Core Viewpoint - The ongoing debate between hyaluronic acid and recombinant collagen in the capital market highlights the challenges faced by companies like Huaxi Biological, which is experiencing a decline in revenue and net profit after reaching a peak in 2022 [2][6]. Group 1: Company Response and Market Dynamics - Huaxi Biological criticized the recent reports from several securities firms that favor recombinant collagen over hyaluronic acid, claiming these reports misrepresent the safety and efficacy of hyaluronic acid [3][4]. - The company emphasized the importance of a healthy industry ecosystem, stating that without it, no company can achieve long-term success or maintain competitive advantages [5][6]. - Huaxi Biological is undergoing a comprehensive management transformation in 2024, including business process restructuring and digitalization, to address the challenges in the current operating environment [2][6]. Group 2: Financial Performance - In 2024, Huaxi Biological reported a revenue of 5.371 billion yuan, a year-on-year decrease of 11.61%, and a net profit of 174 million yuan, down 70.59% [6]. - The skin science innovation business, which accounts for nearly half of the company's revenue, saw a significant decline of 31.62% in revenue, totaling 2.569 billion yuan [6]. - In contrast, the medical terminal business achieved a revenue of 1.44 billion yuan in 2024, marking a growth of 32.03% [7]. Group 3: Industry Trends and Competition - The medical aesthetics industry is witnessing a shift from hyaluronic acid to recombinant collagen and other regenerative products, driven by evolving consumer preferences and technological advancements [5][9]. - The market for recombinant collagen is growing rapidly, with companies like Jinbo Biological and Giant Bio achieving substantial revenue increases in 2024, indicating a competitive landscape with low market concentration [8][9]. - Huaxi Biological is also investing in recombinant collagen research and development, aiming to leverage synthetic biology for technological upgrades and high-quality applications [7][8].

Core Insights - The report highlights the shift in consumption patterns among the "new silver-haired" demographic in China, moving from a frugal approach to a focus on quality and self-indulgence in their spending habits [2][3] - This demographic, primarily consisting of individuals born in the 1960s and 1970s, is characterized by a stable income and a willingness to invest in experiences and products that enhance their quality of life [3][4] Consumption Trends - Travel has become a significant area of interest, with approximately 17.6% of older adults traveling more than three times a year, and 40.8% traveling once or twice a year, reflecting an increased focus on leisure and health [3] - The consumption of beauty and personal care products has also evolved, with a notable interest in high-quality, personalized, and technologically advanced products, as evidenced by the 2024 survey indicating that brands emphasizing safety and quality are gaining traction among older consumers [4] Service and Lifestyle Changes - The report notes a transition in lifestyle philosophies among the new silver-haired group, who are increasingly independent and exploring diverse retirement options, such as high-end retirement communities and smart home care solutions [4][5] - There is a growing trend of "buying time" through service-oriented consumption, with 25% of online grocery orders coming from individuals over 60, and a 36% year-on-year increase in delivery service orders, indicating a preference for convenience [5] Investment Recommendations - The report suggests investing in comprehensive wellness and travel communities that integrate medical and ecological resources to cater to the needs of the aging population [6] - It also recommends focusing on anti-aging medical aesthetics and biotechnology sectors, as well as accelerating the application of smart elderly care technologies to enhance community services and smart home ecosystems [6]

"目前，我们还需要等待专业部门和监管机构来判断，这些券商研报是基于自身独立分析， 还是全面引用了相关企业的招股说明书或其他信息的内容。如果这方面存在问题，则应由相 关监管机构和交易所作出决定。"华熙生物对第一财经称，已向证监会举报上述券商发布不 实报告误导市场。 这些券商所发研报的研究对象，均为港股上市公司巨子生物（02367.HK）。第一财经联系 了相关券商及巨子生物，但尚未有相关回应。 券 商 研 报 夸 赞 重 组 胶 原 蛋 白 比 透 明 质 酸 好 ， 虽 然 未 被 直 接 点 名 ， 但 华 熙 生 物 （688363.SH）仍"忍不住"发文怒怼多家发布相关研报的券商。 华熙生物主营透明质酸相关业务。在驳斥券商的文章中，该公司称，透明质酸"过时论"的 兴起，本质上是一场由"浮躁资本"构建的题材幻象。 华熙生物的文中，点名9家券商相关研报，涉及华泰证券、安信证券（现为"国投证券"）、 国金证券、西部证券、信达证券、方正证券、平安证券、申港证券、华福证券。 其实，华熙生物也曾是资本的"宠儿"。根据东方财富终端数据（前复权，下同），华熙生 物股价最高上攻至313.1元，市值一度超1500亿元。但是2 ...

Core Viewpoint - 九州通 is actively expanding its strategic investments in the pharmaceutical and healthcare sectors, particularly focusing on medical aesthetics and medical devices through various initiatives and partnerships [1][2][3]. Investment Initiatives - 九州通's wholly-owned subsidiary, 九州通孵化器, has partnered with 北京楚昌私募基金 to establish a new investment fund with a total contribution of 25 million yuan, targeting investments in pharmaceuticals, medical devices, medical aesthetics, and anti-aging sectors [2][3]. - The fund's contributions include 22.99 million yuan from 九州通孵化器, accounting for 91.96% of the total, while the remaining contributions come from other partners [2]. Medical Device Expansion - 九州通 has established a new medical device supply chain company in 湖北孝感 with a registered capital of 10 million yuan, further diversifying its business operations [3]. - In the past three months, 九州通 has launched at least six new medical device companies, indicating a strong commitment to expanding its presence in the medical device sector [3]. - The medical device segment accounted for 22.32% of 九州通's total business last year, with sales revenue reaching 33.887 billion yuan in 2024, reflecting a year-on-year growth of 3.26% [3]. Medical Aesthetics Investment - 九州通 plans to invest 673 million yuan in the restructuring of 奥园美谷, acquiring 360 million shares post-restructuring, which positions the company to become a major stakeholder in the medical aesthetics market [4][6]. - 奥园美谷 has faced financial difficulties but possesses a recognized brand and customer base in the medical aesthetics sector, which 九州通 aims to leverage for growth [4]. - 九州通's medical aesthetics business achieved sales revenue of 851 million yuan in 2024, marking a significant year-on-year increase of 120.47% [4][6]. Historical Context - 九州通 has a history of investing in the medical aesthetics sector, including an early investment in 爱美客 and partnerships with other key players in the industry [5][6]. - The establishment of a dedicated medical aesthetics division and collaboration with upstream manufacturers for product development further underscores 九州通's commitment to this sector [6].

2025.05. 21 本文字数：4762，阅读时长大约7分钟 作者 | 第一财经 黄思瑜 齐琦 券商研报夸赞重组胶原蛋白比透明质酸好，虽然未被直接点名，但华熙生物（688363.SH）仍"忍不 住"发文怒怼多家发布相关研报的券商。 华熙生物主营透明质酸相关业务。在驳斥券商的文章中，该公司称，透明质酸"过时论"的兴起，本质 上是一场由"浮躁资本"构建的题材幻象。 华熙生物的文中，点名9家券商相关研报，涉及华泰证券、安信证券（现为"国投证券"）、国金证 券、西部证券、信达证券、方正证券、平安证券、申港证券、华福证券。 "目前，我们还需要等待专业部门和监管机构来判断，这些券商研报是基于自身独立分析，还是全面 引用了相关企业的招股说明书或其他信息的内容。如果这方面存在问题，则应由相关监管机构和交易 所作出决定。"华熙生物对第一财经称，已向证监会举报上述券商发布不实报告误导市场。 这些券商所发研报的研究对象，均为港股上市公司巨子生物（02367.HK）。第一财经联系了相关券 商及巨子生物，但尚未有相关回应。 其实，华熙生物也曾是资本的"宠儿"。根据东方财富终端数据（前复权，下同），华熙生物股价最高 上攻至313.1元 ...

Core Viewpoint - The article discusses the conflict between Huaxi Biological and several brokerage firms regarding the comparison of hyaluronic acid and recombinant collagen protein, with Huaxi asserting that the notion of hyaluronic acid being outdated is misleading and driven by "restless capital" [1][7]. Company Overview - Huaxi Biological specializes in hyaluronic acid-related products and has faced significant stock price and market capitalization declines since reaching a peak in July 2021, with its stock price dropping from 313.1 yuan to 52.61 yuan as of May 21, 2023, resulting in a market cap reduction from over 1500 billion yuan to 253 billion yuan [2][8]. - The company has reported continuous revenue declines, with revenues of 60.76 billion yuan and 53.71 billion yuan for 2023 and 2024, respectively, representing year-on-year decreases of 4.45% and 11.61% [10]. Industry Dynamics - The market has seen a shift in focus towards recombinant collagen protein, with companies like Juzhi Biological and Jinbo Biological experiencing significant stock price increases and revenue growth, contrasting with Huaxi's struggles [2][13]. - The recombinant collagen protein market in China is projected to grow at a compound annual growth rate of 44.93%, reaching 585.7 billion yuan by 2025 [7]. Performance Comparison - Juzhi Biological's revenues for 2022, 2023, and 2024 were 23.75 billion yuan, 35.26 billion yuan, and 55.39 billion yuan, respectively, with year-on-year growth rates around 50% [13]. - Jinbo Biological's revenues during the same period were 3.9 billion yuan, 7.8 billion yuan, and 14.43 billion yuan, with growth rates of 67.15%, 99.97%, and 84.92% [13]. Regulatory and Market Response - Huaxi Biological has reported the brokerage firms to the China Securities Regulatory Commission for allegedly misleading reports that could distort market perceptions [1][3]. - The company has emphasized the need for a healthy industry ecosystem and has engaged with industry associations to advocate for a return to scientific principles in the market [5][7].

Core Viewpoint - Huaxi Biological has publicly criticized several securities firms for promoting collagen products and suggesting that hyaluronic acid is "outdated," indicating a defensive stance amid declining performance and market competition [1][2][3] Company Performance - Huaxi Biological started with hyaluronic acid and holds nearly 50% of the global market share, expanding into medical products, skincare, and functional foods [5][6] - Despite maintaining positive growth during the pandemic years of 2020 and 2021, the company's revenue and profit have declined since 2021, with net profits projected to drop from 9.71 billion yuan in 2022 to 1.74 billion yuan in 2024 [10] - The company's market capitalization has plummeted from over 140 billion yuan in 2021 to 25.3 billion yuan as of May 21, 2025 [10] Market Comparison - In contrast, competitors like Juzhi Biological and Jinbo Biological have seen significant growth, with Juzhi's net profits increasing from 1 billion yuan in 2022 to 20.62 billion yuan in 2024, and Jinbo's from 1.09 billion yuan to 7.31 billion yuan in the same period [14] - Both companies have also achieved substantial stock price increases, with market capitalizations of 87.5 billion HKD and 51.1 billion yuan, respectively [14] Industry Dynamics - The rise of collagen products has created a competitive threat to hyaluronic acid, with market trends favoring new ingredients [15][18] - The demand for collagen is expected to exceed supply, with projections indicating a production of 200,000 tons against a demand of over 220,000 tons by 2025 [19] Challenges Ahead - Despite Huaxi's efforts to defend hyaluronic acid, the company faces challenges due to internal management issues and a tarnished brand image, which may hinder future sales growth [20][21] - The company's recent foray into collagen products has not yet shown significant revenue impact, suggesting ongoing struggles in adapting to market changes [21]

作者 | 远禾 数据支持 | 勾股大数 据（www.gogudata.com） 昔日千亿巨头，华熙生物，急了。 最近，华熙生物发布了名为《概念总在重演，科技永远向前》的文章，节选了华泰证券、安信证券、西部证券等多家券商的研报，抨击这些券商 对于 "玻尿酸过时" 的市场观点。 在华熙生物发文的背后，是近几年来玻尿酸概念和重组胶原蛋白概念的对垒。 2019年上市以来，华熙生物顶着"医美茅"的名头，股价一度上涨至309元/股，市值超过1400亿元。 然而 2021年之后，华熙生物股价急转直下，至今已暴跌超80%，跌去超千亿市值，仅剩200多亿元。在近期医美板块的暴涨之中，华熙生物也 成为逐渐掉队的一批。 与之形成鲜明对比的是，北交所目前市值第一的锦波生物， 2023年北交所上市以来股价已经上涨超10倍，市值近500亿元。 目前，锦波生物股价已经超过 500元/股，仅次于贵州茅台和寒武纪。 如果从锦波生物 2015年在新三板挂牌时的最低价算起，锦波生物在这10年里更是已经暴涨约85倍。 因此，华熙生物这次声势浩大的 "指控"，更像是华熙生物为"玻尿酸"（也称"透明质酸"）概念的一次背书。 一边是狂涨40倍的重组胶原蛋 ...

Core Viewpoint - Oriental Yanmei (Chengdu) Biotechnology Co., Ltd. is pursuing an IPO in Hong Kong despite a high debt-to-asset ratio of 123% and significant financial challenges, including projected losses of nearly 70 million yuan in 2024 and cash reserves of only 33.19 million yuan by the end of 2024 [1][9]. Company Overview - Founded in 2016, Oriental Yanmei focuses on regenerative medical devices and special medical foods, targeting a medical market worth hundreds of billions of yuan [1]. - The company's core product, "Tongyan Needle" XH301, is expected to receive approval in the second half of 2025, while competitors have already established a strong presence in this segment [1][6]. Financial Performance - The company reported revenues of approximately 12.88 million yuan in 2023 and 14.52 million yuan in 2024, primarily from non-core products, with a projected loss of nearly 70 million yuan in 2024 [8][9]. - The gross margin for 2023 and 2024 was 11.4% and 2.6%, respectively, with net losses of 63.5 million yuan and 69.4 million yuan attributed to R&D and operational expenses [9]. Market Potential - The regenerative medical materials injection market has grown from 200 million yuan in 2019 to 2.9 billion yuan in 2023, with a compound annual growth rate (CAGR) of 96.6%, expected to reach 18.5 billion yuan by 2032 [6]. - The special medical food market has also expanded from 2.7 billion yuan in 2019 to 6 billion yuan in 2023, with a CAGR of 17.2%, projected to reach 23.8 billion yuan by 2032 [8]. Management Team - The founder, Zhang Xinming, and key executives have a history of collaboration dating back to their time at Zhi Yuan Pharmaceutical, indicating a strong entrepreneurial bond [2][3]. - Zhang Xinming has extensive experience in the pharmaceutical industry, having worked at various companies including China Resources Sanjiu and Zhi Yuan Pharmaceutical [3][4]. Product Development - Oriental Yanmei has 13 candidate products in the regenerative medical device sector, with XH301 and XH321 currently undergoing registration review [6]. - The company has also developed 7 candidate products in the medical dressing and patch category, with one product already approved [6]. Competitive Landscape - The "Tongyan Needle" market is competitive, with several established players already having products approved, indicating a challenging environment for new entrants [7]. - The average approval cycle for regenerative medical devices is 3 to 5 years, adding to the urgency for Oriental Yanmei to secure funding and expedite its product launch [6][9].

Core Viewpoint - The article highlights a conflict in the biopharmaceutical industry regarding the competition between hyaluronic acid and recombinant collagen, with Huaxi Biological criticizing the notion that hyaluronic acid is outdated, which they attribute to capital-driven speculation [1][4]. Company Performance - Huaxi Biological's performance has declined significantly, with projected revenue for 2024 expected to decrease by 11.61% and net profit to drop by 70.59%, resulting in a market capitalization loss of over 100 billion [1][6]. - In contrast, Juzhi Biological has experienced substantial growth, with a projected revenue increase of 57.2% and net profit growth of 42.4% for 2024, leading to a doubling of its market capitalization [1][6]. Market Dynamics - The article discusses the contrasting market performances of Huaxi Biological and Juzhi Biological, indicating a clear divide in the industry, with Huaxi's stock price falling over 80% from its peak of 309.43 yuan per share in July 2021 to 53.08 yuan per share as of May 20, 2025, resulting in a market cap of less than 25.6 billion [9][6]. - Juzhi Biological's stock has seen a significant increase, reaching a peak of 86.45 HKD, representing a cumulative rise of over 44% from approximately 60 HKD at the end of 2024 [8][6].