首次尝试，集采冲击导致估值基础动摇 朗研生命主要从事高端化学药品制剂及原料药的研发、生产与销售，核心产品包括缬沙坦氢氯噻嗪片、恩 替卡韦片、索磷布韦原料药等，2023年和2024年未经审计的归母净利润分别为3,671万元和5,388万元。 登录新浪财经APP 搜索【信披】查看更多考评等级 2026年1月27日，阳光诺和（688621.SH）发布公告，宣布正式终止以发行股份及可转换公司债券方式收购 朗研生命100%股权的重组计划，并撤回相关申请文件。这是自2022年以来，阳光诺和第二次对同一标的 发起收购并以失败告终。至此，该项目也成为国联民生证券今年以来已终止的第三个项目。 值得注意的是，两次交易，相隔三年，标的相同、实控人一致、中介机构未变——国联民生证券始终担任 独立财务顾问（其中第一次为合并前的民生证券）。从2022年16.11亿元的首次尝试，到2025年12亿元的 再度推进，阳光诺和始终试图打通"CRO（研发外包）+医药工业"一体化平台的战略构想，屡次在政策变 化与估值博弈的双重压力下受阻。 | 项目 | 第一次收购（2022–2023） | 第二次收购 (2025-2026) | | --- | - ...

2026年1月27日， 阳光诺和 （688621.SH）发布公告，宣布正式终止以发行股份及可转换公司债券方式收 购朗研生命100%股权的重组计划，并撤回相关申请文件。这是自2022年以来，阳光诺和第二次对同一标 的发起收购并以失败告终。至此，该项目也成为 国联民生 证券今年以来已终止的第三个项目。 值得注意的是，两次交易，相隔三年，标的相同、实控人一致、中介机构未变——国联民生证券始终担任 独立财务顾问（其中第一次为合并前的民生证券）。从2022年16.11亿元的首次尝试，到2025年12亿元的 再度推进，阳光诺和始终试图打通"CRO（研发外包）+医药工业"一体化平台的战略构想，屡次在政策变 化与估值博弈的双重压力下受阻。 | 项目 | 第一次收购（2022–2023） | 第二次收购 (2025-2026) | | --- | --- | --- | | 交易对价 | 16.11亿元 | 12亿元 | | 标的估值依据 | 2022年收益法评估 | 2025年6月30日收益法评估 | | 核心产品风险 | 缅沙坦类、蚓激酶等集采降价 | 同类产品续标价降幅超90% | | 业绩承诺 | 未明确披露 | 20 ...

炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ 因市场环境变化等因素，阳光诺和终止收购朗研生命100%股权。 阳光诺和（688621）1月27日晚公告，公司于当日召开第二届董事会第二十八次会议，审议通过了相关 议案，同意终止发行股份及可转换公司债券购买资产并募集配套资金暨关联交易事项，并撤回申请文 件；同时，授权公司管理层全权办理本次交易终止的各项事宜。 此前，公司曾公告，拟通过发行股份及可转换公司债券方式购买江苏朗研生命科技控股有限公司（以下 简称"朗研生命"）100%股权，并向不超过35名特定投资者发行股份募集配套资金。本次交易预计构成 重大资产重组及关联交易，不构成重组上市。 朗研生命目前已完成心血管疾病类、抗感染类、内分泌系统疾病类、消化系统疾病类等多个重要领域用 药的研发和生产，主要产品包含高端化学药品制剂和原料药两种类型，高端化学药品制剂主要包括缬沙 坦氢氯噻嗪片、缬沙坦氨氯地平片（I）、蚓激酶肠溶胶囊、盐酸伊伐布雷定片、恩替卡韦片等；原料 药主要包括索磷布韦原料药、氨基己酸原料药等。2023年和2024年，朗研生命未经审计的归母净利润分 别为3671.03万元、5388 ...

Core Insights - Recent trend shows multinational pharmaceutical companies selling parts of their businesses in China to investment firms rather than to industry peers, indicating a shift in investment strategy [1][2] - The divestiture is driven by profit pressures from national procurement and healthcare cost control policies, leading to a reevaluation of asset structures by these companies [2][5] - Investment firms are increasingly acting as industry operators, leveraging their capital and operational expertise to unlock value in mature assets acquired from multinational firms [8][9] Group 1: Recent Transactions - Bristol-Myers Squibb (BMS) is selling 60% of its stake in China-based Shanghai BMS Pharmaceutical to Hillhouse Capital, with the deal expected to close in early 2026 [1] - Bayer is selling the intellectual property and global commercial rights of its antibiotic Avelox to Sequoia China, with completion anticipated in the first quarter of 2026 [1] - Earlier, UCB sold its mature product business in China to Kangqiao Capital and other investment firms, marking a trend of capital firms acquiring pharmaceutical assets [2] Group 2: Market Dynamics - Multinational pharmaceutical companies face significant profit pressure due to policies like national procurement, which has led to a decline in profit margins and market share for original drugs against local generics [2][5] - The market for original drugs is shrinking as local companies gain ground in the generic drug sector, leading to a strategic shift for multinationals to divest non-core assets [5][10] - Investment firms are capitalizing on this trend by acquiring mature products and leveraging their operational capabilities to enhance value [8][9] Group 3: Strategic Shifts - The divestiture of assets is part of a broader strategic realignment for multinational companies, focusing on innovation and local market integration rather than traditional sales models [11][12] - Companies are increasingly investing in local R&D and production capabilities, with significant investments announced by firms like AstraZeneca and Roche in recent months [12] - The evolving landscape suggests a dual competitive structure where multinationals focus on innovative drugs while investment firms specialize in mature product markets [9][10]

Core Viewpoint - The new centralized procurement rules for pharmaceuticals aim to address historical issues and promote sustainable development in the pharmaceutical industry, balancing price control, quality assurance, and supply stability [1][10]. Group 1: Historical Issues and Data - The new procurement rules are designed to resolve past issues such as low-price competition, quality instability, and supply shortages, which have been prevalent since the initiation of the centralized procurement system [2][4]. - The latest round of procurement includes 55 drug varieties across various therapeutic areas, with an average of 15 companies competing for each variety, indicating strong market interest and competition [2][3]. Group 2: Reporting and Supply Assurance - The reporting phase for the latest procurement batch requires medical institutions to submit annual demand volumes that are generally not less than 80% of the average usage from 2023 to 2024, allowing for brand recognition in the reporting process [3][6]. - The new rules designate selected companies as the primary responsible parties for supply assurance, imposing penalties for non-compliance, which aims to reduce the occurrence of supply shortages [3][6]. Group 3: Impact on Pricing and Quality - The optimization of procurement rules is expected to alleviate the pressure on companies that previously relied on extremely low bids, promoting a healthier competitive environment [6][10]. - The new regulations encourage a balance between price and quality, ensuring that patients benefit from affordable medications without compromising on safety and efficacy [7][10]. Group 4: Industry Dynamics and Future Outlook - The changes are likely to accelerate the elimination of weaker players in the pharmaceutical sector, favoring larger, more capable companies that can maintain quality and supply stability [8][10]. - The shift from a price-first approach to one that equally values quality and supply stability is anticipated to enhance public confidence in generic drug quality and support the sustainable development of the healthcare system [10].

Core Viewpoint - The sale of a 60% stake in the Sino-American Shanghai Bristol-Myers Squibb Pharmaceutical Co., Ltd. (SASS factory) by Bristol-Myers Squibb is significant as it marks a strategic shift in the company's operations in China, focusing on resource allocation and external collaboration to enhance its regional strategy and ensure long-term drug supply for patients globally [1][3]. Group 1: Company Actions - Bristol-Myers Squibb has signed an agreement to sell its 60% stake in the SASS factory, which was the first Sino-American joint venture pharmaceutical company established after China's reform and opening up in 1982 [1]. - The company aims to continue investing in the Chinese market under its "China 2030 Strategy," which includes plans to introduce nearly 30 innovative products or indications by 2025 and accelerate the introduction of more global innovations from 2026 to 2030 [4]. - The SASS factory primarily produces mature products, including various medications that have seen profit margins compressed due to China's centralized procurement policies since 2018 [3][4]. Group 2: Industry Trends - Other multinational pharmaceutical companies, such as Eli Lilly and GlaxoSmithKline, have also engaged in asset divestitures in China, focusing on mature products, indicating a broader trend in the industry [3]. - The Chinese government has implemented policies favoring innovative drugs, encouraging pharmaceutical companies to shift their focus towards innovation rather than relying on mature products [3][4]. - Bristol-Myers Squibb is adapting its strategy for its PD-1 monoclonal antibody, O drug, aiming to push for its inclusion in the national medical insurance directory to enhance market access and affordability for patients [5].

Core Insights - The company reported a revenue of 3.358 billion and a net profit of 354 million for the first half of 2025, with a 31% year-on-year increase in operating cash flow [1] - The company maintains a "Traditional Chinese Medicine Health" core strategy and continues to optimize its "one body, two wings" business layout [1] - The company emphasizes shareholder returns, completing a cash dividend for 2024 with a payout ratio of 60.76% and repurchasing 63.579 million shares [2] Financial Performance - Total revenue reached 3.358 billion, with a net profit of 354 million [1] - Operating cash flow increased by 31%, reaching 400 million [1] - Sales expense ratio and debt-to-asset ratio both decreased year-on-year, indicating improved operational quality [1] Business Segments - The traditional Chinese medicine segment generated 583 million in revenue, a 4.6% increase year-on-year [1] - The specialty health consumer products segment saw revenue of 321 million, growing over 10% [1] - Major brand products achieved sales of 2.006 billion, with the "Kang En Bei" intestinal health series exceeding 500 million in sales, a growth of over 15% [1] R&D and Innovation - The company received one approval for a modified traditional Chinese medicine and five approvals for generic drugs, including FDA approval for Entecavir tablets and Acetylcysteine solution [2] - A total of 74 new R&D projects were initiated, focusing on product lifecycle enhancement through formulation improvements and evidence-based research [2] ESG and Governance - The company received an "A" rating and a "AA-" rating from Zhong Chengxin Green Finance, indicating steady improvement in governance [3] - The company plans to continue focusing on its pharmaceutical core business while enhancing innovation and transformation [3]

Core Viewpoint - Renhe Pharmaceutical (000650) has received the registration certificate for Entecavir tablets in 2021, which is an oral antiviral drug used for the treatment of hepatitis B infection [1] Company Summary - The company specializes in Entecavir, which selectively inhibits the hepatitis B virus [1] - Entecavir is primarily used for treating adults with active viral replication and persistently elevated serum transaminases, or with histologically active lesions in chronic hepatitis B [1]

Core Viewpoint - The company has received a drug registration certificate for Entecavir tablets in 2021, which is used for the treatment of hepatitis B infection [2]. Company Products - Entecavir is an oral antiviral medication that selectively inhibits the hepatitis B virus, primarily used for treating adults with active viral replication and elevated serum transaminases, or active disease in liver histology [2].

Core Viewpoint - Recent BD (business development) activities in the biopharmaceutical sector have garnered significant market attention, with companies like Rongchang Biopharmaceutical and China National Pharmaceutical Group announcing strategic partnerships and licensing agreements [1][2]. Group 1: Company Developments - Rongchang Biopharmaceutical's product, Tai'axip, has attracted interest from multinational pharmaceutical companies during the ERA conference, indicating potential for international collaboration and technology licensing [1]. - China National Pharmaceutical Group has identified out-licensing as a key strategic goal, engaging in discussions with multiple multinational pharmaceutical companies regarding innovative assets with global commercialization potential [1][2]. - Rongchang Biopharmaceutical reported a 94.87% year-on-year increase in sales volume for Tai'axip, reaching 1.5244 million units, showcasing strong commercial potential [3]. Group 2: Market Performance - Following positive announcements, Rongchang Biopharmaceutical's stock rose by 20.1% to HKD 57.65 per share, while China National Pharmaceutical Group's stock increased by 19.29% to HKD 5.69 per share [1]. - However, both companies experienced a stock price correction shortly after, with Rongchang Biopharmaceutical's share price dropping by 9.08% and China National Pharmaceutical Group's by 4.92% [1]. Group 3: Industry Trends - The biopharmaceutical sector is witnessing a surge in BD transactions, with the scale of these transactions surpassing traditional financing methods, becoming essential for biotech companies amid tightening capital markets [2][3]. - The Chinese innovative drug market is increasingly gaining international recognition, with a significant rise in the number and value of BD transactions, indicating a shift in global market dynamics [9][10]. - The trend of BD transactions is expected to continue, with a focus on innovative assets and diverse therapeutic targets, driven by both internal corporate strategies and external market conditions [10][11].