Core Insights - The third-generation biorefining technology aims to utilize one-carbon molecules and renewable energy for "negative carbon" production of fuels and chemicals, addressing climate change and food shortages [1] - Acetic acid, derived from syngas fermentation, is increasingly recognized as a viable non-food carbon source in the biosynthesis of bulk chemicals [1] - 3-Hydroxypropionic acid (3-HP) is a renewable bulk chemical with a projected market size exceeding 3.6 million tons per year and a value surpassing $10 billion annually [1] Summary by Sections - **Engineering Achievements**: A research team from East China University of Science and Technology successfully constructed an engineered E. coli strain (ZWR18(MDA)) that synthesizes 3-HP from acetic acid via the propanoyl-CoA pathway, achieving a yield of 5.53 g/L and a conversion rate of 0.732 g/g, which is 97.60% of the theoretical yield [2][6] - **Cell-Catalyzed Production**: Under whole-cell catalysis conditions, the engineered strain can produce 23.89 g/L of 3-HP with a yield of 0.734 g/g, reaching 97.87% of the theoretical yield. When using acetic acid sourced from syngas, the strain still achieves 18.87 g/L of 3-HP with a yield of 0.58 g/g [2][6] - **Metabolic Pathway Insights**: The study outlines the metabolic pathway for converting acetic acid to 3-HP, highlighting the competition between fatty acid synthesis and 3-HP synthesis for propanoyl-CoA. The transcription factor FadR plays a crucial role in fatty acid metabolism, and the use of the antifungal antibiotic can further direct carbon flow towards 3-HP production [5][6] - **Publication Reference**: The research findings were published in "ACS Synthetic Biology" under the title "High-Yield Biosynthesis of 3‑Hydroxypropionic Acid from Acetate in Metabolically Engineered Escherichia coli" [3]

Core Viewpoint - The article discusses the "Qingdao Synthetic Biology Innovation Development Action Plan (2025-2027)", aiming to enhance the synthetic biology industry in Qingdao through innovation, technology breakthroughs, and the establishment of key projects and platforms [1]. Overall Requirements - The plan emphasizes innovation-driven development, focusing on key technologies and products to empower various industries such as healthcare, environmental protection, agriculture, and energy [2]. - By 2027, the goals include achieving at least 30 key technology breakthroughs, 5 internationally advanced innovation results, and the establishment of over 10 landmark industrial projects [2]. Key Tasks Bottom-Level Technology Innovation - The plan outlines actions for advancing foundational technologies in synthetic biology, including artificial life design, gene editing, and microbial genome databases [3]. - A target is set to establish a global marine metagenomic microbial database with over 100,000 entries by 2027 [3]. Platform-Level Tool Innovation - The initiative aims to develop high-throughput and high-precision synthesis platforms using automation and machine learning, with a goal of creating a microbial strain repository of over 40,000 strains by 2027 [4]. Empowering Biopharmaceutical Industry - Focus on mRNA vaccines, gene therapy, and the development of new drug clinical approvals, with a target of obtaining over 5 new drug clinical approvals by 2027 [5]. Empowering Food and Health Industry - The plan includes the development of marine functional sugars and high-value natural products, aiming to establish a library of over 800 marine carbohydrate compounds by 2027 [6]. Empowering Materials and Energy Industry - The initiative targets breakthroughs in biodegradable materials and biofuels, with a goal of developing over 5 landmark synthetic biology products by 2027 [7]. Empowering Agriculture and Environmental Protection - The plan emphasizes precision molecular breeding and the development of new pesticides, aiming to create a special microbial resource library for organic waste degradation by 2027 [8]. Policy Measures Support for Technological Innovation - The plan includes funding support for key technology research and development projects in synthetic biology [10]. Support for Industrial Innovation Platforms - Encouragement for the establishment of key laboratories and innovation centers, with funding for those evaluated as excellent [11]. Accelerating Local Innovation Results - The establishment of a market for technology transfer and the training of specialized technology brokers to facilitate the commercialization of synthetic biology innovations [12]. Financial Empowerment for Industry Development - A financial support system is proposed to cover the entire synthetic biology industry chain, including government-led industry funds [13]. Promotion of Innovative Product Applications - Support for the application of innovative products and the establishment of market application laboratories [14]. Development of Specialized Industrial Parks - The plan includes the construction of specialized synthetic biology parks to incubate projects and support infrastructure development [15]. Guarantee Measures - The article outlines measures for coordination, funding assurance, and industry services to support the implementation of the action plan [18].

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology industry since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference can receive a free copy of the industry map valued at 499 yuan, and eligible biomanufacturing companies can apply to be listed on the map [6][10].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will be held from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Supporters - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Key Speakers and Experts - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes [4][5][7][8][11][15][19][21][27][30]. - The conference will feature discussions on innovative biomanufacturing technologies and applications, including the development of bio-based products and processes [9][12][24][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics such as green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will include a high-level roundtable, youth forums, and specialized sessions focusing on various aspects of biomanufacturing [36][37].

Core Viewpoint - Isomaltulose is a new type of natural sweetener with low calories (4 kcal/g), high stability, and no adverse health effects, widely used in pharmaceuticals and food industries [1]. Market Overview - The global isomaltulose market reached $16.2 million in 2023 and is expected to grow to $48.9 million by 2030, with a compound annual growth rate (CAGR) of 17.19% from 2024 to 2030 [2]. Production Technology - The enzymatic preparation of isomaltulose has high conversion rates and meets green environmental requirements. Sucrose isomerase (SI) is an effective enzyme for catalyzing isomaltulose production. Immobilizing SI can improve its stability, reduce inactivation, and enhance recyclability in industrial applications [3]. Research and Development - Professor Liu Fufeng's team at Tianjin University of Science and Technology developed a directed immobilized enzyme that significantly improves heat resistance and reusability while maintaining high activity after multiple cycles. This work lays a solid foundation for the green manufacturing of isomaltulose and provides innovative ideas for the development of new directed immobilized enzyme technologies [4]. Conference Information - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials. The "Youth Forum on Biological Manufacturing" will highlight scientific issues, solutions, results, scalability, and future directions in the research field [8][11].

Project Overview - The project is named "Biopharmaceutical Raw Materials and Bio-based Materials Production Line Construction Project" [2] - It is a new construction project located in the Weinan Economic and Technological Development Zone [2] - The total investment for the project is 92.871 million yuan, with an environmental investment of 6.737 million yuan, accounting for 7.25% of the total investment [2] - The project aims to establish 9 production lines with an annual output of 200 tons of biopharmaceutical raw materials and bio-based materials, along with various supporting facilities [2] Company Profile - Shaanxi Huasen Shengbang Technology Co., Ltd. is located in the Pucheng Provincial High-tech Industrial Development Zone in Shaanxi Province [4] - The company focuses on high-end biopharmaceutical technology research and development, product manufacturing, and sales [4] - It produces biopharmaceutical intermediates and raw materials, as well as health food raw materials, and collaborates with several universities and research institutes [4] - The company has established research centers in Xi'an and Pucheng, aiming to overcome technical bottlenecks in the biopharmaceutical field through innovative microbial synthesis methods [4] Product Information - The main products currently promoted by the company include ergotioneine, rhodiola rosea glycosides, resveratrol, and tetrahydropyridine [3] Industry Event - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang [6] - The conference focuses on five key areas: AI + biological manufacturing, green chemistry and new materials, future food, future agriculture, and beauty raw materials [7] - It aims to explore the development trends of the biomanufacturing industry and promote the scaling of products and the transfer of scientific achievements [7]

Core Viewpoint - Nanjing Membrane Materials is a key player in the development and supply of specialized membrane materials and equipment, focusing on the biomanufacturing industry and participating in the upcoming SynBioCon 2025 conference [1][16]. Group 1: Company Overview - Nanjing Membrane Materials Industry Technology Research Institute is a collaborative innovation entity established with the support of Nanjing University of Technology, focusing on high-performance membrane material research and production, as well as the manufacturing of complete membrane separation equipment [7]. - The company provides integrated technology and equipment for fermentation, enzyme catalysis, separation, and purification processes in bioproducts, with a strong emphasis on engineering applications in the fields of biobased products such as succinic acid, long-chain dicarboxylic acids, and amino acids [7]. Group 2: Product Introduction - High-precision ceramic membranes are designed for the separation and purification of fermentation and enzyme reaction liquids, featuring small and narrowly distributed pore sizes, high flux, and excellent anti-pollution performance [9][10]. - Special nanofiltration membranes are resistant to acids, bases, and solvents, with molecular weight cut-offs of 200, 400, and 600 Da, enabling specific separation needs such as desalting, concentration, and decolorization [11][12]. - The multi-component concentration detection instrument, SENSAP, allows for rapid detection of various substances, including glucose and lactic acid, with a detection time of less than 1 minute and high precision [13][15]. Group 3: Industry Events - The SynBioCon 2025 conference will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and biomanufacturing, as well as four key application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [16]. - The conference will feature a special session, "Biomanufacturing Youth Forum," aimed at providing insights into scientific issues, solutions, results, scalability, and future directions in the research field [16].

Core Insights - Wuhan Ruijia Kang has been selected as one of the first 100 "Gazelle Selected" enterprises in the China Optics Valley 2025 initiative, standing out among over 5,800 high-tech companies in the region [1][3] - The "Gazelle Selected" enterprises exhibit characteristics such as over 50% of their workforce in R&D, an average of over 60 million yuan in equity financing over the past three years, and a strong presence in cutting-edge fields like integrated circuits, intelligent robotics, and biomanufacturing [1] Company Overview - Wuhan Ruijia Kang specializes in producing cellulose ethanol and high-purity lactic acid from non-grain raw materials, achieving significant breakthroughs in industrial strain gene editing technology and core strain construction [3] - The company has over 70% of its workforce in R&D, with 80% holding master's or doctoral degrees, and has secured 75 million yuan in investments from industry, government, and venture capital [3] - It has received multiple recognitions, including being designated as a national high-tech enterprise and a 2024 seed unicorn enterprise in Wuhan [3] Industry Events - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biomanufacturing, as well as advancements in green chemistry, new materials, future food, future agriculture, and beauty raw materials [5][9] - The conference will feature various forums, including a macro forum on biomanufacturing and specialized sessions on green chemistry and new materials [6][8]

Core Viewpoint - The article emphasizes the significance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, particularly in China, as part of its manufacturing strength initiatives. The upcoming SynBioCon 2025 conference aims to explore the development trends in biomanufacturing and foster collaboration among industry leaders, experts, and investors [1]. Group 1: Conference Overview - The SynBioCon 2025 will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing, along with four application areas: green chemicals and new materials, future food, future agriculture, and beauty ingredients [1]. - The conference will gather international leading companies, industry experts, government representatives, and capital to discuss the trends and innovations in the biomanufacturing sector during the "14th Five-Year Plan" period [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by institutions such as Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Sai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - Key highlights include forums and closed-door discussions on biomanufacturing development trends, sharing of innovative technologies and values, and over 100 financing project roadshows to discover new cooperation opportunities [5]. - The event will feature a high-level closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [9]. Group 4: Agenda and Special Sessions - The first day will include a high-level closed-door seminar and a youth innovation technology forum aimed at discovering potential teams and technologies in biomanufacturing [12]. - The second and third days will feature a macro forum on biomanufacturing, specialized sessions on green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty ingredients [13][15][18]. Group 5: Topics of Discussion - Discussions will cover various topics such as the development of bio-based materials, new carbon source biomanufacturing, and the application of AI in enzyme discovery and industrial fermentation processes [16][17]. - The conference will also explore the biomanufacturing of high-value food ingredients, natural flavors, and the application of biotechnology in cosmetics [20].

Core Insights - The article highlights the growing focus and development of the synthetic biology and biomanufacturing industry in Jiangsu Province, China, emphasizing its strategic importance and the supportive policies in place [2][3]. Policy and Industry Support - Jiangsu Province has identified biomanufacturing as a key development area in its "14th Five-Year Plan," with specific policies aimed at fostering a robust industrial ecosystem [2]. - Local governments in cities like Nanjing, Suzhou, Wuxi, and Changzhou are increasing financial support and subsidies for synthetic biology enterprises [2]. Talent and Research Capabilities - Jiangsu boasts a strong talent pool with leading life sciences universities and research institutions, such as Nanjing University and Southeast University, contributing to advancements in key technologies like gene editing and enzyme engineering [2]. - The province ranks highly in the number of research papers and patents in critical technology areas [2]. Industry Chain Development - The synthetic biology industry chain in Jiangsu is well-structured, covering upstream technologies like gene synthesis and DNA storage, midstream platforms with fermentation and purification capabilities, and downstream applications in pharmaceuticals, agriculture, and materials [2][3]. - Wuxi and Taizhou are noted for their significant biomanufacturing capacity, accounting for over 30% of the national output [2]. Industrial Parks and Company Listings - Jiangsu is accelerating the establishment of synthetic biology industrial parks, including several innovation parks in the Yangtze River Delta region [3]. - A total of 80 companies from Jiangsu have been recognized in the "Top 500 Biomanufacturing Companies in China" list, showcasing the province's competitive landscape [3]. Upcoming Events and Future Plans - The "China Biomanufacturing Industry Map (2025)" will be released in August 2025, featuring over 500 representative companies [1]. - The Fourth Synthetic Biology and Green Biomanufacturing Conference will take place from August 20-22, 2025, in Ningbo, Zhejiang, focusing on key trends and innovations in the industry [17].