Core Viewpoint - The Ministry of Industry and Information Technology of China has officially announced the "First Batch of Iconic Products in Biological Manufacturing," which includes 36 products, marking a significant step in technological innovation and industrial upgrading in the biological manufacturing sector [1][3]. Summary by Sections Iconic Products List - The list includes 36 companies such as: - Shoulang Biotechnology - Micro元合成 - KaiLaiYing - Qinhongdao Huaheng Biotechnology - Qilu Pharmaceutical - JinSai Pharmaceutical - And others [3][5]. Product Details - Each product listed has specific applications and innovations: - **Ethanol Clostridium Protein**: Produced from industrial waste gases, beneficial for animal feed [5]. - **Alotose**: A low-calorie sweetener produced through microbial fermentation, enhancing production efficiency [5]. - **Nakiol Injection**: A CAR-T cell therapy for treating acute lymphoblastic leukemia, showing improved safety and efficacy [5]. - **Vitamin B**: Produced via fermentation, offering higher efficiency compared to traditional extraction methods [7]. - **Recombinant Human Serum Albumin**: Produced using rice cell technology, meeting clinical needs effectively [9]. Industry Significance - The announcement reflects the government's strong emphasis on the development of the biological manufacturing industry, showcasing the potential for innovation and growth in this sector [1][3]. Upcoming Events - The "SynBioCon 2025" conference will be held from August 20-22, focusing on AI in biological manufacturing, green chemistry, and future food and agriculture [11][12].

Core Viewpoint - The article highlights the participation of Meikang in the SynBioCon 2025, focusing on its expertise in international new food ingredient compliance and safety assessment services [1][12]. Summary by Sections Service Overview - Meikang's International Regulatory Department specializes in compliance declaration and safety assessment for international new food ingredients, proficient in regulations from authorities like the FDA and EFSA, providing comprehensive services from raw material evaluation to declaration strategy formulation [5]. Advantages - **Bilingual Technical Team**: The team consists of professional food industry scientists who are bilingual, enabling on-site guidance and efficient communication with clients in China [7]. - **Rich North American Expert Resources**: Meikang has access to various experts in the U.S. for different product declarations, including toxicology experts with successful FDA GRAS and NDI application experience [8]. - **Full-Chain Service Capability**: The company offers a complete range of services including dossier writing, feasibility assessment, GMP system establishment, HACCP system establishment, toxicology laboratory collaboration, and communication with the FDA [10]. Customization and Cost Advantages - Services can be customized based on client capabilities and needs, allowing clients to choose between conducting literature searches themselves or outsourcing to Meikang, which provides time and cost advantages compared to overseas institutions [10]. Event Details - The SynBioCon 2025 will take place from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [12]. - The event will include various activities such as a youth forum, high-level discussions, and a closed-door seminar on AI-enabled bio-manufacturing innovation [12][14].

Core Viewpoint - The article discusses the sustainable production of 1,4-butanediol (BDO) through engineered Escherichia coli, highlighting the potential for antibiotic-free fermentation methods and the optimization of metabolic pathways to enhance yield and efficiency [2][4][20]. Summary by Sections Introduction - 1,4-butanediol (BDO) is a significant non-natural chemical widely used in biodegradable plastics, with a substantial market potential. Traditional production relies on petrochemical methods, while biotechnological approaches face challenges such as low enzyme activity and high production costs [2][4]. Research Content - The study systematically optimized the E. coli chassis by integrating multiple copies of BDO synthesis genes, knocking out byproduct pathways, and engineering key enzymes to enhance metabolic flux. The introduction of a microaerobic fermentation strategy allowed for high BDO yields without antibiotics or inducers [4][5]. Metabolic Engineering Strategies - The research involved various strategies to improve BDO production, including: - Introducing external enzymes and optimizing gene expression to enhance BDO synthesis [7][11]. - Modifying the TCA cycle and enhancing ATP levels to redirect carbon flux towards BDO production [15][18]. - Utilizing the hok/sok system to maintain plasmid stability, achieving a low plasmid loss rate of 5.5% [18][19]. Production Results - In shake flask experiments, BDO production reached 7.88 g/L, the highest reported yield under similar conditions. In a 5-liter bioreactor, BDO production achieved 34.63 g/L with a glucose yield of 0.35 g/g and a production rate of 0.48 g/L/h [20][21]. Conclusion - The study demonstrates a comprehensive metabolic engineering approach for the sustainable industrial production of BDO from glucose, showcasing the potential for antibiotic-free processes and the need for further optimization to address byproduct accumulation [20][22].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemistry, new materials, future food, and agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1][2]. Group 1: Conference Overview - The conference will take place from August 20-22, 2025, at the Sheraton Hotel in Ningbo, Zhejiang [1]. - It will feature various activities including a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Biomanufacturing Industry Innovation Development Blue Book" [1][2]. Group 2: Organizing Institutions - The event is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Biotechnology Co., Ltd. [2]. Group 3: Agenda Highlights - Day 1 will include registration, a high-level discussion on biomanufacturing, and a youth forum focused on innovation [5][9]. - Day 2 will feature an opening ceremony, macro forums on biomanufacturing, and specialized discussions on green chemistry and new materials [6][12]. - Day 3 will focus on AI applications in biomanufacturing and future food and agriculture discussions [27][30]. Group 4: Key Publications - The conference will announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)" which includes a list of over 500 representative companies in the biomanufacturing sector [33].

Core Viewpoint - The article discusses the development of humanized "4D" collagen protein based on natural collagen, aiming to address the immunogenicity and pathogenic risks associated with traditional animal-derived collagen [1]. Group 1: Research and Development - The research team led by Professor Li Shuang from South China University of Technology focuses on biomimetic "honeycomb" porous structures for molecular construction, optimizing collagen triple helix sequences through gene editing [1]. - The team combines computer simulation design with cross-scale self-assembly templates to achieve a synergistic optimization of high specific surface area, strong mechanical strength, and biological activity [1]. - Techniques such as transmission electron microscopy are utilized to analyze the hierarchical structure, and in vitro cell experiments validate the biocompatibility and regenerative efficacy of the developed materials [1]. Group 2: Industry Applications - The innovative collagen material is expected to provide new biological materials for regenerative medicine, promoting upgrades in industries such as medical aesthetics and bone repair [1]. - Professor Li Shuang will present a talk titled "Molecular Design of Humanized '4D' Collagen Protein" at the SynBioCon 2025 conference, which focuses on synthetic biology and green biological manufacturing [1][14]. Group 3: Conference Details - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements in green chemistry, new materials, future food, and agriculture [14]. - The conference will feature various activities, including a youth forum on biological manufacturing, high-level discussions on the industry, and a closed-door seminar on the "2025 Artificial Intelligence Empowering Biological Manufacturing Industry Innovation Development Blue Book" [14][15].

Core Insights - The establishment of the first synthetic biology innovation center in Northwest China at Haesfu marks a significant milestone in the field of technological innovation, enhancing the company's capabilities in synthetic biology technology commercialization [1][3] - Haesfu is recognized as an established leader in the biological manufacturing sector, focusing on the development of next-generation natural active ingredients [3][5] Summary by Sections Synthetic Biology Innovation Center - Haesfu has inaugurated a new research and development center spanning over 2,000 square meters, alongside the Shaanxi Provincial Synthetic Biology Innovation Center, indicating a robust commitment to advancing synthetic biology technology [1] Technological Advantages - The company holds numerous core patents related to synthetic biology, covering the entire chain from gene screening to efficient expression and precision fermentation [5] - Haesfu has assembled a top-tier research team led by PhD graduates from renowned universities, with an average research experience exceeding 10 years [5] - The company has developed a unique "laboratory-pilot-1000-ton factory" conversion platform, significantly shortening the product development cycle [5] Sustainability and Product Focus - Haesfu is pioneering low-carbon and energy-saving fermentation processes, aiming for 100% renewable raw materials to achieve a sustainable future [5] - The company is concentrating on high-value natural products, such as rare natural pigments, natural flavors, and new antioxidants, to build a globally competitive product portfolio [5] Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements in green chemistry, new materials, future food, and agriculture [4][6] - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI Empowering Biological Manufacturing Industry Innovation Development" [4][6]

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will be held from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Support Units - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes [4][5][6][7][10][12][14][18][20][22][30][32]. - The conference will feature presentations on topics such as the construction of efficient cell factories for aromatic compounds and the biomanufacturing of polyamide materials [8][11][23][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics like green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will include a high-level roundtable on biomanufacturing and a youth forum to showcase innovative achievements in the field [36].

Core Viewpoint - Astaxanthin, a highly effective antioxidant pigment, is gaining attention for its applications in food, cosmetics, and pharmaceuticals, with a recent study demonstrating a high-yield production system using Schizochytrium for both astaxanthin and DHA [1][3]. Group 1: Research Findings - The study reported an increase in astaxanthin content from 7.56 μg/g to 55.17 μg/g through electroporation-induced color screening [2]. - Further enhancement of astaxanthin content to 374.85 μg/g was achieved by overexpressing five key genes involved in the astaxanthin synthesis pathway [2]. - The final engineered strain produced astaxanthin at a yield of 29.53 mg/L (1.913 mg/g DCW) while maintaining DHA production at 3.83 g/L, constituting 45% of total lipid content [2]. Group 2: Implications for Industry - The reported astaxanthin yield represents the highest level achieved in Schizochytrium to date, laying a foundation for the commercial scalability of astaxanthin biosynthesis [3]. - The advancements in metabolic engineering and mutagenesis techniques highlight the potential for increased production efficiency in the biotechnology sector [1][3]. Group 3: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, focusing on AI and bio-manufacturing, green chemistry, new materials, future food, and agriculture [6][8]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on AI-enabled innovations in bio-manufacturing [6][7].

Core Viewpoint - The article emphasizes the significance of high-value compounds, such as amino acids and pharmaceutical intermediates, in the field of biomanufacturing, highlighting China's role as a major producer supporting global industry development [1]. Group 1: Biomanufacturing and Synthetic Biology - High-value compounds are crucial in biomanufacturing, with China being a leading producer in this sector [1]. - A major bottleneck in synthetic biology is the insufficient availability of biological components, which can be addressed through breakthroughs in enzyme design and gene editing technologies [1]. - The research team led by Professor Feng Yan from Shanghai Jiao Tong University focuses on developing efficient biocatalysts and new synthetic pathways for artificial compounds, surpassing natural evolution [1][3]. Group 2: Research Innovations - The research team utilizes second-generation sequencing for functional analysis of large mutation libraries, enabling rapid identification of important protein scenarios [1]. - The team has developed methods to create new proteins with over 50% sequence variation, which can be applied in the production of industrial enzymes [1]. Group 3: Upcoming Conference - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, focusing on AI and biomanufacturing, as well as opportunities in green chemistry, new materials, future food, and agriculture [6]. - The conference will feature various activities, including a macro forum on biomanufacturing, youth forums, and discussions on the 2025 Blue Book for AI-enabled biomanufacturing innovation [6][7].

Core Viewpoint - The article discusses the advancements in synthetic biology, particularly focusing on optimizing yeast metabolism for carbon conservation and fixation, which is crucial for reducing CO2 emissions and achieving sustainable chemical production [3][4][5]. Summary by Sections 1. Introduction to Carbon Emissions and Synthetic Biology - The increasing use of fossil resources is leading to higher CO2 emissions, raising global concerns about climate change and the urgent need for alternative solutions to achieve carbon neutrality [4]. - Synthetic biology enables the use of inexpensive substrates, such as lignocellulose, for chemical production, thereby reducing reliance on fossil resources [4]. 2. Yeast as a Platform for Biomanufacturing - Yeast is highlighted as a robust microbial chassis for industrial biomanufacturing, capable of producing various compounds like terpenes and fatty acids [5]. - The complexity of yeast metabolism often results in unavoidable CO2 release during chemical synthesis, primarily through glycolysis, pentose phosphate pathway, and tricarboxylic acid cycle [5][6]. 3. Carbon Conservation Systems in Yeast - The article reviews recent advancements in constructing carbon conservation and fixation systems in yeast, focusing on avoiding unnecessary decarboxylation reactions to reduce carbon loss [6][8]. - Strategies include enhancing natural carboxylation reactions to promote carbon conservation, with specific examples of engineered yeast strains achieving significant improvements in product yields [8][11]. 4. Engineering Strategies and Results - Various engineering strategies are discussed, such as the non-oxidative glycolysis (NOG) pathway, which has been successfully implemented in yeast to improve carbon efficiency and product yields [10][11]. - Specific results include a 25% increase in β-farnesene yield and an 80% increase in β-carotene production through metabolic engineering [11][12]. 5. Future Directions in Low-Carbon Yeast Cell Factories - The future of biomanufacturing involves constructing low-carbon yeast cell factories that can recycle CO2 released during production and potentially utilize CO2 directly as a substrate for product synthesis [19][20]. - The article outlines the integration of carbon fixation pathways, such as the Calvin cycle and reductive glycine pathways, into yeast to enhance CO2 utilization [19][21]. 6. Conclusion - The advancements in synthetic biology and metabolic engineering present promising opportunities for developing sustainable biomanufacturing processes that significantly reduce carbon emissions and enhance product yields [3][4][5].