SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （现场展示科技成果推介墙）， 公开征集100个从0—1—100的合成生物和生物制造领域创新成果 和项目 ，于现场展示、对接。 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30 ...

全球政策进展 | 上海市 2025 年度关键技术研发计划 "合成生物学 "项目立项清单 | 序号 | 1 | | --- | --- | | 项目编号 | 25HC2810100 | | | 基于喷墨打印微阵列芯片的高通量高精度 | | 项目名称 | 低成本长片段核酸合成 | | 项目承担单位 | 上海迪赢生物科技有限公司 | | 项目负责人 | 张满仓 | | 项目实施周期 | 2025.08.01-2028.07.31 | | 序号 | 2 | | 项目编号 | 25HC2810200 | | 项目名称 | 高通量长片段 DNA 酶促合成系统研发 | | 项目承担单位 | 上海人工智能研究院有限公司 | | 项目负责人 | 夏 凯 | | 项目实施周期 | 2025.08.01-2028.07.31 | | 序号 | 3 | 项目编号 25HC2810300 项目名称 重要天然产物生物合成功能元件挖掘及共 享元件库的构建 项目承担单位 上海中医药大学 项目负责人 陈万生 项目实施周期 2025.08.01-2028.07.31 序号 4 项目编号 25HC2810400 项目名称 生物合成新元件的挖掘表征 ...

Core Viewpoint - The article discusses the announcement of a project by Ningxia Zhongke Biological New Materials Co., Ltd. to produce 110,900 tons of bio-fermentation products annually, highlighting the company's technological upgrades and production capabilities in the bio-manufacturing sector [1]. Project Overview - Project Name: Annual production of 110,900 tons of bio-fermentation products - Construction Unit: Ningxia Zhongke Biological New Materials Co., Ltd. - Nature of Construction: Technological upgrade - Industry Category: C2710 Chemical raw materials and pharmaceutical manufacturing - Investment: 100.89 million yuan - Location: Shizuishan Economic and Technological Development Zone - Land Area: 387,309.18 m², utilizing existing facilities without new land acquisition [2]. Construction Scale - The project includes four flexible production lines: 1. **Long-chain dicarboxylic acid production line**: Annual capacity of 18,000 tons, producing various dicarboxylic acids [3]. 2. **Bio-fermentation functional products production line**: Annual capacity of 5,100 tons, including D-chiro-inositol, coenzyme Q10, and DHA algae oil [4]. 3. **Bio-food production line**: Annual capacity of 63,000 tons, producing calcium propionate and L-malic acid [5]. 4. **Amino acid products production line**: Annual capacity of 24,800 tons, producing various amino acids [6]. Technological Upgrade Scope - The upgrade encompasses fermentation workshops, extraction workshops, refining workshops, drying workshops, liquid bio-fertilizer workshops, tank areas, and power centers [7]. Company Background - Ningxia Zhongke Biological New Materials Co., Ltd. was established on June 2, 2017, with a registered capital of 1.3 billion yuan. The company is involved in the production of feed additives, food additives, fertilizers, and bio-based materials [8]. Financial Performance - The company reported revenue of 345 million yuan and a net loss of 539 million yuan during the reporting period. To address its debt crisis, the company entered pre-restructuring in May 2024, with government support extended until the end of 2024 [9]. - In the first quarter of 2025, the company achieved total revenue of 93.82 million yuan, a year-on-year increase of 74.08%, but still reported a net loss of 64.08 million yuan [11].

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the "14th Five-Year Plan" period, discussing innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on biomanufacturing development trends and growth points, inviting 30 industry leaders and experts [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-Forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including the use of AI for enzyme discovery and industrial fermentation process control [11].

Core Viewpoint - Vitamin A is essential for human health, supporting vision, immune regulation, and serving as a key ingredient in anti-aging cosmetics. Traditional chemical synthesis methods for Vitamin A are complex and costly, leading to a shift towards green biomanufacturing using synthetic biology techniques [1][6]. Group 1: Research Findings - A recent study by Zhejiang University has engineered yeast to enhance Vitamin A production by modifying transporter systems, energy metabolism, and precursor supply networks, achieving unprecedented yields [1][6]. - The hydrophobic nature of Vitamin A leads to accumulation within cells, increasing metabolic burden and affecting synthesis efficiency. Approximately 17-20% of retinol remains unextracted during high-density fermentation, limiting production [2]. - The research team introduced transporter engineering strategies, identifying key transport proteins that facilitate the synthesis and secretion of retinol, retinal, and retinoic acid [2]. Group 2: Engineering Strategies - The team optimized the yeast's energy metabolism by overexpressing FZO1 and MGM1 to enhance mitochondrial fusion and introducing Vgb to improve oxygen uptake, thereby increasing ATP levels and energy supply [3]. - A multi-faceted engineering approach, combining transporter engineering, energy metabolism enhancement, and precursor supply optimization, led to significant breakthroughs in yeast strains for Vitamin A production [3][4]. Group 3: Production Results - Post-engineering, the yeast strain achieved a retinal yield of 638.12 mg/L with an extracellular ratio of 98.7%, and a retinoic acid yield of 106.75 mg/L, both representing the highest reported shake flask yields to date [4]. - The engineered yeast strain produced 727.30 mg/L of retinol with a carbon conversion rate of 7.62% using 20 g/L glucose, surpassing previous best strains [4]. Group 4: Implications for Industry - This research provides new insights for the efficient biomanufacturing of Vitamin A and serves as a reference for the green production of other high-value lipophilic products [6]. - As synthetic biology technologies advance, microbial cell factories are expected to play a crucial role in future biomanufacturing, contributing to human health and sustainable development [6].

Core Viewpoint - The article highlights the recognition of Professor Xue Chuang from Dalian University of Technology for his significant contributions to bio-manufacturing in the energy and chemical sectors, particularly through the "Min Enze Energy and Chemical Award" [1][5]. Group 1: Award and Recognition - The "Min Enze Energy and Chemical Award" was established in April 2013 by Min Enze, a prominent figure in green chemistry, to honor outstanding researchers in the energy and chemical fields [5]. - This year's award ceremony recognized 12 exceptional scientists, with only 4 receiving the "Outstanding Contribution Award" nationwide [1]. Group 2: Professor Xue Chuang's Contributions - Professor Xue has made notable advancements in the design and construction of industrial strains such as artificial organelles, yeast, and clostridia, focusing on bio-based products like ethanol and butanol [3]. - He developed a self-assembling protein cage artificial organelle that significantly increased the yield of compounds like lycopene [3]. - His work includes optimizing and enhancing the composition and yield of cellulase-producing strains, as well as developing integrated fermentation technologies for bio-manufacturing [3]. Group 3: Future Events and Trends - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, as well as applications in green chemistry, new materials, future food, agriculture, and cosmetics [6]. - The conference aims to explore the development trends in the bio-manufacturing industry and promote the transfer and commercialization of scientific achievements [6].

特色专场 生物制造青年论坛 8月20日，浙江·宁波 生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 SynBioCon 大会 | 生物制造青年论坛 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Viewpoint - The article discusses the innovative approach of Ecopha Biotech, founded by Dr. Wilson Ling, to significantly reduce the cost of PHA (polyhydroxyalkanoates) production by utilizing non-food plant oils, specifically Pongamia oil, as a raw material, aiming to compete with traditional petroleum-based plastics [2][9][31]. Group 1: Industry Background - The biodegradable materials market, including PLA and PBAT, has faced challenges such as oversupply and performance limitations, leading to a decline in production rates [6][7]. - PHA stands out due to its advantages like "biomanufacturing," "marine biodegradability," and high thermal resistance (up to 100°C), with the global market expected to reach $367 million by 2030 [6][9]. - The current cost of PHA exceeds 40,000 yuan per ton, making it difficult to compete with petroleum-based plastics priced below 10,000 yuan per ton [7][9]. Group 2: Company Background - Ecopha Biotech was established in June 2025, with Dr. Wilson Ling returning to China after years of research and entrepreneurship abroad, driven by the desire to overcome the cost barriers of PHA production [9][19]. - The company aims to leverage a patented strain of bacteria and non-food oils to achieve a significant reduction in production costs [9][22]. Group 3: Raw Material Cost Reduction - The primary focus for cost reduction is on raw materials, which account for over 50% of PHA production costs. Traditional sugar-based routes have a conversion rate capped at 30%, leading to high costs [22][23]. - Dr. Ling's research determined that using plant oils, particularly Pongamia oil, could achieve a conversion rate of over 80%, significantly lowering production costs [22][31]. - Pongamia oil is non-food, cost-effective (half the price of palm oil), and has a high yield, making it suitable for sustainable production [25][30][31]. Group 4: Technological Advancements - Ecopha Biotech has completed laboratory and pilot-scale validations for using Pongamia oil and has designed a process package for a large-scale production line [32]. - The company plans to focus on medical products initially, targeting the Australian market, where there is a high demand for biodegradable medical supplies [33]. - The first production line in China is expected to replace 15,000 to 20,000 tons of petroleum-based plastics annually once operational [33]. Group 5: Future Outlook - Dr. Ling envisions that the real competition for PHA is not other bioplastics but the vast quantities of petroleum-based plastics that contribute to environmental pollution [34]. - The company aims to collaborate with domestic peers to promote the large-scale industrialization of PHA, potentially alleviating plastic pollution issues as production scales up [34].

Core Insights - The article discusses the upgrade of Tushen Zhihuo's protein design platform to ProteinNova, which now features AI-driven full-process protein design capabilities [1][5] - The integration of dry and wet lab processes allows for a closed-loop system in AI protein design, enhancing the efficiency of scientific research and product development [2][5] Group 1: AI-Driven Protein Design - The upgraded platform showcases a complete closed-loop process from AI-generated design to experimental validation, emphasizing the importance of real-world testing in scientific research [2] - The platform's capabilities include task management, data tracking, and feedback integration, enabling users to create personalized iterative tasks for rapid prototype validation [2][5] Group 2: Optimization of Decision-Making - The system's reasoning process has been streamlined to enhance clarity and user experience, allowing users to quickly grasp core insights without being distracted by unnecessary steps [3] - A complete logical chain is maintained for users who wish to delve deeper into the AI's reasoning, ensuring transparency while keeping the process efficient [3] Group 3: Reporting Enhancements - The introduction of structured report templates allows AI to extract key information such as design logic and improvement suggestions, improving report readability and usability [4] - The language of the reports has been optimized to balance scientific rigor with accessibility for researchers [4] Group 4: Future Implications - The launch of the dry-wet iteration system marks a significant advancement in AI's role in scientific research, enabling rapid feedback and self-optimization [5] - The platform aims to support a wider range of disciplines and experimental types, moving towards the realization of "automated science" as a foundational tool for research teams [5] Group 5: Company Background - Tushen Zhihuo focuses on accelerating scientific breakthroughs and product innovation through super-intelligent platforms, significantly reducing the cycle time for new product design [6] - The core team comprises experts from prestigious institutions, bringing extensive experience in AI research and commercialization [6]

Core Viewpoint - The article emphasizes the rapid development and potential of the synthetic biology sector, driven by technological breakthroughs, supportive policies, and increased investment, aiming for the establishment of over 20 pilot platforms for biomanufacturing by 2027 [1][2][12]. Group 1: Policy and Industry Collaboration - The Ministry of Industry and Information Technology and the National Development and Reform Commission have initiated a plan to cultivate biomanufacturing pilot platforms, targeting the establishment of over 20 by 2027 to facilitate industrial scaling [1][2]. - There is a notable synergy between policy and industry, with advancements in biomanufacturing technologies and significant investments from companies like Kasei Biotech and Jinbo Biotech, indicating a robust ecosystem for growth [2][12]. Group 2: Technological Advancements - Synthetic biology is reshaping production models, enabling more efficient and environmentally friendly biomanufacturing processes through breakthroughs in gene editing, enzyme engineering, and metabolic engineering [3][4]. - The CRISPR-Cas9 technology has revolutionized gene editing, making complex genetic operations simpler and more cost-effective, thus laying the groundwork for the synthetic biology industry's expansion [4][15]. Group 3: Company Innovations and Applications - Kasei Biotech focuses on developing bio-based materials, with products that significantly reduce carbon emissions by over 50% compared to traditional petroleum-based counterparts [5][9]. - Fubon Technology has established a comprehensive innovation system in the bio-agriculture sector, developing competitive products that enhance crop nutrient absorption and promote sustainable agricultural practices [5][8]. Group 4: Challenges and Solutions - The transition from laboratory innovations to industrial production is critical, with companies like Huaxi Biotech investing heavily in pilot transformation platforms to enhance China's biomanufacturing competitiveness [7][15]. - Companies face dual technical bottlenecks in synthetic biology, including challenges in microbial cell factory construction and downstream fermentation purification processes [15]. Group 5: Future Trends and Market Dynamics - The synthetic biology sector is expected to experience accelerated technological iterations and expanded application scenarios over the next 3-5 years, driven by AI integration and a focus on quality improvement [14][11]. - The industry is moving towards a more rational investment landscape, with a shift from chasing scale to recognizing the importance of technological capabilities and product validation [14][13].