重要内容提示： 本次 A 股股票上市类型为股权激励股份；股票认购方式为网下，上市股数 为2,076,750股。 本次 A 股股票上市流通总数为2,076,750股。 本次 A 股股票上市流通日期为2025 年 7 月 18 日。 | 证券代码：688428 | A 股简称：诺诚健华 | 公告编号：2025-026 | | --- | --- | --- | | 港股代码：09969 | 港股简称：诺诚健华 | | 诺诚健华医药有限公司 关于 2023 年科创板限制性股票激励计划首次 授予部分第二个归属期及预留授予部分第一个归属期 归属结果暨股份上市的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 根据中国证券监督管理委员会、上海证券交易所、中国证券登记结算有限责 任公司上海分公司相关业务规定，诺诚健华医药有限公司（以下简称"诺诚健华" 或"公司"）于近日收到中国证券登记结算有限责任公司上海分公司出具的《证券 变更登记证明》，公司完成了 2023 年科创板限制性股票激励计划首次授予部分第 二个归属期及预留授予部分第一个 ...

Policy Developments - The National Healthcare Security Administration reported that the basic medical insurance coverage rate in China remains stable at over 95%, with 1.32662 billion people insured by the end of 2024 [2] - The total income of the national basic medical insurance fund for 2024 is projected to be CNY 34,913.37 billion, while total expenditures are expected to be CNY 29,764.03 billion, resulting in a current balance of CNY 4,639.17 billion [2] - Since the establishment of the National Healthcare Security Administration in 2018, 835 new drugs have been added to the medical insurance drug list, with over 5,400 million CNY in sales from newly negotiated drugs between 2018 and 2024 [2] Drug and Device Approvals - Bayer's non-hormonal drug elinzanetant has been approved by the UK Medicines and Healthcare products Regulatory Agency for treating moderate to severe vasomotor symptoms related to menopause [5] - Innovent Biologics' new BCL2 inhibitor mesutoclax has received FDA approval to commence clinical trials for treating myeloid malignancies, including acute myeloid leukemia and myelodysplastic syndromes [6] - Tianyu Co., Ltd.'s subsidiary has passed the review for ezetimibe raw materials by the National Medical Products Administration, pending GMP compliance inspection results for market launch [7] Capital Market Activities - Innostellar Biotherapeutics has signed a ten-year exclusive promotion agreement with Golden Age Health for the commercialization of its gene therapy candidate LX101 in mainland China [9] Earnings Disclosures - Da'an Gene anticipates a net loss of CNY 140 million to 200 million for the first half of 2025 [11] - Huahai Pharmaceutical expects a net profit decline of 40% to 50% year-on-year, projecting a profit range of CNY 374 million to 449 million [12] - KingMed Diagnostics forecasts a net loss of CNY 95 million to 65 million for the first half of 2025, representing a significant year-on-year decline [13] - Xinmai Medical projects a net profit of CNY 304 million to 361 million for the first half of 2025, a decrease of 10.52% to 24.78% compared to the previous year [14] - Wantai Biological Pharmacy anticipates a net loss of CNY 130 million to 160 million for the first half of 2025 due to market pressures and policy adjustments [15] Industry Events - *ST Suwu has received a notice of administrative penalty from the China Securities Regulatory Commission for falsifying financial reports, which may lead to forced delisting [17] - This incident serves as a warning for the pharmaceutical industry to focus on genuine innovation and establish effective internal controls to mitigate risks associated with management [17] Shareholder Movements - Qihe Venture, a shareholder holding over 5% of Xuantai Pharmaceutical, plans to reduce its stake by up to 7 million shares, representing no more than 1.5441% of the company's total shares [19]

Group 1 - The core viewpoint of the article highlights the performance of public funds in the second quarter of 2025, with a focus on the innovative drug sector and the significant increase in short-term bond fund shares [1][4] - The first report from the outstanding fund manager Liang Furui shows a cumulative net value growth rate of 75.18% for the Changcheng Pharmaceutical Industry Select Fund, making it the second-best performing equity fund in the first half of the year [2] - Liang Furui's report indicates that the innovative drug development will focus on overseas licensing and domestic sales expansion in the third quarter, with a continued emphasis on clinical data, pipeline licensing, and sales growth [3] Group 2 - Several short-term bond funds have seen a significant increase in shares during the second quarter, with the Debang Short Bond Fund's total shares rising to 5.482 billion, an increase of over 30 billion shares, representing a growth of over 125% [4] - The fund managers of Dongfanghong Yixin Pure Bond and Dongfanghong Short Bond report that the next phase will focus on benefiting from internal liquidity easing, with a core strategy of investment-grade leverage and duration trading [4][5] - The Debang Short Bond Fund managers express concerns about external demand pressures and the potential slowdown of the "old-for-new" subsidy policy, while maintaining a positive outlook for the bond market in the third quarter [5]

Group 1 - The Shanghai Stock Exchange has released the "Self-Regulatory Supervision Guidelines for Companies Listed on the Sci-Tech Innovation Board No. 5 - Sci-Tech Growth Tier" [1] - The reform does not impose additional listing thresholds for unprofitable companies entering the Sci-Tech Growth Tier, allowing 32 existing unprofitable companies to enter immediately upon the guideline's implementation [1] - Newly registered unprofitable companies will enter the Sci-Tech Growth Tier from the date of their listing [1] Group 2 - Investors participating in the subscription and trading of newly registered stocks in the Sci-Tech Growth Tier must sign a "Risk Disclosure Statement for the Sci-Tech Growth Tier" [2] - The 32 existing companies that have not yet removed the "U" designation include: Zejing Pharmaceutical, Junshi Biosciences, Frontier Biotech, Qingyun Technology, Hehui Optoelectronics, Jingjin Electric, BeiGene, Dize Pharmaceutical, Maiwei Biotech, Aojie Technology, Yuhong Pharmaceutical, Shouyao Holdings, Haichuang Pharmaceutical, CloudWalk Technology, Yifang Biotech, Obsidian Optics, Mengke Pharmaceutical, Nuo Cheng Jianhua, Xinke Mobile, Xinghuan Technology, Yutai Micro, Yuntian Lifa, Tianzhihang, Qi Anxin, Hanwujin, Yihua Tong, Aifute, Huizhiwei, Xinlian Integrated, Zhixiang Jintai, Shengke Communication, and Zhongjuxin [2]

Core Viewpoint - The CFO of Innovent Biologics emphasized the necessity for innovative drug companies to internationalize in order to demonstrate global competitiveness, leveraging solid clinical data and rapid R&D capabilities [2][3]. Group 1: Industry Insights - The Chinese biopharmaceutical industry has seen a significant improvement in fundamentals, supported by government policies, especially from the second half of 2024 onwards, with increasing capital market attention on innovative drugs [2]. - The innovative drug sector is characterized by long investment timelines and high risks, necessitating patient capital to support industry growth [4]. - The establishment of a diversified payment system for innovative drugs will provide systematic support for patients to access high-quality medications, reinforcing the institutional foundation for high-quality development in China's innovative drug industry [4]. Group 2: Company Development - Innovent Biologics, founded in 2015, has evolved into a comprehensive biopharmaceutical enterprise with capabilities in source innovation, clinical development, production, and commercialization [3]. - The company is currently in its 2.0 rapid development phase, with two products already approved for market, and plans to diversify and internationalize its product offerings [3]. - Innovent aims to expand from hematological oncology into solid tumors and autoimmune diseases, addressing significant medical needs in conditions like atopic dermatitis and vitiligo, ensuring accelerated growth over the next 5 to 10 years [3].

金融界2025年7月7日消息，汇添富医疗服务灵活配置混合A(001417) 最新净值1.7320元，下跌2.26%。该 基金近1个月收益率0.35%，同类排名1209|2349；近6个月收益率49.18%，同类排名3|2317；今年来收益 率43.85%，同类排名4|2315。 来源：金融界 汇添富医疗服务灵活配置混合A股票持仓前十占比合计64.17%，分别为：恒瑞医药（10.23%）、科伦药 业（9.09%）、百利天恒（8.94%）、海思科（8.27%）、信立泰（6.66%）、泽璟制药-U（6.10%）、新 诺威（4.69%）、荣昌生物（3.49%）、诺诚健华-U（3.35%）、微电生理（3.35%）。 公开资料显示，汇添富医疗服务灵活配置混合A基金成立于2015年6月18日，截至2025年3月31日，汇添 富医疗服务灵活配置混合A规模44.08亿元，基金经理为张韡。 简历显示：张韡女士:中国。康奈尔大学生物医学硕士,曾任东方证券医药助理研究员,汇添富基金医药研 究员、高级医药研究员及医药行业研究组组长。2021年3月25日至今任汇添富健康生活一年持有期混合 型证券投资基金的基金经理。2021年9月29日至 ...

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [2] Core Insights - The pharmaceutical and biotechnology industry index increased by 5.30%, outperforming the CSI 300 index which rose by 3.52% during the reporting period [3][14] - The PE ratio (TTM, excluding negative values) for the pharmaceutical and biotechnology industry as of July 4, 2025, is 28.52x, up from 27.28x in the previous period, indicating an upward trend in valuation [3][19] - Notable sub-industries include "Other Biological Products" and "Medical R&D Outsourcing," which saw increases of 11.20% and 9.37% respectively, while "Medical Equipment" and "Blood Products" lagged with increases of only 0.98% [3][14] Industry Trends - The report highlights significant policy measures from the National Healthcare Security Administration and the National Health Commission aimed at supporting the high-quality development of innovative drugs [5][6] - The introduction of a commercial health insurance innovative drug directory is a key breakthrough, facilitating better pricing and reimbursement mechanisms for high-value drugs [6] - The report emphasizes the importance of the innovative drug industry chain, particularly focusing on platform pharmaceutical companies, clinical CROs, and high-barrier CDMOs [6] Important Industry News - The approval of several innovative drugs, including "ZEGFROVY" by Dize Pharmaceutical and "TQG203" by Zhengda Tianqing, marks significant advancements in the industry [41][42][46] - The report notes that the global number of hemophilia patients is expected to increase by 25% by 2025, highlighting the growing market for innovative treatments [42] - The approval of "Mastrudep" by Innovent Biologics for weight management in adults showcases the expanding therapeutic applications of GLP-1R/GCGR dual agonists [49][50] Investment Recommendations - Continuous attention is recommended for the innovative drug industry chain, particularly for companies that can navigate the new dual directory system and have international expansion capabilities [6] - The report suggests that the recent policy changes and the successful IPO of a biotech company signal a positive outlook for the innovative drug sector [6]

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年6月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2025年7月3日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 25,000,000,000 | USD | 0.000002 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | USD | | | | 本月底結存 | | | 25,000,000,000 | USD | 0.000002 | USD | | 50,000 | II. ...

Core Viewpoint - The company, Innovent Biologics, announced the approval of its innovative ADC drug ICP-B794 targeting B7-H3 for clinical research by the National Medical Products Administration (NMPA) in China, marking a significant advancement in cancer treatment options [1] Group 1: Product Development - ICP-B794 is an innovative ADC drug that combines a humanized anti-B7-H3 monoclonal antibody with a potent payload, ensuring precise targeting of tumor cells while minimizing off-target effects [1] - Currently, there are no approved therapies targeting B7-H3 globally, making it a promising target for cancer treatment due to its high expression in various solid tumors [1] Group 2: Strategic Vision - The company aims to build a robust ADC pipeline with strong tumor-killing efficacy and improved therapeutic windows, thereby expanding treatment options for cancer patients and enhancing clinical benefits [1] - The development of competitive drug pipelines is a priority for the company, focusing on targeted therapies, immuno-oncology approaches, and advanced ADC technologies to address unmet needs in solid tumors [1] Group 3: Research and Innovation - The research team is dedicated to discovering and developing new platforms for various solid tumors, utilizing innovative technologies to identify and advance potential candidates with significant clinical benefits [1] - The company's proprietary ADC technology platform and precision therapies, such as the TRK inhibitor zurletrectinib (ICP-723), position it strongly in the solid tumor treatment market [1]

Financial Performance - The company achieved total revenue of 381 million RMB in Q1 2025, a 129.92% year-over-year increase[9] - Sales revenue from Orelabrutinib reached 311 million RMB, an 89.22% year-over-year increase[9] - The company reported a net profit of 14 million RMB in Q1 2025[9] - Gross profit margin reached 90.5%, a 5.1 percentage point increase compared to the same period last year[9] - The company holds a strong cash reserve of 7800 million RMB[9] Orelabrutinib (BTK Inhibitor) - Orelabrutinib was approved in China for 1L CLL/SLL[9] - NDA submissions for multiple indications of Orelabrutinib are underway overseas[9] - Orelabrutinib is recommended in the 2025 CSCO lymphoma guidelines for CLL/SLL, MZL and MCL[20, 21] Pipeline Progress - Tafasitamab BLA for r/r DLBCL was accepted and granted priority review in mainland China[9] - Zurletrectinib NDA was submitted at the end of March 2025 and granted priority review[9] - A Phase III registrational clinical trial of Mesutoclax in combination with Orelabrutinib for 1L CLL/SLL is ongoing[9] Strategic Collaborations - Prolium Bioscience will gain rights to develop, register, produce, and commercialize ICP-B02 globally in non-oncology fields and in oncology fields outside of Asia[15] Autoimmune Disease - Phase III registrational clinical trials for Orelabrutinib in PPMS and SPMS are expected to enroll the first patient in the second half of 2025[9] - A Phase III registrational clinical trial for Orelabrutinib in ITP is expected to submit an NDA in the first half of 2026[9] - A Phase IIb trial for Orelabrutinib in SLE has completed patient enrollment, with data readout expected in Q4 2025[9]