Group 1 - The A-share market indices experienced a collective upward trend, with the STAR Market Biopharmaceutical Index showing significant strength [1] - The STAR Market Biopharmaceutical Index ETF (588700) rose by 2.25%, with a trading volume exceeding 18 million yuan and a turnover rate of 7.97%, indicating active trading [1] - Key constituent stocks such as Yuyuan Pharmaceutical, Shouyao Holdings-U, and Nuotai Bio saw increases of over 7% [1] Group 2 - Harvard University's Belfer Center report indicates that China has a strong opportunity to surpass the U.S. in biotechnology, particularly in drug development [2] - The report highlights that while the U.S. leads in five key technology areas, the gap in biotechnology is narrowing, with China emerging as a source of original innovation [2] - CITIC Securities notes that the American Society of Clinical Oncology (ASCO) annual meeting is the largest and most authoritative clinical oncology conference, with increasing representation of domestic innovative drug data [2] Group 3 - Century Securities reports that there are ongoing developments in the innovative drug sector, particularly with the collaboration between Bristol-Myers Squibb and BioNTech for a $9 billion joint development of a PD-L1/VEGF dual antibody [3] - The ASCO meeting showcased significant progress in dual antibodies and ADC fields, with new mechanisms and targets emerging, indicating a differentiated layout in early clinical stages [3] - The competitiveness of domestic innovative drug pipelines on a global scale is expected to continue to rise, with a long-term positive outlook on the international expansion of innovative drugs [3]

Group 1 - The company has announced a cash dividend distribution plan for the year 2024, approving a distribution of 0.96 yuan per 10 shares to all shareholders [2] - The dividend distribution will not include capital reserve transfers or bonus shares, and any changes in the total share capital before the distribution date will lead to adjustments in the total distribution amount [2] - The company will adjust the conversion price of "Bright Convertible Bonds" in accordance with the relevant regulations after the implementation of the dividend distribution plan [2] Group 2 - The trading of "Bright Convertible Bonds" will be suspended from June 12, 2025, until the equity distribution registration date, with resumption of trading on the first trading day after the registration date [3] - The company will disclose the implementation announcement of the equity distribution, the adjustment of the conversion price for "Bright Convertible Bonds," and the total cash dividend amount on June 13, 2025 [3] - Holders of convertible bonds wishing to enjoy the dividend distribution must convert their bonds before June 11, 2025 [3]

证券代码：688166 证券简称：博瑞医药 公告编号：2025-033 重要内容提示： 证券停复牌情况：适用 因实施 2024 年年度权益分派, 博瑞生物医药（苏州）股份有限公司（以下简 称"公司"）的相关证券停复牌情况如下： | 证券代码 | 证券简称 | 停复牌类型 | 停牌起始日 | 停牌期间 | 停牌终止日 | 复牌日 | | --- | --- | --- | --- | --- | --- | --- | | 118004 | 博瑞转债 | 可转债转股停牌 | 2025/6/12 | | | | 转债代码：118004 转债简称：博瑞转债 博瑞生物医药（苏州）股份有限公司 关于实施 2024 年年度权益分派时 "博瑞转债"停止转股的提示性公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 二、本次权益分派方案实施时停止转股的安排 （一）公司将于 2025 年 6 月 13 日在上海证券交易所网站（www.sse.com.cn） 及指定媒体上披露权益分派实施公告、"博瑞转债"转股价格调整公告和调整 2024 年度利 ...

Group 1 - The A-share market saw a positive trend with the Shanghai Stock Exchange Science and Technology Innovation Board Biopharmaceutical Index rising by 1.95% as of the report time [1] - The Science and Technology Innovation Medicine Index ETF (588700) increased by 2.18%, with a turnover rate of 8.76% and a transaction volume exceeding 23.75 million [1] - Among the constituent stocks, Yifang Biotechnology-U surged over 12%, Borui Pharmaceutical rose over 8%, and Microchip Biotech increased over 7% [1] Group 2 - According to Industrial Securities, the innovative drug sector's prosperity is expected to be sustainable, with "innovation + internationalization" remaining the core direction of the pharmaceutical sector [2] - The report highlights that the innovative drug industry chain's fundamentals are beginning to improve, with overseas orders and performance starting to recover [2] - The demand in the domestic market is anticipated to rebound by 2025, with potential recovery in the consumption medical field, including medical services and OTC traditional Chinese medicine [2]

Core Viewpoint - The Chinese innovative pharmaceutical industry is transitioning from imitation to original innovation, with significant growth in outbound transactions and a promising future for internationalization [4] Group 1: Market Performance - As of May 29, 2025, the Sci-Tech Innovation Board 100 Index (000698) rose by 1.63%, with notable increases in constituent stocks such as Borui Pharmaceutical (688166) up 9.66% and Zhixiang Jintai (688443) up 6.57% [3] - The Sci-Tech 100 Index ETF (588030) increased by 1.60%, with a latest price of 0.95 yuan and a turnover rate of 1.16%, totaling 71.56 million yuan in transactions [3] - Over the past year, the average daily transaction volume of the Sci-Tech 100 Index ETF reached 424 million yuan, ranking first among comparable funds [3] Group 2: Fund Growth and Performance - The Sci-Tech 100 Index ETF saw a significant increase in scale, growing by 94.45 million yuan over the past two weeks, ranking second among comparable funds [4] - In the past week, the ETF's shares increased by 99 million, also ranking first among comparable funds [5] - The ETF has experienced a net inflow of 71.08 million yuan over the last five trading days, indicating strong investor interest [5] Group 3: Financial Metrics - As of May 28, 2025, the Sci-Tech 100 Index ETF's net value increased by 19.94% over the past year, with a maximum monthly return of 27.67% since inception [5] - The ETF's management fee is 0.15% and the custody fee is 0.05%, making it the lowest among comparable funds [5] - The tracking error for the ETF over the past six months is 0.016%, indicating high tracking precision compared to similar funds [5] Group 4: Industry Insights - From the beginning of 2025 to the present, the total outbound transaction amount for innovative drugs has reached 45.5 billion USD, with upfront payments totaling 2.2 billion USD, suggesting a record year ahead [4] - Most domestic innovative drugs currently in the U.S. are in clinical stages, with significant potential for future growth as they progress towards commercialization [4]

Company Overview - The company, 博瑞生物医药 (Suzhou) Co., Ltd., primarily engages in the research, production, and sales of high-end generic active pharmaceutical ingredients (APIs) and formulations, maintaining a strong competitive position in niche markets [3][11] - As of March 2025, the company reported total assets of 52.85 billion yuan and equity of 26.16 billion yuan, with a debt-to-asset ratio of 43.95% [5][11] - The company has a robust R&D capability, with a 25.42% year-on-year increase in R&D investment in 2024, accounting for 24.31% of its revenue [6][20] Financial Performance - In 2024, the company achieved an operating income of 2.49 billion yuan, with a gross profit margin of 43.95%, although both figures showed a decline compared to the previous year [16][20] - The revenue from the API segment was 8.85 billion yuan, while the formulation segment contributed 1.38 billion yuan, indicating a growing share of formulation sales [17][20] - The company’s total debt has been increasing, and significant investments in ongoing projects may pose challenges if market conditions change [5][7] Market Position and Competitive Landscape - The company maintains stable partnerships with major players like Teva and 恒瑞医药, benefiting from increased demand for antifungal and immunosuppressive products [6][7] - The company’s products are primarily exported, with 46.10% of its revenue coming from international sales, making it susceptible to fluctuations in global trade and currency exchange rates [7][8] - The pharmaceutical manufacturing industry is experiencing a transformation, with ongoing price governance and procurement policies impacting revenue and profit margins [14][15] R&D and Innovation - The company is advancing its pipeline of innovative drugs, including BGM0504 injection, which is in phase III clinical trials for diabetes and weight loss indications [20] - In 2024, the company received 33 new domestic and international patent authorizations, enhancing its competitive edge in the market [6][20] - The company’s focus on both generic and innovative drugs positions it well to capitalize on the growing demand for pharmaceuticals driven by an aging population and increasing healthcare needs [14][15] Industry Trends - The pharmaceutical manufacturing industry is expected to grow due to rising disposable incomes and an aging population, despite challenges from external trade dynamics [13][14] - The industry is characterized by high R&D costs and long product development cycles, necessitating strong financial and technical capabilities for sustained competitiveness [14][15] - Recent government policies aimed at supporting innovation in drug development are likely to create opportunities for companies with strong R&D capabilities [15]

Core Viewpoint - The announcement provides an update on the conversion status of the "博瑞转债" (Bright Gene Convertible Bonds) and outlines the current state of the company's convertible bonds, including the amount converted and remaining unconverted bonds. Group 1: Convertible Bond Issuance Overview - The company issued 4.65 million convertible bonds with a total value of RMB 46.5 million on January 4, 2022, with a maturity period of six years starting from the issuance date [2]. - The bonds began trading on the Shanghai Stock Exchange on January 27, 2022, under the name "博瑞转债" and code "118004" [2]. Group 2: Conversion Status - As of March 31, 2025, RMB 100,000 worth of bonds had been converted into 2,870 shares, representing 0.0007% of the total shares before conversion [1][5]. - By the same date, a total of RMB 159,000 had been converted into 4,550 shares, which is 0.0011% of the total shares before conversion [1][5]. - The remaining unconverted amount of the convertible bonds is RMB 464,835,000, accounting for 99.9645% of the total issuance [1][5]. Group 3: Share Capital Changes - The total share capital before the conversion was 422,466,646 shares, which increased to 422,469,516 shares after the conversion of the bonds [5].

Core Viewpoint - The company maintains its credit rating of "AA-" with a stable outlook for both its corporate entity and the "Bory Pharmaceutical Convertible Bonds" [1][2] Group 1: Credit Rating Information - The previous credit rating for the company was "AA-" with a stable outlook, and the same rating applies to the "Bory Convertible Bonds" [1] - The recent credit rating report from Dongfang Jincheng International Credit Assessment Co., Ltd. confirms the maintenance of the company's credit rating at "AA-" and the stable outlook [2] - The credit rating report is available on the Shanghai Stock Exchange website, detailing the company's and bonds' ratings for the year 2025 [2]

证券代码：688166 证券简称：博瑞医药 公告编号：2025-032 转债代码：118004 转债简称：博瑞转债 博瑞生物医药（苏州）股份有限公司 可转债转股结果暨股份变动公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 转股情况："博瑞转债"自 2022 年 7 月 11 日起开始进入转股期。2025 年 1 月 1 日至 2025 年 3 月 31 日期间，"博瑞转债"共有人民币 100,000 元已转 换为公司股票，转股数量为 2,870 股，占"博瑞转债"转股前公司已发行股份总 额的 0.0007%。截至 2025 年 3 月 31 日，"博瑞转债"共有人民币 159,000 元已 转换为公司股票，转股数量为 4,550 股，占"博瑞转债"转股前公司已发行股份 总额的 0.0011%。 未转股可转债情况：截至 2025 年 3 月 31 日，"博瑞转债"尚未转股的 可转债金额为 464,835,000 元，占"博瑞转债"发行总量的 99.9645%。 因公司实施 2022 年年度权益分派，"博 ...

证券代码：688166 证券简称：博瑞医药 公告编号：2025-031 转债代码：118004 转债简称：博瑞转债 根据《上市公司证券发行注册管理办法》《上海证券交易所科创板股票上市 规则》等有关规定，博瑞生物医药（苏州）股份有限公司（以下简称"公司"） 委托信用评级机构东方金诚国际信用评估有限公司（以下简称"东方金诚"）对 公司于 2022 年 1 月向不特定对象发行的可转换公司债券（以下简称"博瑞转债"） 进行了跟踪信用评级。 公司前次主体信用评级结果为"AA-"，评级展望为"稳定"，"博瑞转债" 前次信用评级结果为"AA-"，评级机构为东方金诚，评级时间为 2024 年 6 月 20 日。 评级机构东方金诚在对公司经营状况及相关行业进行综合分析与评估的基 础上，于近期出具了《博瑞生物医药（苏州）股份有限公司主体及"博瑞转债" 2025 年度跟踪评级报告》（东方金诚债跟踪评字【2025】0018 号），评级结果如 下：维持公司主体信用等级为"AA-"，评级展望为"稳定"，同时维持"博瑞转 债"信用等级为"AA-"。 本次信用评级报告内容详见公司同日披露于上海证券交易所网站的《博瑞生 博瑞生物医药（苏州）股 ...