Economic Indicators - US Manufacturing and Services ISM data fell below consensus, indicating potential slowing growth[1] - Non-Farm Payrolls (NFP) growth slightly exceeded expectations, but the unemployment rate remained flat, suggesting a mixed economic outlook[1] Monetary Policy and Interest Rates - The European Central Bank (ECB) reduced the deposit rate by 25 basis points and lowered its 2026 inflation projection to 1.6%[1] - Yield curves flattened across regions, with US bonds experiencing a sell-off due to higher front-end and real rates[2] Foreign Investment and Currency Forecasts - Section 899 highlighted concerns regarding foreign investors' appetite for US assets, potentially leading to further USD weakness[3] - EUR/USD forecasts were adjusted to 1.17, 1.20, and 1.25 for 3, 6, and 12 months respectively[3] Equity Market Reactions - US high dividend yield (DY) stocks slightly underperformed compared to the broader market, while non-US stocks with high US exposure showed muted returns[4] - Estimated impact on STOXX 600 earnings is projected at 5% by year four, with companies having options to mitigate this impact[4] Asset Allocation Strategy - The firm maintains a neutral stance in asset allocation, advocating for increased international diversification in equities and bonds[7] - US equities have partially recovered year-to-date underperformance, primarily driven by mega-cap stocks, while the S&P 500 equal weight remains flat against global indices[7]

Defence Spending Outlook - The UK government plans to increase defence spending to 2.5% of GDP by 2027, up from 2.3% in 2024, with a long-term goal of reaching 3.0% in the next Parliament[4] - This increase is expected to generate a near-term demand boost of approximately 0.15%[6] - Additional demand from increased European defence spending could raise demand by a further 0.1%[19] Economic Implications - The fiscal impulse model indicates that the increase to 2.5% of GDP will boost demand, but broader fiscal consolidation keeps the overall fiscal impulse negative[14] - If defence spending reaches 3.0% of GDP, the demand boost could be limited to an additional 0.15% due to potential tax increases and spending restraint in other departments[34] - The long-term impact on GDP growth is contingent on whether increased spending enhances supply capacity, particularly through R&D investments[41] Funding and Fiscal Constraints - The increase in defence spending will be financed by cuts to the foreign aid budget, which should not significantly offset the demand impact[14] - The Chancellor has limited fiscal headroom of £9.9 billion against the deficit rule, restricting the ability to increase day-to-day spending without offsetting measures[28] - The government may need to consider tax increases or spending cuts in other areas to fund further increases in defence spending[33]

Economic Indicators - Global hard data shows resilience while soft data normalizes, indicating a stable economic environment[3] - The Global Financial Conditions Index (FCI) eased primarily due to equities, short rates, and credit spreads, reflecting tighter financial conditions[8] - The Current Activity Indicator (CAI) for May shows a global increase of +1.6% month-on-month annualized, with emerging markets leading at +3.6%[12][47] GDP Forecasts - Goldman Sachs revised its GDP forecast for 2025, with notable increases in Japan and the Euro Area, while Canada saw a decrease[10][93] - The change in GDP forecast since 60 days ago shows Taiwan with an increase of +1.9 percentage points, while Turkey increased by +1.2 percentage points in the last week[10][93] Inflation Trends - The trimmed core inflation forecast for 2025 indicates a decrease across several regions, with Turkey showing the largest increase of +1.9 percentage points[88][90] - The inflation forecast for 2026 also reflects similar trends, with notable adjustments in various countries, including a decrease in the UK and Canada[90][91] Labor Market Insights - The jobs-workers gap has shown significant changes since December 2019, with the US and UK experiencing notable declines[21][70] - Wage trackers indicate a steady increase in wage growth across G10 economies, with the US showing a composition-adjusted increase[63][64]

9 June 2025 | 3:53PM EDT Americas Media TV Viewership Tracker: L3 through week ending June 8th, 2025 We refresh our Nielsen TV ratings tracker for our US Media coverage (DIS, CMCSA, PARA, WBD, FOXA) that includes traditional ACM (average commercial minute) prime time and total day ratings across broadcast and cable. This edition focuses on the C3 cable and broadcast ratings through week ending May 25th, 2025 (14 day delay), and L3 cable ratings through week ending June 8th, 2025. Prime time commercial ratin ...

Investment Rating - The report assigns a "Buy" rating to Summit Therapeutics Inc. (SMMT) with a 12-month price target of $41, indicating an upside potential of 90.2% from the current price of $21.56 [9]. Core Insights - The report highlights positive Phase 3 (HARMONi) data for ivonescimab combined with chemotherapy in second-line EGFR-mutant non-small cell lung cancer (NSCLC), suggesting that data from China can be translated to Western patients [2][3]. - Management anticipates full data from the Akeso Phase 3 HARMONi-6 study, which shows ivonescimab's benefits in first-line squamous NSCLC, to be presented at the ESMO meeting in October 2025 [2][5]. - Recent overall survival (OS) data from the HARMONi-2 study supports the translatability of ivonescimab's progression-free survival (PFS) benefits to OS, with management expecting statistically significant OS results in ongoing global studies [6][7]. - The company plans to explore partnership opportunities to accelerate the global development of ivonescimab and expand its indications beyond NSCLC [7]. Summary by Sections Phase 3 Trials - The global Phase 3 HARMONi trial involves approximately 420 patients and compares ivonescimab against placebo in combination with chemotherapy for second-line treatment of non-squamous EGFRm NSCLC [3][5]. - Initial topline data from the trial indicates a statistically significant PFS hazard ratio of 0.52, suggesting a strong efficacy profile [5]. Business Development - Management is focused on identifying partnership opportunities to facilitate rapid global development of ivonescimab, emphasizing the need for collaboration with larger players in the industry [7]. - The competitive landscape for PD-1/L1xVEGF therapies is seen as validating for the class, with SMMT aiming to maintain its leadership position [6][7]. Future Outlook - The report anticipates that the upcoming full data from the HARMONi-6 study will provide clarity on the efficacy of ivonescimab in combination with chemotherapy compared to existing standards of care [6]. - Management plans to provide updates on the timelines for the HARMONi-3 study in the second half of 2025, with strong enrollment noted to date [6].

TSMC (2330.TW/TSM) Risk/reward now skewed to the upside June 2025 Bruce Lu Goldman Sachs (Asia) L.L.C., Taiwan 886-2-2730-4185 bruce.lu@gs.com For Reg AC certification and other important disclosures, go to https://research.gs.com and https://www.gs.com/research/hedge.html. c45a43530f604d12bcb9a82b5aa6b9f6 Improving sentiment with limited earnings downside Supply chain mismatch mitigated; AI order cut now seems less likely Limited earnings downside from here 70 118 322 585 923 1,287 69% 173% 82% 58% 200% 18 ...

Investment Rating - The report does not explicitly provide an investment rating for the industry Core Insights - China's trade growth moderated in May, with exports increasing by 4.8% year-over-year (yoy) and imports decreasing by 3.4% yoy, falling short of consensus expectations [1][9] - The decline in exports to the US continued, with a sequential decline of 17% after seasonal adjustment, following a 25% decline in April [1][9] - The trade surplus for May was reported at US$103.2 billion, an increase from US$96.2 billion in April [1][3] Summary by Sections Trade Growth - Year-over-year trade growth in May showed exports rising by 4.8% yoy compared to 8.1% yoy in April, while imports fell by 3.4% yoy from a decline of 0.2% yoy in April [2][9] - Sequentially, exports decreased by 0.7% non-annualized in May, while imports dropped by 6.3% non-annualized [2][9] Regional Analysis - Exports to the US fell significantly, with a 34.5% yoy decline in May, while exports to the EU rose by 12.0% yoy [10] - Imports from the US also declined by 18.1% yoy, while imports from the EU remained roughly unchanged [10] Product Categories - Export values for housing-related products fell, with home appliances declining by 8.9% yoy, while automobile exports increased by 13.7% yoy and chip exports rose by 33.4% yoy [11] - Import values for energy products and metal ores saw notable declines, with crude oil imports falling by 22.1% yoy [12]

Investment Rating - The report does not explicitly state an investment rating for the industry Core Insights - CTAs are currently net short on RTY by $1.8 billion, with expectations of buying approximately $2.5 billion in the next week and $5.2 billion in the next month [2] - The GS Equity Fundamental L/S Performance Estimate increased by 1.29% from May 30 to June 5, outperforming the MSCI World TR which rose by 0.73% during the same period [2] - A significant portion of stocks (approximately 40%) is expected to enter a blackout period starting around June 16, estimated to last until July 25 [2] Summary by Relevant Sections CTA Corner - Over the next week, buyers are expected to contribute $2.77 billion, with $2.40 billion directed into the US market [5] - For the upcoming month, buyers are projected to contribute $8.19 billion, with $5.79 billion into the US [5] Key Levels for SPX - Short-term pivot level is at 5786, medium-term at 5793, and long-term at 5554 [5] Market Flows - Global equities saw net buying for the fifth consecutive week, with long buys outpacing short sales at a ratio of 1.7 to 1 [40] - Hedge funds have net bought US equities for five weeks, primarily driven by long buys in single stocks [42] - The US Energy long/short ratio is currently at 1.46, the highest level since October 2023 [42] Sentiment Indicators - The GS Sentiment Indicator decreased despite a market rally of 1.5%, indicating cautious investor sentiment [60] - The SPX put-call skew experienced a significant decline, suggesting increased demand for upside through call options [65]

Investment Rating - The report does not explicitly state an investment rating for the transportation industry or specific companies within it. Core Insights - There has been a notable uptick in inbound freight from China to the US, with container rates from China/Asia to the West Coast surging by 94% due to tightened supply and demand conditions [1][10][37] - The ongoing uncertainty regarding tariffs and their impact on shipping plans for the upcoming peak seasons creates challenges for shippers [2][7] - The report suggests that if consumer demand remains strong, the anticipated surge in freight may not fully meet the needs of retailers during peak seasons [2] Summary by Sections Freight Flow Trends - Laden vessels from China to the US increased by 9% week-over-week, with a year-over-year decline of 25%, showing signs of recovery [4][15] - Port Optimizer data indicates a projected 26% increase in expected imports into the Port of Los Angeles in the coming weeks [4][41] - Overall throughput at Chinese ports remains solid, up 11% year-over-year, indicating resilience in trade patterns despite tariff impacts [4][30] Tariff Impact and Future Scenarios - The report outlines two potential scenarios for 2025: a pull-forward surge ahead of a tariff pause or a slowdown in orders due to uncertainty [7][14] - Analysts lean towards the first scenario, suggesting a potential surge in freight demand if consumer spending remains robust [8][14] - The report highlights the challenges posed by high tariffs and the end of de-minimis exemptions for e-commerce, which could dampen demand [9][10] Stock Recommendations - Freight forwarders such as EXPD and CHRW are expected to benefit from increased volatility and potential surges in freight demand during the tariff pause [12][14] - Parcel companies like UPS and FedEx are also positioned to gain from increased air freight demand, particularly if imports spike [12][14] - The report notes that intermodal traffic has declined by 3% year-over-year, reflecting ongoing challenges in the supply chain [10][47] Container Rates and Shipping Dynamics - Container rates have seen a significant increase of 94% due to heightened demand for shipping capacity during the tariff pause [10][37] - Despite recent increases, year-over-year comparisons for ocean rates remain challenging, with rates down 9% compared to the previous year [12][14] - Planned TEUs into the Port of Los Angeles rose by 45% sequentially, indicating a potential recovery in shipping activity [41][44]

Investment Rating - The report maintains a "Buy" rating on Trip.com Group and Tongcheng Travel Holdings, indicating a positive outlook on their market positions and growth potential [31][33]. Core Insights - JD is entering the travel booking industry, enhancing its competitive pricing on airfares and hotel bookings, and expanding its business development team by recruiting talent from other OTAs [1][2]. - The travel booking market in China is valued at Rmb4.5 trillion, with a higher online penetration rate of 53%, but it is less sizeable compared to e-commerce and local services [3][7]. - JD's strategy includes leveraging synergies with its existing e-commerce and local services, aiming for cross-selling opportunities [7][10]. - The competitive landscape is intensifying, with JD's entry potentially impacting the revenue growth and profit margins of established players like Trip.com and Tongcheng [10][31]. Market Analysis - The travel booking market is characterized by lower consumption frequency, with the average Chinese passenger traveling four times a year and spending Rmb1,000 per trip [3]. - JD's hotel listings primarily range from Rmb100-500 in average daily rates (ADR), offering discounts of 10-22% for existing users and 12-30% for new users [8][19]. - The report highlights that JD's competitive pricing is more attractive for new users compared to existing ones, where it tends to be 5-10% above its peers [8][17]. Competitive Dynamics - The report notes that JD's reliance on existing OTAs for hotel and airline inventory presents a significant entry barrier, as most hotel rooms in China are already contracted with established OTAs [10][9]. - The management of Trip.com and Tongcheng believes their comprehensive nationwide coverage gives them a competitive edge in supply chain management against new entrants like JD [10][9]. - JD is expected to adopt a gradual approach in expanding its travel segment, prioritizing investments in high-frequency food delivery services over lower-frequency travel businesses [10][9]. Financial Projections - The report anticipates potential downside risks to earnings estimates for Trip.com and Tongcheng if competition intensifies, projecting a 13% downside risk under certain scenarios [10][29]. - Trip.com is projected to achieve a revenue growth of 14% year-on-year, while Tongcheng is expected to benefit from its focus on short-haul domestic travel [29][31].