Core Viewpoint - The study highlights the role of ALDH2*2 mutation in exacerbating acute heart failure post-myocardial infarction by promoting ferroptosis through selective translation of specific mRNAs [4][7]. Group 1: ALDH2 and Its Mutation - ALDH2 plays a crucial role in detoxifying lipid peroxidation products and alcohol metabolism, with the common mutation ALDH2*2 present in 40% of East Asian populations, leading to reduced enzyme activity and increased myocardial infarction risk [3]. - The ALDH2*2 mutation results in decreased ALDH2 protein levels, which disrupts its interaction with the eIF3 complex, promoting the formation of the eIF3E-eIF4G1-mRNA complex that drives the translation of ferroptosis-related genes [6][7]. Group 2: Research Findings - The research involved 177 Chinese patients with acute heart failure, comparing wild-type and ALDH2*2 genotypes, and established a myocardial infarction model in mice [5]. - ALDH2*2 carriers exhibited more severe heart failure post-acute myocardial infarction, characterized by increased bioactive lipids and decreased antioxidants in plasma, indicating ferroptosis [5]. - Inhibition of ferroptosis using Fer-1 significantly improved cardiac function in ALDH2*2 mouse models, reversing markers of ferroptosis [5]. Group 3: Mechanism of Ferroptosis - ALDH2 interacts with the eIF3 complex to prevent the formation of the eIF3E-eIF4G1-mRNA complex, which is disrupted by the ALDH2*2 mutation, leading to increased translation of mRNAs that promote ferroptosis [6]. - Continuous knockdown of eIF3E in myocardial cells can restore cardiac function in ALDH2*2 carriers by alleviating ferroptosis [6][7]. Group 4: Therapeutic Implications - Targeting ferroptosis presents a viable cardiac protection strategy, particularly for ALDH2*2 carriers, to mitigate myocardial injury [5][7].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 肿瘤相关巨噬细胞 （TAM） 通过促进血管生成、细胞外基质重塑和免疫抑制来增强癌症的进展。 神经浸润 （ Nerve infiltration ） 也会促进肿瘤生长。然而， 肿瘤相关巨噬细胞 （TAM） 在促进肿瘤内神经生长方面的作用，目前仍不清楚。 2026 年 1 月 26 日， 维罗纳大学和米兰大学的研究人员在 Cell 子刊 Immunity 上发表了题为： Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair 的研究论文。 该研究表明， 肿瘤相关巨噬细胞 （TAM） 能够 促进外周神经的肿瘤浸润 ，这一能力可被用于促进严重脊髓损伤后的神经组织再生和运动功能恢复。 该研究的核心发现： 人类和小鼠的肿瘤相关巨噬细胞 （TAM） 表现出独特的功能性神经生长基因特征； TAM 增强肿瘤神经支配； TAM 促进严重脊髓损伤后的神经组织再生和运动功能恢复； SPP1 是 TAM 诱导神经元生长所必需的。 在这项研究中，研究团队揭示了肿瘤 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在细胞免疫中，细胞毒性淋巴细胞利用 颗粒酶 A （ Granzyme A， GZMA） 切割并激活成孔蛋白 GSDMB，从而对靶细胞进行焦亡性杀伤。然而，GZMA 是如何识别并切割 GSDMB 的，目前仍不清楚。 2026 年 1 月 26 日，北京生命科学研究院 邵峰 院士团队、中国科学院生物物理研究所 丁璟珒 研究员团 队合作，在 Immunity 期刊 发表了题为： Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing 的研究论文。 该研究表明， 颗粒酶 A （ Granzyme A， GZMA） ，通过独特的"二聚体"结构，像一把精准的钥匙，解 锁了对 GSDMB 蛋白的切割，从而引发"细胞焦亡"。这不仅揭示了淋巴细胞来源的颗粒酶用于杀伤靶细胞 的一种底物靶向机制，还为癌症免疫治疗提供了新思路。 GZMA 的二聚体结构：一把双刃钥匙 在这项新研究中，研究团队通过高精度的晶体结构分析，发现 GZMA 有一个独特之处：它是以"二聚体"形 式 ...

Core Viewpoint - Trends Open is a new open-access multidisciplinary journal launched by Cell Press, focusing on reviews and evaluations across various fields including life sciences, physical sciences, medicine, sustainable development, and applied sciences, without considering original research articles, meta-analyses, or systematic reviews [2][5]. Group 1: Journal Overview - The journal is led by Dr. Ilaria Carnevale, who has a diverse research background in biology and has been the editor of Trends in Cell Biology since 2020 [3]. - Trends Open aims to provide a platform for both early-career and experienced researchers to share insightful evaluations and innovative ideas, fostering a community that encourages interdisciplinary dialogue [4][6]. Group 2: Importance and Goals - Trends Open is inspired by the Trends series of journals and aims to facilitate communication across different scientific disciplines, addressing the need for a multidisciplinary approach in scientific research [5]. - The journal seeks to publish a wide range of topics, particularly those related to sustainability, medicine, and physical sciences, and will actively engage with the scientific community to identify urgent themes that require attention [5][6]. Group 3: Author Expectations and Features - Authors can expect a balanced platform to express their ideas and reach a broader audience, as the journal aims to represent contemporary science while maintaining a foundation of expertise [8]. - New features will include key reference boxes highlighting important literature and an importance box summarizing the significance of the research, along with a personal profile section for authors to share their backgrounds and future work [9]. Group 4: Editorial Support - The editorial team, led by Dr. Carnevale, emphasizes collaboration with authors, aiming to support them through the publication process and expand their professional networks [10].

撰文丨王聪 编辑丨王多鱼 排版丨水成文 衰老 会损害 人类脂肪来源干细胞 （ human adipose-derived stem cell， hASC ） 的再生能力和分化潜能，但其功能衰退的潜在机制，目前仍不清楚。 2026 年 1 月 20 日， 空军军医大学 胡大海 、 申亮亮 、 宋保强 等人在 Cell Discovery 期刊发表了题为： IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration 的研究论文。 该研究表明， IGF2BP3 依赖的谷氨酰胺/支链氨基酸代谢重编程，使衰老的 人类脂肪来源干细胞 （hASC） 恢复年轻活力，以增强组织再生。 https://www.nature.com/articles/s41421-025-00860-7 设置 星标 ，不错过精彩推文 在这项新研究中，研究团队通过系统的功能检测和体内实验，首先证实了 人类脂肪来源干细胞 （hASC） 的自我更 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 在次级淋巴器官内， 树突状细胞 和 T 细胞 的移动，对于适应性免疫反应的形成至关重要。这一过程的核 心是 成纤维网状细胞 （FRC） 网络 ，它形成了一套高度有序的管道系统 ，有助于树突状细胞和 T 细胞的 移动以及它们之间的相互作用。 之前的研究已在一定程度上阐明了 FRC 是如何支持这些相互作用的，然而，其在生理条件下发挥作用的分 子机制，目前仍不清楚。 2026 年 1 月 21 日，莫纳什大学的研究人员在 Nature 期刊发表了题为： Fibroblastic reticular cells direct the initiation of T cell responses via CD44 的研究论文。 该研究表明， 成纤维网状细胞 （FRC） 通过 CD44 指导 T 细胞应答的启动，而 巨细胞病毒 （CMV） 能 够通过产生 m11 蛋白来结合并阻断 CD44，从源头上扰乱免疫细胞的移动，从而削弱抗病毒反应。 这一发现揭示了一种病毒免疫逃逸新机制，从根本上改变了我们对于塑造免疫功能的信号的理解。 病毒 会劫持细胞功能以利己。在长期共同进化的过程中，病毒 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 1950 年代，第一批 塑料 制成的消费品问世，很快人们就发现这种材料用途广泛，应用领域似乎无穷无 尽。毫无疑问，塑料的使用使消费品的设计和生产变得更容易、更便宜，而且塑料的普及也提高了食品和 医疗产品的微生物安全性。然而，塑料制品广泛应用也导致了全球塑料垃圾的累积。这些遍布全球陆地和 海洋的塑料垃圾会分解成更小的颗粒，最终通过空气、食物和水被野生动物以及人类所吸收。 1972 年， 首次有关海洋环境中存在各种大小塑料颗粒的报道出现， 微塑料 （microplastic，MP） 被定 义为 1 微米至 5 毫米大小的塑料颗粒，其来源可分为原生 （例如轮胎磨损、研磨剂和化妆品） 和次生 （由较大塑料碎片化形成） 两类。微塑料已被检测出存在于水生环境、沉积物、污水污泥、空气中，甚至 是人体组织中。大气排放源自轮胎和刹车磨损、工业和个人塑料使用、海洋、土壤等。微塑料颗粒能够在 大气中远距离传播，甚至到达北极和南极等偏远地区。 微塑料，作为一类备受关注的全球性污染物，我们对于其在大气中的分布情况却仍知之甚少，尽管大气中 微塑料的测量数据日益丰富 ， 但其向大气中排放量的估算值， ...

Core Insights - The Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a tick-borne virus that has rapidly spread across Asia since its discovery in 2011, with a mortality rate ranging from 16.2% to 30% [2][6] - Currently, there are no effective antiviral treatments or vaccines for SFTSV, and treatment is primarily supportive, highlighting the urgent need for the development of effective therapeutic antibodies to reduce mortality and public health burden [2][6] Group 1: Research Findings - A recent study published in the journal Vita identified a fully human super-neutralizing antibody, ZS1C5, which targets the SFTSV virus and demonstrated 100% protection in lethal mouse models [3][10] - ZS1C5 was shown to significantly reduce viral load in both mouse and non-human primate models, with a 90% reduction in viral load within 24 hours and complete viral clearance within three days in treated monkeys [10][15] - The antibody's unique mechanism involves binding to a previously undiscovered cross-domain epitope on the SFTSV Gn protein, which enhances its neutralizing capability [8][10] Group 2: Immune System Restoration - ZS1C5 not only clears the virus but also restores immune balance, preventing the cytokine storm and excessive inflammatory response typically seen in untreated patients [12] - The treatment group maintained normal immune cell function, which helped mitigate thrombocytopenia and coagulation abnormalities [12] Group 3: Vaccine Development Insights - The study utilized AI algorithms to scan healthy human B cell receptor gene libraries, identifying germline antibodies similar to ZS1C5, providing a new blueprint for universal vaccine design [14] - This approach could lead to the development of vaccines that stimulate immune responses akin to those generated by ZS1C5, potentially offering broader protection against SFTSV and similar emerging viral threats [14][17]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 随着全球气候变化加剧， 热浪 事件愈发频繁，给人类健康带来严重威胁。此外，全球城市化进程导致人为热量排放过多以及不透水表面增加，加剧了 城市热岛 效应 ，从而增加了 高温相关疾病和死亡 风险，尤其是对老年人和有基础疾病的人群。 在此背景下， 绿地 作为有效的自然调节机制，其在减轻高温暴露、改善生活环境质量和降低热浪相关死亡风险方面的潜力日益受到重视。 2026 年 1 月 15 日，中国疾病预防控制中心 周脉耕 研究员、 复旦大学公共卫生学院 阚海东 教授等 （ 复旦大学 何成 、中国疾病预防控制中心 殷鹏 、复旦大 学 陈仁杰 为论文共同第一作者 ） 在 Nature 新子刊 Nature Health 上发表了题为 ： Small accessible urban parks mitigate heat-related mortality 的研究论 文。 该研究 首次在全国范围内系统评估了不同绿地空间配置对热浪相关死亡风险的修饰效应，结果表明， 小型且易达的城市公园，可缓解热浪相关的死亡风险。 越来越多的证据表明，城市的绿地覆盖率能有效调节热浪相关健康风险，但绿地的 ...

Core Findings - The study provides a detailed protein atlas of lysosomes in various brain cell types, identifying previously unannotated lysosomal proteins and revealing the diversity of lysosomal composition across different brain cell types [4][10][11] - SLC45A1, a neuron-specific lysosomal protein, is redefined as a lysosomal storage disorder (LSD) due to its mutation leading to significant lysosomal dysfunction [4][8][16] Lysosomal Function and Importance - Lysosomes are membrane-bound organelles responsible for degrading macromolecules and clearing damaged organelles, crucial for maintaining cellular homeostasis [6] - They play a key role in nutrient and energy sensing pathways, impacting cellular metabolism and are involved in various cellular functions such as membrane repair and programmed cell death [6] Research Methodology - The research utilized a LysoTag mouse model combined with cell-type specific Cre recombinase expression to generate a comprehensive lysosomal protein map covering major brain cell types, including neurons, astrocytes, oligodendrocytes, and microglia [8][11] - The study highlights the impact of SLC45A1 on the stability of the V-ATPase complex on lysosomal membranes, linking its deficiency to impaired lysosomal acidification and mitochondrial dysfunction [4][8][16] Implications for Future Research - This research lays the groundwork for future studies on lysosomal biology and its role in neurodegenerative diseases, emphasizing the need to explore the specific functions of different lysosomal proteins in various brain cell types [11]