Group 1 - The core viewpoint of the news highlights the significant performance of the innovative drug sector, with the Tianhong Innovative Drug ETF (517380) showing a nearly 20% increase year-to-date as of May 29, 2023 [1] - The Tianhong Innovative Drug ETF, launched in 2021, tracks the "Hang Seng Shanghai-Shenzhen Hong Kong Innovative Drug Selected 50" index, providing comprehensive coverage of the innovative drug industry across A-shares and Hong Kong stocks [1] - On May 29, the National Medical Products Administration approved 11 new drugs, with five being from innovative companies listed on the Sci-Tech Innovation Board, covering various therapeutic areas including oncology and autoimmune diseases [1] Group 2 - The upcoming 2025 ASCO Annual Meeting in Chicago is expected to showcase significant data from domestic innovative drug companies, with 71 original research results from Chinese pharmaceutical companies selected for presentation [2] - The innovative drug sector is anticipated to gain increased attention and positive market sentiment, with institutional holdings currently at low levels and the sector's valuation significantly below historical averages [2] - The total amount of outbound transactions for innovative drugs has reached $45.5 billion since the beginning of 2025, indicating a strong trend towards internationalization and potential for future growth [3] Group 3 - The Chinese innovative drug industry has transitioned from imitation to rapid following and now to original innovation, marking a significant evolution in its development [3] - Most domestic innovative drugs currently in the U.S. are in clinical stages, with future milestones expected to validate the growth and internationalization of Chinese innovative drugs [3]

Group 1 - The core viewpoint is that the innovative drug sector is experiencing a significant recovery in stock prices, attracting attention from brokers for research and investment opportunities [2] - The Tianhong Innovative Drug ETF (517380) has seen a net inflow of 3.6 million yuan, with a current scale of 389 million yuan as of May 26 [1] - The Tianhong ETF is the only product that comprehensively covers the innovative drug sector across A-shares and Hong Kong stocks, with a focus on the "Hengsheng Huasheng Hong Kong Innovative Drug Selected 50" index [1] Group 2 - The innovative drug industry is entering a new cycle of value reassessment due to a combination of policy, industry, and performance factors [2] - Longjiang Securities suggests that the previous valuation methods used during the bear market may no longer be applicable, indicating a need for a re-evaluation of the valuation system for innovative drug companies [2] - There has been significant interest from brokers, with nearly 60 companies in the pharmaceutical and biotechnology sector being researched this month, highlighting the sector's attractiveness [2]

Core Viewpoint - The recent surge in the Hong Kong innovative drug sector, particularly for Xiansheng Pharmaceutical, is driven by favorable factors such as the cyclical resurgence of COVID-19 and record-breaking domestic innovative drug business development (BD) deals [1] Group 1: Stock Performance - Xiansheng Pharmaceutical's stock price has experienced a continuous rise since May 16, achieving a maximum increase of 28.33% by May 21, with a cumulative increase of nearly 50% year-to-date [1] - The stock has shown significant trading activity, with over 25 million shares traded on three consecutive days from May 19 to 21, indicating strong market interest [4] Group 2: Business Development Potential - The recent $60.5 billion BD deal between Innovent Biologics and Pfizer has spotlighted the potential of Chinese innovative drugs, with Xiansheng Pharmaceutical being a key player in this growth [2] - Xiansheng Pharmaceutical has developed multiple ADC (antibody-drug conjugate) candidates targeting various biomarkers, with products like SCR-A006 showing Best-in-Class potential [2] Group 3: International Expansion - Xiansheng Pharmaceutical has established a track record in international markets, with its first overseas deal for SIM0278 setting a record for domestic autoimmune drug BD at the time [3] - The company has secured a licensing agreement exceeding $1 billion for SIM0500 with AbbVie, currently undergoing clinical trials in the U.S. and China [3] Group 4: Innovation and R&D - The company has invested over 8.5 billion yuan in R&D over six years, developing over 60 innovative drug candidates across various therapeutic areas [5] - Three new drug molecules are in the NDA approval process, while four are in Phase III clinical trials, indicating a robust pipeline [5] - The anticipated launch of significant new drugs will further enhance the company's position in the global biopharmaceutical market [5]

Group 1 - The pharmaceutical sector in Hong Kong is experiencing a strong rally, with notable gains in stocks such as Kailaiying, which rose over 14%, and Sangfor Pharmaceuticals, which increased by 7.6% [1][2] - Sangfor Pharmaceuticals announced a licensing agreement with Pfizer, receiving an upfront payment of $1.25 billion, which significantly boosted investor confidence [1] - The China National Medical Products Administration has accepted a new drug application for cyclosporine eye gel from Zhaoke Ophthalmology, indicating positive regulatory developments in the industry [1] Group 2 - Longcheng Securities expressed optimism about the pharmaceutical sector, citing frequent favorable policies that are expected to lead to a steady recovery in industry sentiment [1] - Morgan Stanley's research report maintains a positive outlook on the Chinese pharmaceutical industry, highlighting supportive policies for innovation and low dependency on U.S. exports, which mitigates risks from geopolitical tensions and uncertainties in U.S. drug pricing [1]

Core Viewpoint - The sales of the COVID-19 drug Xianoxin from Xiansheng Pharmaceutical have significantly increased since May, with notable growth in both year-on-year and month-on-month comparisons, although specific figures have not been disclosed [1] Sales Performance - Sales growth in early April was primarily driven by regions such as Shanghai, Zhejiang, Beijing, and Jiangsu [1] - Sales in Guangdong began to rise in early May, contributing to a substantial overall increase in sales since then [1] - As of now, Xianoxin has reached 32 provinces, 371 cities, and over 3,700 medical institutions across the country [1] Market Context - The latest report from the Chinese Center for Disease Control and Prevention indicates an upward trend in the positive rate of COVID-19 tests from March 31 to May 4, with southern provinces showing higher positivity rates compared to northern provinces [1] - Some provinces that experienced an early increase in positivity rates are seeing a slowdown in the growth of the epidemic [1]

Group 1 - The Hong Kong stock market opened lower on May 19, with the Hang Seng Index down 0.73% and the Hang Seng Tech Index down 1.58% [1] - The Hong Kong Innovative Drug ETF (159567) rose by 0.58% with a turnover rate of 8.02% and a trading volume exceeding 1.15 billion yuan, indicating active trading [1] - The innovative drug ETF closely tracks the Hong Kong Stock Connect Innovative Drug Index, reflecting the performance characteristics of biotech companies listed in Hong Kong [1] Group 2 - The pharmaceutical sector has shown a strong rebound this year, with several pharmaceutical funds reporting net value increases exceeding 30% [1] - Institutions are focusing on investment opportunities in AI healthcare, brain-computer interfaces, and innovative drugs following a period of deep adjustment in the pharmaceutical sector [1] - Guojin Securities emphasizes that innovative drugs and certain semi-innovative drugs remain key investment areas, with upcoming policy changes and data releases expected to catalyze stock price movements [1] Group 3 - Guoxin Securities highlights the rapid growth phase of the innovative drug sector, driven by commercialization and external licensing, which is accelerating revenue growth and profitability [2] - The traditional Chinese medicine sector faces short-term pressure but retains long-term branding and innovation potential [2] - The medical device sector is under short-term pressure due to slow policy implementation and inventory issues, but there are expectations for recovery driven by improved bidding processes [2]

Group 1 - The "zero tariff" policy for medical devices and drugs in Hainan is enhancing the competitiveness and attractiveness of the Boao Lecheng International Medical Tourism Pilot Zone by allowing hospitals to import foreign drugs and devices that are not yet available in China while reducing operational costs for hospitals and patients [1] - Since the implementation of the "zero tariff" policy on December 25, 2024, the Haikou Customs has supervised a total declared value of 60.239 million yuan for "zero tariff" medical devices and drugs, resulting in a tax exemption of 8.187 million yuan [1] - The Lecheng International Medical Tourism Pilot Zone is becoming a major channel for international innovative medical devices and drugs to enter China, supported by policies for licensed medical practices, research, and international medical exchanges [1] Group 2 - Hainan's efforts to attract international innovative medical device and drug companies reflect a broader initiative to promote high-quality development in the pharmaceutical industry through regulatory reforms and increased openness [2] - The Hainan Provincial Drug Administration has proposed five measures to enhance regulatory innovation, including creating a high ground for real-world research applications and facilitating product imports [2] - Over the next three years, Hainan aims to accelerate the application of real-world research, expand local production of innovative medical devices and drugs, and enhance international collaboration in medical technology projects [2] Group 3 - The "Lecheng research and application + Haikou production" model has enabled the successful import and local production of the drug "Kexaira" by First Voice Pharmaceutical, which was approved for full market entry in China through the real-world research green channel [3] - The Haikou National High-tech Zone is becoming a core area for Hainan's biopharmaceutical industry, with the pharmaceutical industry expected to account for nearly 80% of the province's total output value in 2024 [3] - The establishment of the Lecheng Medical Engineering Transformation Platform by the end of this year will serve as Hainan's first technology transfer and incubation platform in the field of innovative medical devices and drugs, promoting the transformation and incubation of innovative products [3]

Financial Performance - The group's revenue for the year ended December 31, 2024, was RMB 6.635 billion, an increase of 0.4% compared to RMB 6.608 billion in 2023[8]. - The profit attributable to equity shareholders was RMB 733 million, an increase of 2.6% from RMB 715 million in 2023[8]. - Adjusted profit attributable to equity shareholders was RMB 1.018 billion, a significant increase of 41.6% from RMB 719 million in 2023[8]. - Revenue from the neuroscience segment was RMB 2.174 billion, accounting for 32.8% of total revenue, representing a growth of 10.4% from RMB 1.969 billion in 2023[112]. - Revenue from the autoimmune segment was RMB 1.811 billion, making up 27.3% of total revenue, with a significant increase of 28.0% from RMB 1.415 billion in 2023[112]. - Revenue from the oncology segment was RMB 1.298 billion, which accounted for 19.6% of total revenue, showing a decline of 17.6% from RMB 1.576 billion in 2023[112]. - Total R&D expenditure for the year was RMB 1.523 billion, a decrease of 22.3% from RMB 1.960 billion in 2023, with R&D expenditure accounting for 23.0% of revenue, down from 29.7% in 2023[115]. - The net cash generated from operating activities for the year ended December 31, 2024, was RMB 1.391 billion, a substantial increase from RMB 151 million in 2023[119]. - As of December 31, 2024, the company had cash and cash equivalents of RMB 1.943 billion, down from RMB 2.007 billion in 2023[119]. - The current ratio as of December 31, 2024, was 200.4%, slightly down from 209.9% in 2023, while the debt-to-asset ratio increased to 38.6% from 33.5%[120]. Product Development and Pipeline - The group has eight innovative drugs approved for sale and has over 60 innovative drug candidates in its pipeline, with 16 undergoing registration clinical trials[9]. - The company has entered a critical phase for its R&D pipeline, with three new drug molecules in Phase III clinical trials[19]. - The company has made significant progress in clinical trials, with a Phase III trial for Enzashu® achieving its primary endpoint and NDA submitted to NMPA on March 11, 2024[25]. - The company has over 60 innovative drug candidates in its pipeline, with three in the NDA approval process and four in Phase III clinical trials[30]. - The company has received approval for 11 new INDs, including SIM0501 for advanced malignant solid tumors expected in January 2024 and SIM0505 for advanced solid tumors expected in December 2024 in the US and January 2025 in China[23]. - The company has established a partnership with Shenzhen Tajiri Biopharmaceutical Co., Ltd. for the exclusive commercialization rights of TGRX-326 in mainland China, enhancing its lung cancer product portfolio[25]. - The company plans to submit multiple innovative drug applications within the year, including new drugs for ovarian cancer and insomnia, which are expected to drive strong performance growth[12]. - The company is focusing on four key areas: neuroscience, oncology, autoimmune diseases, and anti-infection, while deepening international cooperation to promote more globally innovative drugs[12]. Market and Commercialization - The marketing network covers over 3,000 tertiary hospitals and approximately 17,000 other hospitals and medical institutions across China[9]. - The overseas licensing transaction value for Chinese innovative drugs exceeded $15 billion in 2024, representing a 45% year-on-year increase[13]. - Two products, Kexaila® and Enlituzumab®, were successfully included in the National Reimbursement Drug List (NRDL) in 2024, significantly enhancing patient accessibility and market penetration[16]. - The company has accelerated the clinical entry of its self-developed pipeline, with multiple products entering the key POC data phase[20]. - The company aims to enhance production capacity and efficiency under its "Innovation 2.0" strategy, with a new production base completed in 12 months, exceeding industry averages[28]. Employee and Corporate Governance - As of December 31, 2024, the group had a total of 6,584 full-time employees, with employee costs amounting to RMB 2.127 billion[129]. - The company has established a training academy to provide regular training for employees, including onboarding and skills training[129]. - The company’s employee compensation includes basic salary, performance bonuses, and long-term incentives, with a focus on attracting and retaining talent[129]. - The board approved the grant of a total of 3,828,000 restricted share units on March 21, 2024, and 2,968,100 restricted share units on August 22, 2024, to eligible participants[130]. - The company has appointed independent non-executive directors who have confirmed their independence according to the listing rules[194]. - All executive directors have service contracts with the company, while independent non-executive directors have signed appointment letters for a term of three years[193]. Risks and Challenges - The pharmaceutical industry is highly competitive, and failure to effectively compete may lead to decreased sales, price reductions, and loss of market share[158]. - The company may face challenges in maintaining sales volume, pricing levels, and profit margins for its key products due to various factors[158]. - The development of in-progress products is time-consuming and costly, with uncertain outcomes, which may hinder timely regulatory approvals and commercialization[160]. - The company relies on third parties for oversight and support of in-progress products, and any failure by these parties could delay regulatory approvals[160]. - The company may face increased operational costs or inability to fulfill customer orders due to failure to maintain optimal inventory levels[161]. - The company is exposed to risks related to the quality and production processes of third-party manufactured products, which may not consistently meet necessary quality standards[160]. Shareholder and Financial Activities - The company declared a final dividend of RMB 0.16 per share for the year ended December 31, 2024, totaling approximately RMB 397.81 million[135]. - The company raised RMB 970 million through a capital increase agreement, which will result in approximately 11.45% of the enlarged issued share capital being held by new investors[127]. - The company repurchased a total of 130,402,000 shares at a total cost of HKD 753,736,820 during the period from January 1, 2024, to December 31, 2024[146]. - The board believes that the share repurchase demonstrates confidence in the company's business prospects and will ultimately create value for shareholders[147]. - The company has not made any changes to its main business operations during the reporting year[134].

Investment Rating - The investment rating for the company is "Buy" [4] Core Views - The company is expected to see rapid growth in adjusted profits in 2024, with business development (BD) achievements highlighting its innovative capabilities, leading to potential valuation increases [1][2] - The company reported a revenue of 6.635 billion RMB in 2024, a year-over-year increase of 0.4%, and an adjusted net profit of approximately 1.018 billion RMB, reflecting a year-over-year growth of 41.6% [1][2] - The innovative drug segment is projected to continue its upward trend, with revenues from innovative drugs reaching 4.928 billion RMB in 2024, accounting for 74.3% of total revenue [2] Summary by Sections Performance - In 2024, the company achieved a group revenue of 6.635 billion RMB and a net profit of 733 million RMB, with an adjusted net profit of approximately 1.018 billion RMB [1] - The company has made significant progress with multiple innovative drugs, including the approval of two new drugs and the acceptance of three new drug NDAs [1] Innovation - The revenue from innovative drugs is expected to grow, driven by existing products and new launches, maintaining a high growth rate [2] - The partnership with AbbVie for the licensing of a new candidate drug demonstrates the strength of the company's innovation platform [2] Earnings Forecast and Valuation - The earnings per share (EPS) forecast for 2025-2027 is projected to be 0.43, 0.55, and 0.63 RMB, respectively, with a price-to-earnings (P/E) ratio of 19 times based on the closing price on April 24, 2025 [3] - The company is expected to maintain rapid growth in performance driven by both existing and new innovative drug products [3]

今年4月，先声药业(02096)先后宣布自身多款差异化创新的ADC品种将亮相今年的AACR年会。此时正值港股医药板块的自主创新周期，叠加ADC新秀映恩 生物挂牌上市，市场聚光灯再次聚焦于港股ADC赛道。而作为国内创新ADC赛道的领头羊之一，先声药业也同样受到业界和市场的双重关注。 智通财经APP观察到，在多重利好推动下，4月22日，先声药业股价高开高走，盘中最大涨幅达到15.44%，远高于当日恒生医疗保健指数6.07%的涨幅。 拉长时间线来看，港股创新药板块中为数不多的先于2024年9月牛市率先启动的标的，先声药业在去年4月5日触及阶段性底部后，便走出了一段不惧外部因 素干扰、稳步上升的长牛行情，实现季度"五连阳"，至今区间最高累涨高达81.35%。 虽然近期恒指大盘波动不止，但投资者依旧选择用脚投票助力先声药业股价实现快速反弹和向上突破。究其原因则在于创新驱动下，公司的"投资确定性"正 得到持续验证。 投资确定性背后的创新驱动 自2000年首款ADC药物获批以来，该领域经历了多次技术迭代，从早期因毒性问题屡遭挫折，到近年来凭借新型连接子、高活性载荷和优化抗体设计的"三 位一体"突破，逐渐成为肿瘤治疗的主流方 ...