Core Insights - The National Healthcare Security Administration and the Ministry of Human Resources and Social Security have released the new National Medical Insurance Directory and the first Commercial Health Insurance Innovative Drug Directory, set to be implemented nationwide from January 1, 2026 [1][2] Summary by Sections National Medical Insurance Directory - A total of 114 new drugs have been added to the National Medical Insurance Directory, with 111 of them being new products launched within the last five years, representing 97.3% of the new additions [2] - Among the new drugs, 50 are classified as Category 1 innovative drugs, with a success rate of 88%, an increase from 76% in 2024 [2] - The total number of drugs in the directory has increased to 3,253, including 1,857 Western medicines and 1,396 traditional Chinese medicines [2] Company Announcements - Several listed companies, including Heng Rui Medicine, Fosun Pharma, and Hai Si Ke, announced new drug inclusions or renewals in the updated National Medical Insurance Directory [3] - Heng Rui Medicine reported that 20 products/indications were included, with significant coverage across various diseases such as tumors and cardiovascular conditions [3][4] - Hai Si Ke's two Category 1 innovative drugs were included, with one being a new addition and the other a renewal [4] Commercial Health Insurance Innovative Drug Directory - The first Commercial Health Insurance Innovative Drug Directory includes 19 new drugs from 18 innovative pharmaceutical companies, with 9 being Category 1 innovative drugs [7] - Notably, five CAR-T products were included, representing over half of the CAR-T products available in China, which previously faced challenges in entering the insurance market due to high pricing [7][8] - The directory also includes treatments for rare diseases and high-profile conditions such as Alzheimer's disease, enhancing the complementarity with the basic medical insurance [7][10] Notable Drug Inclusions - The directory includes drugs for significant diseases such as triple-negative breast cancer and pancreatic cancer, as well as treatments for rare diseases like Gaucher disease [5][9] - In the diabetes sector, several domestic drugs were newly included, such as a long-acting GLP-1 receptor agonist [6] - Companies like Bei Hai Kang Cheng and Bai Ji Shen Zhou have also successfully included their innovative drugs in the Commercial Health Insurance Directory [9]

Core Points - The company has successfully included several of its products in the National Medical Insurance Catalog for 2025, which is expected to enhance sales and improve operational performance [1] - The total estimated sales for the included drugs in 2024 is approximately 8.66 billion yuan, and for the first three quarters of 2025, it is about 7.55 billion yuan [1] Drug Inclusion in National Medical Insurance Catalog - The following drugs have been newly included: - Injection of Rukang Qutuzumab - Apixaban Famitinib Capsules - Injection of Funaqi Zhumab - Sulfate of Amatuximab Tablets - Injection of Phosphorola Pitant Palonosetron - Injection of Ruikasi Zhumab - Acetate of Abiraterone Tablets (II) - Lipid Injection of Irinotecan Hydrochloride (II) - Regaglitin Metformin Tablets (I)/(II) - Perfluorohexyl Octane Eye Drops [1] - The following drugs have successfully added new indications: - Injection of Karelizumab - Fluorazepam Capsules - Injection of Fumaric Acid Tegafur [1] - The following drugs have been renewed and retained in the National Medical Insurance Catalog: - Maleate of Pyrotinib Tablets - Hecorapam Ethanolamine Tablets - Phosphate of Regaglitin Tablets - Injection of Methylsulfonylmethane Remazolam - Sulfate of Pevonedistat Injection [1] - The following drugs have new indications and have been adjusted to regular catalog management: - Mesylate of Apatinib Tablets - Lipid Injection of Bupivacaine [1] Impact on the Company - The inclusion of these drugs in the National Medical Insurance Catalog is expected to positively impact sales, although the exact effect on the company's operational performance is currently indeterminate [1] - The National Medical Insurance Catalog will officially take effect on January 1, 2026, with further details on payment standards and reimbursement rules to be announced by relevant government departments [1]

证券代码：600276 证券简称：恒瑞医药 公告编号：临2025-194 江苏恒瑞医药股份有限公司关于公司药品纳入国家医保目录的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性承担法律责任。 根据国家医保局、人力资源社会保障部关于印发《国家基本医疗保险、工伤保险和生育保险药品目录 （2025年）》的通知（"《国家基本医疗保险、工伤保险和生育保险药品目录》"以下简称"国家医保目 录"），江苏恒瑞医药股份有限公司（以下简称"恒瑞医药"或"公司"）部分产品纳入国家医保目录。 通过医保谈判，注射用瑞康曲妥珠单抗、苹果酸法米替尼胶囊、夫那奇珠单抗注射液、硫酸艾玛昔替尼 片、注射用磷罗拉匹坦帕洛诺司琼、注射用瑞卡西单抗、醋酸阿比特龙片（Ⅱ）、盐酸伊立替康脂质体 注射液（Ⅱ）、瑞格列汀二甲双胍片（Ⅰ）/（Ⅱ）、全氟己基辛烷滴眼液首次纳入国家医保目录；注 射用卡瑞利珠单抗、氟唑帕利胶囊、富马酸泰吉利定注射液新增适应症成功纳入国家医保目录；马来酸 吡咯替尼片、海曲泊帕乙醇胺片、磷酸瑞格列汀片、注射用甲苯磺酸瑞马唑仑、硫培非格司亭注射液续 约成功保留在国家 ...

Core Viewpoint - The company reported Q3 2025 financial results that exceeded expectations, with significant growth in revenue and profit metrics, indicating strong operational performance and market demand [1][2]. Financial Performance - Q3 2025 revenue reached 17.12 billion, representing a year-over-year increase of 28.7%, while adjusted operating profit was 1.38 billion, up 59.9%. Adjusted net profit stood at 1.90 billion, reflecting a 42.4% increase, surpassing market expectations of approximately 24% revenue growth and 27% net profit growth [1]. - For the first three quarters of 2025, total revenue was 52.41 billion, up 25.8%, with operating profit at 3.37 billion, a remarkable increase of 112.4%, and adjusted net profit at 5.47 billion, up 37.5% [1]. Growth Drivers - The primary drivers for the exceeded expectations include: 1. **Pharmaceutical Sales Growth**: In H1 2025, pharmaceutical and health product sales generated 29.33 billion in revenue, a year-over-year increase of 22.7%, driven by strong growth in original research drugs and chronic disease categories [2]. 2. **Increased Advertising Revenue**: Online platform and digital marketing revenue reached 5.96 billion in H1 2025, up 34.4% year-over-year, attributed to an increase in advertisers [2]. 3. **AI Integration**: AI-driven consultation services improved user engagement and conversion rates [2]. 4. **Supply Chain Advantages**: Adjusted net profit margin for Q3 2025 was 11.1%, up 1.1 percentage points year-over-year, with a margin of 10.4% for the first three quarters, up 0.9 percentage points, indicating improved procurement costs and policies [2]. Strategic Collaborations - In Q3 2025, the company signed strategic cooperation agreements with major pharmaceutical firms such as Eli Lilly, Innovent Biologics, and Bayer, launching several new drugs on its platform [2]. Market Performance - During the Double 11 shopping festival, over 7,000 brands saw their transaction volumes double year-over-year, with more than 2,500 pharmaceutical brands and health products also experiencing similar growth [3]. - AI consultations showed significant value, with over 30% of user inquiries occurring late at night, a 60%+ increase in consultation numbers, and a user satisfaction rate exceeding 98% [3]. Future Outlook - The company plans to expand its AI health ecosystem, collaborating with brands to establish a smart interconnected ecosystem for health management, with future expansions into various health monitoring areas [3]. - Revenue forecasts for 2025-2027 have been revised upward to 70.95 billion, 82.00 billion, and 93.49 billion, respectively, with net profit estimates adjusted to 4.74 billion, 5.66 billion, and 6.76 billion, reflecting optimism about sustained growth driven by supply chain and AI advantages [3].

Investment Rating - The report maintains a "Buy" rating for the company [4][6]. Core Insights - The company achieved a revenue of 23.188 billion yuan in the first three quarters of 2025, representing a year-on-year increase of 14.85%. The net profit attributable to the parent company was 5.751 billion yuan, up 24.50%, and the net profit after deducting non-recurring gains and losses was 5.589 billion yuan, an increase of 21.08% [1][4][6]. Summary by Sections Internationalization and Partnerships - In Q3 2025, the company secured three overseas licensing agreements, including a collaboration with GSK to develop up to 12 innovative drugs, receiving an upfront payment of 500 million USD, with potential total payments of approximately 12 billion USD [2]. - The company also entered into a New-Co transaction with Braveheart Bio for HRS-1893, receiving an upfront payment of 65 million USD and potential milestone payments of up to 1.013 billion USD [2]. - Additionally, the company licensed part of its international market rights for a drug to Glenmark, receiving an upfront payment of 18 million USD and potential milestone payments of up to 1.093 billion USD [2]. Innovation and R&D - The company increased its R&D expenditure to 4.945 billion yuan in the first three quarters of 2025. New products were approved for market, including EZH2 inhibitors and a new oral hypoglycemic combination [3]. - The company has over 100 self-developed innovative products in clinical development and more than 400 clinical trials ongoing domestically and internationally [3]. - At the 2025 ESMO annual meeting, the company presented 46 research results in the oncology field, with significant findings published in The Lancet [3]. Financial Forecast - The company is projected to achieve net profits of 8.803 billion yuan, 10.277 billion yuan, and 12.151 billion yuan for 2025, 2026, and 2027, respectively, with year-on-year growth rates of 38.9%, 16.8%, and 18.2% [4][10].

Core Viewpoint - The launch of the OC-01 nasal spray by Yuan Da Pharmaceutical marks a significant advancement in the treatment of dry eye syndrome, transitioning from passive hydration to active tear production, which is expected to disrupt the current market dominated by eye drops [1][2][5]. Group 1: Product Overview - The OC-01 nasal spray is the only approved product in China designed to increase tear secretion for dry eye patients, utilizing a method that activates the trigeminal nerve pathway to stimulate the lacrimal glands [2][3]. - This product aims to promote the production of natural tears, which contain various nutrients and protective factors, rather than merely replacing moisture [2][5]. Group 2: Market Potential - The dry eye syndrome market in China is projected to reach 18 billion yuan by 2030, driven by the increasing prevalence of the condition due to the widespread use of electronic devices [1][4]. - The overall ophthalmic drug market in China is expected to grow to 44 billion yuan by 2025 and reach 108.4 billion yuan by 2030, with the dry eye drug segment anticipated to grow at a compound annual growth rate (CAGR) of 16.17% from 2020 to 2024 [4]. Group 3: Competitive Landscape - Other companies, including Xingqi Eye Medicine and Heng Rui Pharmaceutical, are also entering the dry eye market, with various products in development, particularly in the cyclosporine eye drop segment [6][7]. - The competition is intensifying with the approval of several new products, including sodium hyaluronate eye drops by Kanghong Pharmaceutical and Huaxi Biological, indicating a rapidly evolving market [7].

Investment Rating - The investment rating for the company is "Buy" (maintained) [5] Core Views - The company's main business is experiencing steady growth, and the value of its innovative pipeline continues to be realized [5] - The company reported a revenue of 231.88 billion yuan for the first three quarters of 2025, representing a year-on-year growth of 14.85%, with a net profit attributable to shareholders of 57.51 billion yuan, up 24.50% year-on-year [7] - The company has achieved significant milestones in its internationalization efforts, including three overseas business development (BD) agreements that could provide regular profits [7] Financial Performance Summary - Revenue projections for 2023 to 2027 are as follows: 22,820 million yuan (2023), 27,985 million yuan (2024), 34,074 million yuan (2025E), 40,899 million yuan (2026E), and 49,373 million yuan (2027E) with corresponding growth rates of 7.26%, 22.63%, 21.76%, 20.03%, and 20.72% [6] - Net profit attributable to shareholders is projected to be 4,302 million yuan (2023), 6,337 million yuan (2024), 9,431 million yuan (2025E), 11,331 million yuan (2026E), and 13,693 million yuan (2027E), with growth rates of 10.14%, 47.28%, 48.84%, 20.14%, and 20.85% respectively [6] - The company has maintained a low debt ratio of 12.14% and a net asset value per share of 8.97 yuan [3] Product Development and Innovation - The company has launched new products such as EZH2 inhibitor and has received approvals for multiple new indications, indicating the ongoing realization of its innovative pipeline [7] - The company has received 48 clinical approvals and has several products included in the breakthrough therapy list, showcasing its strong R&D capabilities [7] International Expansion - The company has accelerated its internationalization process, with significant overseas BD transactions that could lead to substantial future revenues [7] - The agreements include collaborations with GSK and other companies, with potential milestone payments reaching up to 120 billion yuan [7]

Core Viewpoint - The company has demonstrated significant revenue growth driven by its core products, cyclosporine eye drops and atropine sulfate eye drops, while implementing strategies to mitigate competitive pressures and optimize production capacity [1][2][3]. Group 1: Revenue Growth and Core Products - The company's revenue has consistently increased, with figures of 1.25 billion, 1.468 billion, and 1.943 billion from 2022 to 2024, and 536 million in Q1 2025, reflecting year-on-year growth rates of 32.42% and 53.24% [1]. - The net profit attributable to the parent company also rose, reaching 208 million, 240 million, 348 million, and 136 million during the same periods, with year-on-year increases of 44.54% and 285.96% [1]. - Cyclosporine eye drops, approved in June 2020 and included in the medical insurance directory in 2022, saw revenue growth from 448 million to 1.366 billion, projected to account for 100% of eye drop revenue in 2024 [1]. - Atropine sulfate eye drops, approved in March 2024, are the first product in China aimed at slowing the progression of myopia in children and are currently in a market monopoly phase [2]. Group 2: Competitive Landscape and Response Strategies - The industry is experiencing increased competition, with new products from companies like Hengrui Medicine and Kanghong Pharmaceutical expected to enter the market by mid-2025 [3]. - The company has established a comprehensive marketing system covering public hospitals, private eye care groups, retail pharmacies, and e-commerce platforms, with atropine eye drops available in approximately 17,000 retail pharmacies by mid-2025 [3]. - A professional promotion team of over 1,000 members has been formed, and core products have been included in more than 20 clinical guideline consensus documents [3]. - The company is expanding its research pipeline, with 78 projects under development, including 0.02%/0.04% concentration atropine and a biological agent for dry eye treatment [3]. Group 3: Production Capacity and Financial Health - The production capacity utilization rate for eye drops was 67.33% in 2024 and 60.37% in the first half of 2025, primarily due to new production lines ramping up and some outsourced production [4]. - The sales-to-production ratio remained high at 119.67% in the first half of 2025, indicating strong market demand [4]. - The company reported a decrease in accounts receivable turnover from 10.77 in 2022 to 8.94 in Q1 2025, but over 99% of accounts receivable are due within one year, with a collection rate of 93.73% [4]. - The company maintains a prudent approach to inventory management, with a provision for inventory impairment at 3.56%, higher than peers like Kanghong Pharmaceutical and Hengrui Medicine [4]. Group 4: R&D Investment and Future Plans - R&D expenditures from 2022 to 2024 were 190 million, 182 million, and 235 million, with capitalization ratios of 23.44%, 7.89%, and 6.22% respectively, primarily for clinical research on cyclosporine and atropine [5]. - As of June 2025, the company holds 73 invention patents and employs 271 R&D personnel, accounting for 11.17% of total staff [5]. - The company plans to raise 850 million through a private placement, with 650 million allocated for R&D center construction and 200 million for working capital, addressing current space constraints and aiming to add 280 R&D personnel over the next decade [6]. - The company clarified that adjustments to project investments were necessary due to rapid business growth, ensuring alignment with strategic planning without veering into real estate investments [6].

Fixed Income Research - The People's Bank of China (PBOC) announced the resumption of government bond trading operations, indicating a shift in monetary policy tools to enhance liquidity management [2][3] - Since August 2024, the PBOC has conducted net purchases of government bonds totaling 1 trillion yuan, with a gradual increase in bond buying until January 2025 when operations were paused due to market imbalances [3][4] - The resumption of bond trading is expected to enrich the monetary policy toolkit, enhance the financial functions of government bonds, and improve the pricing benchmark for the yield curve [5][8] Company Research: Heng Rui Medicine (600276) - Heng Rui Medicine reported a revenue of 23.188 billion yuan for the first three quarters of 2025, a year-on-year increase of 14.85%, with a net profit of 5.751 billion yuan, up 24.50% [14][15] - The company achieved significant overseas expansion, securing three overseas business development agreements and launching three new drugs in Q3 2025 [15][16] - The forecast for net profit from 2025 to 2027 is set at 8.045 billion, 9.866 billion, and 11.702 billion yuan respectively, maintaining a "buy" rating [16] Company Research: YTO Group (601038) - YTO Group reported a revenue of 9.703 billion yuan for the first three quarters of 2025, a decrease of 9.63%, with a net profit of 994 million yuan, down 9.69% [20][21] - Despite the decline, Q3 showed improvement with a net profit of 225 million yuan, a year-on-year increase of 15.14% [21] - The company continues to focus on the trend of agricultural machinery intelligence and high-end products, launching a new heavy-duty tractor at an agricultural machinery exhibition [21][22] Company Research: Luoyang Molybdenum (603993) - Luoyang Molybdenum reported a revenue of 145.485 billion yuan for the first three quarters of 2025, a decrease of 5.99%, while net profit increased by 72.61% to 14.280 billion yuan [24][25] - The company achieved production completion rates exceeding 75% for major products, with significant cost reductions in cobalt production [25][27] - The company plans to invest 1.084 billion USD in the KFM Phase II project, expected to be completed by 2027, which will enhance copper processing capacity [27][28] Company Research: Aluminum Corporation of China (601600) - Aluminum Corporation of China reported a revenue of 176.516 billion yuan for the first three quarters of 2025, a year-on-year increase of 1.57%, with a net profit of 10.872 billion yuan, up 20.65% [30][31] - The company experienced steady growth in production, with alumina and primary aluminum output increasing by 3.74% and 6.76% respectively [31][32] - The profit forecast for 2025 to 2027 is adjusted to 14.553 billion, 16.036 billion, and 17.076 billion yuan, maintaining an "accumulate" rating [32][33]

Investment Rating - The investment rating for the company is "Buy" [2][17] Core Insights - The company achieved a revenue of 23.188 billion yuan in the first three quarters of 2025, representing a year-on-year increase of 14.85%. The net profit attributable to shareholders reached 5.751 billion yuan, up 24.50% year-on-year [1] - In Q3 2025, the company reported a revenue of 7.427 billion yuan, a year-on-year increase of 12.72%, driven by both internal growth and overseas expansion [2] - The company has successfully completed three overseas business development (BD) authorizations, indicating strong international collaboration and potential revenue growth [2][3] Financial Performance - The gross profit margin for the first three quarters of 2025 was 86.22%, an increase of 0.25 percentage points year-on-year. The net profit margin improved to 24.84%, up 1.97 percentage points year-on-year [4] - Research and development expenses for the first three quarters reached 4.945 billion yuan, contributing to a cumulative R&D investment exceeding 50 billion yuan, which enhances the company's innovation capabilities [4] - The company launched three new drugs in Q3 2025, including the first self-developed EZH2 inhibitor in China, indicating a strong pipeline of innovative products [3][4] Profit Forecast - Under a neutral scenario, the company is expected to achieve net profits of 8.045 billion yuan, 9.866 billion yuan, and 11.702 billion yuan for the years 2025, 2026, and 2027, respectively [6]