Core Viewpoint - Changde City has passed the "Regulations on Promoting the Development of Synthetic Biology Manufacturing Industry," marking the first local legislation in China for this sector, aimed at enhancing the development of synthetic biology manufacturing as a strategic emerging industry [1][2]. Summary by Sections Legislative Background - The "Regulations" are part of a broader initiative to support the high-quality development of the synthetic biology manufacturing industry in Changde, which has been recognized as a key area for new productive forces and strategic emerging industries [2][4]. Industry Development Measures - In February, the Hunan Provincial Government issued measures to support Changde's synthetic biology manufacturing, focusing on areas such as enzyme preparations, pharmaceutical intermediates, agricultural chemicals, future foods, health products, and bio-based materials [4]. Legislative Process - The legislative project for promoting synthetic biology manufacturing began in September 2024, with multiple reviews and revisions leading to the final draft of the "Regulations," which consists of 19 articles addressing various aspects of industry development [5][6]. Key Provisions of the Regulations - The first three articles outline the legislative purpose, scope, and responsibilities of government departments. Articles four to fifteen focus on core industry development issues, including enhancing investment attraction, R&D capabilities, and talent acquisition, while also addressing high operational costs and approval efficiency [6]. - Article sixteen introduces a "no penalty for two situations, four prohibitions" system to optimize the business environment, while article seventeen establishes a fault-tolerance mechanism [6]. Next Steps - The Changde Municipal People's Congress will submit the "Regulations" to the Provincial People's Congress for approval, after which it will be published and implemented [6]. Upcoming Events - The Fourth Synthetic Biology and Green Manufacturing Conference will be held in Ningbo from August 20-22, focusing on AI and biological manufacturing, with discussions on trends and innovations in the industry [7][9].

Core Viewpoint - The article announces a training program focused on the application of artificial intelligence in materials science, emphasizing the importance of AI in driving innovation and industrial progress in the materials industry [1][2]. Summary by Sections Training Content - The program will cover various topics including: 1. New paradigms in materials science driven by AI 2. AI-enabled data acquisition, processing, and standardization in materials 3. AI's role in the discovery and design of new materials 4. AI applications in predicting material structures and properties 5. Use of AI in material characterization and testing 6. Multi-scale high-throughput computing in materials science 7. Automation in materials science experiments and design using AI 8. Core principles of AI-enabled materials science technologies 9. Applications of machine learning in materials science 10. Case studies of deep learning in materials science 11. Applications of reinforcement learning in key materials science technologies 12. Neuromorphic and brain-like computing applications in materials science 13. AI's contribution to intelligent manufacturing and industrialization of materials 14. Analysis of outstanding achievements in AI-enabled materials science [1][2]. Participants - The program is targeted at leaders, researchers, and technical personnel from enterprises, research institutes, and universities engaged in materials science, as well as individuals interested in the field [2]. Schedule and Location - The third session is scheduled from July 24 to 27, 2025, in Beijing (with online participation available) - The fourth session will take place from September 11 to 14, 2025, in Guangzhou (also with online participation) [2]. Invited Experts - Experts from renowned institutions such as the Chinese Academy of Sciences, Tsinghua University, Beijing University of Science and Technology, and Shanghai Jiao Tong University will be invited to teach [2]. Fees and Registration - The fee for participation is 4,980 yuan per person, which includes costs for experts, venue, meals, materials, and teaching services. Accommodation is available but at the participant's expense. The training is organized by Beijing Dingji Technology Consulting Co., Ltd. [3].

Core Viewpoint - The company Angel Yeast (600298.SH) plans to implement a biomanufacturing center construction project with an estimated total investment of 502.25 million yuan, funded by the company's own resources. This project aims to enhance the company's biomanufacturing technology innovation capabilities and aligns with its strategic goals [1][3]. Project Details - The project will consist of a 7-story above-ground structure and a 2-story underground facility, covering a total building area of approximately 44,115.97 square meters, including 27,687.65 square meters above ground and 16,427.32 square meters underground, with 297 parking spaces [3]. - The site is located on the south side of the company's headquarters R&D complex, occupying about 23 acres [3]. - The construction period is expected to last 24 months, with plans for completion and operational use in the second half of 2027, subject to actual conditions [3]. - The total estimated investment for the project is 502.25 million yuan, with funding sourced from the company's own capital [3]. Company Performance - Angel Yeast is the largest yeast company in Asia and the second largest globally, holding nearly 60% of the domestic market share and close to 20% of the global market share [3]. - From 1998 to 2024, the company's revenue grew from 138 million yuan to 15.2 billion yuan, a 110-fold increase, with consistent year-on-year growth. Net profit increased from 30.78 million yuan to 1.325 billion yuan, a 43-fold increase [3]. - In the first quarter of 2025, the company's revenue reached 3.794 billion yuan, representing a year-on-year growth of 8.95%, while net profit was 370 million yuan, up 16.02% year-on-year [3].

2'-FL：母乳关键成分，赋能健康营养 作为母乳中含量最高（约30%）的人乳寡糖，2'-FL具有显著的营养与医学价值：促进婴幼儿生长发育及认知能力；增强 免疫力，抗病毒、抗过敏；调节肠道菌群平衡。其应用已覆盖多国婴幼儿配方奶粉，是极具潜力的新型营养强化剂。 未来食品&农业 | 柯泰亚 关于柯泰亚 【SynBioCon】 获 悉 ， 柯泰亚生物科技（上海）有限公司（以下简称"柯泰亚"）宣布，其自主研发的母乳低聚糖 （HMO）核心产品 2'-岩藻糖基乳糖 (2'-FL) 正式通过美国食品药品监督管理局 (FDA) 的GRAS (一般认为安全， Generally Recognized As Safe) 认证。 2025年初柯泰亚向FDA提交了关于2'-FL作为食品配料的申请，2025年6月18日收到FDA的"No Question Letter"， 确认柯泰亚2'-FL可作为食品添加剂应用于婴儿配方奶粉、儿童食品及传统食品及饮料 。此举标志着柯泰亚成为国内少数 获得该认证的本土企业，其研发创新、生产质量与安全管控体系获得国际权威认可。 此次认证是柯泰亚凭借自主知识产权进军全球HMO市场的重要突破。获得FDA GR ...

生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry players, top universities, and capital from various sectors will gather to discuss advancements in biomanufacturing [4]. Group 4: Special Activities and Agenda - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - The conference will host specialized forums on various topics, including green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - Each forum will address specific themes such as the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

Core Viewpoint - The article discusses the advancements in synthetic biology tools for customizing yeast cell factories, highlighting their potential in producing high-value compounds efficiently [3]. Group 1: Innovative Tools for Yeast Cell Factories - The paper titled "Innovative tools for customized yeast cell factory" outlines significant progress in synthetic biology tools, including genome editing, computational tools, adaptive laboratory evolution, and standardization of biological DNA components [3]. - These tools aim to provide practical guidelines for the effective development of customized yeast cell factories [3]. Group 2: Genome Editing Tools - Genome editing has evolved from single-gene editing to simultaneous multi-gene editing, with CRISPR-Cas systems enabling precise modifications in yeast genomes, including knockouts, insertions, and replacements [6]. - New variants of CRISPR-Cas, such as base editing and prime editing, allow for single nucleotide changes to alter gene functions [6]. Group 3: Computational Tools - Computational tools, including metabolic modeling and the integration of omics technologies, guide engineering strategies and expected flux adjustments [7]. - Genome-scale metabolic models (GEMs) have been widely applied in yeast metabolic engineering, with large-scale kinetic models playing a crucial role in designing and understanding metabolic reactions [7]. Group 4: Adaptive Laboratory Evolution - Adaptive laboratory evolution (ALE) is a powerful strategy for enhancing yeast strain performance by applying selective pressure over generations, leading to the emergence of more adaptive strains [8]. - Combining ALE with whole-genome sequencing helps identify beneficial mutations and provides insights into the genetic basis of adaptability [8]. Group 5: Standardization of Biological DNA Components - The increasing complexity of yeast cell factory designs necessitates precise control and regulation of biological components, gene circuits, or biological systems [9]. - Synthetic biology offers standardized biological components, allowing researchers to assemble these components into complex systems with predictable behaviors [9].

Core Viewpoint - Xinhua Medical, a leading enterprise in China's medical device industry, will participate in the SynBioCon 2025, focusing on synthetic biology and green bio-manufacturing [1][29]. Company Overview - Shandong Xinhua Medical Instrument Co., Ltd. was established in 1943 and is a comprehensive leader in the medical device industry in China, specializing in nine core areas including laboratory technology, infection control, radiological diagnosis, and surgical instruments [10]. - As the top company in the domestic infection control equipment market, Xinhua Medical has a national-level enterprise technology center and has participated in the formulation of over a hundred industry standards, with products exported to more than 100 countries and regions [11]. Technological Focus - In the laboratory technology sector, Xinhua Medical focuses on cytology and microbiology, aiming for breakthroughs in laboratory automation and providing various standalone and systematic solutions to support high-quality development in laboratory research [12]. - The company employs advanced technologies such as fully automated cell culture, AI algorithm recognition, multi-axis collaborative robotic arms, and efficient hydrogen peroxide sterilization to address issues like inconsistent cell culture and low survival rates during subculturing [13]. Product Offerings - Xinhua Medical offers a range of products including: - Fully automated microbiological sample processing systems for food safety, biomedicine, environmental monitoring, and public health [15]. - CO2 incubators designed for biopharmaceutical companies and research institutions, featuring patented airflow and smart IoT technology for optimal cell culture environments [16]. - Vertical sterilizers for various research institutions and medical facilities, equipped with features like automatic drainage and biological safety design [17]. - Hydrogen peroxide disinfectors capable of sterilizing air in closed spaces, achieving a log6 sterilization level [19]. - Cell counters that utilize intelligent image recognition for precise cell analysis in various research fields [21]. - Automated culture medium dispensing systems for hospitals and laboratories, enhancing efficiency and reducing manual labor [23]. Industry Event - The SynBioCon 2025 will take place from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials [29].

Core Viewpoint - The fermentation industry is facing challenges related to carbon source costs, which are traditionally reliant on food crops, leading to high prices and volatility, as well as conflicts over food security. The Chinese government is increasingly focusing on the development of non-food bio-based industries [1][2]. Group 1: Industry Challenges - Traditional fermentation carbon sources, primarily derived from sugars like glucose, account for 40%-50% of production costs, with costs ranging from 2 to 8 USD per kilogram, impacting both production costs and food security [3]. - The reliance on food crops for carbon sources creates a dilemma, as it competes with food supply, prompting the need for alternative solutions [1][3]. Group 2: Innovative Solutions - Qingdao Bioward Biotechnology Co., Ltd. has developed two new non-food carbon sources, Filtration Membrane Carbon Source and Co-Produced Glycol Carbon Source, derived from by-products of the oil industry, which reduce dependence on food crops and lower carbon source costs [2][3]. - These new carbon sources contain essential nutrients such as small organic acids and vitamins, promoting the growth of various microorganisms, and have been tested successfully in industrial-scale fermentation [3][4]. Group 3: Market Opportunities - The introduction of these innovative carbon sources not only addresses the challenges of traditional carbon sources but also provides cost advantages and enhances market competitiveness for companies in the fermentation industry [4]. - Qingdao Bioward offers various collaboration models for the utilization of these carbon sources, aiming to explore new opportunities in the fermentation sector [4].

Core Viewpoint - The K&K team from Nanjing University of Technology has successfully industrialized over 500,000 tons per year of high-performance bio-based materials, showcasing the potential of bio-based materials in various applications and their advantages over petroleum-based materials [1][2]. Group 1: Advantages of Bio-based Materials - Bio-based materials allow for precise structural tuning, overcoming the limitations of traditional petrochemical materials which have a single structure and are difficult to modify [4][5]. - The natural endowment of raw materials, such as amino acids and lignin, provides significant advantages over petrochemical raw materials, enabling more efficient polymerization processes [6]. - Bio-based materials contribute to a closed-loop resource cycle, enhancing sustainability [6]. Group 2: K&K Team's Successful Strategies - The K&K team emphasizes integrated research rather than isolated studies, focusing on fundamental research to explore micro-scale effects and overcome engineering bottlenecks, resulting in over 300 published SCI papers [7][8]. - They have developed common technologies and engineering equipment, securing over 20 international patents and completing the application transformation of more than 60 patents [8][9]. - The team has achieved significant cost reductions of over 65% in production through technological innovations in multi-component processes and polymerization [9]. Group 3: Product Applications and Achievements - The K&K team has established a comprehensive product system based on common biomass raw materials, achieving over 500,000 tons per year of bio-based materials [10][11]. - Notable products include bio-based polyurethane (50,000 + 150,000 tons/year), bio-based plasticizers, and bio-based spandex, with several products receiving global bio-based material certifications [13][17]. - These materials have been applied in major engineering projects, including the Belt and Road Initiative and various infrastructure developments [14][16].