证券研究报告 | 医药生物 | 2025年4月12日 www.hczq.com 华创医药投资观点&研究专题周周谈·第121期 海外CXO 2024财报总结 本周周专题联系人：万梦蝶 | 华创医药团队： | | | --- | --- | | 首席分析师 郑辰 | 执业编号：S0360520110002 邮箱：zhengchen@hcyjs.com | | 联席首席分析师 刘浩 | 执业编号: S0360520120002 邮箱: liuhao@hcyjs.com | | 医疗器械组组长 李婵娟 | 执业编号：S0360520110004 邮箱：lichanjuan@hcyjs.com | | 中药和流通组组长 高初蕾 | 执业编号：S0360524070002 邮箱：gaochulei@hcyjs.com | | 分析师 万梦蝶 | 执业编号: S0360523080008 邮箱: wanmengdie@hcyjs.com | | 分析师 王宏雨 | 执业编号：S0360523080006 邮箱：wanghongyu@hcyjs.com | | 分析师 朱珂琛 | 执业编号：S0360524070007 邮箱 ...

Group 1 - The recent announcement by President Trump to suspend tariffs for 90 days on countries that do not retaliate has led to a significant rise in US stock markets, with major indices experiencing collective gains [1] - The Hong Kong stock market responded positively, with the Hang Seng Index rising by 2.69%, the National Index by 2.43%, and the Hang Seng Tech Index by 3.96% [1] - Biopharmaceutical stocks, particularly those related to WuXi AppTec, saw substantial gains, with WuXi AppTec's subsidiary rising over 14%, and other related stocks also experiencing increases of over 6% [1] Group 2 - The imposition of tariffs on pharmaceuticals by the US is expected to impact the industry, particularly affecting raw materials and generic drugs, while innovative drugs may face less disruption [1] - Experts suggest that the tariff plan serves as a threat to encourage US pharmaceutical companies to relocate production back to the US, given the limited domestic production capacity [1] - The Hang Seng Medical ETF (513060) saw a significant increase, rising over 5% with a trading volume exceeding 600 million yuan, indicating active trading in the sector [1] Group 3 - Recent US-China tariff increases have created disturbances in the pharmaceutical industry, but China's pharmaceutical exports are relatively small and mainly consist of raw materials and low-value consumables [2] - The domestic pharmaceutical outsourcing service companies are becoming crucial in the global pharmaceutical supply chain, supporting US pharmaceutical companies in enhancing R&D efficiency [2] - The innovative drug industry chain is showing active performance, with a focus on high-growth areas such as ADCCDMO and weight-loss drug supply chains, as well as companies in third-party testing laboratories and consumer healthcare sectors [2] Group 4 - The Hang Seng Medical ETF (513060) closely tracks the Hang Seng Healthcare Index, which reflects the overall performance of healthcare-related securities listed in Hong Kong, making it a key focus for investors [3]

Group 1 - The core viewpoint is that the Hong Kong innovative drug sector is experiencing significant growth, driven by supportive government policies and increased participation in international events like the JPMorgan Healthcare Conference [1][2] - The National Index for Hong Kong Innovative Drugs has seen a strong increase of 5.21% as of April 10, 2025, with notable gains in constituent stocks such as WuXi AppTec (up 14.19%) and Kelun-Biotech (up 12.95%) [1] - The Hong Kong Innovative Drug ETF (159567) has also performed well, rising 8.00% recently and showing a cumulative increase of 14.88% over the past three months, ranking in the top third among comparable funds [1] Group 2 - The 43rd JPMorgan Healthcare Conference in San Francisco highlighted the active participation of Chinese innovative drug companies, indicating a promising outlook for the industry with expected project collaborations and pipeline advancements in 2025 [2] - The Hong Kong Innovative Drug ETF closely tracks the National Index for Hong Kong Innovative Drugs, allowing for T+0 trading and reflecting the operational characteristics of listed companies in the innovative drug sector [2] Group 3 - As of April 9, 2025, the Hong Kong Innovative Drug ETF has seen an average daily trading volume of 827 million yuan over the past week, with a total net inflow of 426 million yuan in the last eight days [3] - The ETF's net asset value has increased by 26.67% over the past year, ranking it in the top 8.52% among 2710 index equity funds [3] - The current price-to-earnings ratio (PE-TTM) of the index tracked by the ETF is 24.3, indicating a valuation that is lower than 98.9% of the time over the past year, suggesting it is at a historical low [3]

今年以来，创新药板块迎来强势反弹，港股创新药指数年内涨幅一度超过35%，成为今年投资回报最大的主 题之一。多只创新药主题基金更是扎堆跻身今年基金业绩排名前列。 不过，受到海外关税风险持续扰动，叠加外围市场持续大跌抑制风险偏好等综合影响，创新药板块也出现较大 回撤。4月8日，美国总统特朗普甚至放话称，美国将对药品征收关税。 4月9日，港股创新药指数盘中巨震，从开盘的下跌8.6%到收盘的上涨1.05%，盘中拉升近10个百分点。对 此，券商中国记者针对市场关切的问题采访了多家机构。多家机构普遍表示，加征关税对创新药板块影响有 限，看好其中长期投资价值。 创新药主题基金扎堆跻身业绩排名前列。 对此，平安医药精选基金经理周思聪表示，此次特朗普对药品加征关税对创新药基本无影响，创新药出海授权 商业化具备较强韧性。 加征关税对创新药影响有限 长城基金基金经理梁福睿对记者表示，美国拟对药品征收关税，预计对创新药影响有限。根据中国医药保健品 进出口商会数据，2024年中国对美国出口额190.5亿美元，同比增长11.7%，其中西药64.25亿 美元 ；进口额 150.6亿美元，同比下降4.3%，其中西药63.33亿 美元 ，药品 ...

Policy Developments - Shenzhen has issued measures to support the development of innovative drugs and medical devices, focusing on areas such as nucleic acid drugs, protein and peptide drugs, cell drugs, and small molecule innovative drugs, with a total of 32 specific measures proposed [1] Drug Approvals - Eli Lilly's application for the new drug imlunestrant, a selective estrogen receptor degrader for treating ER+ and HER2- advanced breast cancer, has been accepted by China's National Medical Products Administration [2] - Heng Rui Medicine's SHR0302 (aimatinib), a JAK1 inhibitor, has received approval for a new indication for treating moderate to severe atopic dermatitis in adults and adolescents aged 12 and above [3] Capital Market Activities - Kehua Bio has signed an investment cooperation agreement to establish a medical device and testing reagent production base and an innovation center in Xi'an, covering approximately 90 acres [4] - TianKang Bio plans to introduce external investors through a capital increase, with two investors subscribing to a total of RMB 27.5 million for new registered capital [6] Research and Development - Innovent Biologics has announced that its tumor pipeline products ICP-248, ICP-723, and ICP-B05 have been selected for presentation at the 2025 ASCO Annual Meeting [5] - Pian Zai Huang has signed a technology transfer contract worth RMB 13.58 million for a new traditional Chinese medicine, which aligns with the trend of innovation in the TCM industry [8] Financial Reports - Sunshine Nuohua reported a revenue of RMB 1.078 billion for 2024, a year-on-year increase of 15.7%, but a net profit of RMB 177 million, down 3.98% [9] - David Medical's revenue for 2024 was RMB 527.03 million, a decrease of 14.76%, with a net profit decline of 61.21% [10] - Bai O Tai reported a revenue of RMB 743 million for 2024, a 5.44% increase, but a net loss of RMB 510 million, compared to a loss of RMB 395 million in the previous year [11]

Investment Rating - The report recommends a "Buy" rating for multiple companies in the pharmaceutical sector, including Junshi Biosciences, Hualing Pharmaceutical-B, Aorite, Tonghe Pharmaceutical, and others [3]. Core Insights - The pharmaceutical sector has outperformed the market, with a 1.20% increase, surpassing the CSI 300 index by 2.57 percentage points. Sub-sectors such as innovative drugs, new medical infrastructure, and pharmacies performed well, while pharmaceutical outsourcing, medical devices, and hospitals lagged behind [6][36]. - There is a significant unmet need for Obstructive Sleep Apnea (OSA) treatment, with GLP-1RA drugs showing remarkable efficacy. The FDA approved Tirzepatide as the first and only prescription drug for treating moderate to severe OSA in adults with obesity [5][26]. Summary by Sections Industry Perspective and Investment Recommendations - OSA is linked to various health issues, including hypertension, and has a high prevalence among adults in China, with 176 million affected. The prevalence of hypertension among OSA patients is notably high [16][17]. - Investment strategies should focus on innovative drugs, particularly in the context of increased liquidity and risk appetite in the market. The upcoming AACR and ASCO meetings are expected to catalyze interest in biotech innovations [30][31]. Industry Performance - The pharmaceutical sector's performance is highlighted, with innovative drugs and medical infrastructure leading the gains. The overall industry P/E ratio stands at 26.88, with a premium of 30.38% compared to the broader A-share market [36]. Company Dynamics - Notable company updates include: - Fuyuan Pharmaceutical reported a revenue of 3.446 billion yuan for 2024, a 3.17% increase year-on-year [37]. - Jingxin Pharmaceutical announced a share buyback totaling approximately 350 million shares [37]. - Heng Rui Medicine received approval for a new indication for its innovative drug, indicating ongoing development and regulatory progress [37].

Core Views - The report maintains a positive outlook on the biopharmaceutical industry, expecting it to outperform the market due to minimal impact from recent U.S. tariff policies on drug sectors [4][5] - The report emphasizes continued optimism for innovative drugs and sectors related to consumer recovery, highlighting the resilience of the pharmaceutical sector amidst tariff changes [4][5] Industry Insights - The recent U.S. tariff policy has a limited effect on the pharmaceutical sector, with most drugs, including various chemical drugs, vaccines, and biological products, exempt from tariffs. Raw materials like vitamins and amino acids are also on the exemption list [4][27] - The report suggests that the innovative drug sector has shown significant growth, providing a selection of quality stocks based on criteria such as strong fundamentals, potential in research pipelines, and favorable cash positions [4][5] Investment Strategy - The report recommends focusing on four main themes: "Innovation," "Going Global," "Equipment Upgrades," and "Consumer Recovery" [5] - **Innovation**: Invest in globally competitive innovative drugs and promising categories, with specific companies highlighted such as BeiGene and East China Pharmaceutical [5] - **Going Global**: Identify opportunities in overseas markets, with companies like Mindray Medical and Sinocare suggested for investment [5] - **Equipment Upgrades**: Expect support for medical equipment updates from government policies, with companies like Mindray Medical and United Imaging Healthcare recommended [5] - **Consumer Recovery**: Anticipate a rebound in sectors like ophthalmology and aesthetic medicine, with companies like Prue Eye Hospital and Tongce Medical highlighted [5] Key Companies to Watch - **Nocare Biopharma**: Expected to achieve revenue of 1.009 billion in 2024, with a 49% year-on-year growth in sales of its core product, Oubatinib [6] - **Sihuan Pharmaceutical**: Strong fundamentals with a stable performance, and a promising pipeline with multiple products expected to be approved between 2025 and 2027 [9] - **East China Pharmaceutical**: Anticipated growth driven by the commercialization of domestic nuclear medicine products and a robust R&D pipeline [10] - **China Biopharmaceutical**: Rapid revenue growth with an increasing proportion of innovative products, indicating potential for accelerated profit growth [11] - **Aier Eye Hospital**: Benefiting from growing demand in ophthalmology and favorable policies for private specialty hospitals, with significant expansion plans [21]

Investment Rating - The report maintains an optimistic outlook on the pharmaceutical industry, suggesting a potential for diverse investment opportunities by 2025 [11]. Core Insights - The pharmaceutical sector is currently undervalued, with public funds showing low allocation to this sector. Positive macroeconomic factors, such as the recovery of U.S. Treasury rates, are expected to drive growth in the industry [11]. - The report emphasizes a shift from quantity to quality in the domestic innovative drug sector, highlighting the importance of product differentiation and internationalization [11]. - The medical device market is experiencing a rebound in bidding volumes, particularly in imaging equipment, and there is a growing focus on home medical devices [11]. - The report identifies a recovery in the innovative chain (CXO + life sciences services) and anticipates a return to high growth for the sector by 2025 [11]. - The traditional Chinese medicine sector is expected to benefit from the introduction of new essential drug directories and state-owned enterprise reforms [13]. - The report highlights the potential for the pharmacy sector to thrive due to prescription outflow and market optimization [13]. - The blood products industry is projected to grow significantly during the 14th Five-Year Plan period, with increased approval for plasma stations [13]. Summary by Sections Market Review - The report notes that the CITIC pharmaceutical index rose by 1.15%, outperforming the CSI 300 index by 2.52 percentage points, ranking third among 30 primary industries [8]. - The top ten stocks by growth include Duorui Pharmaceutical, Oukang Pharmaceutical, and Weisi Medical, while the bottom ten include Dongfang Biological and Nengte Technology [8]. Overall View and Investment Themes - The report suggests that the pharmaceutical industry is at a low valuation, with public fund allocations also low, indicating a potential for growth driven by macroeconomic factors [11]. - It highlights the importance of focusing on differentiated products and internationalization in the innovative drug sector, recommending companies like Hengrui, BeiGene, and others [11]. - The medical device sector is seeing a recovery in bidding volumes, particularly in imaging and home medical devices, with a focus on domestic companies [11]. - The innovative chain is expected to see a rebound in investment, with CXO and life sciences services poised for growth [11]. - The report emphasizes the potential for traditional Chinese medicine and pharmacies to benefit from regulatory changes and market dynamics [13]. Company-Specific Insights - Yuan Dong Biological has maintained a high R&D investment intensity, with 22% of its revenue allocated to R&D in 2023, indicating a strong focus on innovative drug development [17]. - The company has a robust pipeline of high-end generic drugs and is exploring innovative drug candidates, particularly in the area of small molecules and monoclonal antibodies [17][20]. - Yuan Dong's internationalization strategy is focused on the U.S. opioid detoxification market, with several products expected to contribute to revenue by 2025 [23]. - The company is also developing a range of innovative drugs, including NGF monoclonal antibodies and TL1A monoclonal antibodies, which are in various stages of clinical development [32][38].

证券研究报告|医药生物|2025年4月5日 www.hczq.com 华创医药投资观点&研究专题周周谈·第120期 苑东生物研发管线更新 联系人:朱珂琛 | 华创医药团队： | | | --- | --- | | 首席分析师 郑辰 | 执业编号: S0360520110002 邮箱: zhengchen@hcyjs.com | | 联席首席分析师 刘浩 | 执业编号：S0360520120002 邮箱：liuhao@hcyjs.com | | 医疗器械组组长 李焯娟 | 执业编号：S0360520110004 邮箱：lichanjuan@hcyjs.com | | 中药和流通组组长 高初蕾 | 执业编号：S0360524070002 邮箱：gaochulei@hcyjs.com | | 分析师 万梦蝶 | 执业编号: S0360523080008 邮箱: wanmengdie@hcyjs.com | | 分析师 王宏雨 | 执业编号: S0360523080006 邮箱: wanghongyu@hcyjs.com | | 分析师 朱珂琛 | 执业编号: S0360524070007 邮箱: zhukechen ...

-凯铃 管 行情回顾 01 02 板块观点和投资组合 03 行业和个股事件 本周行情回顾 =半创研究 本周中信一级行业指数涨跌幅 本周涨幅排名前/后十名的股票 东方生物 多瑞医药 能特科技 欧康医药 48.62% 双成药业 伟思医疗 31.80% 百普塞斯 哈三联 31.15% 1% 迪瑞圆疗 润都股份 27.01% 0% 昭衍新药 圣诺生物 21.54% -1% 海创药业-U 20.74% 未名医药 -29 药明康德 赛开药业 19.00% 海泰新光 金河生物 18.80% 留非经非 海昇药业 18.39% 30% 10% 20% 40% 609 证监会审核华创证券投资咨询业务资格批文号：证监许可（2009）1210 号 未经许可, 禁止转载 资料来源：Wind，华创证券 w · 本周，中信医药指数上涨1.15%，跑赢沪深300指数2.52个百分点，在中信30个一级行业中排名第3位。 · 本周涨幅前十名股票为多瑞医药、欧康医药、伟思医疗、哈三联、润都股份、圣诺生物、海创药业-U、赛开药业、金河生物、海昇药业, 本周跌幅前十名股票为东方生物、能特科技、双成药业、百普赛斯、迪瑞医疗、昭衍新药、未名医药、药明康德 ...