证券代码：300633 证券简称：开立医疗 公告编号：2025-032 深圳开立生物医疗科技股份有限公司 2025 年半年度募集资金存放与使用情况专项报告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 一、募集资金基本情况 （一）实际募集资金金额及资金到账情况 经中国证券监督管理委员会证监许可〔2021〕668 号文核准，并经深圳证券 交易所同意，本深圳开立生物医疗科技股份有限公司（以下简称"公司"）由主 承销商长城证券股份有限公司（以下简称"长城证券"）采用定向发行方式，向 特定对象非公开发行股份人民币普通股（A 股）股票 27,851,745 股，发行价为每 股人民币 27.79 元，共计募集资金 773,999,993.55 元，坐扣承销费用 1,886,792.45 元后的募集资金为772,113,201.10元，其中245,167,501.10元已由长城证券于2021 年 12 月 21 日汇入公司在中国工商银行股份有限公司南山支行开立的账号为 4000020319200789913 的人民币账户，526,945,700.00 元已由长城证券于 2 ...

本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 深圳开立生物医疗科技股份有限公司 2025 年半年度报告及其摘要于 2025 年 8 月 22 日在中国证监会指定的创业板信息披露网站巨潮资讯网（http://www.c ninfo.com.cn/）上披露，请投资者注意查阅。 特此公告。 深圳开立生物医疗科技股份有限公司董事会 证券代码：300633 证券简称：开立医疗 公告编号：2025-029 深圳开立生物医疗科技股份有限公司 关于 2025 年半年度报告披露的提示性公告 2025 年 8 月 21 日 ...

证券代码：300633 证券简称：开立医疗 公告编号：2025-031 深圳开立生物医疗科技股份有限公司 第四届监事会第八次会议决议公告 本公司及监事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 一、监事会会议召开情况 2025 年 8 月 20 日，深圳开立生物医疗科技股份限公司（以下简称"公司"） 第四届监事会第八次会议在深圳市光明区光电北路 368 号开立医疗大厦一楼会 议室召开。本次会议由监事会主席陈欣主持。应出席监事 3 名，实际出席监事 3 名。符合《公司章程》规定的法定人数，本次监事会会议决议合法有效。 二、监事会会议审议情况 经与会监事审议表决，一致通过了如下决议： 1、审议通过《关于公司 2025 年半年度报告及其摘要的议案》 经审核，监事会认为：董事会编制和审核公司 2025 年半年度报告的程序符 合法律、行政法规和中国证监会的规定，报告内容真实、准确、完整地反映了上 市公司的实际情况，不存在任何虚假记载、误导性陈述或者重大遗漏。 具体内容详见公司在中国证监会指定的创业板信息披露网站巨潮资讯网披 露的《2025 年半年度报告》以及《2025 年半年度 ...

证券代码：300633 证券简称：开立医疗 公告编号：2025-030 一、董事会会议召开情况 2025 年 8 月 20 日，深圳开立生物医疗科技股份有限公司（以下简称"公司"） 第四届董事会第九次会议以现场和通讯表决相结合的方式在深圳市光明区光电 北路 368 号开立医疗大厦一楼会议室召开。本次会议已于 2025 年 8 月 11 日以电 话、电子邮件等方式通知全体董事。 本次会议应出席董事 7 人，实际出席董事 7 人，会议由董事长陈志强先生主 持，符合《公司章程》规定的法定人数，会议的召集、召开符合《公司法》和《公 司章程》的有关规定。 二、董事会会议审议情况 经与会董事投票表决，审议通过了如下决议： 1、审议通过《关于公司 2025 年半年度报告及其摘要的议案》 具体内容详见公司在中国证监会指定的创业板信息披露网站巨潮资讯网披 露的《2025 年半年度报告》以及《2025 年半年度报告摘要》。 深圳开立生物医疗科技股份有限公司 第四届董事会第九次会议决议公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 本议案中的财务报告部分已经公司董事会审计委员 ...

深圳开立生物医疗科技股份有限公司 2025 年半年度报告全文 深圳开立生物医疗科技股份有限公司 2025 年半年度报告 2025 年 8 月 1 深圳开立生物医疗科技股份有限公司 2025 年半年度报告全文 第一节 重要提示、目录和释义 公司董事会、监事会及董事、监事、高级管理人员保证半年度报告内容的真实、准 确、完整，不存在虚假记载、误导性陈述或者重大遗漏，并承担个别和连带的法律责任。 公司负责人陈志强、主管会计工作负责人罗曰佐及会计机构负责人(会计主管人员)徐 婷婷声明：保证本半年度报告中财务报告的真实、准确、完整。 所有董事均已出席了审议本次半年报的董事会会议。 本报告中所涉及的未来计划、发展战略等前瞻性描述不构成公司对投资者的实质承 诺，能否实现取决于宏观经济、市场状况变化等多种因素，存在不确定性，并提请投资者 注意公司在经营过程中面临的以下风险： 1、研发风险 医疗器械行业是国家重点监管行业，行业受医疗卫生政策的影响较大。随着国内医疗 体制改革的不断深化，医疗器械的集采比例逐渐增加，对国内医疗器械的产品单价、毛利 率带来负面影响。 5、营销团队稳定性风险 近几年来，公司的研发费用占当期营业收入的比例 ...

Core Insights - The Chinese AI + medical imaging industry is rapidly developing, with a market size projected to reach 7.6 billion yuan in 2024, representing a year-on-year growth of 109.94% [1][11] - AI technology is capable of quickly identifying small lesions from vast amounts of imaging data, facilitating precise early screening for various diseases and providing significant diagnostic support for doctors [1][11] - The product types in AI medical imaging are diversifying, with a trend towards integrated hardware and software solutions becoming the preferred choice for medical institutions [1][11] Industry Overview - AI + medical imaging refers to the use of AI technologies, such as deep learning and computer vision, to analyze and process medical images (e.g., X-rays, CT scans, MRIs, ultrasounds) to assist doctors in disease diagnosis, treatment planning, and prognosis evaluation [1][4] - The core function includes auxiliary diagnosis, treatment planning, prognosis assessment, and early detection screening [1][4] Industry Value Chain - The upstream of the AI + medical imaging industry includes medical imaging equipment, chips, servers, storage devices, imaging acquisition and processing software, cloud services, network operation platforms, and algorithm and data platforms [4] - The midstream involves the development and manufacturing of AI + medical imaging technologies, while the downstream primarily serves medical institutions, health check centers, and research and educational institutions [4] Market Size - The market size of the Chinese medical imaging equipment industry is expected to reach 69.3 billion yuan in 2024, with a year-on-year growth of 9.83% [6] Relevant Policies - The Chinese government has issued several policy documents to support and regulate the development of the AI + medical imaging industry, emphasizing the optimization of medical device standards and the establishment of standardization organizations for AI and medical robotics [8][10] - The policies aim to accelerate approval processes, enhance innovation ecosystems, and improve international competitiveness [8][10] Key Companies and Performance - Major companies in the AI + medical imaging sector include United Imaging Healthcare, Wandong Medical, Mindray, and Shukun Technology, each leveraging unique strengths in hardware and AI software integration [13][15] - United Imaging Healthcare reported a revenue of 10.3 billion yuan in 2024, a decrease of 9.73% year-on-year, while its R&D investment increased by 17.84% to 2.261 billion yuan [15] - Shukun Technology focuses on providing comprehensive AI solutions for medical institutions, achieving significant market penetration with its innovative products [17] Industry Development Trends 1. The industry is expected to advance towards multi-modal data integration and deep learning, enhancing diagnostic accuracy and personalized treatment [20] 2. Applications of AI in medical imaging will expand from auxiliary diagnosis to full-process management, improving service efficiency and quality [21] 3. Regulatory frameworks will evolve to include data privacy protections and accountability mechanisms for AI-generated content [22]

Core Viewpoint - The stock of Kaili Medical (300633) has shown a decline in both price and key financial metrics, indicating potential challenges in its operational performance and market perception [1][3]. Financial Performance - As of August 20, 2025, Kaili Medical's stock closed at 34.49 yuan, down 0.32% with a trading volume of 33,300 hands and a transaction value of 114 million yuan [1]. - The company's Q1 2025 report revealed a main revenue of 430 million yuan, a year-on-year decrease of 10.29%, and a net profit of 8.07 million yuan, down 91.94% year-on-year [3]. - The company's gross profit margin stands at 63.19%, which is significantly higher than the industry average of 51.29% [3]. Market Sentiment and Fund Flow - On August 20, 2025, the net outflow of main funds was 11.98 million yuan, accounting for 10.5% of the total transaction value, while retail investors saw a net inflow of 9.59 million yuan, representing 8.41% of the total [1][2]. - Over the past five days, the stock has experienced fluctuating fund flows, with significant net outflows from main funds on multiple days [2]. Industry Comparison - Kaili Medical's total market capitalization is 14.92 billion yuan, which is higher than the industry average of 12.11 billion yuan, ranking 23rd out of 123 companies in the medical device sector [3]. - The company's price-to-earnings ratio (P/E) is 462.07, significantly higher than the industry average of 82.01, indicating potential overvaluation [3]. Analyst Ratings - In the last 90 days, 10 institutions have rated the stock, with 8 buy ratings and 2 hold ratings, and the average target price set at 41.6 yuan [4].

Group 1 - The core viewpoint of the articles highlights the financial performance and market position of Kaili Medical, indicating a significant decline in revenue and profit, alongside a high PE ratio compared to industry averages [1][2] - As of August 19, Kaili Medical's stock closed at 34.6 yuan, with a PE ratio of 297.76, marking a new low in 168 days, and a total market capitalization of 14.972 billion yuan [1] - The company experienced a net outflow of 1.0265 million yuan in major funds on August 19, with a total outflow of 59.3642 million yuan over the past five days [1] Group 2 - Kaili Medical specializes in the research, development, production, and sales of medical diagnostic and treatment equipment, with key products including ultrasound diagnostic devices and minimally invasive surgical products [1] - The company has over 20 years of experience in the ultrasound industry and is recognized as a high-tech enterprise, holding leading positions in core technologies for ultrasound equipment in China [1] - In terms of market share, Kaili Medical ranks second among domestic manufacturers and tenth globally in the ultrasound product market, demonstrating strong brand influence and competitiveness [1]

Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical and biotechnology sector [5][39]. Core Insights - The pharmaceutical sector has shown stronger performance compared to the overall market, with a total A-share increase of 2.04% and a decline of 0.84% in the biotechnology sector [1][30]. - The brain-computer interface (BCI) industry is rapidly developing, supported by recent government policies and successful clinical trials, indicating significant growth potential [2][11]. - The report emphasizes the importance of innovative drugs and their supporting infrastructure, highlighting the positive impact of adjustments in medical insurance and commercial health insurance on domestic innovative drug sales [3][39]. Summary by Sections Market Performance - The overall A-share market increased by 2.04%, while the biotechnology sector decreased by 0.84%, indicating a weaker performance relative to the market [1][30]. - The current price-to-earnings (P/E) ratio for the pharmaceutical sector is 38.77x, which is at the 80.28th percentile of its historical valuation over the past five years [1][35]. Brain-Computer Interface Industry - The BCI industry is characterized by a growing number of supportive policies and technological advancements, with a focus on both invasive and non-invasive methods [2][11]. - The market for non-invasive BCIs is the primary research direction, accounting for 86% of the market share [11][16]. - The potential market size for serious medical applications of BCIs is estimated between $15 billion and $85 billion, while consumer medical applications could reach $25 billion to $60 billion [16]. Key Companies and Investment Recommendations - **Mindray Medical (300760.SZ)**: Rated "Outperform" with projected net profits increasing from 116.7 billion in 2024 to 161.9 billion in 2027 [4]. - **WuXi AppTec (603259.SH)**: Rated "Outperform" with expected net profits rising from 93.5 billion in 2024 to 145.1 billion in 2027 [4]. - **Aier Eye Hospital (300633.SZ)**: Rated "Outperform" with a focus on expanding its service network and enhancing service prices [39]. - **Huitai Medical (688617.SH)**: Rated "Outperform" with a strong focus on electrophysiology and interventional medical devices [40]. - **Innovative Medical (002173.SZ)**: Rated "Outperform" with ongoing clinical trials and expected registration of medical devices [39].

Investment Rating - The industry investment rating is maintained at "Outperform the Market" [4] Core Viewpoints - The total bid amount for medical devices in July 2025 reached 12.643 billion yuan, representing a year-on-year increase of 20% and a cumulative total of 96.785 billion yuan from January to July, with an overall year-on-year growth of 57% [5][11] - Domestic device bidding amounts are recovering, with categories like endoscopes showing high year-on-year growth rates [6] - Imported brands experienced a slight decline in bidding amounts, but categories such as CT and DSA showed significant year-on-year growth [7] Summary by Sections Medical Device Bidding Overview - The total bidding amount for medical devices in July 2025 was 12.643 billion yuan, a 20% increase year-on-year, but a 6% decrease month-on-month [11] - From January to July 2025, the total bidding amount was 96.785 billion yuan, reflecting a 57% year-on-year increase [11] Domestic Brands - Mindray Medical's total bidding amount in July was 1.017 billion yuan, up 84% year-on-year, with a cumulative total of 5.854 billion yuan from January to July, also up 57% [15] - Aohua Endoscopy's total bidding amount in July was 68.22 million yuan, a 23% increase year-on-year, with a cumulative total of 303.27 million yuan from January to July, reflecting a 48% increase [21] - Kailing Medical's total bidding amount in July was 101 million yuan, a 67% increase year-on-year, with a cumulative total of 740 million yuan from January to July, showing a 106% increase [24] - Shanfeng's total bidding amount in July was 49 million yuan, a staggering 392% increase year-on-year, with a cumulative total of 236 million yuan from January to July, reflecting a 239% increase [27] - Wandong Medical's total bidding amount in July was 66.17 million yuan, a 19% increase year-on-year, with a cumulative total of 794.41 million yuan from January to July, showing a 95% increase [30] Imported Brands - Philips' total bidding amount in July was 467.37 million yuan, a 41% decrease year-on-year, with a cumulative total of 5.045 billion yuan from January to July, reflecting a 39% increase [33] - Siemens' total bidding amount in July was 554 million yuan, an 11% decrease year-on-year, with a cumulative total of 6.620 billion yuan from January to July, showing a 49% increase [36] - GE's total bidding amount in July was 701.17 million yuan, a 17% decrease year-on-year, with a cumulative total of 7.414 billion yuan from January to July, reflecting a 44% increase [39]