of treatment, including a proteasome inhibitor (Pl), an immunomodulatory drug (IMiD), and an anti-CD38 monoclonal antibody [1] - IBI3003 is developed using Cinda Biologics' proprietary Sanbody platform and is currently undergoing Phase I/II clinical trials in China, Australia, and soon in the U.S. to explore its efficacy and safety in R/R MM [1]

以下文章来源于阿基米德Biotech ，作者阿基米德君 1月2 0日，历史上一个平淡的日子，唯一的热闹，可能是大寒之日上海飘雪。同日，另 一 场 寒 潮 却 无 声 无 息 ， 恒 生 生 物 科 技 指 数 （ HSHKBIO ） 成 交 额 跌 破 1 0 0 亿 港 币 ， 与 2 0 2 5年最高点相比下降近8 0 %，1 5家港股1 8A公司日成交额不足1 0 0万港币。 创新药在研发主战场外，正在开辟争夺流动性的第二战场。 技术和资本，一体两面，是创新药企的两大属性。早期生物科技没有自我造血功能，全 靠资本输血。成熟创新药企在每一个重要节点，跃升到更高发展阶段，也靠资本支持。 当前，通过港股1 8A通道上市的生物科技企业已达8 5家(含摘B)，还有超过8 0家递表排 队，而流动性却在指缝间溜走。自研能力不够硬，又不做市值管理的公司，等于自动退 出流动性争夺战，被边缘化，被遗忘，直至丧失融资能力。 阿基米德Biotech . 生物科技第三方独立观察，提前感知行业边际变化，客观中立，深入浅出，松弛愉悦 流动性。 作者 / 阿基米德君 来源 / 阿基米德Biotech （ID：ArchimedesBio ...

有望凭借高可及性、优异的疗效成为不逊于pluvicto（50亿美元销售峰值预期）的前列腺癌重磅药物。 （映恩生物） B7-H3 ADC 爆发前夜：III 期密集落地，千亿市场雏形初现 事件：2026年1月26日，clinicaltrials网址显示，BioNTech启动了BNT324（DB-1311）的首个III期临床试验（化疗未 经治的转移性去势抵抗性前列腺癌mCRPC，DB-1311vs多西他赛+泼尼松/泼尼松龙标准治疗方案，主要终点rPFS、 OS），招募736人，2031年1月取得结果。 202 （映恩生物） B7-H3 ADC 爆发前夜：III 期密集落地，千亿市场雏形初现 事件：2026年1月26日，clinicaltrials网址显示，BioNTech启动了BNT324（DB-1311）的首个III期临床试验（化疗未 经治的转移性去势抵抗性前列腺癌mCRPC，DB-1311vs多西他赛+泼尼松/泼尼松龙标准治疗方案，主要终点rPFS、 OS），招募736人，2031年1月取得结果。 2023年映恩生物DB-1311被授权至BioNTech，是第5款进入III期阶段的B7-H3 ADC，具全球商业 ...