Core Viewpoint - The Hong Kong stock market is expected to open higher, with a positive pre-market performance in the innovative drug sector, driven by significant approvals for new drugs in China [1] Group 1: Market Performance - The Hong Kong innovative drug index constituents saw notable gains, with Innovent Biologics rising over 6%, and other companies like Zai Lab and WuXi AppTec increasing by over 2% [1] - The Hong Kong innovative drug ETF (159567) experienced a net inflow of over 165 million yuan in the past 20 trading days, indicating high market enthusiasm [1] - The price-to-earnings ratio of the Hong Kong innovative drug index decreased from 64 times on February 21 to 27 times on June 4, highlighting improved value for investors [1] Group 2: Regulatory Developments - On May 29, the National Medical Products Administration of China approved 11 innovative drugs, including 7 first-class innovative drugs, marking a historic moment for the sector [1] - Over 20 first-class innovative drugs have been approved from January to May, setting a record for the same period in the past five years [1] - The Chinese pharmaceutical industry is transitioning from "follow-up innovation" to "global leadership," focusing on clinical value in key areas like targeted cancer therapies and immunotherapy [1] Group 3: Investment Opportunities - The innovative drug ETF (159567) tracks the National Index of Hong Kong Innovative Drugs, with 90% of its weight in innovative drug companies, positioning it to benefit from trends like AI-enabled drug development and the expansion of domestic innovative drugs [1] - The innovative drug ETF (159992) encompasses leading companies in the innovative drug industry chain, benefiting from AI advancements and the introduction of new drug reimbursement policies [2] - The domestic innovative drug sector is expected to show strong growth and investment value in the first half of 2025, driven by ongoing international collaborations and the approval of new drugs [2]

长江商报消息 ●长江商报记者 汪静 百利天恒（688506.SH）持续加码创新药。 近日，百利天恒公告称，公司计划向特定对象发行A股股票并募集资金不超过37.64亿元，全部用于创新 药研发项目。本次募资较原计划的39亿元略有缩水。 2024年，百利天恒收到核心产品BL-B01D1的海外合作伙伴BMS基于合作协议支付的8亿美元首付款， 由此实现净利润37.08亿元。截至2024年末，公司现金储备净额为30.27亿元。 收到大额授权收入为何还要进行融资？百利天恒称，根据研发及经营活动的资金需求测算，公司未来三 年来资金缺口为48.19亿元。 长江商报记者注意到，今年一季度，百利天恒研发依旧在"烧钱"，净亏损5.31亿元。目前公司在全球开 展80余项临床试验，已拥有15款处于临床阶段的候选药物。 创新药研发有着高投入、高风险、长周期等特点，存在不确定性。除了计划在A股定增之外，百利天恒 还在推进赴港上市。 2024年7月，百利天恒在港交所首次递交IPO申请。同年12月，公司港股IPO计划获得中国证监会的备案 批准，香港联交所上市委员会举行上市聆讯，审议公司本次发行上市的申请。 不过，今年1月，因文件期满失效，百利天 ...

Group 1 - The company, 博安生物 (06955.HK), has entered into a placement agreement with UBS Group to sell a total of 38.4 million shares, representing approximately 7.17% of the total issued shares as of the announcement date [1] - The placement price is set at HKD 10.42 per share, which is a discount of about 13.88% compared to the last closing price of HKD 12.10 on the Stock Exchange [1] - The total expected proceeds from the placement are approximately HKD 400 million, with a net amount of about HKD 396 million anticipated [2] Group 2 - The company plans to allocate approximately 50% of the net proceeds for the research and development of innovative candidate products, including clinical trials for BA1106, BA1301, and BA1302, as well as non-clinical and clinical studies for BA1304 and PR201 [2] - About 20% of the net proceeds will be used for the commercialization of already launched and upcoming products [2] - Approximately 30% of the net proceeds will be allocated to supplement the company's working capital and for general corporate purposes [2]

Core Viewpoint - Hunan Fangsheng Pharmaceutical Co., Ltd. plans to increase capital in its subsidiary Fangsheng R&D Co. with a total investment of 24 million yuan from the company and its partners, aiming to enhance its drug research and development capabilities in the Guangdong-Hong Kong-Macao Greater Bay Area [2][3][12] Summary by Sections 1. Transaction Overview - Fangsheng Pharmaceutical intends to invest 24 million yuan in Fangsheng R&D Co., with New Yuan Investment contributing 46 million yuan, and both Tongmu Technology and the core talent holding entity contributing 5 million yuan each. Post-investment, the shareholding structure will be Fangsheng Pharmaceutical 35%, New Yuan Investment 55%, Tongmu Technology 5%, and the core talent holding entity 5% [2][3] - The investment is classified as a related party transaction due to the involvement of New Yuan Investment, which is an affiliated entity. Related directors abstained from voting [2][3] - The investment does not constitute a major asset restructuring as per regulations, and it has been approved by the independent directors and the board of directors without needing shareholder approval [2][4] 2. Purpose and Reason for the Capital Increase - The capital increase aims to support the company's strategic development in the Guangdong-Hong Kong-Macao Greater Bay Area, leveraging local resources and policies to accelerate the R&D of traditional Chinese medicine projects and mitigate R&D risks [3][12] 3. Related Party Information - New Yuan Investment is controlled by the same individual as Fangsheng Pharmaceutical, establishing a related party relationship. The core talent holding entity will consist of key personnel from the company, which may include current directors and senior management [6][7] 4. Capital Increase Details - The registered capital of Fangsheng R&D Co. will increase from 20 million yuan to 100 million yuan, with the new capital structure reflecting the contributions from all parties involved [9][10] - The governance structure will include a board of directors with three members, where Fangsheng Pharmaceutical appoints two directors and the chairman [10][12] 5. Impact on the Company - Following the capital increase, Fangsheng R&D Co. will remain under the control of Fangsheng Pharmaceutical, allowing it to consolidate its financial statements. This move is expected to enhance the sustainability of R&D investments and facilitate the commercialization of innovative traditional Chinese medicine [12]

证 券 研 究 报 告 行业周报 创新价值重估，重视转型类公司 医药行业周报 | 投资评级： | 推荐 （ 维持 | ） | | --- | --- | --- | | 报告日期： | 2025年06月03日 | | 分析师：胡博新 SAC编号：S1050522120002 分析师：吴景欢 SAC编号：S1050523070004 医 药 行 业 观 点 1. 重磅交易落地持续推升创新价值，创新价值重估持续推进中 继三生制药达成一项超60亿美元的交易之后，石药集团也预告6月拟达成一项约50亿美元的创新药交易，6月2日，BMS与 BioNTech达成一项超90亿美元的交易，项目合作主体来自于BioNTech收购自普米斯的双抗。近年来双抗、ADC领域，屡屡 创下交易记录，一方面EGFR阳性的非小细胞肺癌拥有巨大的使用人群，EGFR三代小分子药物的销售额已证明其大品种的 能力。另一方面中国创新药技术在ADC、双抗领域持续迭代更新，在临床上对目前一线治疗方案发起优效挑战。自年初以 来，已有多个重磅交易的落地，根据医药魔方数据，2025年Q1，中国医药交易数量同比增加34%，交易总金额同比增加 222%，单个项目的BD ...

6月3日，港股市场高开高走，港股创新药板块涨势居前。港股创新药指数成分股中，绿叶制药、联邦制 药、乐普生物-B涨超6%，泰格医药、三生制药、康龙化成、和黄医药、君实生物涨超4%。港股创新药 ETF（159567）连续2个交易日成交额超11亿元，市场热度较高。 消息面上，2024 年中国创新药 Lisence out授权总金额突破 500亿美元，达 519 亿美元，同比增长 27.4%，占全球同类交易总额的30%。从产业趋势来看，新药放量+Biotech逐步减亏盈利+重磅BD频出 催化的年初至今的创新药大行情已经说明了国内创新药完成了'0—1'的过程，正在走向'1—10'国际化的 快速发展过程中，未来中国创新药出海交易仍然值得期待。 港股创新药板块高盈利持续消化估值。港股创新药指数2月21日市盈率为64倍，6月3日最新市盈率仅为 27倍，不足3个月前的一半，当前布局性价比突出。 相关产品：港股创新药ETF（159567）、创新药ETF（159992）。 小而美、高弹性：港股创新药ETF（159567）跟踪国证港股通创新药指数，创新药企业权重90%为全市 场医药主题类指数中最高，有望把握AI赋能创新药研发、国产创 ...

创新药旗手新增重点推荐：创新药再次沸腾，千红制药！千红制药：创新转型进入收获期，QHRD106、107潜在 40-50亿、20亿大单品，CD3/DPP4双抗上临床，不考虑海外权益看翻倍空间！【东吴医药朱国广团队】 创新转型兑现，下半年催化丰富。 5年研发投入5.5亿元，已进入收获期。 创新药旗手新增重点推荐：创新药再次沸腾，千红制药！千红制药：创新转型进入收获期，QHRD106、107潜在 40-50亿、20亿大单品，CD3/DPP4双抗上临床，不考虑海外权益看翻倍空间！【东吴医药朱国广团队】 创新转型兑现，下半年催化丰富。 脑卒中新药QHRD106预计6-7月2期数据读出，疗效优于同类药物。 下半年进入3期临床，26年 新增布局DPP-4/CD3双抗上临床，深化创新转型。 公司研发平台众红生物已于2024年12月取得ZHB015注射液临床批件，为DPP-4/CD3双抗，适应症为实体瘤。 5年研发投入5.5亿元，已进入收获期。 脑卒中新药QHRD106预计6-7月2期数据读出，疗效优于同类药物。 下半年进入3期临床，26年NDA，目前国内卒中千亿市场，患者数量高达1300万，每年新增550万，恩必普2024院 ...

智通财经6月3日早间新闻精选 1、美国贸易代表办公室宣布，延长对中国在技术转让、知识产权和创新方面的行为、政策及做法的301 调查中的豁免期限。豁免期限原定于2025年5月31日到期，现已延长至2025年8月31日。 2、近日，美方不断有消息称，中方违反中美日内瓦经贸会谈共识。商务部表示，敦促美方与中方相向 而行，立即纠正有关错误做法，共同维护日内瓦经贸会谈共识，推动中美经贸关系健康、稳定、可持续 发展。如美方一意孤行，继续损害中方利益，中方将继续坚决采取有力措施，维护自身正当权益。 3、据报道，美防长在第22届香格里拉对话会上发表涉华消极言论，渲染"中国军事威胁"。国防部表 示，美方所作所为全世界都看得清清楚楚。其为一己私利，发动关税战、贸易战，到处横征暴敛； 拉"小圈子"、搞阵营对抗，引发各国深切担忧；强化亚太军力部署，粗暴干涉他国内政，煽动制造紧张 局势。事实一再证明，美方逆潮流大势、一意孤行，必将反噬自身。 4、国家统计局数据显示，5月份中国制造业采购经理指数为49.5%，较上月上升0.5个百分点。 6、全国多地多措并举、加强管控，严防战略矿产非法外流。国家出口管制工作协调机制办公室《加强 战略矿产出 ...

Core Viewpoint - The company is committed to enhancing operational efficiency and management quality through its 2025 "Quality Improvement and Efficiency Enhancement" action plan, focusing on innovation in drug development and protecting the rights of investors, especially small and medium-sized investors [1][12]. Group 1: Business Strategy and Development - The company aims to accelerate the layout of its core pipeline, focusing on major diseases such as cancer, metabolic disorders, and autoimmune diseases, with a commitment to developing innovative drugs with independent intellectual property rights [1][2]. - The company has two authorized products on the market, one in the registration clinical trial stage, two in Phase II clinical trials, and multiple preclinical projects, indicating a strong position in research and development [2]. - The company plans to advance the clinical research of its D-2570 product, which has shown promising results in Phase II trials for psoriasis, and will explore its potential in other autoimmune diseases [2][3]. Group 2: Research and Development Capabilities - The company has established a comprehensive R&D system that enhances the success rate of its products and shortens drug development cycles through precise target selection and clinical development processes [2][4]. - The company has a core R&D team with over 20 years of experience in multinational pharmaceutical companies, which strengthens its capabilities in drug design and clinical trial execution [4][5]. - The company has applied for 370 domestic and international invention patents, with 129 granted, ensuring the commercial value of its innovations and reducing potential patent infringement risks [6]. Group 3: Team and Talent Management - The R&D team constitutes over 90% of the company's workforce, with leaders possessing extensive industry experience, which is crucial for the drug development process [7]. - The company plans to implement a new round of equity incentive plans to attract and retain talent, aligning the interests of shareholders and the core team [7]. Group 4: Financial Management and Fund Utilization - The company is focused on improving the efficiency of its fundraising projects and has made adjustments to its headquarters construction project to better meet R&D needs [8]. - In 2025, the company will increase investment in new drug R&D projects, aiming to enhance the efficiency of clinical trials and expand its clinical pipeline [8]. Group 5: Corporate Governance and Compliance - The company is revising its governance structure, including the cancellation of the supervisory board and the enhancement of the board's responsibilities to improve oversight and protect investor rights [9][17]. - The company emphasizes the importance of internal controls and compliance with relevant laws and regulations to ensure effective management of significant matters [9]. Group 6: Information Disclosure and Investor Relations - The company is committed to enhancing the quality of information disclosure and actively engages with investors through various communication channels [10][11]. - The company plans to conduct at least three performance briefings annually to maintain transparency and keep investors informed about its operations and financial status [11].

| 日期 | 2025/5/30 | | --- | --- | | 当前股价(元) | 44.70 | | 一年最高最低(元) | 45.30/25.96 | | 总市值(亿元) | 784.07 | | 流通市值(亿元) | 783.12 | | 总股本(亿股) | 17.54 | | 流通股本(亿股) | 17.52 | | 近 3 个月换手率(%) | 50.78 | 股价走势图 数据来源：聚源 -32% -16% 0% 16% 32% 48% 2024-06 2024-10 2025-02 华东医药 沪深300 相关研究报告 医药生物/化学制药 华东医药（000963.SZ） 创新转型再出发，多产品步入收获期 2025 年 06 月 02 日 投资评级：买入（维持） | ——公司深度报告 | | --- | | 余汝意（分析师） | 余克清（分析师） | 刘艺（联系人） | | --- | --- | --- | | yuruyi@kysec.cn | yukeqing@kysec.cn | liuyi1@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S079052 ...