Core Viewpoint - The company plans to issue a total of 24.2 million new H-shares at a price of HKD 14.50 per share, representing a discount of approximately 12.97% from the closing price of HKD 16.66 on October 8, 2025 [1] Fundraising Details - The total estimated gross proceeds from the placement are approximately HKD 350.9 million, with net proceeds estimated at around HKD 345 million [1] - The net proceeds will be allocated as follows: - Approximately 40% for funding the research and development of IMM2510 and IMM27M for the treatment of solid tumors - Approximately 20% for funding the research and development of IMM01 (Tideglusib) - Approximately 10% for funding the research and development of IMM0306 - Approximately 30% for supplementing the company's working capital and general corporate purposes [1]

Core Viewpoint - Binhui Biotech has submitted a listing application to the Hong Kong Stock Exchange, with Huatai International, CMB International, and Bank of China International as joint sponsors [1] Company Overview - Binhui Biotech is a biotechnology company focused on the discovery, development, and commercialization of cancer immunotherapy, specifically on oncolytic virus therapy [1] - The company's lead product, BS001 (OH2 injection), is an oncolytic virus candidate based on type II herpes simplex virus (HSV-2) that selectively replicates in tumor cells and activates systemic immunity [1] Product Development - BS001 is the first oncolytic virus candidate based on HSV-2 to reach clinical stage and enter Phase III pivotal trials globally, currently undergoing a Phase III clinical trial for melanoma in China [1] - BS001 has received orphan drug designation from the FDA for the treatment of stage III-IV melanoma and malignant glioma, as well as fast track designation for treating refractory or progressive melanoma [1] - In a Phase Ia/Ib trial, BS001 demonstrated a median overall survival of 31.06 months, with an objective response rate of 34.48%, and up to 42.1% in patients resistant to PD-1 therapy [1] Leadership and Expertise - The company is led by Dr. Liu Binlei, who has over 30 years of experience in tumor immunology and oncolytic virology, and was a core member of the development team for the FDA-approved oncolytic virus drug IMLYGIC® (T-VEC) [1]

Core Insights - Simply Wall St's report highlights Heptagon Pharmaceuticals as a biotech company with significant growth potential, noting a 243% increase in revenue over the past year, which outpaces the industry growth rate, while its price-to-earnings ratio remains below the average of 52 times for the biotech sector [1] - On October 8, Heptagon Pharmaceuticals' stock surged by 7.08%, closing at HKD 16.48, with a price-to-earnings ratio of approximately 25 times and a total market capitalization of around HKD 14.3 billion [1] - The company focuses on immunological diseases and oncology, leveraging core technological advantages and a differentiated product pipeline through self-development, joint development, and diverse international collaborations [1] Financial Performance - Heptagon Pharmaceuticals reported total revenue of approximately CNY 725 million for the first half of the year, representing a year-on-year increase of 327% [2] - The company's profit reached approximately CNY 523 million, reflecting a year-on-year growth of 51 times [2] - Cash reserves are robust, amounting to approximately CNY 2.291 billion, which is a 92% increase compared to the end of the previous year [2] Investment Activity - The Government of Singapore Investment Corporation (GIC) recently increased its stake in Heptagon Pharmaceuticals by acquiring 40.22 million shares at an average price of HKD 12.7133 per share, totaling approximately HKD 511 million [2] - Following this acquisition, GIC's ownership in Heptagon Pharmaceuticals rose significantly from 1.62% to 6.37%, indicating strong confidence in the company's technological capabilities and commercial prospects [2] - As of October 8, the increase in GIC's stake has resulted in an unrealized gain of nearly 30% based on the closing price [2]

Core Viewpoint - The company announced a licensing agreement with Zenas for its core product, Orelabrutinib, in the field of multiple sclerosis and other non-oncological treatments, while retaining rights in oncology [1][2]. Group 1: Licensing Agreement Details - The agreement includes a $100 million upfront payment and potential milestone payments, with a total deal value exceeding $2 billion [1]. - Zenas will also issue 7 million shares of common stock to the company, with additional payments tied to clinical development and commercialization milestones [1]. - The agreement allows Zenas to develop and commercialize Orelabrutinib globally for multiple sclerosis and other non-cancer indications [1][2]. Group 2: Product and Market Insights - Orelabrutinib is currently approved for three indications in hematological cancers in China, with ongoing clinical trials for multiple sclerosis [2]. - The company retains exclusive global rights for Orelabrutinib in oncology, establishing a dual strategy of self-research in oncology and licensing in autoimmune diseases [2]. - The new oral IL-17 AA/AF inhibitor and the brain-penetrant oral TYK2 inhibitor are in preclinical stages, targeting autoimmune diseases like psoriasis and psoriatic arthritis [3]. Group 3: Market Context and Future Prospects - The global market for multiple sclerosis treatments is significant, particularly in Europe and North America, where the disease has a higher prevalence [5]. - The company’s Orelabrutinib shows advantages in kinase selectivity and binding affinity, indicating strong clinical development potential [5]. - The oral IL-17 AA/AF inhibitor addresses the challenge of injection-based therapies, which may improve patient compliance [5]. Group 4: Financial Position - As of June 30, 2025, the company holds approximately 7.68 billion yuan in cash and equivalents, indicating a strong financial position within the biotech sector [6].

Core Viewpoint - Zenas BioSciences has entered into a transformative global licensing agreement worth over $2 billion with InnoCare Pharma, acquiring rights to three autoimmune disease drug candidates, including the previously abandoned BTK inhibitor orelabrutinib, indicating a growing trend of collaboration between multinational pharmaceutical companies and Chinese biotech firms [3][5][6]. Group 1: Financial Details - The agreement includes an initial payment of $100 million in cash, with additional milestone payments expected in the following year. Zenas will also issue up to 7 million shares of common stock to InnoCare, contingent on achieving specific milestones by early 2026 [6]. - InnoCare will receive milestone payments throughout the development, registration, and commercialization phases of the three drugs, with the total value of the agreement potentially exceeding $2 billion. Additionally, InnoCare will earn a tiered royalty rate of "high teens" (approximately 15%-19%) on the annual net sales of these drugs [6]. Group 2: Key Drug Candidates - The core asset of the deal is orelabrutinib, an oral BTK inhibitor capable of penetrating the central nervous system, which is crucial for treating multiple sclerosis (MS). This drug was previously licensed to Biogen, which terminated the agreement in early 2023 [8]. - Orelabrutinib is currently approved in China for treating chronic lymphocytic leukemia and mantle cell lymphoma, and it is in Phase III clinical trials globally for primary progressive MS, with plans for a late-stage global trial to start in Q1 2026 [8]. - In addition to orelabrutinib, Zenas has acquired two other drug candidates: obexelimab, a monoclonal antibody targeting B cells for various autoimmune diseases, and an oral IL-17AA/AF inhibitor, along with a brain-penetrating oral TYK2 inhibitor, both of which are still in early development stages [8][9].

今年前三季度的港股IPO可以用"火爆"来形容，赴港上市的企业名单长的写不下。 仅9月29日及30日两天，就有长春高新、贝达药业、百利天恒、晶合集成、极米科技、聚芯微电子等29 家公司递表港交所，其中有不少是A+H双重上市。 港交所网站显示，截至9月30日，2025年受理的新申请高达286家，是去年的两倍有余。与此同时，今年 前三季度，港股共迎来66只新股IPO上市，新股首发募集资金累计约1829亿港元(含超额配售)，折合 1673.7亿元人民币，募资额同样已超2024年全年的两倍。 对于一级市场来说，港股变成了"香饽饽"。 有双币投资机构的负责人对创投日报记者表示，港股是手上的国内项目IPO的首选目的地，最近已经把 适合的项目都盘了一遍，催着项目尽快推进。华中地区的某国资机构则告诉创投日报记者，近期一直在 尝试拿下港股IPO项目的基石份额。他们都提到，"港股行情已经起来了，要把握住这轮窗口期。" "A+H"与硬科技 今年港股IPO行情的热离不开"A+H"。 位居募资额榜首的是宁德时代，募了约410亿港元；在9月底上市的紫金黄金国际，以249.84亿港元排在 第二。 此外，恒瑞医药、三花智控、海天味业的募资额都 ...

（股 份 代 號：9887） 自願公告 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 2款創新藥研究成果將亮相第67屆ASH年 會 本公告由南京 維 立志博生物科技股份有限公司（「本公司」，連 同 其 附 屬 公 司 統 稱「本集團」）自 願 作 出，以 告 知 本 公 司 股 東 及 潛 在 投 資 者 有 關 本 公 司 的 最 新 業 務 發 展 情 況。 Nanjing Leads Biolabs Co., Ltd. 南 京 維 立志博生物科技股份有限公司 （於 中 華 人 民 共 和 國 成 立 的 股 份 有 限 公 司） 本 公 司 股 東 及 潛 在 投 資 者 在 買 賣 本 公 司 股 份 時 務 請 審 慎 行 事。 承董事會命 Nanjing Leads Biolabs Co., Ltd. 南 京 維 立志博生物科技股份有限公司 董 事 長、執 行 董 事 兼 首 席 ...

Group 1 - The company, Yantai Dongcheng Pharmaceutical Group Co., Ltd., is proceeding with the spin-off of its subsidiary, Yantai Lanacheng Biotechnology Co., Ltd., for a listing on the main board of the Hong Kong Stock Exchange [2][3] - The board of directors and the company have approved the spin-off plan during meetings held on August 28 and September 15, 2025 [2] - On September 29, 2025, Lanacheng submitted its application for an initial public offering and listing on the Hong Kong Stock Exchange [3]

证券代码：600161 证券简称：天坛生物 公告编号：2025-048 北京天坛生物制品股份有限公司关于下属企业获得药物临床试验批准通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性承担法律责任。 近日，北京天坛生物制品股份有限公司下属国药集团昆明血液制品有限公司（以下简称"天坛昆明"）获 得国家药品监督管理局签发的《药物临床试验批准通知书》，同意天坛昆明开展"人纤维蛋白原"临床试 验。现将有关信息披露如下： 一、概况 （一）产品信息 ■ （二）产品主要市场情况 国内市场： 登录新浪财经APP 搜索【信披】查看更多考评等级 ■ *注：上述国内市场主要情况来自国家药品监督管理局官方网站（http://www.nmpa.gov.cn）。 国际市场： ■ 二、风险提示 天坛昆明"人纤维蛋白原"产品后续尚需完成开展临床试验、提交药品上市许可申请、通过国家药品监督 管理局药品审评中心审评及国家药品监督管理局审批、获得药品注册证书等审批程序，方可实现生产及 上市销售。药品的研发是一项长期工作，存在诸多内外部不确定因素，敬请广大投资者注意投资风 ...

Group 1 - The company has proposed to adjust the annual remuneration for independent directors from 180,000 RMB to 240,000 RMB, which aligns with industry standards and aims to enhance corporate governance [1][2] - The adjustment requires approval from the upcoming extraordinary general meeting of shareholders [1] Group 2 - The company plans to issue H-shares and list on the Hong Kong Stock Exchange to enhance its international presence and optimize its capital structure [3][4] - The issuance will comply with relevant laws and regulations and requires approval from regulatory bodies [4][5] - The company is currently discussing the issuance with relevant intermediaries, and specific details are yet to be finalized [4] Group 3 - The company has scheduled the extraordinary general meeting for October 17, 2025, to discuss the proposed H-share issuance and other matters [9][10] - Voting will be conducted through both on-site and online platforms [10][11] Group 4 - The company has appointed Crowe (Hong Kong) CPA Limited as the auditing firm for the H-share issuance [23][24] - The auditing firm has a strong track record and is expected to meet the company's needs for the H-share issuance [27][28] Group 5 - The board of directors has approved several resolutions regarding the H-share issuance, including the types of shares, issuance methods, and fundraising plans [31][34] - The proposed fundraising will be used for drug research and development, overseas commercialization, and working capital [62]