美国维克森林大学医学院科学家研发出一款无电池的可穿戴贴片，能更早、更精准地筛查皮肤癌。相关 成果发表于新一期《生物医学创新》杂志。 皮肤癌，尤其是黑色素瘤，是最危险的癌症类型之一。早期发现对治疗至关重要，但目前主要依赖医生 目视检查，这种方式主观性强，容易遗漏早期病变。更精密的诊断手段，如活检和影像学检查，通常只 在专业医疗机构才能开展。 为此，研究团队设计出一款柔性、无需芯片与电池的贴片，可直接贴附于皮肤表面，配合便携式阅读器 无线操作。 这款新型贴片能以无创方式测量皮肤病变处的电特性，即"生物阻抗"。生物阻抗反映了电信号在活体组 织中传导的顺畅程度。癌变区域的电特性往往异于健康皮肤，通过测量生物阻抗，贴片可识别出需要进 一步医学评估的异常区域。标准统计方法已证实，健康皮肤与异常皮肤之间存在显著差异。 研究表明，无论肤色深浅，该贴片都能清晰区分健康皮肤与可疑斑点，并能从痣或病变中捕捉到独特的 电信号。 与主观性较强的目视检查不同，该贴片能提供客观的数字数据，从而减少不必要的活检，降低漏诊与误 诊风险，还可改善患者治疗效果。此外，贴片生成的是非视觉数字数据，既保护患者隐私，也便于存储 和共享检测结果。 （文章 ...

Core Insights - Two Japanese research teams, including Nobel Prize winner Shimon Sakaguchi, have developed an efficient method to convert pathogenic T cells into regulatory T cells, showing promise for treating autoimmune diseases in mouse models [1][2] Group 1: Research Methodology - The Osaka University team established an innovative strategy to generate antigen-specific regulatory T cells from existing T cell resources in the human body, successfully activating effector T cells and promoting the expression of the key transcription factor Foxp3 [2] - The method demonstrated broad applicability across various human and mouse memory and effector T cells, effectively controlling autoimmune responses in inflammatory bowel disease and graft-versus-host disease [2] Group 2: Clinical Applications - Keio University applied the same technology to a mouse model of pemphigus vulgaris, a disease driven by autoreactive CD4+ T cells, successfully converting pathogenic T cells into stable regulatory T cells [2] - The converted regulatory T cells migrated to skin-associated lymph nodes, effectively suppressing the activation of pathogenic T cells and the production of autoantibodies, leading to alleviation of skin lesions [2]

Core Viewpoint - The rapid development of artificial intelligence (AI) technology is enhancing the accuracy and efficiency of weather and climate predictions, with AI models expected to match or exceed traditional physical models in both temporal and spatial resolution [1]. Group 1: AI Weather Models - AI weather models, such as Pangu, Fengwu, and Fuxi, are increasingly being utilized in typhoon prediction and short-term climate forecasting, showcasing their potential to improve prediction accuracy and efficiency [2]. - The advantages of AI weather models include faster computation times, higher accuracy in forecasts (e.g., typhoon path predictions), and built-in optimization modules for various predictive studies [2][3]. - AI models have successfully predicted the El Niño-Southern Oscillation (ENSO) phenomenon for over 18 months, significantly surpassing traditional models [2]. Group 2: Integration of AI and Traditional Methods - Current AI weather models face challenges, such as unclear physical mechanisms behind predictions and insufficient temporal resolution, with some models refreshing data only every six hours compared to traditional models that do so in minutes [4]. - The integration of high-performance computing (HPC) with AI is proposed as a solution to enhance prediction accuracy and overcome computational limitations [4][5]. - Future developments in weather forecasting are expected to rely on a combination of HPC and AI, requiring advanced supercomputing systems capable of handling massive computational demands [5].

Core Insights - The research conducted by professors from Harbin Institute of Technology and Tianjin University highlights the transformative role of virtual team collaboration in the healthcare sector, particularly in enhancing individual service capabilities amidst digital transformation [1][3] - The study reveals that virtual team collaboration not only improves the quality of individual consultations by doctors but also optimizes the allocation of medical resources through peer effects [2][3] Group 1: Research Findings - The study utilized data from two online consultation platforms, one offering individual consultations and the other providing team-based consultations, employing advanced causal inference methods [2] - Key findings indicate that virtual team collaboration leads to significant improvements in doctors' individual consultation quality, characterized by longer response content, increased emotional support terminology, and more frequent updates of medical terminology [2] - The peer effects driving service collaboration manifest in four main aspects: transparency mechanisms fostering healthy competition, high-performance demonstration effects setting benchmarks, geographical and organizational proximity enhancing collaboration depth, and low-performance uplift effects benefiting previously underperforming doctors [2] Group 2: Implications for the Industry - This research fills a theoretical gap regarding the cross-boundary effects of virtual teams and provides empirical evidence for the ecological operation of global online medical platforms [3] - As online healthcare becomes the "new normal," the service collaboration effects of virtual teams are positioned as key drivers for enhancing equity and efficiency in healthcare delivery [3] - The findings signify a shift in online medical services from "single-point breakthroughs" to "ecological collaboration," injecting new momentum into the digital transformation of the healthcare industry [3]

Core Insights - Significant progress has been made in cotton biotechnology breeding in China, with the successful cultivation and application of high-yield, high-quality, and stress-resistant cotton varieties, providing strong technological support for the high-quality development of the cotton industry [1][3] Group 1: Industry Overview - Cotton is a crucial economic crop related to national economy and people's livelihood, with stable production capacity and quality improvement being vital for ensuring the supply of textile raw materials and increasing farmers' income [1] - Xinjiang is the main cotton-producing region in China, accounting for approximately 92.2% of the national total output [1] Group 2: Technological Advancements - Under the support of major agricultural biotechnology breeding projects, domestic seed companies and research institutions have collaborated to utilize modern breeding technologies such as molecular marker selection and gene aggregation, focusing on traits like high yield, quality, disease resistance, and suitability for mechanical harvesting [2] - More than 30 new cotton varieties with outstanding comprehensive traits have been successfully cultivated, showing excellent performance in key quality indicators such as fiber length and strength, along with good disease resistance and adaptability to modern production methods [2] Group 3: Specific Varieties and Their Impact - The new variety Jinmian No. 2 demonstrates high-temperature tolerance, strong resistance to wilt and yellow wilt diseases, and excellent fiber quality, with a yield increase of 13.2% compared to the control in two years of regional trials, with a planned promotion area of 850,000 mu in 2024 and over 1 million mu in 2025 [2] - Another variety, Xintamian No. 11, aggregates multiple excellent traits for fiber quality and yield, showing a yield increase of 14.2% compared to the control in two years of regional trials, with a cumulative demonstration promotion of 320,000 mu planned for 2024-2025 [2] - Other notable varieties include Zhongmian Suo 1813, a high-yield salt-alkali resistant variety, Xinlu Mian No. 3, an early-maturing disease-resistant variety, and Guoxin Mian No. 37, a high-yield stable variety, all of which have been widely promoted in production [2] Group 4: Future Outlook - With the promotion and application of new varieties, the cotton industry in China is entering a new stage of simultaneous improvement in yield, quality, and efficiency, driven by continuous breakthroughs in biotechnology [3]

Core Insights - The 2025 Intelligent Connected Vehicle Conference showcased advancements in China's smart vehicle industry, highlighting innovations in autonomous driving and vehicle operation systems [1] - China's new energy vehicle (NEV) industry has achieved significant breakthroughs in production scale, core technologies, and supply chain ecosystems during the 14th Five-Year Plan, leading to a rise in global exports [1][3] Group 1: Industry Developments - The conference featured a fully autonomous Robotaxi operation model and a new generation of autonomous vehicles equipped with 33 high-precision sensors for comprehensive environmental recognition [1] - The integration of domestic chips in vehicles is emphasized, showcasing a model that incorporates products from ten leading Chinese chip manufacturers [1] - The Ministry of Industry and Information Technology noted the establishment of a complete industrial system encompassing smart cockpits, autonomous driving, and connected cloud control [1] Group 2: Technological Innovations - A new material developed by the Chinese Academy of Sciences enables a flexible battery that can withstand 20,000 cycles, improving energy density by 86% when used in composite cathodes [2] - Over the past five years, the charging efficiency of power batteries in China has increased by more than four times, with a domestic vehicle localization rate exceeding 95% [3] Group 3: Smart Mobility Transformation - The definition of "automobile" is evolving into a smart mobility terminal, integrating advanced voice interaction systems and real-time monitoring technologies for driver safety and comfort [3] - The automotive industry is entering an era of deep exploration in artificial intelligence, with innovations leading to five major transformations in new vehicles [3] Group 4: Collaborative Innovation - The "vehicle-road-cloud integration" system addresses challenges in signal recognition for autonomous driving, enhancing safety through real-time traffic information sharing [4] - The demand for over 2,000 chips per vehicle is accelerating the growth of the electronic information manufacturing sector [4] - The NEV sector is projected to exceed 2 trillion yuan in consumption by 2024, driving rapid development across the supply chain and related industries [5] Group 5: Global Market Impact - In the first nine months of the year, China's NEV exports reached 1.758 million units, marking a year-on-year increase of 89.4%, with over 5,000 vehicles exported daily [5] - Chinese brands are progressively establishing a presence in the global market, contributing significantly to the electrification transformation of the automotive industry [5]

Group 1: Photon Industry - The "Chasing Light Plan" aims to illuminate new industrial tracks, with the first silicon photonics pilot line in Northwest China set to open in November, providing R&D and pilot services for various photonic innovations [3] - Since 2021, the photon industry has been recognized as a key industrial chain in Shaanxi, with the number of photon enterprises increasing from under 100 in early 2021 to 379 by 2024, and the industry scale growing from 15 billion to 36.5 billion [4] - The establishment of the Qin Chuang Yuan Photon Industry Innovation Cluster in 2024 aims to connect high-growth tech companies with resources and funding, enhancing the innovation ecosystem [4][5] - The application scenarios for the photon industry are expanding, including laser radar for vehicles, 3D sensing for smartphones, satellite communication, and precision manufacturing [4] Group 2: New Energy Vehicles - In the first three quarters of this year, Shaanxi's new energy vehicle exports reached 207,000 units, with an export value of 28.02 billion, marking year-on-year increases of 73.3% and 79.7% respectively [6] - The annual production of new energy vehicles in Shaanxi is projected to grow from 59,500 units in 2020 to 1.198 million units by 2024, representing a nearly 20-fold increase [6] - The automotive industry in Shaanxi has seen a rise in domestic supply rate from 32% in 2020 to 57% currently, with plans to exceed 1.5 million units in annual production by 2027 [9] Group 3: Solar Energy - Longi Green Energy ranked first in China's photovoltaic industry for R&D investment, reflecting the transformation of Shaanxi's photovoltaic sector from manufacturing to intelligent manufacturing [10] - The photovoltaic industry in Shaanxi has maintained the world's leading position in silicon wafer shipments for nine consecutive years, with a market share in photovoltaic modules also ranking first globally [11] - By 2025, the photovoltaic industry in Shaanxi is expected to achieve an annual output value exceeding 350 billion, contributing significantly to the energy revolution [11]

Core Insights - The "Taihang 7" gas turbine generator set has achieved a significant operational milestone of 25,000 hours in Dongfang City, Hainan Province, generating a total of 122 million kilowatt-hours, surpassing its design lifespan [1] Company Highlights - The "Taihang 7" gas turbine is a 7-megawatt aviation modified gas turbine featuring dual fuel capability, quick start, low energy consumption, stable operation, and easy maintenance [1] - This generator set is a collaborative project between China Aviation Engine Group and China National Offshore Oil Corporation, recognized as one of the first batch of gas turbine innovation development demonstration projects by the National Energy Administration [1]

Core Insights - NASA's Perseverance rover has made significant discoveries that suggest the possibility of ancient microbial life on Mars, particularly in the Jezero Crater [1][2] - The findings include unique rock samples that may contain evidence of biological activity dating back 3.5 billion years [1][3] Group 1: Discovery Details - The Perseverance rover identified a rock layer called "Bright Angel" in the Nerretwa Canyon, which may have formed in a water-rich environment [2][3] - The rover found green spots, referred to as "poppy seeds," containing a phosphorus-rich mineral called blue iron ore [2][3] - The "Chiawa Falls" rock sample contains small circular structures known as "leopard spots," which are composed of iron minerals that could indicate past microbial activity [2][3] Group 2: Scientific Interpretation - Researchers are cautious in labeling these findings as definitive signs of life, preferring the term "potential biosignatures" [3][4] - The study emphasizes the need for multiple lines of evidence to confirm any signs of life, as non-biological processes could produce similar mineral formations [4][5] - The current evidence is considered indirect, and further analysis is required to establish a direct link to ancient life [3][5] Group 3: Future Exploration - Returning Martian samples to Earth is deemed crucial for validating the findings and conducting more advanced analyses [5][6] - Various countries, including China, are advancing their Mars exploration missions, with plans for sample return missions to further investigate potential life signs [6][7] - The European Space Agency's Rosalind Franklin rover is also set to join the Mars exploration efforts, highlighting the global interest in uncovering the mysteries of Martian life [7]

Core Viewpoint - The incident involving a woman who suffered burns from a homemade solution of vinegar and sugar highlights the potential dangers of following unverified life hacks for cleaning, emphasizing the need for scientific understanding of such methods [1][2][3][4] Group 1: Chemical Reactions and Safety - The use of white vinegar to remove limescale is scientifically valid, as vinegar (acetic acid) reacts with calcium carbonate and magnesium hydroxide in limescale to produce soluble compounds [1] - The woman's burns were caused by the high temperature of the solution and the rapid production of carbon dioxide gas, which increased pressure in the sealed thermos, leading to an explosive release [1][2] - To safely use vinegar for descaling, it is advised to keep the thermos open and use room temperature vinegar, avoiding the introduction of high-temperature liquids into sealed containers [2] Group 2: Common Household Hazards - Mixing toilet cleaner (containing hydrochloric acid) with bleach (sodium hypochlorite) can produce toxic chlorine gas, posing serious health risks such as respiratory distress and potential fatality [3] - The combination of cleaning agents like toilet cleaner and dish soap can neutralize each other, reducing cleaning effectiveness [3] - Other popular life hacks, such as using matches to enhance mosquito repellent, can also be dangerous due to the flammable nature of the components involved [2][3] Group 3: General Advice on Life Hacks - While some online life hacks may be effective, it is crucial to verify their scientific basis and understand the underlying principles before attempting them [4]