撰文丨王聪 编辑丨王多鱼 排版丨水成文 裸鼹鼠 （ Heterocephalus glaber ） 是一种寿命极长的啮齿类动物，其 寿命可达 30-40 年，是同体型啮齿动物 （例如小鼠） 寿命的 10 倍以上。 一直以来， 裸鼹鼠 因为其 长寿 和 抵抗衰老相关疾病 （包括 癌症 、 心血管疾病 、 神经退行性疾病 ） 的强大能力而备受科学界关注。 尽管人们认为其超长寿 命是由影响多种生物过程的多种适应性变化共同作用的结果，但保护裸鼹鼠免受基因组不稳定 （衰老的主要标志） 影响的分子机制，目前仍不清楚。 DNA 修复 是维持基因组稳定的关键机制。早在 2018 年，同济大学 戈宝学 、 毛志勇 合作团队在 Nature 期刊发表论文，发现在人类细胞中，DNA 传感器 cGAS 通过抑制同源重组 （HR） 途径参与调控 DNA 双链断裂的修复，从而 促进基因组不稳定 。尽管 DNA 修复蛋白功能的增强有助于长寿的进化，但进化是 否选择减弱诸如 cGAS 这样的负调控因子，仍不得而知。 裸鼹鼠 在这项发表于 Science 期刊的最新研究中，研究团队发现，与人类及小鼠的 cGAS 相比， 裸鼹鼠的 cGAS 增 ...

Core Viewpoint - Peanuts are a nutritious food source that offers various health benefits, including high-quality protein, healthy fats, and essential vitamins and minerals, making them a valuable addition to a balanced diet [2][3][7][10][13]. Nutritional Composition - Peanuts contain 574 kcal, 24.8g of protein, 44.3g of fat, and 21.7g of carbohydrates per 100g [2]. - The fat composition includes 19.8% saturated fat, 38.6% monounsaturated fat, and 38.6% polyunsaturated fat, indicating a high proportion of "good" fats [7][8]. Health Benefits - Peanuts are a good source of plant-based protein, containing all eight essential amino acids, making them suitable for vegetarians and those looking to increase plant protein intake [3]. - They are rich in B vitamins, particularly B1 and niacin, which support energy metabolism and maintain healthy skin and nervous system [8][10]. - Peanuts contain antioxidants like resveratrol and flavonoids, which help reduce oxidative stress and may contribute to longevity [10][13]. - Regular consumption of peanuts is associated with a lower risk of cardiovascular diseases and improved blood sugar control due to their low glycemic index (GI) of 14 [15][16][18]. Consumption Guidelines - The recommended daily intake of peanuts is 25-35g, depending on other dietary sources of protein and fats [22]. - Different cooking methods can affect the nutritional value of peanuts, with raw and boiled options being healthier compared to fried [23][24]. Special Considerations - Individuals with peanut allergies should avoid peanuts entirely due to the risk of severe allergic reactions [25]. - Overweight individuals should monitor their intake due to the high caloric content of peanuts [26]. - Young children should consume peanuts in forms that reduce choking hazards, such as peanut butter [28]. - Those with metabolic disorders should consult healthcare professionals for appropriate consumption levels [29].

Core Insights - Peanuts, despite their high fat content, are often recommended in healthy diets due to their rich nutritional profile and health benefits [1][16] Nutritional Composition - Peanuts contain 574 kcal of energy, 24.8g of protein, 44.3g of fat, and 21.7g of carbohydrates per 100g [3] - They are a good source of plant-based protein, comparable to legumes, providing all eight essential amino acids [5][6] - The fat composition is primarily unsaturated, with 38.6% being monounsaturated and 38.6% polyunsaturated fats, which are beneficial for heart health [8][10] Health Benefits - Peanuts are rich in B vitamins, including 0.72mg of vitamin B1 and 17.9mg of niacin per 100g, which support energy metabolism and nervous system health [11][12] - They contain powerful antioxidants like resveratrol and flavonoids, which help reduce oxidative stress and may delay aging [13][18] - Regular consumption of peanuts is associated with a lower risk of cardiovascular diseases and stroke, particularly in older adults [19] - Peanuts have a low glycemic index (GI) of 14, making them suitable for blood sugar management [20][22] Consumption Guidelines - Recommended daily intake is 25-35g for those not consuming other legumes or nuts, and 15-20g if other sources are included [25] - Cooking methods affect nutritional content; raw or low-temperature roasted peanuts retain more nutrients compared to fried ones [27] Caution for Specific Groups - Individuals with peanut allergies should avoid peanuts entirely due to severe allergic reactions [30] - Overweight individuals should monitor their intake due to high caloric density [33] - Young children should consume peanuts in forms that reduce choking risks, such as peanut butter [34] - Those with metabolic disorders should consult healthcare providers for appropriate consumption levels [35]

Key Points - The article discusses two critical age milestones in the aging process: around 30 years old and between 45 to 55 years old, where significant biological changes occur in the body [2][3] - At around 30 years old, the adrenal tissue shows early signs of aging, and endocrine homeostasis may be disrupted, which could be an early driving factor for aging [2] - The age range of 45 to 55 years marks a milestone where most organ protein groups experience a "molecular cascade storm," indicating a significant biological transition towards systemic aging [3] - The article emphasizes the importance of maintaining a slight feeling of hunger by eating until 70-80% full, which can help delay aging and extend lifespan [5][8] - Research indicates that limiting food intake can rewrite aging genes and potentially extend lifespan by 35% by promoting autophagy and clearing aging cells [7] - It is advised to gradually reduce food intake to adapt to a new eating habit without feeling deprived [13]

Group 1 - The core idea of the research is to identify environmental factors that accelerate biological aging, revealing that smoking, cadmium, and lead are significant contributors to accelerated aging [1][7][13]. - The study utilized two main research tools: exposome analysis and epigenetic clocks to assess the relationship between environmental chemicals and aging [4][5][6]. Group 2 - The exposome encompasses all environmental exposures from conception to death, influencing gene expression and aging speed [4]. - The epigenetic clocks measure biological age and health risks, with the second generation predicting health risks and the third generation measuring the speed of aging [5][6]. Group 3 - High levels of cotinine, a marker for tobacco exposure, correlate with increased biological aging, with each standard deviation increase in cotinine accelerating the death risk clock by 1.40 years [10][11]. - Cadmium is identified as the primary environmental factor accelerating biological aging, with each standard deviation increase in serum cadmium leading to significant increases in both death risk clocks [14][16]. Group 4 - Lead exposure is linked to accelerated aging, with each standard deviation increase in blood lead levels resulting in notable increases in death risk clocks [20][21]. - Interestingly, exposure to certain toxic chemicals like dioxins and PCBs was found to correlate with a decrease in epigenetic aging, suggesting a complex relationship between exposure and biological age [22][23]. Group 5 - The study highlights the importance of socioeconomic status and dietary choices in influencing aging speed, with higher income and better food choices associated with slower biological aging [26][27]. - The findings suggest that individuals can manage their aging process by making informed lifestyle choices, such as quitting smoking and diversifying their diet [28][29].

Core Viewpoint - Aimeike Technology Development Co., Ltd. reported a decline in revenue and net profit for Q1 2025, indicating challenges in the medical aesthetics industry amid increased competition and regulatory pressures [1][2]. Financial Performance - In Q1 2025, Aimeike achieved revenue of 663 million yuan, a year-on-year decrease of 17.90% - The net profit attributable to shareholders was 444 million yuan, down 15.87% year-on-year [1]. Market Trends - The non-surgical light medical aesthetics market is expected to grow at a rate of 10% in 2024, down from previous highs in 2023, as the industry transitions from "technical dividends" to "comprehensive competitiveness" [2]. - Increased competition has led to a downward trend in product prices, while consumer decision-making periods for high-end medical aesthetics have lengthened due to macroeconomic uncertainties [2]. Strategic Positioning - Aimeike is one of the few leading companies not actively participating in price wars, maintaining a gross margin of 93.85% in Q1 2025, a slight decrease of 0.7 percentage points year-on-year [4]. - The company emphasizes brand value and product quality over short-term price advantages, aiming for long-term market resilience [4]. Research and Development - Aimeike's R&D expenses reached 58.54 million yuan in Q1 2025, accounting for 8.82% of revenue, an increase of 1.65% year-on-year, reflecting a strong commitment to innovation [4]. - Ongoing projects focus on cutting-edge areas such as regenerative materials and collagen, which may not yield immediate sales but are expected to drive long-term growth [4]. Product Expansion - Aimeike has received approval for a new product, a medical-grade gel for jawline filling, which will soon be launched, marking it as the third approved product in this category in China [5]. - The company is also expanding its market presence through the acquisition of 85% of South Korea's REGEN Biotech Inc. for approximately 190 million USD, positioning itself as the only domestic company with two regenerative medical aesthetics products [5].