12月18日晚，百济神州公告，聘任公司全球研发负责人汪来博士担任公司总裁，全球研发负责人，负责管理公司研发、业务拓展以及业 务联盟关系管理等职能。同时，吴晓滨博士的所有职务与职责保持不变。 汪来于2011年加入百济神州，最初担任生物标志物和体内药理学组的负责人，自2021年4月起担任公司全球研发负责人。 加入百济神州 之前，2008年至2011年，汪来在位于美国德克萨斯州达拉斯的生物技术公司JoyantPharmaceuticals担任研究主管。汪来于1996年获得复 旦大学理学学士学位，2001年获得德克萨斯大学圣安东尼奥健康科学中心博士学位。 公告一经发出，业内纷纷猜测吴晓滨是否不再担任总裁一职。据智通财经、每日经济新闻等多家媒体向百济神州求证，吴晓滨职务并未 发生变化，依旧任公司总裁兼首席运营官，也就是说百济神州目前处于"双总裁"的情况。 公开资料显示，吴晓滨2018年加入百济神州。1982年，吴晓滨通过考试获取公派留学德国的机会，前往德国留学，获得德国康斯坦茨大 学分子生物学硕士学位和生物化学与药理学博士学位。 在加入百济神州之前，吴晓滨曾在拜耳、惠氏、辉瑞等药企工作，他在拜耳工作了13年，在辉瑞工作 ...

美国证券交易委员会 华盛顿特区 20549 8-K 表格 根据 1934 年证券交易法 第 13 或 15（d）条规定提交的 临时报告 报告日期（所报告最早事件之日期）：2025 年 12 月 16 日 百济神州有限公司 BEONE MEDICINES LTD. （注册人章程中列明的注册人准确名称） 瑞士 001-37686 98-1209416 （如自上一份报告起有改动，则为公司曾用名或原地址） 若 8-K 表格的呈递旨在同时满足下列任何条例项下的注册人报告义务，请勾选相应方格： ☐ 根据证券法第 425 条发出书面通讯 (17 CFR 230.425) ☐ 根据交易法第 14a-12 条的征集资料 (17 CFR 240.14a-12) ☐ 根据交易法第 14d-2(b)条发出生效日期前通讯 (17 CFR 240.14d-2(b)) ☐ 根据交易法第 13e-4(c)条发出生效日期前通讯 (17 CFR 240.13e-4(c)) 根据证券交易法第 12(b)条注册的证券： | 各类别名称 | | | 交易代码 | 注册所在之各交易所名称 | | --- | --- | --- | --- | --- ...

（编辑 任世碧） 证券日报网讯 12月18日晚间，百济神州发布公告称，2025年12月17日，经公司董事会审议通过，公司 董事会同意聘任公司全球研发负责人汪来博士担任公司总裁，全球研发负责人。聘任生效后，汪来博士 担任公司总裁，全球研发负责人职务，负责管理公司研发、业务拓展以及业务联盟关系管理等职能。 ...

Core Viewpoint - BeiGene has made significant changes to its core management team, establishing a "dual president" position in the pharmaceutical industry with the appointment of Dr. Wang Lai as President while retaining his role as Global Head of R&D [1] Group 1: Management Changes - Dr. Wang Lai has been appointed as President of BeiGene, overseeing R&D, business development, and alliance management [1] - Dr. Wu Xiaobin remains in his position as President and Chief Operating Officer, indicating a unique dual leadership structure within the company [1] - The company previously underwent a major personnel change in August, with the appointment of Shan Guohong as General Manager for Greater China, Central Asia, and South Asia, reporting to Dr. Wu Xiaobin [1] Group 2: Clarifications and Future Communication - BeiGene has addressed concerns regarding Dr. Wu Xiaobin's position, stating that he remains a core management member and any future changes will be disclosed promptly [1]

Group 1 - The core point of the news is the appointment of Wang Lai as the new President of BeiGene, while the previous President, Wu Xiaobin, retains his position, leading to a "dual presidency" structure [2][4]. - Wang Lai has been with BeiGene since 2011 and has held various leadership roles in research, most recently serving as the Global Head of R&D since April 2021 [2][4]. - Wu Xiaobin has over 25 years of experience in the pharmaceutical industry and has been with BeiGene since 2018, previously holding significant positions at major pharmaceutical companies [4][6]. Group 2 - BeiGene is the first biotech company to be listed on NASDAQ, Hong Kong Stock Exchange, and Shanghai Stock Exchange, with two major products: the BTK inhibitor Bruton’s Tyrosine Kinase (Zebutinib) and the PD-1 inhibitor Tislelizumab [6]. - Zebutinib achieved global sales exceeding $1 billion for the first time in 2023, with total sales reaching $1.3 billion, marking it as the first drug in China to enter the "billion-dollar club" [6]. - For the first three quarters of 2025, BeiGene reported revenue of 27.595 billion yuan, a year-on-year increase of 44.2%, and a net profit attributable to shareholders of 1.139 billion yuan, successfully turning a profit [7][8].

Group 1 - The core announcement is the appointment of Wang Lai as the new President and Global Head of R&D at BeiGene, effective December 18 [1][3] - Wang Lai has been with BeiGene since 2011 and has held various leadership roles in R&D, previously serving as the Research Director at Joyant Pharmaceuticals from 2008 to 2011 [1][3] - The previous President, Wu Xiaobin, will retain all his positions and responsibilities, leading to a "dual presidency" at the company [3][5] Group 2 - Wu Xiaobin has over 25 years of experience in the pharmaceutical industry and has worked with major companies like Bayer, Wyeth, and Pfizer [5][15] - BeiGene is the first biotech company to be listed on NASDAQ, Hong Kong Stock Exchange, and Shanghai Stock Exchange, with two major products: the BTK inhibitor Zanubrutinib and the PD-1 inhibitor Tislelizumab [5][15] - Zanubrutinib achieved global sales of $1.3 billion in 2023, marking it as the first domestic drug to exceed the billion-dollar sales threshold [5][15] Group 3 - BeiGene is the only innovative pharmaceutical company with two drugs included in commercial insurance: Zhenida Monoclonal Antibody and Dato-DXd [6][16] - For the first three quarters of 2025, BeiGene reported revenue of 27.595 billion yuan, a year-on-year increase of 44.2%, and a net profit of 1.139 billion yuan, successfully turning a profit [6][16] - The company raised its revenue guidance for the full year of 2025 to between 36.2 billion and 38.1 billion yuan, up from the previous estimate of 35.8 billion to 38.1 billion yuan [7][17] Group 4 - On December 19, BeiGene's A-shares rose by 0.86%, closing at 274 yuan per share, with a total market capitalization of 422.1 billion yuan [8][18]

玛仕度肽是信达生物自主开发的全球首个且唯一获批上市的GCG/GLP-1天然双靶减重降糖药物。 据介绍，GLP-1是胰高血糖素样肽-1的英文简称，它在餐后分泌，可促进胰岛素分泌、降低进食后的血 糖，并减缓胃肠道蠕动，造成饱腹感。GLP-1类药物可通过激活GLP-1的受体，增加胰岛素分泌，从而 达到降低血糖和减轻体重的治疗效果。GCG是胰高血糖素的英文缩写，由胰腺中的胰岛α细胞分泌，其 受体主要在肝脏中表达。激活GCG受体可增强脂肪氧化、促进能量消耗、改善肝脏脂肪代谢。 专家介绍，GCG与GLP-1靶点联合，通过"抑制食欲+加速代谢"的双重作用机制，可更好解决肥胖患者 内脏脂肪堆积、胰岛素抵抗等复杂代谢问题。 据介绍，玛仕度肽已在中国获批用于糖尿病和减重两项适应证，并已开展7项Ⅲ期研究，涵盖糖尿病、 肥胖及相关并发症领域。 《自然》发表的两项临床研究结果表明，玛仕度肽在血糖控制和减重方面均优效于安慰剂或度拉糖肽 （1.5mg），同时均显示可改善多项心血管代谢、肝脏和肾脏相关指标，为全球糖尿病合并肥胖等代谢 疾病的治疗提供了新的解决方案。 由我国多家研发单位联合完成的两项关于降糖减重药物的Ⅲ期临床研究成果，北京时间 ...

A股代码：688235 A股简称：百济神州 公告编号：2025-042 2025年12月19日 汪来博士自2021年4月起担任公司全球研发负责人。在此之前，自2011年加入公司以来，他担任过多个 研发领导职务，职责逐渐扩大。加入公司之前，于2008年至2011年，汪来博士在位于美国德克萨斯州达 拉斯的生物技术公司Joyant Pharmaceuticals担任研究主管。汪来博士于1996年获得复旦大学理学学士学 位，于2001年获得德克萨斯大学圣安东尼奥健康科学中心博士学位。 2025年12月17日，经百济神州有限公司（以下简称"公司"）董事会审议通过，公司董事会同意聘任公司 全球研发负责人汪来博士担任公司总裁，全球研发负责人。聘任生效后，汪来博士担任公司总裁，全球 研发负责人职务，负责管理公司研发、业务拓展以及业务联盟关系管理等职能。 特此公告。 百济神州有限公司董事会 港股代码：06160 港股简称：百济神州 美股代码：ONC 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性依法承担法律责任。 ...

Group 1 - The core announcement is the appointment of Wang Lai as the new President and Global Head of R&D at BeiGene, effective January 1, 2026, while the previous President, Wu Xiaobin, retains his position as President and COO [1][2] - Wang Lai has been with BeiGene since 2011 and has held various R&D leadership roles, most recently serving as the Global Head of R&D since April 2021 [2] - Wang Lai's annual salary will be $750,000 (approximately 5.28 million RMB), with the potential for a performance-based bonus and a one-time equity incentive of $10 million in restricted stock units [1][2] Group 2 - BeiGene reported a revenue of 10.077 billion RMB for Q3 2025, representing a year-on-year growth of 41.1%, and a net profit of 689 million RMB, marking a return to profitability [3] - For the first three quarters of 2025, BeiGene's revenue reached 27.595 billion RMB, with a year-on-year increase of 44.2%, and a net profit of 1.139 billion RMB [3] - The company's leading product, Zebrutinib, generated global sales of 7.423 billion RMB in Q3 2025, ranking first among similar BTK inhibitors, with U.S. sales contributing 5.266 billion RMB [3]

12月19日，百济神州发布公告称，经百济神州有限公司（以下简称"公司"）董事会审议通过，公司董事 会同意聘任公司全球研发负责人汪来博士担任公司总裁，全球研发负责人。聘任生效后，汪来博士担任 公司总裁，全球研发负责人职务，负责管理公司研发、业务拓展以及业务联盟关系管理等职能。 (编辑：杨燕 林辰)关键字： 医疗 公告显示，汪来自2021年4月起担任公司全球研发负责人。在此之前，自2011年加入公司以来，他担任 过多个研发领导职务，职责逐渐扩大加入公司之前，于2008 年至2011年，汪来在位于美国德克萨斯州 达拉斯的生物技术公司 Joyant Pharmaceuticals 担任研究主管。汪来于1996年获得复旦大学理学学士学 位，于2001年获得德克萨斯大学圣安东尼奥健康科学中心博士学位。 （百济神州公告） ...