Group 1 - The core viewpoint of the news is that Maiwei Biotech has shown significant financial activity, with a notable increase in revenue and changes in shareholder structure [1][2]. Group 2 - As of November 6, 2023, Maiwei Biotech's stock price increased by 0.50%, with a trading volume of 304 million yuan. The financing buy-in amount was 22.19 million yuan, while the financing repayment was 30.38 million yuan, resulting in a net financing buy of -8.19 million yuan [1]. - The total margin balance for Maiwei Biotech reached 613 million yuan, with the financing balance accounting for 6.74% of the circulating market value, indicating a high level compared to the past year [1]. - The company has not engaged in any short selling on November 6, 2023, with a short selling balance of 93.38 million yuan, also reflecting a high level compared to the past year [1]. Group 3 - For the period from January to September 2025, Maiwei Biotech reported a revenue of 566 million yuan, representing a year-on-year growth of 301.03%. However, the net profit attributable to the parent company was -598 million yuan, showing a year-on-year increase of 13.89% [2]. - As of September 30, 2025, the number of shareholders for Maiwei Biotech reached 19,600, an increase of 9.15% from the previous period. The average circulating shares per person decreased by 8.38% to 10,425 shares [2]. - Among the top ten circulating shareholders, E Fund Medical Healthcare Industry Mixed A ranked as the fourth largest shareholder with 3.17 million shares, while Hong Kong Central Clearing Limited ranked sixth with 2.87 million shares, showing a decrease of 1.87 million shares from the previous period [2].

Summary of the Conference Call for Maiwei Biotech Company Overview - **Company**: Maiwei Biotech - **Date**: November 4, 2025 Key Points Financial Performance - As of September 30, the company reported cash and cash equivalents of 1.439 billion RMB, an increase of over 200 million RMB compared to the end of last year [5] - Revenue for the first three quarters reached 566 million RMB, a year-on-year increase of 300%, driven by growth in technical service fees and a 70% increase in the sales of Dizu monoclonal antibody [5] - The loss for the third quarter significantly reduced to 49 million RMB, a year-on-year decrease of 200 million RMB, marking the first substantial reduction in losses [5] Business Development (BD) Achievements - The company achieved multiple breakthroughs in BD, including collaborations on Bai Jie 11, small nucleic acids, and long-acting Shengmai injections, resulting in over 800 million RMB in cash inflow [6][7] - Several BD pipelines are in progress, including 94 ADR BTC, CDED, and STE U monoclonal antibodies, with expectations for more results in the future [7] Core Projects and Pipeline Progress - The core pipeline includes 9KT 4 ADC, B713 ADC, and CD17 ADC, with multiple products expected to be approved and initiate patient enrollment in both China and the U.S. [8] - The SE2 monoclonal antibody for COPD has completed enrollment of 80 patients in the EB27 clinical trial, with expectations to complete follow-up by the end of the year [3] - The company is also advancing the CDH17 ADC project, which has received overseas authorization with a total amount exceeding 1 billion USD for liver delivery exploration [3][4] Market Expansion and Product Launches - Dizu monoclonal antibody sales approached 100 million RMB in the first half of the year, ranking first among domestic products [16] - The company has signed agreements with over 10 countries to expand biosimilars into emerging markets, with the first launch in Pakistan in August [16] - A supplemental application for bone metastasis indications is expected to be approved in the first half of next year, which could significantly increase revenue [16] Future Development Plans - The company is focusing on four key platforms: antibody discovery, ADC, TCE, and small nucleic acids, with plans to launch more TCE products into clinical trials next year [8] - The company is also developing treatments for age-related diseases, such as the SE2 monoclonal antibody for COPD, with plans for larger sample size trials [8] Clinical Trials and Regulatory Approvals - The company is actively communicating with the FDA regarding clinical trial designs and endpoints, particularly for the Bai Jie 11 project targeting pathological scars [9][28] - The 2,821 project is expected to focus on single endpoint PFS (Progression-Free Survival) to shorten clinical cycles and sample sizes [18][25] Innovations in Drug Development - The siRNA platform has been authorized to Editas, with ongoing development of dual-target siRNA and exploration of liver and CNS delivery systems [12][33] - The company is also developing a new oral small molecule drug for osteoarthritis, which is currently advancing to phase II clinical trials [14] Market Outlook - The company anticipates significant revenue growth from traditional products like Dizu and Adalimumab, with a complete transition to Maiwei's invoicing by 2026 [22] - The aging population in China is expected to drive demand for ophthalmic preparations, particularly for age-related macular degeneration [38] Conclusion - Maiwei Biotech is positioned for growth with a robust pipeline, significant financial improvements, and strategic collaborations, aiming to expand its market presence and enhance its product offerings in the coming years [39]

Investment Rating - The report maintains a "Buy" rating for the company, with a target price of 56.44 CNY, indicating a potential upside from the current price of 47.48 CNY [3][6]. Core Insights - The company has shown significant revenue growth, with a 301.0% increase in revenue for the first three quarters of 2025, amounting to 5.66 billion CNY. The net profit attributable to the parent company was -5.98 billion CNY, reflecting a 13.9% year-on-year improvement [10]. - The report highlights successful clinical advancements and commercialization efforts, with multiple new clinical trials set to commence and ongoing collaborations expected to enhance revenue streams [10]. - The financial forecasts have been adjusted, with a downward revision for 2025 revenue and R&D expenses, while 2026 revenue and management expenses have been increased. The projected net profits for 2025-2027 are -7.35 billion CNY, -6.55 billion CNY, and -2.91 billion CNY respectively [3][10]. Financial Summary - Revenue projections for 2025 are set at 747 million CNY, with a year-on-year growth of 274.1%. By 2026, revenue is expected to reach 1.066 billion CNY, growing at 42.6% [5]. - The company is expected to incur a net loss of 735 million CNY in 2025, improving to a loss of 655 million CNY in 2026, and further narrowing to 291 million CNY by 2027 [5]. - The gross margin is projected to be 93.5% in 2025, with a net margin of -98.4% [5]. - The company’s market capitalization is estimated at 225.55 billion CNY based on discounted cash flow valuation [11].

Core Insights - Maiwei Biotech (688062.SH) has repurchased a total of 437,474 shares, representing 0.11% of the company's total share capital [1] - The highest repurchase price was RMB 58.02 per share, while the lowest was RMB 40.61 per share [1] - The total amount spent on the repurchase was RMB 20.695 million, excluding transaction fees such as stamp duty and commissions [1]

Company Summary - Maiwei Bio announced on November 3 that as of October 31, 2025, it has repurchased approximately 440,000 shares, accounting for 0.11% of the company's total share capital [1] - The highest repurchase price was RMB 58.02 per share, while the lowest was RMB 40.61 per share [1] - The total amount spent on the share repurchase was RMB 20.695 million [1]

证券代码：688062 证券简称：迈威生物 公告编号：2025-065 公司于 2025 年 8 月 5 日召开第二届董事会第二十次会议，审议通过了《关于 调整回购股份价格上限的议案》，同意将回购股份价格上限由人民币 35.00 元/股（含） 调整为人民币 48.00 元/股（含）。具体内容详见公司于 2025 年 8 月 6 日在上海证 券交易所网站（www.sse.com.cn）上披露的《关于调整回购股份价格上限的公告》 （公告编号：2025-041）。除上述调整外，回购股份方案的其他内容不变。 公司于 2025 年 9 月 17 日召开第二届董事会第二十二次会议，审议通过了《关 于调整回购股份价格上限的议案》，同意将回购股份价格上限由人民币 48.00 元/股 （含）调整为人民币 66.46 元/股（含）。具体内容详见公司于 2025 年 9 月 18 日在 上海证券交易所网站（www.sse.com.cn）上披露的《关于调整回购股份价格上限的 公告》（公告编号：2025-053）。除上述调整外，回购股份方案的其他内容不变。 二、 回购股份的进展情况 根据《上市公司股份回购规则》《上海证券交易所上市公司 ...

Core Insights - The company reported a significant revenue increase of 301% year-on-year, reaching 566 million yuan, while the net profit attributable to shareholders was -598 million yuan [1] - The revenue growth was primarily driven by substantial income recognition from licensing agreements with Qilu Pharmaceutical and DISC MEDICINE, INC, along with increased drug sales compared to the previous year [1] Group 1: Licensing Agreements - The company granted Qilu Pharmaceutical rights for the development, production, and commercialization of the long-acting white blood cell booster injection, receiving an upfront payment of 380 million yuan [1] - An exclusive license for the IL-11 monoclonal antibody 9MW3811 was granted to CALICO LIFE SCIENCES LLC for all regions outside Greater China, with an upfront payment of 25 million USD [1] - The company also licensed the dual-target small nucleic acid drug 2MW7141 to Kalexo Bio, Inc. for global exclusive rights, receiving an upfront payment of 12 million USD [1] Group 2: Clinical Development Pipeline - The core product NECTIN-4 ADC 9MW2821 is currently undergoing three pivotal Phase 3 clinical trials in China, targeting various cancer treatments [2] - The ST2 monoclonal antibody 9MW1911 is advancing rapidly in Phase 2 clinical trials, with plans to initiate Phase 3 trials by the end of 2026 [2] - The TMPRSS6 monoclonal antibody 9MW3011 completed its first patient dosing in a Phase 2 clinical trial for PV patients in September 2025 [2] - The IL-11 monoclonal antibody 9MW3811 has had its Phase 2 clinical trial application accepted by the National Medical Products Administration, with a potential start by the end of 2025 [2] Group 3: Financial Projections - Revenue projections for the company are estimated at 886 million yuan, 1.145 billion yuan, and 2.285 billion yuan for 2025, 2026, and 2027 respectively [3] - Net profit projections are expected to be -676 million yuan, -618 million yuan, and -173 million yuan for the same years [3] - The company maintains a "Buy-A" investment rating, with a 6-month target price set at 54.40 yuan based on DCF modeling [3]

Core Insights - Maiwei Biotech, established in May 2017 and listed on the Shanghai Stock Exchange in January 2022, focuses on the research, development, production, and sales of therapeutic biological products, with several products in various clinical stages [1] Financial Performance - For Q3 2025, Maiwei Biotech reported revenue of 566 million yuan, ranking 76th in the industry, significantly lower than the top players like Huadong Medicine (32.664 billion yuan) and Fosun Pharma (29.393 billion yuan), as well as below the industry average of 280 million yuan and median of 83.8 million yuan [2] - The company recorded a net loss of 600 million yuan, ranking last in the industry, while the top performers, Heng Rui Medicine and Fosun Pharma, reported net profits of 5.76 billion yuan and 3.056 billion yuan respectively [2] Financial Ratios - As of Q3 2025, the company's debt-to-asset ratio was 79.11%, up from 57.64% the previous year, significantly higher than the industry average of 35.26%, indicating potential pressure on debt repayment capabilities [3] - The gross profit margin for Q3 2025 was 93.15%, slightly up from 92.46% year-on-year, and well above the industry average of 57.17%, reflecting strong profitability potential [3] Management and Shareholder Structure - The chairman, Liu Datao, received a salary of 2.7047 million yuan in 2024, an increase of 298,700 yuan from 2023 [4] - The major shareholder is Langrun (Shenzhen) Equity Investment Fund, with actual controllers being Tang Chunshan and Chen Shanna [4] Shareholder Dynamics - As of September 30, 2025, the number of A-share shareholders increased by 9.15% to 19,600, while the average number of shares held per shareholder decreased by 8.38% to 10,400 [5] Business Development and Growth - The company achieved a revenue of 465 million yuan in Q3 2025, a year-on-year increase of 1717.41%, with total revenue for the first three quarters reaching 566 million yuan, up 301.03% [6] - Drug sales revenue for Q3 2025 was 55.32 million yuan, a 120.85% increase year-on-year, and for the first three quarters, it was 156 million yuan, up 72.10% [6] - The company has established three business development partnerships with Qilu Pharmaceutical, Calico, and Kalexo [6] Market Outlook - According to Guolian Minsheng Securities, the company’s drug sales are steadily increasing, with the core driver for performance improvement being the drug for osteoporosis, Mailishu [7] - The company has a pipeline of 10 innovative drugs and 4 biosimilars, covering differentiated areas such as ADC and monoclonal antibodies [7]

Investment Rating - The report maintains a "Buy-A" investment rating for the company, with a 6-month target price of 54.40 CNY [5][4]. Core Insights - The company reported a revenue of 566 million CNY for Q3 2025, representing a year-on-year growth of 301%. However, it recorded a net profit loss of 598 million CNY [1]. - The significant revenue growth is attributed to substantial income from licensing agreements with Qilu Pharmaceutical and DISC MEDICINE, INC, as well as increased drug sales compared to the previous year [1][2]. - The company has made progress in its innovative drug pipeline, with multiple products licensed and ongoing clinical trials for key products [2][3]. Financial Projections - Revenue projections for 2025, 2026, and 2027 are estimated at 886 million CNY, 1.145 billion CNY, and 2.285 billion CNY, respectively. Net profits are projected to be -676 million CNY, -618 million CNY, and -173 million CNY for the same years [4][11]. - The expected earnings per share (EPS) for 2025, 2026, and 2027 are -1.69 CNY, -1.55 CNY, and -0.43 CNY, respectively [4][11]. Clinical Development - The company is advancing its core product NECTIN-4 ADC (9MW2821) through three critical Phase III clinical trials in China and has initiated patient dosing in the U.S. for a clinical trial involving ADC in triple-negative breast cancer [3]. - Other products, such as ST2 monoclonal antibody (9MW1911) and IL-11 monoclonal antibody (9MW3811), are also progressing through clinical trials, with expectations for further advancements by the end of 2025 [3]. Market Performance - As of October 30, 2025, the company's stock price was 42.27 CNY, with a total market capitalization of approximately 16.89 billion CNY [5][6]. - The stock has shown a relative return of -15.4% over the past month, but a positive return of 63.5% over the past year [6].

Investment Rating - The investment rating for the company is "Accumulate" (maintained) [2] Core Views - The company reported a significant increase in revenue and has multiple business development (BD) collaborations that are expected to drive future growth [8] - The company has a strong pipeline with clinical advancements in its CDH17 ADC and TCE platform, showcasing its R&D capabilities [8] - Revenue projections for 2025-2027 are estimated at 9.03 billion, 14.31 billion, and 22.72 billion RMB respectively, with a path to profitability expected by 2027 [8] Financial Performance - For the third quarter of 2025, the company achieved a revenue of 465 million RMB, representing a year-on-year growth of 1717.41% [8] - The total revenue for the first three quarters of 2025 reached 566 million RMB, a year-on-year increase of 301.03% [8] - The company's drug sales revenue for the third quarter was 55.32 million RMB, up 120.85% year-on-year, and for the first three quarters, it was 156 million RMB, up 72.10% year-on-year [8] Business Development Collaborations - The company has secured three BD collaborations, including a partnership with Qilu Pharmaceutical for the Agrestin α product, which includes a 380 million RMB upfront payment [8] - Collaborations with Calico and Kalexo involve significant upfront payments and milestone payments, indicating strong commercial potential [8] Clinical Development - The company’s self-developed CDH17 ADC has received approval for clinical trial applications from both the National Medical Products Administration and the FDA [8] - The TCE platform has established a comprehensive antibody library, enhancing its capabilities for targeted cancer therapies [8] Earnings Forecast - Projected revenues for 2025, 2026, and 2027 are 9.03 billion, 14.31 billion, and 22.72 billion RMB respectively, with corresponding net profits expected to be -648 million, -301 million, and 80 million RMB [7][8] - The company is expected to achieve an EPS of -1.62, -0.75, and 0.20 RMB for the years 2025, 2026, and 2027 respectively [7]