每周 一 景 ：甘孜藏族自治州四川省贡嘎雪山 点击右上角菜单，收听朗读版 【基金 】 国泰海通证券2月基金投资策略 基金投资策略 股混基金： 从基金投资的角度来看，在成长主线下，价值和成长风格中均具备结构性投资机会的市场格局或将延续，因此我们建议后续基金配置在整体维持 均衡风格的前提下，适度偏向成长，并且关注基金经理的选股和风控能力，重视主投科技领域基金，兼顾周期、金融等资产。 指数主题基金： 我们从基本面景气度、超预期水平、量价水平和资金流强度四个维度出发，构建行业轮动模型，2月最新高景气度行业分别为基础化工、建筑 材料、环保、石油石化、通信和钢铁，结合ETF产品的流动性和相关性，我们构建的ETF行业轮动投资组合。 债券基金： 从基金投资角度来看，建议关注久期灵活的利率债和重配高流动性信用债的产品。此外，随着权益市场回暖，我们认为固收+基金同样具备一定配 置价值，建议持续关注。 QDII和商品型基金： 全球地缘政治局势的不确定性上升以及各国央行持续购金有利于支撑长期金价中枢，从长期投资和避险投资的角度来看，我们认为可适 当配置黄金ETF，但趋势配置者短期需要谨慎。美国经济韧性较强，内生性通胀粘性逐渐减弱，投 ...

国泰海通发布研报称，在英国首相访华期间，阿斯利康宣布计划在中国投资150亿美元，为中国及全球 患者提供尖端治疗方案。该行认为，本次投资再次证明在中国工程师红利及生物医药能力的持续验证 下，MNC对于中国本土研发能力及中国市场的兴趣和认可。 国泰海通主要观点如下： 在英国首相访华期间，阿斯利康宣布计划在中国投资150亿美元 近日，英国首相斯塔默开启为期4天的访华行程，随同斯塔默访问的有超50家企业高管和机构代表。其 中，阿斯利康全球首席执行官苏博科、葛兰素史克董事会主席司明麒作为英国医药产业的代表随团访 华。这项投资用于扩大药品制造和研发。这项投资将充分利用中国卓越的科学实力、先进的制造能力以 及中英医疗健康生态系统合作优势，为中国及全球患者提供尖端治疗方案。 150亿美元投资主要用于细胞疗法+RDC药物 鉴于中国在新型治疗模式(new modalities)领域的先进科学水平，此项投资将大幅提升公司在细胞疗法和 放射性偶联药物方面的能力，以推动其广泛而多样化的研发管线，帮助癌症、血液疾病和自身免疫性疾 病等患者。这些投资涵盖整个价值链，从药物发现、临床开发到生产制造，并通过与领先生物技术公司 (包括AbelZ ...

Investment Rating - The investment rating for the company is "Buy" [1] Core Insights - The company has established a unique business model that transitions from traditional self-research to a sustainable business development (BD) model, significantly increasing cash flow and revenue [5][7] - The company possesses a globally rare, clinically validated fully human antibody transgenic mouse platform, Harbour Mice®, which breaks traditional antibody development bottlenecks [4][6] - The company has successfully attracted collaborations with top multinational pharmaceutical companies, marking its evolution from a traditional biotech to a globally influential biotechnology innovator [4][5] Summary by Sections Company Overview - The company, Harbour BioMed (2142.HK), was founded in 2016 and has a dual-engine strategy of "technology platform + innovative products" [15] - It has a strong R&D advantage and global business capabilities, with a focus on developing innovative drugs for oncology and immune diseases [18] Business Model and Financial Performance - The company has transformed its business model to a continuous BD authorization model, achieving a revenue increase of 327% year-on-year to $101 million in the first half of 2025 [5][31] - The net profit for the same period reached $71.72 million, with a net profit margin of 72% [5][31] - The company holds $320 million in cash as of mid-2025, providing a strong safety margin for long-term R&D and business expansion [35] Pipeline and Innovation - The company focuses on differentiated clinical value with a pipeline that includes First-in-Class (FIC) and Best-in-Class (BIC) assets, such as HBM4003, a fully human heavy-chain CTLA-4 inhibitor [6][19] - The Nona Biosciences subsidiary has developed the Hu-mAtrIx™ AI platform, leveraging extensive experimental data to enhance drug development efficiency [58] Investment Forecast - Revenue projections for 2025 to 2027 are $178 million, $293 million, and $210 million, respectively, with corresponding net profits of $91 million, $174 million, and $134 million [10][7] - The company is expected to maintain a high gross margin of around 95% due to the low marginal cost of its technology licensing revenue [10][35]

Investment Rating - The report assigns an "Overweight" rating for the industry, indicating a projected increase of over 15% relative to the CSI 300 index [10]. Core Insights - AstraZeneca announced a plan to invest $15 billion in China during the visit of the UK Prime Minister, focusing on cell therapy and radiolabeled conjugates [2][5]. - This investment aims to enhance drug manufacturing and R&D capabilities, leveraging China's scientific strengths and advanced manufacturing [5]. - The investment will significantly boost AstraZeneca's capabilities in new treatment modalities, particularly in addressing cancer, blood diseases, and autoimmune disorders [5]. - The investment will cover the entire value chain from drug discovery to clinical development and manufacturing, with collaborations with leading biotech companies [5]. - AstraZeneca will establish global strategic R&D centers in Beijing and Shanghai, expand existing production bases, and increase its skilled workforce in China to over 20,000 [5]. Summary by Sections Investment Highlights - AstraZeneca's $15 billion investment will be allocated primarily to cell therapy and radiolabeled conjugates [5]. - The investment is expected to enhance AstraZeneca's R&D pipeline and manufacturing capabilities in China [5]. Strategic Collaborations - The investment will involve partnerships with leading biotech firms, aiming to bring Chinese innovations to the global market [5]. Workforce Expansion - AstraZeneca plans to expand its workforce in China to over 20,000 skilled employees as part of this investment [5].

Core Viewpoint - AstraZeneca announced a plan to invest over 100 billion RMB (approximately 15 billion USD) in China by 2030, marking its largest strategic investment in the country since entering the market in 1993. This investment aims to enhance its drug production and R&D capabilities, reflecting a shift in China's role from an "important market" to a "global innovation hub" [1][2]. Group 1: Investment and Strategic Goals - The investment will cover the entire value chain from drug discovery to clinical development and manufacturing, significantly enhancing AstraZeneca's capabilities in cell therapy and antibody-drug conjugates [5][6]. - AstraZeneca's investment is expected to deepen its R&D presence in China, with major strategic R&D centers in Beijing and Shanghai collaborating with over 500 clinical hospitals [5][6]. - The company aims to leverage partnerships with leading biotech firms in China to promote local innovations globally, with a focus on breakthrough therapies [6][9]. Group 2: Market Dynamics and Trends - China's pharmaceutical market is undergoing structural changes, with a record number of innovative drugs approved for market entry, indicating a trend towards diversified innovative therapies [2][9]. - Approximately one-third of global licensing transactions are related to Chinese biopharmaceutical companies, with clinical trials in cutting-edge fields like cell therapy and ADCs accounting for over 30% of global totals [2][9]. - The collaboration between AstraZeneca and Chinese firms, such as the recent deal with CSPC Pharmaceutical Group worth up to 18.5 billion USD (approximately 128.5 billion RMB), exemplifies the growing trend of win-win partnerships in the industry [2][6]. Group 3: Policy and Regulatory Environment - Recent reforms in China's drug approval system have allowed for synchronized global R&D pipelines, significantly reducing the time for new drugs to enter the Chinese market [9][15]. - The Chinese government is actively promoting foreign investment in the healthcare sector, creating a more stable and predictable environment for multinational pharmaceutical companies [15][16]. - AstraZeneca's investment aligns with China's "Healthy China 2030" initiative, focusing on improving disease prevention and access to innovative drugs for underserved populations [15][16]. Group 4: Innovation and Talent Development - AstraZeneca's investment strategy includes a strong emphasis on talent development, with plans to expand its workforce in China to over 20,000 employees and establish programs to cultivate future scientific leaders [12][13]. - The company has already invested in over 31 Chinese innovative enterprises, facilitating numerous global licensing agreements, which highlights the "foreign enterprise + local innovation" model as a new paradigm for foreign pharmaceutical companies in China [12][13]. - The implementation of advanced manufacturing technologies at AstraZeneca's facilities, such as the Wuxi base, has led to significant improvements in production efficiency and energy consumption [12][13].

Core Insights - The global biopharmaceutical industry is still experiencing a "capital winter" in 2025, undergoing deep structural adjustments and facing a critical period of transformation and reconfiguration [1] - Shanghai's biopharmaceutical industry has shown resilience and steady growth, with manufacturing output reaching 209.9 billion yuan, driven by a shift towards innovative and high-quality enterprises [2] Structural Optimization: Full-Chain Innovation Development - The shift from generic drugs to innovative drugs is exemplified by the success of Silver诺药业, which launched the first original human long-acting GLP-1 drug in China, benefiting many patients with type 2 diabetes [3] -艾力斯医药's revenue surged from 530 million yuan in 2021 to 3.56 billion yuan in 2024, with a compound annual growth rate of 88.6% [3] - In 2025, Shanghai approved nine domestic Class 1 innovative drugs, ranking second nationally, and accounted for 33% of business development transactions in the country, leading the nation [3] Policy Support and Innovation Ecosystem - Over the past five years, Shanghai has approved 32 domestic Class 1 innovative drugs, maintaining its position as a leader in the industry [4] - The city has implemented forward-looking policies, such as the drug listing license holder system, to address the challenges of "having technology but no factory" [4] New Growth Areas: Diverse Expansion - Shanghai is emerging as a leader in brain-computer interface technology, with nearly 30 registered companies and significant funding in this sector [5] - The city also leads in cell and gene therapy, with 57% of the country's products launched between 2021 and September 2025 [5] AI-Driven Pharmaceutical Innovation - AI-driven drug development is reshaping research paradigms, with 英矽智能 discovering 27 preclinical candidates, 13 of which have received clinical trial approvals [6] - By the end of 2025, 英矽智能 is expected to become the first AI pharmaceutical company listed on the Hong Kong Stock Exchange, raising a record 2.277 billion HKD [6] Global Value Co-Creation - Shanghai's innovative drugs are increasingly entering global markets, transitioning from a one-time sale model to a co-creation model, enhancing their bargaining power [8] - 和铂医药's licensing transactions exceeded 7 billion USD in 2025, reflecting the growing international recognition of Shanghai's innovative drug development capabilities [8] Globalization of Innovative Medical Devices - 联影医疗 has launched over 140 proprietary products, entering more than 90 countries and regions, showcasing the global reach of Shanghai's innovative medical devices [9] - The city has established supportive policies for innovative drugs and devices that achieve registration and sales in multiple countries, providing up to 10 million yuan in support for qualifying projects [9]

Core Insights - The collaboration between CSPC Pharmaceutical Group and AstraZeneca has resulted in unexpected outcomes, particularly the large scale of the business development (BD) deal exceeding market expectations [1][2] - Despite the substantial financial terms of the agreement, including a $1.2 billion upfront payment and potential milestone payments totaling up to $18.5 billion, the market reacted negatively, with CSPC's stock price dropping significantly [2][3] Summary by Sections Business Development Deal - CSPC's agreement with AstraZeneca is one of the largest in the history of Chinese innovative pharmaceuticals, with a total potential deal value of $18.5 billion [2] - The deal includes a $1.2 billion upfront payment, which is the second-largest in overseas licensing transactions among Chinese pharmaceutical companies [2][3] - The potential milestone payments are subject to uncertainties related to research progress and market sales, making them less reliable [2] Market Reaction - Following the announcement, CSPC's stock price fell by 10.2%, with its A-share subsidiary also experiencing a decline of over 17% [2][3] - This negative market response contrasts sharply with previous instances where pre-announced BD deals led to significant stock price increases, indicating a shift in market sentiment towards BD announcements [3][6] Changing Market Dynamics - The previous effectiveness of BD announcements as a catalyst for stock price increases has diminished, as the pharmaceutical sector has transitioned from a "negative expectation" phase to a more normalized valuation [5][7] - The market has begun to anticipate BD news, leading to preemptive stock price adjustments that result in profit-taking once the announcements are made [6][7] Future Outlook - The long-term prospects for the pharmaceutical sector remain strong, driven by the inherent performance potential of innovative drug assets [9][10] - Continuous policy support and improving fundamentals for companies are expected to foster a favorable environment for growth, shifting focus back to performance and fundamentals rather than BD speculation [10]

Core Viewpoint - AstraZeneca plans to invest over 100 billion RMB in China by 2030, indicating a strategic shift in its global innovation focus, positioning China as a key node in its global innovation system [6][9]. Investment Strategy - The investment spans the entire value chain from drug discovery to commercialization, focusing on cutting-edge areas like cell therapy and radiolabeled drugs, which are characterized by high technical barriers and competition [6][7]. - AstraZeneca is not merely investing in traditional chemical or mature biologics but is betting on disruptive technology platforms that have the potential to reshape treatment paradigms [7]. Local Collaboration - AstraZeneca's strategy involves deep integration into China's innovation network through partnerships with local biotech firms, exchanging capital and global capabilities for early-stage innovative assets [8]. - The acquisition of Gensight Biologics in 2024 positions AstraZeneca as one of the few multinational companies with end-to-end cell therapy capabilities in China, which is strategically valuable amid rising global regulatory and supply chain uncertainties [8]. R&D and Clinical Trials - The global strategic R&D centers in Beijing and Shanghai are now leading global clinical trials, reflecting China's increasing influence in the global new drug development process [9]. - Collaborations with over 500 clinical hospitals enhance AstraZeneca's advantages in real-world data and patient recruitment efficiency [9]. Manufacturing Expansion - AstraZeneca's manufacturing bases in Wuxi, Taizhou, Qingdao, and Beijing are not only serving the Chinese market but are also supplying to over 70 global markets, indicating a shift from being a part of the global pharmaceutical supply chain to becoming a multi-regional drug export center [9]. - The establishment of a multi-center, switchable production system is part of AstraZeneca's risk management strategy in light of geopolitical and regulatory uncertainties [9]. Employment and Industry Impact - AstraZeneca's workforce in China is expected to exceed 20,000, creating high-value jobs in R&D, clinical, engineering, and quality systems, indicating a shift in the strategic position of local teams within the company [9]. - This investment aligns with China's "Healthy China 2030" goal, reflecting a complex market that offers both policy certainty and innovative returns for multinational pharmaceutical companies [9].

苏博科称，这笔超千亿元人民币的投资，开启了阿斯利康在华发展的新篇章。阿斯利康通过进一步扩展 在细胞治疗、放射偶联药物等突破性疗法的能力，将下一代创新疗法带给更多患者。通过这些投资，阿 斯利康在中国的员工规模将超过20000人。 阿斯利康是在中国市场销售额最高的外资药企，中国是阿斯利康在全球的第二大市场。在经历2024年的 公司治理风暴后，阿斯利康在2025年仍在加大对中国的投资。2025年3月初，阿斯利康宣布了一笔25亿 美元的投资计划(包括三项BD交易及一笔收购)，苏博科称这笔投资体现了阿斯利康对中国的坚定承 诺。 经济观察报记者张英 2026年1月28日至31日，英国首相基尔.斯塔默对中国进行正式访问，这是英国首相时隔8年再次访问中 国。 跨国药企阿斯利康全球首席执行官苏博科亦随团来华。1月29日，阿斯利康宣布，计划2030年前在中国 投资超1000亿元人民币(150亿美元)，以扩大在药品生产与研发领域的布局。 在2025年中国创新药火热的专利授权交易中，阿斯利康是最活跃的跨国药企，全年共出手5次，签下的 合同金额超100亿美元。其合作方包括石药集团(01093.HK)、和铂医药(02142.HK)、加科 ...

热点栏目 自选股 数据中心 行情中心 资金流向 模拟交易 客户端 热点栏目 自选股 数据中心 行情中心 资金流向 模拟交易 客户端 和铂医药-B（02142）早盘股价上涨3.61%，现报12.34港元，成交额3099.05万港元。 和铂医药-B（02142）早盘股价上涨3.61%，现报12.34港元，成交额3099.05万港元。 1月29日，和铂医药-B发布公告，根据公司股东于公司2025年6月11日举行的股东周年大会上批准的购回 股份的一般授权及（如适用）未来股东于公司不时的股东大会上批准的购回股份的任何一般授权，其拟 不时于公开市场上购回价值不超过3亿港元的公司股份。 值得关注的是，近日，和铂医药-B介绍AI智药业务的最近进展情况。此前，公司曾推出Hu-mAtrIx™人 工智能平台，并在此基础上建立了首个全人源AI HCAb模型——全人源重链抗体（HCAb）生成和筛选 模型。和铂医药-B将AI智药提升到战略意义层面的高度，打造整合抗体工程、AI辅助药物发现、自动 化湿实验室三位一体的A3大分子创新药物研发平台，干湿结合以实现AI智药的真实落地场景，海量湿 实验数据反哺AI模型实现高质量训练的正反馈循环。 ...