Core Viewpoint - The article discusses the recent policy developments in the petrochemical industry in China, emphasizing the shift towards high-end and green transformation, particularly focusing on non-grain biomass utilization and bio-based materials as new growth areas [2][5][6]. Group 1: Policy Developments - On September 25, 2023, seven Chinese government departments released a work plan aimed at stabilizing and optimizing the petrochemical industry from 2025 to 2026, addressing challenges such as intensified competition in organic raw materials and slowing domestic demand [2]. - The work plan encourages the development of emerging fields like bio-based chemicals and non-grain biomass utilization, providing new momentum for the industry's green transformation [2][4]. Group 2: Focus on Bio-based Materials - The policy has shifted from "technology transformation" to "supply and demand quality improvement," indicating a maturation of industry technology and a focus on enhancing the quality of bio-based materials [5][6]. - The emphasis on non-grain bio-based materials has evolved from "industrial demonstration" to "typical case collection and promotion," suggesting that some bio-based materials can achieve a replicable business model [6]. Group 3: Growth in Bio-chemicals - The new work plan introduces a focus on "bio-chemicals," highlighting the rapid growth of synthetic biology in the chemical sector due to its green and efficient characteristics [7]. - Multiple government departments have issued documents supporting the development of bio-based and bio-manufacturing sectors throughout 2023, indicating a strong governmental push towards these industries [8][10].

Core Insights - The article discusses the establishment of a Synthetic Biology Innovation and Entrepreneurship Center in Jiang'an District, Hubei Province, in collaboration with Hubei University, aimed at fostering the synthetic biology industry and linking local industrial needs with academic research resources [2][4]. Group 1: Establishment of the Center - Jiang'an District signed an agreement with Hubei University to co-establish a Synthetic Biology Innovation and Entrepreneurship Center, which will serve as a crucial link between local industry demands and university research capabilities [2][4]. - The center will accelerate the gathering of synthetic biology industries in Jiang'an, leveraging Hubei University's strengths in this field [4]. Group 2: High-Tech Enterprises Involvement - Several high-tech companies, including Wuhan Xingquan Gene and Health Technology Co., Ltd. and Wuhan Ruidu Biotechnology Co., Ltd., have moved into the collaborative innovation building, showcasing the effectiveness of the university-industry cooperation platform [5]. - Xingquan Gene focuses on early cancer screening technologies based on canine olfactory capabilities, while Ruidu Biotechnology specializes in unique DNA synthesis and assembly technologies derived from academic research [5]. Group 3: Supportive Infrastructure - The collaborative building offers a "zero-cost entrepreneurship space," providing two years of rent-free and three years of reduced rent for university entrepreneurs, promoting the growth of the synthetic biology innovation center and related industries [5]. - The initiative aims to create a comprehensive support system that includes industry funds, intellectual property, and professional services to enhance innovation and entrepreneurship [5]. Group 4: Future Plans and Policies - Jiang'an District plans to launch the "Bian Plan" in 2024, introducing nine key policies to support technological innovation in various sectors, including environmental protection and artificial intelligence [6]. - The district has also implemented a plan to promote zero-cost entrepreneurship, fostering a conducive ecosystem for innovation and job creation [6].

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Event Overview - The NFUCon 2025 will be held from November 27 to 29, 2025, in Hangzhou, Zhejiang, under the theme "Top Talent Gathering, Industry Symbiosis" [2]. - The forum will invite representatives from government, enterprises, and experts to discuss key strategic directions such as biomass green pretreatment, non-grain sugars, biomass-based chemicals and materials, and biomass energy [2]. Group 2: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and the National Key Laboratory of Biomass Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 3: Guest Speakers - Notable speakers include Zhu Jin, who has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other biomass materials [4]. - Li Zhenglong focuses on the conversion and utilization of low-carbon resources, particularly in renewable aviation fuel and biomass separation technologies [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 4: Forum Agenda - The forum will feature various activities, including a youth forum on non-grain biomass, a sustainable aviation fuel industry exchange, and thematic discussions on biomass chemicals and energy [15][16]. - A technology achievement display area will be set up to showcase 50 innovative projects with commercial potential in the biomass utilization field [17]. Group 5: Laboratory Focus - The National Key Laboratory of Biomass Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel technology, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

/生物制造产业社群/ 让上下游聚在一起, 未来食农、绿色化工、大健康、美妆个护 等产业同行❤️↓ 资本事件 | 美尚洁生物 【SynBioCon】 获 悉 ，近日，江苏美尚洁生物科技有限公司 （以下简称 "美尚洁生物"）宣布已 成功完成数千万人民币的新一轮 A+ 轮 融资。 本轮募集资金将用于进一步加速公司在基因工程合成生物领域的研发投入， 推动其重组人源化胶原 蛋白产品的临床转化与市场拓展，并持续优化其技术平台 ，计划在宜兴落地新的三类器械生产管线 。 此外， 本轮跟投还有数千万的跟投额度，其它数家投资机构仍在积极跟进中。 自2018年成立以来，美尚洁生物始终深耕于基因工程合成生物科技领域，尤其在 重组人源化胶原蛋 白产品的研发及医疗应用 方面取得了突破性进展。此次融资的成功，不仅是对我们现有成果和未来 潜力的肯定，更是对我们坚持技术创新的有力证明。我们将以此为契机，进一步加大研发力度，加快 产品上市步伐，为医疗健康领域带来更安全、更有效的解决方案。" 美尚洁生物的核心竞争力在于其创新性的技术平台。 作为 国内首家基于 AI 技术进行重组融合蛋白 研发 的公司， 已成功运用 AI模型技术完成了序列片段的多样 ...

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research achievements and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. and the National Key Laboratory of Bio-based Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 2: Guest Highlights - Zhu Jin has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other bio-based materials [4]. - Li Zhenglong focuses on the conversion and utilization of low-carbon resources, particularly in renewable aviation fuel and C1 catalysis [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 3: Forum Agenda - The forum will feature various activities, including a youth forum and discussions on sustainable aviation fuel [16]. - The main sessions will cover topics such as biomass green pretreatment, non-grain sugars, bio-based chemicals, and materials [16]. - A technology achievement display area will be set up to showcase 50 innovative projects with commercial potential [17]. Group 4: Laboratory Overview - The National Key Laboratory of Bio-based Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel technology, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

Core Viewpoint - The article discusses the advancements in glycosyltransferase engineering for the efficient glycosylation of flavonoids, highlighting the potential applications in health and wellness products, as well as in the fields of agriculture and biomedicine [5][11]. Summary by Sections Glycosylation of Flavonoids - Flavonoids are important plant secondary metabolites with significant biological activities used in disease prevention and treatment [3]. - The glycosylation of flavonoids is catalyzed by plant UDP-glycosyltransferases (UGTs), which is a green and economical method compared to traditional chemical synthesis [3][4]. Research Findings - The study identified a rare glycosyltransferase, UGT75AJ2, capable of catalyzing the glycosylation at C-3' and C-7 hydroxyl positions of flavonoids, leading to the directed synthesis of bioactive flavonoid glycosides [5][6]. - The research demonstrated that glycosylation at these positions enhances antioxidant and blood sugar-lowering activities [4]. Engineering Strategies - A custom FRISM strategy was developed for the rational design of UGTs, resulting in a quadruple mutant (Mut4-1) of UGT75AJ2 with 128 times the catalytic activity of the wild type [7]. - The strategy was also successfully applied to other glycosyltransferases, validating its effectiveness and versatility [7][8]. Implications and Applications - The study provides a new paradigm for enhancing the activity, donor promiscuity, and regioselectivity of plant glycosyltransferases, which is crucial for the biosynthesis of high-value flavonoid glycosides [11]. - This research integrates multiple disciplines, including food science, synthetic biology, artificial intelligence, and pharmacology, contributing to the development of health products with medicinal value [11].

Core Viewpoint - The article discusses the recent policy developments in Shanghai aimed at promoting agricultural technology innovation, particularly in the fields of agricultural biotechnology and modern facility agriculture, to enhance the competitiveness and sustainability of urban agriculture [2][3]. Summary by Sections Policy Framework - The Shanghai Municipal Agricultural and Rural Committee, in collaboration with the Finance Bureau, has established guidelines for managing agricultural science and technology innovation projects and funding [2][3]. Funding Support - The policy emphasizes the importance of ensuring project funding safety while stimulating technological innovation, with dedicated funding for various projects [4]. - Key technology projects can receive up to 4 million yuan over a 3 to 5-year period, while important innovation projects can receive up to 2 million yuan over 2 to 3 years, with flexibility for longer projects [5]. Application and Industry Enhancement - Application scenario projects aim to create a comprehensive agricultural technology application ecosystem, with funding up to 3 million yuan for a 2 to 3-year implementation period [5]. - Industry enhancement projects focus on promoting advanced agricultural varieties, technologies, and models, with funding up to 8 million yuan for a maximum of 3 years [5]. Collaborative Breeding and Talent Development - Joint breeding projects support collaboration between seed companies and research institutions, with annual funding up to 500,000 yuan for a maximum of 5 years [6]. - The policy also includes support for cultivating young agricultural technology talents, with funding up to 20,000 yuan per project [6].

Core Viewpoint - The NFUCon 2025 forum will focus on the innovative research and commercial feasibility in the non-grain biomass sector, aiming to promote large-scale applications of non-grain biomass and support carbon neutrality goals [2]. Group 1: Organizing Institutions - The forum is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. and the National Key Laboratory of Bio-based Transportation Fuel Technology [3]. - Key figures include Zhu Jin, Li Zhenglong, and Zhang Xinghong, who hold significant positions in relevant research institutions and laboratories [3][4][5]. Group 2: Guest Highlights - Zhu Jin has achieved multiple industrialization results in heat-resistant polylactic acid foaming materials and other bio-based materials [4]. - Li Zhenglong focuses on the conversion of low-carbon resources and has made advancements in renewable aviation fuel and C1 catalysis [5]. - Zhang Xinghong is involved in polymer synthesis research and CO2-based polycarbonate technology [6]. Group 3: Forum Agenda - The forum will feature various activities including a youth forum, discussions on bio-based chemicals and materials, and a sustainable aviation fuel industry exchange [15][16]. - The agenda includes specialized topics on biomass green pretreatment, non-grain sugars, and bio-based energy sources such as methanol and sustainable aviation fuel [15]. Group 4: Technology Showcase - The forum will host a technology showcase to connect 50 innovative projects in biomass utilization with commercial potential [17]. - This initiative aims to facilitate industry-academia-research collaboration and promote the transfer of quality results [17]. Group 5: Laboratory Overview - The National Key Laboratory of Bio-based Transportation Fuel Technology focuses on four core areas: fiber ethanol technology, bio-aviation fuel development, CO2-based polycarbonate technology, and biofuel evaluation standards [22].

Core Viewpoint - The article highlights the investment in Sichuan Yingjia Hesheng Technology Co., Ltd., a major producer of steviol glycosides, emphasizing its role in the synthetic biology sector and its potential for growth in various markets, particularly in the U.S. and Southeast Asia [2][5]. Company Overview - Yingjia Hesheng, established in 2015, focuses on using synthetic biology to manufacture natural products, with applications in pharmaceuticals, health care, and food and beverage industries [4]. - It is the largest supplier of steviol glycosides in China and one of only three companies globally to receive GRAS certification for its rare steviol glycoside, Rebaudioside I [3][5]. Market Position - Since 2019, Yingjia Hesheng has successfully entered the U.S. market and is part of the supply chains of several international food and beverage companies, with increasing sales in the UK and Southeast Asia [5]. - The company is also planning to expand into emerging markets such as Japan and South Korea [5]. Product Line - In addition to steviol glycosides, Yingjia Hesheng's product portfolio includes Coenzyme Q10, new types of steviol glycosides, β-Nicotinamide Mononucleotide (NMN), and vanillin, covering multiple sectors including pharmaceuticals and health supplements [5]. Industry Development - Chengdu is positioning itself as a significant hub for synthetic biology and biomanufacturing, with over 300 biopharmaceutical projects introduced by the end of 2024, and a total industry scale exceeding 350 billion yuan [9][10]. - The local government has implemented policies to support the development of synthetic biology, recognizing its potential to replace traditional chemical processes and enhance the local economy [10][11].

Core Insights - The article discusses the rapid development and investment in the biomanufacturing sector in China, highlighting various projects and initiatives aimed at establishing mid-test platforms across multiple regions [5][6][12]. Investment and Project Developments - In Chongqing, a total of 32 projects with an investment of 14.53 billion yuan were signed, focusing on biomanufacturing, biomedicine, and other high-tech industries [5]. - The Chongqing Biomanufacturing Industry Pilot Platform aims to create a national-level mid-test platform for biomanufacturing, emphasizing intelligent biological fermentation and related technologies [6]. - The platform is part of a broader initiative that includes 1,252 key projects with a total investment of approximately 3.2 trillion yuan planned for 2025 [6]. Regional Initiatives - Changde Economic Development Zone is also advancing its synthetic biomanufacturing mid-test conversion platform, with significant construction progress reported [7][8]. - The Changde platform has a total investment of 169 million yuan and will feature multiple mid-test production lines to cater to various scales and types of biomanufacturing [8]. National Support and Policy Framework - Multiple provinces, including Guangdong, Shanghai, and Sichuan, are actively supporting the establishment of mid-test platforms, with specific funding and policy frameworks in place [10][11][12]. - The Ministry of Industry and Information Technology and the National Development and Reform Commission have set a goal to cultivate over 20 mid-test capability construction platforms by 2027, aiming to serve more than 200 enterprises [12].