5月份开始，业绩真空期到来，市场关注点由业绩转变为行业与基本面，市场及行业主题的细分投资主线也更加 值得关注。当前，我国创新药进入成果兑现阶段，研发进展催化较多，且受到贸易战影响较小，或有较大的市场 发展潜力。 一、全球舞台彰显实力，ASCO数据印证国产创新药崛起 2025年美国临床肿瘤学会（ASCO）年会将于美国东部时间5月30日至6月3日在芝加哥以线上结合线下的形式拉开 帷幕。根据统计，今年口头汇报研究中共有73项为中国研究，各专场分布情况分别为：口头摘要专场为32项，摘 要速递专场为33项，临床科学研讨会为8项。就摘要重磅程度而言，广受关注的Late Breaking Abstract（LBA） 中，中国研究为11项。数量和占比相比往年都有明显提升。多家国产创新药企携针对不同病症的抗癌药参会，届 时多种兼具疗效与安全性的创新药有望逐步进入收获期。 图：2023-2025中国创新药报告对比，2025年数量和占比均提升 来源：中信建投 除了医药行业的政策利好，消费领域的重要政策也有望促进创新药领域发展。4月7日，商务部、国家卫生健康委 员会等12部门印发《促进健康消费专项行动方案》，提出了十项主要任务： （ ...

Investment Rating - The report assigns a "Buy" rating to the company, indicating a potential upside of 15% to 35% [6][11]. Core Insights - The company reported a Q1 2025 revenue of 7.21 billion RMB, representing a year-over-year increase of 20.1%, and a net profit of 1.87 billion RMB, up 36.9% year-over-year, which aligns with expectations [6]. - The significant profit growth in Q1 is attributed to a $75 million upfront payment from IDEAYA for a licensing agreement related to a targeted ADC product, with an estimated core revenue growth of approximately 11% after excluding this payment [8]. - The company has a robust pipeline with 26 innovative molecules entering clinical stages in 2024, covering various therapeutic areas, and is expected to showcase 15 innovative drugs at the upcoming ASCO conference [8]. - Future profit projections estimate net profits of 6.98 billion RMB, 8.75 billion RMB, and 10.4 billion RMB for 2025, 2026, and 2027, respectively, with year-over-year growth rates of 10.2%, 25.3%, and 18.9% [10]. Summary by Sections Company Overview - The company operates in the pharmaceutical and biotechnology sector, with a market capitalization of 328.9 billion RMB and a share price of 51.56 RMB as of May 7, 2025 [1]. Financial Performance - The company achieved a gross margin of 85.2% in Q1 2025, an increase of 0.9 percentage points year-over-year, while the expense ratio decreased by 1.3 percentage points to 55.6% [8]. - The projected earnings per share (EPS) for 2025, 2026, and 2027 are 1.09 RMB, 1.37 RMB, and 1.63 RMB, respectively [10]. Shareholder Information - The major shareholder is Jiangsu Hengrui Medicine Co., Ltd., holding 24.11% of the shares [1]. - Institutional investors hold 9.1% of the circulating A-shares, while general corporations hold 68.1% [2].

Investment Rating - The report assigns a "Buy" rating for the company, indicating a potential upside of 15% to less than 35% [6][11]. Core Insights - The company reported a Q1 2025 revenue of 7.21 billion RMB, representing a year-over-year increase of 20.1%, and a net profit of 1.87 billion RMB, up 36.9% year-over-year [6]. - The significant profit growth in Q1 is attributed to a $75 million upfront payment from IDEAYA for a licensing agreement, with an estimated core revenue growth of approximately 11% after excluding this payment [8]. - The company has a robust pipeline with 26 innovative molecules entering clinical stages in 2024, covering various therapeutic areas, and is expected to showcase 15 innovative drugs at the upcoming ASCO conference [8]. - Future net profits are projected to be 6.98 billion RMB, 8.75 billion RMB, and 10.4 billion RMB for 2025, 2026, and 2027 respectively, with year-over-year growth rates of 10.2%, 25.3%, and 18.9% [10]. Summary by Sections Company Overview - The company operates in the pharmaceutical and biotechnology sector, with a market capitalization of 328.9 billion RMB and a share price of 51.56 RMB as of May 7, 2025 [1]. Financial Performance - The company achieved a gross margin of 85.2% in Q1 2025, an increase of 0.9 percentage points year-over-year, while the expense ratio decreased by 1.3 percentage points to 55.6% [8]. - The projected earnings per share (EPS) for 2025, 2026, and 2027 are 1.09 RMB, 1.37 RMB, and 1.63 RMB respectively, with corresponding price-to-earnings (P/E) ratios of 47X, 38X, and 32X [10]. Shareholder Information - The major shareholder is Jiangsu Hengrui Medicine Group Co., Ltd., holding 24.11% of the shares, while institutional investors account for 9.1% of the circulating A-shares [2][1].

Market Performance - As of May 7, 2025, the Hang Seng Healthcare Index (HSHCI) decreased by 3.02%, with mixed performance among constituent stocks [3] - Leading gainers included Yuan Da Pharmaceutical (00512) up 12.52%, Shanghai Pharmaceuticals (02607) up 2.23%, and China Traditional Chinese Medicine (00570) up 1.96% [3] - Major decliners were Sangfor Technologies (01530) down 8.40%, Ascentage Pharma-B (06855) down 8.13%, and BeiGene (06160) down 7.70% [3] - The Hang Seng Healthcare ETF (513060) fell by 2.65%, closing at 0.48 yuan, with an active trading volume of 1.096 billion yuan [3] Investment Insights - Dongfang Securities noted that the continuous release of diagnostic and treatment demand, along with the commercialization of domestic innovative products, is leading to marginal improvements in certain sectors [3] - The firm believes that the upcoming quarters will see confirmed industry growth due to supply-side innovations driving rapid demand growth, suggesting that now is an excellent time to allocate resources to the healthcare sector [3] Future Investment Trends - Guolian Minsheng Securities anticipates that overseas expansion of innovative drugs, AI integration, and left-side asset valuation recovery will be key investment themes in the pharmaceutical sector for 2025 [4] - Recommendations include traditional pharmaceutical companies with manageable risks and reasonable valuations, as well as innovative drug companies with strong R&D foundations and competitive products for overseas markets [4] ETF Performance Metrics - As of May 6, 2025, the Hang Seng Healthcare ETF has seen a 28.71% increase in net value over the past year [5] - The ETF's highest monthly return since inception was 28.34%, with an average monthly return of 6.79% [5] - The ETF's management fee is 0.50%, and the tracking error is 0.041%, indicating high tracking precision compared to similar funds [5] Top Holdings - The top ten weighted stocks in the Hang Seng Healthcare Index account for 57.17% of the index, with major players including BeiGene (06160) and WuXi Biologics (02269) [6][8]

Core Viewpoint - The company plans to complete its H-share issuance and listing as part of its "innovation + internationalization" strategy, marking its first external equity financing since its A-share listing in 2000 [2][3]. Group 1: Timing and Market Context - The timeline for the company's Hong Kong listing has been rapid, with key milestones achieved within five months, reflecting a strategic response to the evolving pharmaceutical regulatory and market landscape in China [3]. - The international capital market's increasing acceptance of Chinese innovative drugs is a significant factor in the company's decision to list in Hong Kong, which serves as a bridge to global markets [5]. - The listing will provide the company with flexible financing tools to support its international expansion efforts [5]. Group 2: Strategic Goals and Achievements - The listing is aimed at expanding the company's overseas business and enhancing international research collaborations, thereby achieving breakthroughs in foreign markets [6]. - The current trend of high-quality Chinese companies listing in Hong Kong is expected to attract capital returning from a weakening US dollar [7]. - The company has made significant strides in its global presence, with products registered in over 40 countries and regions, and has established 14 global R&D centers [8]. Group 3: Financial Performance and Future Plans - The company reported a revenue of 27.985 billion yuan in 2024, a year-on-year increase of 22.6%, and a net profit of 6.337 billion yuan, up 47.3% [11]. - The funds raised from the listing will primarily be used for innovative drug development, international expansion, and operational capital, aiming to enhance its market presence [11]. - The company is positioned to transition from a domestic leader in innovative drugs to a global pharmaceutical player, with the Hong Kong listing seen as a starting point rather than an endpoint [11].

Investment Rating - The report indicates a cautious outlook for the pharmaceutical sector in 2024 and early 2025, with a strong focus on the innovative drug segment as a key investment opportunity [1][5]. Core Insights - The pharmaceutical sector is expected to face continued pressure on overall performance and profit margins due to factors such as healthcare payment environment, industry regulation, and changing consumer conditions in 2024 and Q1 2025 [1][18]. - Despite the challenges, there is optimism for a recovery in the pharmaceutical sector in the second half of 2025, driven by easing pressures from policies and fundamentals, leading to a potential turnaround in performance and stock prices [1][21]. - The innovative drug segment is highlighted as a primary focus for investment, with expectations for significant growth and valuation recovery for leading companies in this space [2][5]. Summary by Sections Pharmaceutical Sector Overview - The innovative drug segment is performing well, with leading companies like BeiGene and Hengrui Medicine showing strong revenue and business development (BD) income growth [2][22]. - The overall pharmaceutical sector is under pressure, with profit margins declining, except for the innovative drug segment which is experiencing independent growth [1][18]. Biopharmaceuticals - The biopharmaceutical sector is facing challenges, but there are opportunities for growth in specific areas such as long-acting interferons and insulin products, which are expected to see a turnaround [2][4]. Retail Pharmacy - The retail pharmacy sector is showing signs of marginal improvement, with expectations for a gradual return to normal growth in 2025 [2][4]. Medical Services and Aesthetic Medicine - The medical services and aesthetic medicine sectors are experiencing a mild recovery, with expectations for sustained performance in 2025 [3][4]. Traditional Chinese Medicine - The traditional Chinese medicine sector is expected to improve gradually throughout the year, following a challenging 2024 [4][12]. Medical Devices - The medical device sector is anticipated to recover gradually, with significant growth expected from overseas market expansion [4][12]. Investment Recommendations - The report emphasizes the importance of focusing on innovative drug opportunities throughout 2025, particularly in companies with strong international capabilities and those involved in business development [5][21].

Investment Rating - The investment rating for the company is "Buy" (maintained) [5] Core Views - The long-term landscape for large-volume infusion and intermediates is stable, and the innovative drugs have market potential overseas [5] - The company has a strong competitive position in the large-volume infusion market and is expected to achieve significant cost reductions in 2025 [7] - The company has a leading global ADC research platform, with substantial potential in overseas markets [7] - The company is transitioning successfully from generics to innovation, with significant R&D investments expected to yield results [7] - The forecasted net profit for 2025-2027 is 27.4 billion, 33.7 billion, and 39.6 billion RMB, with corresponding growth rates of -6.7%, 23.2%, and 17.5% [7] Financial Summary - The company's revenue for 2023 is projected at 21,454 million RMB, with a year-on-year growth rate of 13.44% [6] - The net profit for 2023 is estimated at 2,456 million RMB, reflecting a year-on-year growth of 43.74% [6] - The earnings per share (EPS) for 2023 is expected to be 1.54 RMB [6] - The company’s total market capitalization is approximately 57,865.51 million RMB, with a closing price of 36.21 RMB [3][4]

值得关注的是，据Wind数据统计，截至发稿，港股通创新药ETF工银（159217）当前管理费率与托管 费率分别为0.4%、0.07%，其费率在同为跟踪国证港股通指数的产品中最低。 消息面上，多家A股、港股创新药企发布亮眼财报以及在研产品的阶段性突破进展。此外据证券时报， 近期全国多地政府相继出台政策，鼓励医药行业并购重组壮大发展，并提出医药产业基金的相关规划。 在更高层面，国务院国资委党委近日在《民主与法制》周刊发表署名文章中提出，对于生物医药等产业 基础比较薄弱的领域，鼓励国有企业运用并购重组、股权投资、产业基金等多种方式，加快形成产业影 响力。 中信建投证券表示，我国创新药全球竞争力持续增强，NewCo模式成为创新药出海新选择，国家政策 鼓励创新药发展，新技术推动行业快速发展，持续看好创新药行业。 Wind数据显示，截至4月29日收盘，国证港股通创新药指数（987017）近一年涨幅达48.11%，在同类指 数中居首。相关ETF方面，跟踪国证港股通指数的港股通创新药ETF工银（159217）交投活跃。港股通 创新药ETF工银当日成交额达1.54亿元，换手率5.58%，最新规模为27.27亿元。资金流向方面， ...

Group 1 - The Hong Kong innovative drug sector has rebounded rapidly due to a favorable external environment, with the China Securities Hong Kong Innovative Drug Index (931787) experiencing a significant recovery since its low on April 9, 2023 [1][3] - As of April 25, 2023, the index reached a peak of 979.92 points, showing a maximum cumulative increase of 37.43% from its previous low [1] - The overall increase in the Hong Kong innovative drug sector has outperformed the Hang Seng Technology Index, which has only seen a year-to-date increase of 12.48% compared to the innovative drug index's 31.03% [3] Group 2 - Recent data indicates a collective performance improvement among Hong Kong innovative drug companies, significantly exceeding market expectations [4] - In 2024, 10 out of 12 Hong Kong innovative drug companies with a market capitalization over 10 billion HKD reported positive revenue growth, with 8 companies also showing positive profit growth [4] - The company with the highest revenue growth is CloudTop New Drug-B (01952), with a revenue growth rate of 341.8%, while Innovent Biologics (01801) reported a net profit growth of 91.8% [4] Group 3 - The trend of "going global" has become a key topic, with Chinese pharmaceutical companies achieving significant growth in overseas licensing transactions [6][8] - The total transaction amount for licensing-out by Chinese pharmaceutical companies reached a historical high of 51.9 billion USD in 2024, indicating a strong global competitiveness in innovative drug development [6] - The NewCo model has emerged as a favorable strategy for domestic biotech companies, allowing for cash flow support and risk sharing in international collaborations [8] Group 4 - New industry trends in pharmaceuticals, such as weight-loss drugs, dual-antibody drugs, ADC drugs, and innovative medical devices, are expected to create new investment opportunities [9] - The Chinese government is increasing support for innovative drug exports, as evidenced by recent policies aimed at facilitating the import of research materials for biopharmaceutical companies [9] - Despite market fluctuations due to trade tensions, the pharmaceutical sector remains relatively insulated, presenting a favorable opportunity for large-scale investments [9] Group 5 - The Hong Kong innovative drug sector is poised for a valuation recovery, with significant inflows of capital from southbound investors since the beginning of the year [11] - As of April 24, 2023, net capital inflows from A-share investors into Hong Kong stocks reached 611.1 billion HKD, with healthcare becoming the second most net inflow sector [11] - The current price-to-earnings ratio (TTM) for the pharmaceutical and biotechnology sector is 27.1, indicating that the sector is undervalued compared to other growth sectors [12][13]

Group 1: Pet Economy Performance - The pet economy sector has shown remarkable performance, with leading companies "Guai Bao Pet" and "Zhong Chong Co." both reaching historical highs in stock prices [4][8] - Guai Bao Pet reported a revenue of 5.245 billion in 2024, a year-on-year increase of 21.22%, and a net profit of 625 million, up 45.68% [8] - Zhong Chong Co. achieved a revenue of 4.465 billion in 2024, growing 19.15%, with a net profit of 394 million, reflecting a 68.89% increase [8] Group 2: Market Trends - The performance of the pet economy is part of a broader trend in the new consumption sector, with various brands like Wei Long and Mao Ge Ping also achieving significant growth [9] - New consumer brands are characterized by strong consumer recognition and independent performance from the industry, with many achieving historical highs this year [10] Group 3: Pharmaceutical Sector Activity - The pharmaceutical sector has been active, with stocks like Jin Kai Sheng Ke and Er Kang Pharmaceutical seeing significant gains, with some stocks hitting the daily limit [12] - Jin Kai Sheng Ke reported a revenue of 176 million in Q1 2025, a 41.83% increase, and a net profit of 47.42 million, up 183.24% [12] - The innovation drug sector is expected to continue growing due to supportive government policies and increasing global competitiveness [15]