Core Viewpoint - The company has successfully completed the Phase III clinical trial for its innovative anti-IL-1β humanized monoclonal antibody injection (project code "GJ-613") for the treatment of acute gouty arthritis, achieving the primary efficacy endpoints and has submitted a new drug application to the National Medical Products Administration [1] Group 1 - The drug GJ-613 is developed independently by the company and possesses its own intellectual property rights, differentiating itself from existing products targeting the same pathway, such as Canakinumab and Gevokizumab, by having completely different binding epitopes [1] - The completed Phase III clinical study demonstrated that GJ-613 effectively alleviates pain in acute gouty arthritis and prevents recurrence, achieving dual primary efficacy endpoints comparable to the positive control drug, compound betamethasone injection, and significantly outperforming it [1]

Group 1: Market Performance - Major indices experienced a strong rebound, with the Shanghai Composite Index rising by 0.7%, Shenzhen Component Index by 1.24%, and ChiNext Index by 1.37% [2] - Over 4,200 stocks in the two markets saw gains, with a total trading volume of approximately 1.19 trillion yuan [2] Group 2: Digital Currency and Software Sector - The digital currency and software sectors led the market rally, with notable stocks like Lakala (300773.SZ) and Sifang Jingchuang (300468.SZ) hitting the daily limit with a 20% surge [2] - New Guodu (300130.SZ) rose over 14%, while Feitian Chengxin (300386.SZ) and Shenzhou Information (000555.SZ) also saw significant increases of 12.84% and 10%, respectively [2] Group 3: Autonomous Driving and Intelligent Connected Vehicles - Stocks related to autonomous driving and intelligent connected vehicles surged, with companies like Fulongma (603686.SH) and Jintour Environment (001230.SZ) hitting the daily limit [3] - A strategic cooperation agreement was signed between Xiaoma Zhixing and Guangzhou Public Transport Group, focusing on autonomous vehicle services [3] Group 4: Innovative Pharmaceuticals - The innovative pharmaceutical sector remains active, with companies like Sanofi Guojian (688336.SH) rising over 12% [4][3] - The sector is supported by policy backing, global competitiveness, and improving fundamentals, with a focus on "innovation + internationalization" [4] Group 5: Automotive Sector - The automotive sector showed strong performance, with Jinlong Automobile (600686.SH) and Dongfeng Co. (600006.SH) both increasing by 10% [5] - The launch of new models by XPeng and supportive government policies in Fujian province are contributing factors to the sector's growth [5] Group 6: Weak Sectors - The precious metals and food processing sectors experienced declines, with companies like Western Gold (601069.SH) and Laiyifen (603777.SH) seeing significant drops [5]

Group 1 - The innovative pharmaceutical ETF (560900) has seen a 2.20% increase as of May 29, 2025, with significant trading volume [1] - The CSI Innovative Pharmaceutical Industry Index (931152) rose by 2.32%, with notable gains from constituent stocks such as Zhixiang Jintai (688443) up 8.91%, Sangfor Technologies (688336) up 7.41%, and Maiwei Biotech (688062) up 5.78% [1] - Over the past two weeks, the innovative pharmaceutical ETF (560900) has accumulated a 3.94% increase, ranking it among the top comparable funds [2] Group 2 - CITIC Securities believes that leading innovative pharmaceutical companies have entered a profit phase, with potential for nonlinear profit explosions as commercialization expands [2] - The investment opportunities in the innovative pharmaceutical sector are linked to the clinical progress of molecules under research and the entire commercialization phase, which can last up to ten years [2] - The innovative pharmaceutical ETF closely tracks the CSI Innovative Pharmaceutical Industry Index, which selects no more than 50 representative listed companies involved in innovative drug research and development [2] Group 3 - Morgan Asset Management is integrating its "Global Vision Investment Technology" product line to help investors capitalize on quality technology companies amid a new wave of AI-driven technological advancements [2] - Various actively managed funds focus on emerging industry trends, including the Morgan Emerging Power Fund and the Morgan Smart Connectivity Fund, which targets opportunities in artificial intelligence [3] - The Morgan Hang Seng Technology ETF (513890) and the Morgan CSI Innovative Pharmaceutical Industry ETF (560900) provide passive investment options for technology and innovative pharmaceutical sectors, respectively [3]

Core Viewpoint - The Chinese innovative pharmaceutical industry is transitioning from imitation to original innovation, with significant growth in outbound transactions and a promising future for internationalization [4] Group 1: Market Performance - As of May 29, 2025, the Sci-Tech Innovation Board 100 Index (000698) rose by 1.63%, with notable increases in constituent stocks such as Borui Pharmaceutical (688166) up 9.66% and Zhixiang Jintai (688443) up 6.57% [3] - The Sci-Tech 100 Index ETF (588030) increased by 1.60%, with a latest price of 0.95 yuan and a turnover rate of 1.16%, totaling 71.56 million yuan in transactions [3] - Over the past year, the average daily transaction volume of the Sci-Tech 100 Index ETF reached 424 million yuan, ranking first among comparable funds [3] Group 2: Fund Growth and Performance - The Sci-Tech 100 Index ETF saw a significant increase in scale, growing by 94.45 million yuan over the past two weeks, ranking second among comparable funds [4] - In the past week, the ETF's shares increased by 99 million, also ranking first among comparable funds [5] - The ETF has experienced a net inflow of 71.08 million yuan over the last five trading days, indicating strong investor interest [5] Group 3: Financial Metrics - As of May 28, 2025, the Sci-Tech 100 Index ETF's net value increased by 19.94% over the past year, with a maximum monthly return of 27.67% since inception [5] - The ETF's management fee is 0.15% and the custody fee is 0.05%, making it the lowest among comparable funds [5] - The tracking error for the ETF over the past six months is 0.016%, indicating high tracking precision compared to similar funds [5] Group 4: Industry Insights - From the beginning of 2025 to the present, the total outbound transaction amount for innovative drugs has reached 45.5 billion USD, with upfront payments totaling 2.2 billion USD, suggesting a record year ahead [4] - Most domestic innovative drugs currently in the U.S. are in clinical stages, with significant potential for future growth as they progress towards commercialization [4]

Investment Rating - The investment rating for the company is "Buy" [6] Core Views - The company has achieved a significant business development (BD) authorization, granting Pfizer exclusive rights to develop, produce, and commercialize a dual-specific antibody product targeting PD-1 and VEGF in regions outside mainland China [1][2] - The innovative pipeline is actively advancing, with clinical trials validating the efficacy and safety of the PD-1/L1 antibody combined with VEGF antibody in various tumors [3] - The company anticipates substantial revenue growth due to the upcoming approvals of multiple new products, with revised revenue forecasts for 2025-2027 being 40.2 billion, 22.4 billion, and 26.3 billion respectively, reflecting a year-on-year growth of 236.4%, -44.1%, and 17.4% [4][10] Financial Summary - The projected revenue for 2025 is 40.2 billion, with a net profit of 28.5 billion, resulting in an earnings per share (EPS) of 4.63 [4][10] - The company expects a gross margin of 92.8% in 2025, with a return on equity (ROE) of 35.2% [10][11] - The financial outlook includes a significant increase in net profit for 2025, projected at 2,854 million, which is a 305.0% increase year-on-year [10][11]

Core Viewpoint - The company has granted Pfizer exclusive rights to develop, produce, and commercialize a dual-targeting antibody product aimed at PD-1 and VEGF, which is expected to enhance anti-tumor effects while reducing potential side effects [1][3]. Group 1: Licensing Agreement - Sanofi Health has granted Pfizer exclusive rights for the development and commercialization of the 707 project in regions outside mainland China [1]. - The licensing agreement involves a distribution of rights based on prior R&D investments and asset ownership, with Sanofi Health receiving 30% and Shenyang Sanofi receiving 70% [2]. Group 2: Clinical Development - The efficacy and safety of the PD-1/L1 antibody combined with VEGF antibody have been validated in clinical trials for various tumors, including renal cell carcinoma and hepatocellular carcinoma [3]. - The product has multiple ongoing clinical trials, with a single-agent treatment for PD-L1 positive non-small cell lung cancer having received approval for Phase III, while combination therapies for non-small cell lung cancer, metastatic colorectal cancer, and advanced gynecological tumors are in Phase II [3]. Group 3: Financial Projections - Following the significant licensing agreement and the anticipated approval of new products, the company has adjusted its revenue forecasts for 2025-2027 to 40.2 billion, 22.4 billion, and 26.3 billion yuan, reflecting a year-on-year growth of 236.4%, -44.1%, and 17.4% respectively [4]. - The projected net profits for the same period are 28.5 billion, 11.2 billion, and 13.9 billion yuan, with year-on-year growth of 305.0%, -60.6%, and 23.4% respectively [4]. - Earnings per share (EPS) are expected to be 4.63, 1.82, and 2.25 yuan, with corresponding price-to-earnings (PE) ratios of 12, 30, and 24 times based on the closing price of 54 yuan per share on May 28, 2025 [4].

Investment Rating - The investment rating for the company is "Buy" [6]. Core Insights - The company has achieved a significant business development (BD) authorization, granting Pfizer exclusive rights to develop, produce, and commercialize a dual-specific antibody product targeting PD-1 and VEGF in regions outside mainland China [1][2]. - The innovative pipeline is actively progressing, with clinical trials validating the efficacy and safety of the PD-1/L1 antibody combined with VEGF antibody in various cancers [3]. - Future revenue growth is anticipated due to the upcoming approvals of multiple new products, leading to a substantial increase in revenue and net profit forecasts for 2025-2027 [4]. Financial Projections - Revenue projections for 2025-2027 are estimated at 40.2 billion, 22.4 billion, and 26.3 billion CNY, reflecting year-on-year growth rates of 236.4%, -44.1%, and 17.4% respectively [4][10]. - The net profit forecasts for the same period are 28.5 billion, 11.2 billion, and 13.9 billion CNY, with year-on-year growth rates of 305.0%, -60.6%, and 23.4% respectively [4][10]. - Earnings per share (EPS) are projected to be 4.63, 1.82, and 2.25 CNY for 2025, 2026, and 2027 respectively, with corresponding price-to-earnings (PE) ratios of 12, 30, and 24 [4][10]. Clinical Development - The licensed product has initiated multiple clinical trials, with a monotherapy for PD-L1 positive non-small cell lung cancer having received approval for Phase III clinical trials [3]. - Combination chemotherapy for non-small cell lung cancer and other indications are currently in Phase II clinical trials [3].

Core Points - The company is holding a second extraordinary general meeting of shareholders in June 2025 to discuss several key proposals [1][8] - The meeting will ensure the rights of shareholders and maintain order, with specific rules for attendance and participation [2][4] Proposal Summaries - Proposal 1: The company plans to sign a licensing agreement with its affiliates and Pfizer Inc. for a dual-targeting antibody product, granting exclusive rights for development and commercialization outside mainland China [4][6] - Proposal 2: A supplementary agreement regarding the distribution of payments from Pfizer under the licensing agreement will be established, with a proposed distribution ratio of 30% for the company and 70% for its affiliate [6][7] - Proposal 3: The company intends to temporarily use surplus funds of 66.6282 million yuan from various projects to supplement working capital and adjust the investment amounts for specific projects, reducing one project’s funding from 400 million yuan to 320 million yuan and increasing another from 610 million yuan to 690 million yuan [7][8]

证券代码： 688336 证券简称：三生国健 三生国健药业（上海）股份有限公司 2025 年第二次临时股东大会会议资料 二〇二五年六月 1 目录 | 2025 | 年第二次临时股东大会会议须知 | 3 | | --- | --- | --- | | 2025 | 年第二次临时股东大会会议议程 | 6 | | 2025 | 年第二次临时股东大会会议议案 | 8 | | 议案 | 1、《关于与关联方共同签署许可协议的议案》 | 8 | | 议案 | 2、《关于与关联方签署许可协议之补充协议的议案》 | 10 | | 议案 | 3、《关于将部分项目节余资金用于暂时补充流动资金以及调整部分募投项目拟投 | | | | 入募集资金金额的议案》 | 11 | 2 三生国健药业（上海）股份有限公司 2025 年第二次临时股东大会会议须知 为了维护全体股东的合法权益，确保股东大会的正常秩序和议事 效率，保证大会的顺利进行，根据《中华人民共和国公司法》《中华 人民共和国证券法》《上市公司股东会规则》以及《三生国健药业（上 海）股份有限公司章程》（以下简称"《公司章程》"）、《三生国 健药业（上海）股份有限公司股东大会议事规则》 ...

Group 1 - The innovative drug concept stocks are experiencing a downturn, with several companies seeing declines of over 5% [1] - Notable companies affected include Sanofi, Haisun Pharmaceutical, Huisheng Biological, Rejing Biological, Haichuang Pharmaceutical, and Ruizhi Pharmaceutical [1] - Other companies such as Saiseng Pharmaceutical and Hasan Union are also following the downward trend [1]