Company Overview - Arvinas, Inc. is a clinical-stage biotechnology company focused on developing a new class of drugs based on targeted protein degradation [3] - The company is headquartered in New Haven, Connecticut and is listed on Nasdaq under the ticker ARVN [3] Drug Development - Arvinas is pioneering the PROTAC (PROteolysis Targeting Chimera) protein degrader platform, which aims to selectively and efficiently degrade disease-causing proteins [3] - The company is advancing multiple investigational drugs through clinical development, including: - Vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer [3] - ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma [3] - ARV-102, targeting LRRK2 for neurodegenerative disorders [3] Upcoming Events - Management will participate in a fireside chat at the Jefferies Global Healthcare Conference on June 5 at 2:35 p.m. ET in New York City [1] - A live audio webcast of the presentation will be available on the company's website [2]

导读 ： 荣耀进军机器人赛道；多家公司加速布局Robotaxi ； 解锁【第一财经智享会员】实时解读 市场动态，把握投资先机。 【第一财经智享会员专属】 【 今 日 速 读 】 精选行业研报，助您捕捉行业风口 【精选快读】 1 .荣耀进军机器人赛道，关注产业链带来的增量机遇 5月2 8日晚间，荣耀CEO李健在回应进军机器人赛道时表示，机器人无疑是公司重点关注的核心赛 道。"我们的核心思路围绕不同场景与用户需求展开，若特定场景需要与相关厂商合作，我们会以 开放姿态推进，同时，荣耀具备自主技术实力，包括长期积累的硬件研发能力与算法优势，这些自 主可控的技术足以支撑新产业的自主开发。" 2025.05.30 点击一键解锁 2. 国内外公司纷纷加码，Robotaxi商业化有望提速 近期，特斯拉、小马智行等多家国内外公司纷纷发布有关Ro b o t a x i的计划。 在当晚的荣耀4 0 0系列发布会上，荣耀展示了一款机器人，跑步速度已经达到4m/s，打破了之前的 机器人行业记录。 万联证券表示，人形机器人产业正处于技术突破与商业化落地的关键节点，政策支持、入局者不断 增加及AI大模型赋能共同推动行业加速发展，2 0 ...

Financial Data and Key Metrics Changes - The company has a long-term view on inflation and interest rates, expecting them to remain higher for longer, which aligns with historical trends [4][5][9] - The company has $116 billion of dry powder available for investment, indicating strong capital reserves for future opportunities [7] Business Line Data and Key Metrics Changes - The private equity portfolio is marked at over 60% at more than 1.5 times the cost, while public names are marked at an average of four times the cost, reflecting strong performance [18][19] - The company has been actively exiting investments, including sales in Japan and infrastructure, contributing to a mature portfolio [19] Market Data and Key Metrics Changes - More than 70% of the company's deployment in infrastructure over the last five years has been outside the United States, showcasing a global investment strategy [34] - The company has seen a shift in investor sentiment, with a more balanced approach to global allocations, particularly towards Europe and Asia [36] Company Strategy and Development Direction - The company is focusing on building portfolios that can navigate different economic cycles, emphasizing long-term investments [15][16] - Strategic holdings have been introduced to capture lower-risk, attractive reward investments, diversifying the company's offerings [23][25] Management's Comments on Operating Environment and Future Outlook - Management remains optimistic about the realization outlook, citing a strong pipeline of realizations and a disciplined investment approach [15][21] - The company does not foresee significant stress in its portfolios despite macroeconomic concerns, indicating confidence in its investment strategy [12][14] Other Important Information - The company is expanding its product offerings for high-net-worth individuals through partnerships, aiming to capture a larger share of the market [45][49] - The insurance segment is expected to see growth in earnings as the business model transitions and third-party capital is raised [92][93] Q&A Session Summary Question: What is the company's view on inflation and economic growth? - The company expects inflation and interest rates to remain higher for longer, which is consistent with historical trends [4][5] Question: How is the company managing its portfolio amidst macroeconomic concerns? - The company has not seen significant stress in its portfolios and feels confident due to its portfolio construction and historical experience with economic cycles [12][14] Question: What is the outlook for the company's strategic holdings? - The strategic holdings segment is designed to capture lower-risk investments with attractive returns, and the company is optimistic about its growth potential [23][25] Question: How is the company addressing client demand for alternative products? - The company is seeing significant adoption of its alternative products and is expanding its offerings to cater to high-net-worth individuals [38][45] Question: What is the company's strategy regarding direct lending and asset-based finance? - The company is actively involved in both direct lending and asset-based finance, with a focus on scaling third-party business alongside its own insurance growth [76][80]

Group 1: Cheniere Energy and LNG Industry - The U.S. has become the largest liquefied natural gas (LNG) exporter, exporting 11.9 billion cubic feet per day (Bcf/d) in 2024, surpassing Qatar and Australia [2] - Cheniere Energy exported 2.33 trillion British thermal units (TBtu) in 2024, equating to 6.37 Bcf/d, and has a total production capacity of 45 million tonnes per annum (mtpa) across its terminals [3] - The current administration supports LNG growth, and Cheniere's CEO believes there is a strategic imperative to secure permits for future capacity expansion to over 90 mtpa [5] Group 2: GE Aerospace and Aerospace Industry - GE Aerospace is a market leader in commercial aerospace and defense engines, with its joint venture CFM International producing the LEAP engine, which powers the Boeing 737 MAX and is one of two options for the Airbus A320neo family [7] - GE's GE9X engine is the sole option for the Boeing 777X, and its GEnx engine dominates orders for the Boeing 787, indicating strong market presence [8] - The next generation of engines, RISE, is expected to achieve a 20% improvement in fuel efficiency over the LEAP, potentially ensuring GE's leadership in commercial aerospace engines for decades [9] Group 3: Tesla and Electric Vehicle Industry - Tesla's Model Y is the best-selling car globally and is set to improve sales with refreshed production lines in 2025 [10] - Upcoming catalysts for Tesla include the launch of its robotaxi in June 2025 and the mass production of the Cybercab in 2026, alongside lower-cost models [11] - Tesla has significantly reduced its cost of goods per vehicle, falling below $35,000 by the end of 2024, which enhances profit margins and competitiveness in the EV market [12][13] - CEO Elon Musk has positioned Tesla as a leader in the SUV market, and the company's advancements in EVs and robotaxis suggest a strong future in the industry [15]

OTA运营中，流量和转化是酒店业永不过时的话题，在酒店供给过剩与消费分化的市场环境下，酒店业如何借势OTA进一步释放增长潜力？ 5月22日，在2025环球旅讯数智论坛·上海站，携程集团副总裁兼大住宿事业部大中华酒店业务总经理许一心以《如何在不确定的市场中明确增长策略》为 题，进行了主题分享。 以下是演讲实录，内容有删减： 今天我想和大家聊聊过去一年酒旅市场的一些情况，以及我们在波动中如何去把握市场机会、挖掘潜力。 先从一组数据说起，2024年国内旅游人次，同比增长了14.8%，今年一季度国内旅游人次同比增长了26.4%，五一的旅游人次再次创了历史新高，从某种 程度上反映出国人出行的意愿其实是在增强的。 从携程的数据来看，我们拿去年五一和今年五一的数据做了对比，发现了一个有意思的现象，去年五一的数据是"高开低走"，前面几天冲的很高，后面跳 水很明显，包括去年国庆、春节也基本是这个趋势，但到了今年五一，五天的走势基本上比较平稳，说明现在的出行市场又有了新的变化。 同时我们也注意到，2023年和2024年这两年酒店数量增长的很快，预计2025年高星级酒店也会保持12%左右的增长。侧面反应，实际上国内酒店供给是非 常 ...

ToplineTesla stock has soared 58% after CEO Elon Musk announced plans to leave DOGE. Can he restore the company’s brand value? If not, company shares are too high.WALNUT CREEK, CA - MAY 14: Matthew LeBrot is photographed with his Tesla cybertruck, bearing anti ... More Musk slogans, in a park near his home in Walnut Creek, California on May 14, 2025. Lebrot lost his job as a Tesla sales manager after calling for Elon Musk to step down from the company after Tesla posted huge losses. (Photo by Martin Klimek ...

来源|华尔街见闻 全球消费者对特斯拉品牌的兴趣持续下滑，华尔街投行瑞银维持"卖出"评级，特斯拉或正面临前所 未有的挑战。 据追风交易台消息，瑞银5月27日发布的2025年全球电动车消费者调查报告显示，全球消费者对特 斯拉品牌的兴趣持续下滑，在中国、美国和欧洲三大核心市场，特斯拉都面临品牌吸引力下降的困 境。 调查报告还指出，更令人担忧的是，特斯拉自动驾驶业务前景堪忧，盈利模式面临考验。 消费者对 自动驾驶功能的付费意愿有限，仅12%的受访者愿意为自动驾驶功能支付超过7600美元，而特斯拉 FSD目前售价8000美元。 瑞银调查显示，全球考虑购买特斯拉的消费者比例从去年的39%降至36%，作为消费者首选纯电品 牌比例从22%下滑至18%。深究背后原因，特斯拉在主要市场都面临本土化或传统豪华品牌的有力 挑战，马斯克的政治身份对品牌形象造成冲击。瑞银维持特斯拉目标价190美元，较当前股价存在 44%的下跌空间。 作为消费者首选纯电动车品牌的比例更是从22%大幅下滑至18%。 基于这一趋势，瑞银维持对特斯拉股票的"卖出"评级， 目标价190美元 ，较当前339.34美元的股价 存在44%的下跌空间 。今年以来，瑞银已 ...

Group 1 - Fidus Investment (NASDAQ: FDUS) recently reported its Q1 earnings for 2025, prompting a reassessment of the Business Development Company (BDC) sector [1] - The analysis highlights the potential of combining classic dividend growth stocks with BDCs, REITs, and Closed End Funds to enhance investment income while achieving total returns comparable to traditional index funds [1] - The approach taken by the company creates a hybrid system that balances growth and income, aiming for total returns on par with the S&P [1]

Core Viewpoint - Global consumer interest in Tesla is declining, leading UBS to maintain a "sell" rating with a target price of $190, indicating a potential 44% downside from the current price of $339.34 [1][2] Group 1: Consumer Interest Decline - The proportion of consumers considering purchasing a Tesla globally has decreased from 39% last year to 36% [3] - Tesla's status as the preferred electric vehicle brand has dropped significantly from 22% to 18% [6] - In the U.S., Tesla retains about 48% of the electric vehicle market share, but its preferred brand status has plummeted from 38% to 29%, a decline of 9 percentage points [9] Group 2: Challenges in Key Markets - In China, Tesla's preferred brand status has fallen from 18% to 14%, being surpassed by BYD and emerging brand Xiaomi [11] - Tesla's technological leadership perception in China is eroding, with BYD now viewed as the technology leader [12] - In Europe, Tesla's brand consideration has dropped to 33%, being overtaken by Audi and BMW, with its preferred brand status declining from 20% to 15%, a drop of 4.6 percentage points [17][19] Group 3: Autonomous Driving Concerns - Only about 12% of consumers are willing to pay over $7,600 for Tesla's autonomous driving feature, while the current price for FSD is $8,000 [20] - The mismatch between pricing and consumer willingness to pay may hinder Tesla's software service revenue growth potential [24] Group 4: Market Pricing and Affordability - The starting price for Model Y is approximately $45,000 in the U.S., aligning with about 50% of consumers' budgets; in China, it is 263,500 RMB, fitting about 58% of consumers; while in Germany, the €45,000 starting price aligns with less than 37% of consumers' budgets [24]

Core Viewpoint - The ride-hailing industry in China is experiencing a bifurcation, with second-tier platforms pushing for IPOs while facing market saturation and profitability challenges [1][3]. Group 1: IPO Activity - On April 30, Cao Cao Travel updated its prospectus for an IPO on the Hong Kong Stock Exchange, having received approval from the China Securities Regulatory Commission [2]. - On May 9, Enjoy Travel, a subsidiary of SAIC Group, announced it had completed a C-round financing of 1.3 billion yuan, marking the largest single financing in the industry in nearly three years, and is accelerating its IPO process [2]. - Other second-tier platforms, such as T3 Travel and Shengwei Times, are also at critical junctures in their IPO plans, with T3's CEO indicating that the IPO timeline is imminent [5]. Group 2: Market Saturation and Profitability Issues - Shengwei Times' IPO prospectus became invalid due to ongoing losses and regulatory penalties, highlighting the profitability struggles within the industry [3]. - The market is characterized by a "pyramid" competition structure, with Didi holding over 70% market share, while other players are fragmented into four distinct factions [3][7]. - Cao Cao Travel's reliance on third-party platforms for 85% of its orders indicates a shift from self-sourced to aggregated orders, raising concerns about profitability [5][12]. Group 3: Dependency on Aggregation Platforms - The increasing dependency on aggregation platforms has led to a significant rise in commission payments, with Cao Cao's commission expenses growing from 322 million yuan in 2022 to 1.046 billion yuan in 2024 [17][18]. - The share of orders from third-party platforms for Cao Cao has increased from 49.9% in 2022 to 85.4% in 2024, indicating a shift in the operational model [14][15]. - User retention rates are declining, with Cao Cao reporting a drop in user retention to below 28% in 2023 due to increased reliance on third-party platforms [19][21]. Group 4: Differentiation Strategies - To achieve higher valuations, second-tier platforms are attempting to tell differentiated stories, such as Cao Cao's focus on customized vehicles leveraging its parent company, Geely's resources [22][23]. - Enjoy Travel is pursuing a mixed operation model that includes Robotaxi services, although its commercial progress has been slow [24][25]. - The competition in the autonomous driving sector is intense, with significant barriers to entry, and the success of these strategies remains uncertain [25][28].