Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry [1] Core Insights - The trend of Chinese innovative drugs going overseas is a long-term phenomenon, with external environmental changes having limited impact. In the first half of 2025, there were 72 License-out transactions, exceeding half of the total for 2024, with a total transaction amount 16% higher than in 2024. Notably, there were 16 transactions exceeding $1 billion each [2] - The small nucleic acid drug sector has seen significant breakthroughs, particularly in the treatment of chronic diseases such as hypertension and hyperlipidemia, with major collaborations and potential milestone payments indicating a robust commercial outlook [3] - The trend towards oral autoimmune drugs is gaining attention, with significant partnerships and clinical advancements in this area, highlighting the importance of oral formulations in autoimmune therapies [4] - Recent clinical data on long-acting insulin analogs shows promising weight loss results, with ongoing developments in combination therapies for metabolic diseases, indicating a growing market potential [5] - The CXO sector is gradually recovering, with an increase in License-out transactions serving as a vital funding source for biotech companies, leading to a resurgence in innovation and clinical development [6] - The 2025 national medical insurance negotiations and the commercial insurance innovative drug directory are crucial for companies involved, with a focus on orphan drugs and imported PD-1/L-1 products [7] Summary by Sections Industry Tracking - The pharmaceutical sector has underperformed compared to the CSI 300 index, with a recent weekly decline of 1.20% and a monthly decline of 3.38%, ranking 25th among 31 industry indices [22][26] Industry Trends and Valuation - The pharmaceutical industry index currently has a PE ratio of 39.05, above the five-year historical average of 31.36, indicating a higher valuation compared to historical trends [48][50] Recent Research Achievements - The research team has published several in-depth reports on various pharmaceutical topics, including the growth of the blood products industry and the potential of GLP-1 drugs in chronic disease management [53] Important Policies and News - Recent regulations have been introduced to standardize clinical research and ensure drug traceability, which will impact the pharmaceutical landscape significantly [55][56]

行 业 及 产 业 医药生物 2025 年 10 月 12 日 本 周 申 万 医 药 生 物 指 数 下 跌 行 业 研 究 / 行 业 点 评 本期投资提示： ⚫ 市场表现：本周申万医药生物指数下跌 1.2%，同期上证指数上涨 0.4%，万得全 A（除 金融石油石化）下跌 0.5%。本周医药生物指数在 31 个申万一级子行业中表现排名第 25 。 各 三 级 板 块 涨 跌 幅 为 ： 原 料 药 （ -0.7% ） 、 化 学 制 剂 （ -2.5% ） 、 中 药 （+1.5%）、血液制品（+1.4%）、疫苗（+0.7%）、其他生物制品（-1.7%）、医疗 设备（-0.2%）、医疗耗材（+0.2%）、体外诊断（-0.6%）、医药流通（+0.8%）、 线下药店（+0.3%）、医疗研发外包（-5.3%）、医院（+1.8%）。当前医药板块整体 估值 30.9 倍，在 31 个申万一级行业(2021)中排名第 10。 本研究报告仅通过邮件提供给 中庚基金 使用。1 《本周医药上涨 3.1%，医保局发布按病种 付费管理暂行办法和医保"双目录"初审 名单，司美在美获批治疗 MASH ——医药 行业周报（2025/ ...

药明合联再遭到股东药明康德减持！ 10月10日，药明康德发布公告称，于10月8日通过大宗交易方式，出售了其间接控股子公司所持有的药 明合联（2268.HK）3030万股股票，约占药明合联当前总股本的2.47%，套现逾23亿港元。 受此影响，药明康德港股、A股分别下跌5.86%、7.2%；报收于112.400港元/股、104.72元/股，总市值分 别为3333亿港元、3106亿；同时，药明合联也下跌7.29%，报收于71.850港元/股，总市值882.83亿港 元。 药明康德表示，出售的药明合联股票在账面上列为"长期股权投资"。经公司财务部门初步测算，本次出 售药明合联的投资净收益对公司2025年度税后净利润的影响约为16.79亿元，占公司2024年归属净利润 的比例超过10%。 值得注意的是，2024年药明康德曾出现营收、净利双双下滑。去年该公司实现营业收入约为392.41亿 元，同比下降2.73%；归属净利润约为94.5亿元，同比下降1.63%，主要是因为CXO企业海外业务遭遇 更严苛的合规审视。 到了2025年，药明康德业绩开始回暖。财报数据显示，2025年上半年，药明康德营收为208亿元，较去 年同期增 ...

周五（10月10日），A股、港股市场同频震荡，沪指失守3900点，创指大跌4.55%，恒生指数收出5连 阴。大盘承压，AH医药板块全线走低。 A股医疗板块低开低走，CXO跌幅靠前，巨头药明康德领跌7.2%，规模最大医疗ETF（512170）场内跌 2.03%止步三连阳，盘中下穿3根均线，交投仍在高位，全天成交6.4亿元。拉长时间看，近期医疗板块 走势整体震荡上行，短线回调或无碍趋势走向，作为低位板块，补涨机遇仍值得关注。 A股制药板块相对抗跌，主要系中药股逆市飘红，华润三九、吉林敖东涨逾2.5%，创新药则跌多涨少， 百济神州-U领跌6.2%。全市场唯一药ETF（562050）重仓创新药，兼顾中药，场内收跌1.07%，水下区 间溢价走高，反映低吸资金涌动，上日已有223万元资金逢跌加码。 | 分时 6日 1分 5分 15分 30分 · | | | | | | F9 盘前盘后 露加 九排 面线 工具 @ 1 > | | | | | | METF (D) | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | - ...

Core Viewpoint - Since September, domestic investors have increased their holdings in pharmaceutical stocks through the Hong Kong Stock Connect, while foreign investment has slightly declined since mid-year. However, the overall trend of increasing investment in innovative drugs remains unchanged [1] Group 1: Investment Trends - Domestic investors are focusing on innovative drug stocks, while foreign investors are also increasing their positions in high-value innovative drug targets and service-related stocks, including CXO companies and "AI + healthcare" concepts [1] - The upcoming ESMO conference in mid to late October is expected to be a catalyst for the industry, with recommendations to focus on companies like CanSino Biologics (09926), Kelun-Biotech (06990), Rongchang Biologics (09995), and Hansoh Pharmaceutical (01276) that are expected to release significant data [1] Group 2: Recommended Sectors - The report suggests a focus on innovative drugs, highlighting companies such as 3SBio (01530) and Eucure Biopharma-B (06996) which have rich short-term catalysts and whose valuations do not yet reflect the value of their core products. Companies like Ascletis Pharma (02096), Hutchison China MediTech (000113), and Legend Biotech are considered significantly undervalued with clear long-term growth logic [1] - In the CXO sector, leading companies benefiting from high downstream demand and marginal recovery in financing, such as WuXi AppTec (02268), are recommended for attention [1]

Core Insights - The report highlights that foreign capital continues to invest in high-cost performance targets within the pharmaceutical sector, suggesting a focus on catalysts and undervalued quality innovation opportunities in Q4 [1][2] - The Hang Seng Healthcare Index increased by 3.1% this week, outperforming the broader market, with medical devices, biopharmaceuticals, and prescription drugs showing superior performance [1] - There is a notable increase in domestic capital holdings in pharmaceutical stocks through the Hong Kong Stock Connect since September, while foreign holdings have slightly decreased since mid-year, indicating a sustained interest in innovative drugs [1][2] Market Review - The report indicates that foreign investors have been increasing their positions in high-cost performance innovative drug targets and service-related companies, particularly those benefiting from potential interest rate cuts and "AI + healthcare" concepts [1] - The upcoming Nobel Prize in Physiology or Medicine awarded for research in Treg and peripheral immune tolerance is expected to further stimulate investment interest in related innovative drug companies [2] - The ESMO conference scheduled for mid to late October is highlighted as a key event, with recommendations to focus on companies like Kangfang Biotech, Kelun-Biotech, Rongchang Biopharma, and Hengrui Medicine, which are expected to release significant data [2] Investment Recommendations - The report recommends focusing on specific segments within the pharmaceutical industry, including: 1. Innovative drugs: Companies like 3SBio and Eucure Biopharma are noted for having rich short-term catalysts and valuations that do not yet reflect the value of their core products [2] 2. CXO: Companies benefiting from high downstream demand and marginal recovery in financing, such as WuXi AppTec, are highlighted as key players in this segment [2]

Group 1: Technology Sector - The technology sector is highlighted by 11 out of 13 brokerages, with SMIC being the top pick due to its leading position in domestic wafer foundry and a backlog of orders extending to 2026, ensuring stable capacity [3] - SMIC has recently added a 28nm mature process production line, with a gross margin expected to remain above 25%, providing visible performance support [3] - The focus on long-term investment in SMIC is emphasized, as the overall trend of domestic substitution remains intact, allowing for continuous performance realization [3] Group 2: Pharmaceutical Sector - WuXi AppTec is included in the "golden stock" list by 8 brokerages, driven by a recovery in global pharmaceutical R&D demand and an increase in outsourcing orders from multinational pharmaceutical companies [3] - The company is expanding its innovative drug service business in China, collaborating with several biotech firms to develop new cancer drugs, with a growth rate projected around 30% [3] - The pharmaceutical sector is deemed suitable for long-term investment, with WuXi AppTec's global business support enhancing its risk resilience compared to smaller firms [3] Group 3: New Energy Sector - CATL is favored by 7 brokerages, with two main reasons: the recent implementation of export license management for lithium batteries, which helps eliminate disordered competition, stabilizing overseas orders, particularly from European automakers, which now account for 45% of its orders [4] - The mass production of CATL's Kirin battery technology, which has a 20% higher energy density than traditional batteries, is expected to convert technological advantages into profits as it supplies to companies like Li Auto and NIO [4] - Investors are advised to focus on technological iterations and order volumes in the new energy sector rather than short-term fluctuations [4] Group 4: Consumer Sector - Kweichow Moutai remains a "cornerstone" choice for 5 brokerages, supported by strong sales data during the National Day holiday and stable batch prices around 1900 yuan, indicating steady demand [4] - The company is expanding its direct sales channels, with a 20% increase in advertising on e-commerce platforms, which is expected to directly enhance profit margins [4] - Moutai is considered a suitable long-term investment for its strong cash flow and brand power, providing a stable foundation for investors amid market fluctuations [4] Group 5: Overall Investment Strategy - The investment logic of the 13 brokerages aligns with a long-term investment approach, focusing on companies with performance support and industry prospects rather than chasing hot stocks [4] - The highlighted companies possess core advantages in their respective fields, and any market corrections should be viewed as potential opportunities for increasing positions, provided the fundamentals remain unchanged [4]

10月9日晚间，中环环保公告称，公司控股股东、实际控制人张伯中及其一致行动人拟通过协议转让方式，转让所持中环环保7054.14万股股份予北京鼎 垣、嘉兴鼎康，占中环环保总股本的16.6171%。 交易完成后，北京鼎垣和嘉兴鼎康合计持有公司7054.14万股，占公司总股本的比例为16.6171%。公司控股股东将变更为北京鼎垣，公司实际控制人将变 更为刘杨。 交易完成后，中环环保控股股东将变更为北京鼎垣，公司实际控制人将变更为刘杨。 刘杨系国家级专精特新"小巨人"企业北京赛赋医药研究院有限公司（以下简称赛赋医药）创始人及董事长。 斥资5.98亿元入主 根据协议，张伯中将其持有的1639.14万股公司股票（占公司总股本的3.8612%）转让给嘉兴鼎康，中辰投资将其持有的493.62万股公司股票（占公司总股 本的1.1628%）转让给嘉兴鼎康，中辰投资将其持有的4921.38万股公司股票（占公司总股本的11.5931%）转让给北京鼎垣。 转让股份数量合计7054.14万股（占公司总股本的16.6171%），股份转让单价约为8.48元/股，转让对价合计5.98亿元。 张伯中承诺，不可撤销地放弃个人持有的公司1917.4 ...

证券研究报告：医药生物 | 公司点评报告 发布时间：2025-10-09 股票投资评级 买入|首次覆盖 个股表现 公司基本情况 | 最新收盘价（港元） | 74.50 | | --- | --- | | 总股本/流通股本（亿股）12.28/12.28 | | | 总市值/流通市值（亿港 | 914.86/914.86 | | 元） | | | 52 周内最高/最低价 | 78.55/ 18.52 | | 资产负债率(%) | 29.94 | | 市盈率 62.9 | | | 第一大股东 | 药明生物技术有限公司 | 研究所 分析师:盛丽华 SAC 登记编号:S1340525060001 Email:shenglihua@cnpsec.com 分析师:陈灿 SAC 登记编号:S1340525070001 Email:chencan@cnpsec.com 药明合联(2268.HK) 业绩维持快速增长，产能扩张节奏顺利 ⚫ 事件 公司公布 2025 年上半年业绩，25H1 实现收入 27.0 亿元（+62.2%， 同比增速，下同）、净利润 7.5 亿元（+52.7%）、不含利息收支经调整 净利润 7.3 亿元（+6 ...

医药股今日普遍重挫，截至发稿，三叶草生物-B(02197)跌14.43%，报2.49港元；荣昌生物(09995)跌 11.54%，报105.4港元；诺诚健华(09969)跌11.48%，报16.65港元；歌礼制药-B(01672)跌9.16%，报10.51 港元；泰格医药（300347）(03347)跌7.08%，报43.86港元。 国盛证券指出，过节期间，辉瑞和特朗普达成协议，部分解除了海外MNC的政策担忧，海外MNC迎来 修复，同时也带动港股医药情绪有所修复，对CXO带来正面影响，在这个影响下，中小市值创新药-B 公司尤其是未进通的表现弹性较大。这段时间CXO确实表现相对强势，有业绩期比较优势，也有降息 预期影响，也有行业趋势拐点向上预期影响，几点共振，中长期值得期待。创新药近期因为缺少催化， 借势消化筹码，也有企稳迹象，看好十一后，尤其是Q4创新药表现。 消息面上，中泰证券（600918）认为，9月板块延续震荡调整，主要由于3月以来医药板块超额明显，短 期内板块催化相对较少，板块缺少持续上行强动力；此外创新药板块年初以来涨幅较大，资金有兑现收 益的需求。该行认为阶段的震荡调整是相对良性的，且基本面来看创 ...