Core Viewpoint - The article discusses the increasing focus on low-volatility and stable value investments in 2026, particularly in the context of a significant wave of long-term deposits maturing and the prevailing low interest rate environment [1][3][4]. Group 1: Investment Environment - A surge in resident fixed deposits occurred from 2022 to 2023, coinciding with a weakening stock market and declining expectations [3]. - The unprecedented low interest rates faced by maturing funds create a need for reallocation, which is expected to drive demand for various fixed income plus (固收+) products [4][6]. - The investment landscape for fixed income products in 2026 is anticipated to be more challenging than in 2025 due to the current low interest rates and stock market levels around 4000 points [6]. Group 2: Fund Performance - A selection of "fixed income plus" funds was made based on criteria such as positive returns since 2020, fund size over 500 million, and equity exposure below 30% [6]. - The top-performing funds since 2020 include: - 华夏智泰LOF (160323.SZ) with a return of 73.99% and a fund size of 32.59 billion [7]. - 华泰柏瑞新利混合A (001247.OF) with a return of 67.84% [7]. - 招商添利两年债券 (006150.OF) with a maximum drawdown of only 1.09% [36]. - 华夏磐泰LOF has shown a net value growth of 73.9% since 2020, outperforming the沪深300 index by 20 percentage points in 2018 [10][11]. Group 3: Fund Characteristics - 华夏磐泰 LOF has maintained an average equity allocation of 26.7% since 2020, with a significant bond allocation averaging 81.5% over the past 23 quarters [13]. - The fund's defensive strategy focuses on bonds, primarily financial bonds and corporate bonds, while keeping convertible bonds and asset-backed securities at lower levels [15]. - The fund's top equity holdings include industry leaders such as 宁德时代 and 立讯精密, with the largest single stock holding being 工业富联 at only 2.74% of the equity portfolio [19]. Group 4: Other Notable Funds - 安信稳健增值混合A (001316.OF) has achieved a return of 34.2% since 2020, with a maximum drawdown of 7.2% [24]. - 安信新趋势混合A (001710.OF) has a return of 29.1% and a maximum drawdown of only 3.2% [24]. - 招商添利两年债券 has consistently outperformed its benchmark with an annualized return of 6.8% since inception [38].

Group 1 - In 2025, the IPO activity of biopharmaceutical companies rebounded, with 21 companies successfully going public, including 18 on the Hong Kong Stock Exchange, raising approximately HKD 23.5 billion [2] - The Hong Kong biopharmaceutical sector saw a strong rebound in 2025, contrasting with 2022 when all 21 newly listed companies experienced a decline in share price [2] - In 2025, Heng Rui Medicine raised a record HKD 11.3 billion in a single IPO, showcasing its strong innovative drug development capabilities with 24 approved first-class innovative drugs and over 100 products in clinical development [2] Group 2 - Heng Rui Medicine's revenue for 2022, 2023, and 2024 was CNY 21.275 billion, CNY 22.820 billion, and CNY 27.985 billion respectively, with net profits of CNY 3.906 billion, CNY 4.302 billion, and CNY 6.337 billion, maintaining a gross margin of over 83% [3] - In the first three quarters of 2025, Heng Rui Medicine achieved revenue of CNY 23.188 billion, a year-on-year increase of 14.85%, and a net profit of CNY 5.751 billion, up 24.50% year-on-year, indicating strong performance [3] - Ying En Bio's stock surged over 110% on its first day of trading, focusing on innovative drugs for cancer and autoimmune diseases, with two core products entering the global antibody-drug conjugate (ADC) industry chain [3] Group 3 - In 2025, three companies, including Biobetter and Baiaosaitu, went public on the Sci-Tech Innovation Board and the main board, raising a total of CNY 5.466 billion [4] - Baiaosaitu's successful listing on the Sci-Tech Innovation Board marks a significant step in its capital market strategy, having previously listed on the Hong Kong Stock Exchange [4] - The biopharmaceutical sector is entering a new growth phase since 2020, with a more mature industrial foundation and a longer-lasting trend, as capital is increasingly willing to invest in truly innovative technologies with clinical value [4]

资料图。本文来 源 ： 澎湃新闻 记者 李潇潇 恒瑞前董事长周云曙履新先声药业，曾在恒瑞工作 超25年 从恒瑞离职四年多后，周云曙履新港股创新药企先声药业（2096.HK）。 据"江苏省肿瘤医院官方平台"2025年12月30日发布的消息，江苏省肿瘤医院（南京医科大学附 属肿瘤医院）"江苏省恶性肿瘤先进诊疗重点实验室"与先声药业"神经与肿瘤药物研发全国重点 实验室"正式签署战略合作协议。出席此次会议的嘉宾包括先声药业集团总裁周云曙。 周云曙出席江苏省肿瘤医院活动 周 云 曙 曾 是 恒 瑞 医 药 （ 600276 ） 元 老 级 人 物 ， 还 曾 担 任 恒 瑞 医 药 董 事 长 。 先 声 药 业 （2096.HK）尚未就此次人事变动发布官方消息。 澎湃新闻记者从业内人士处获悉，目前对周云曙的任命是江苏先声药业有限公司总裁。根据先 声药业年报显示，江苏先声药业有限公司为上市公司先声药业集团有限公司的间接全资附属公 司。 根据恒瑞医药2020年报资料，2003年至2020年1月，周云曙为公司董事、总经理，作为董事长、 总经理，其任职终止时间原本为2023年1月15日。但2021年7月9日，恒瑞医药公告称， ...

从恒瑞离职四年多后，周云曙履新港股创新药企先声药业（2096.HK）。 据"江苏省肿瘤医院官方平台"2025年12月30日发布的消息，江苏省肿瘤医院（南京医科大学附属肿瘤医 院）"江苏省恶性肿瘤先进诊疗重点实验室"与先声药业"神经与肿瘤药物研发全国重点实验室"正式签署 战略合作协议。出席此次会议的嘉宾包括先声药业集团总裁周云曙。 公开资料显示，周云曙出生于1971年，高级工程师、博士，1995年毕业于中国药科大学，1995年起在江 苏恒瑞医药股份有限公司工作，历任发展部副部长、副总经理、总经理、董事，先后分管过研发、人力 资源、企业运营等业务，并于2014年开始主抓销售工作。 根据恒瑞医药2020年报资料，2003年至2020年1月，周云曙为公司董事、总经理，作为董事长、总经 理，其任职终止时间原本为2023年1月15日。但2021年7月9日，恒瑞医药公告称，董事会近日收到公司 董事长、总经理周云曙的辞职报告，周云曙因身体原因申请辞去公司董事长、总经理以及董事会专门委 员会相应职务，创始人孙飘扬回归。 2022年9月，中国证券监督管理委员会黑龙江监管局公布的一则行政处罚决定书显示，周云曙在2020年 涉嫌内幕 ...

Core Insights - The successful IPO of Insilico Medicine (stock code: 3696.HK) on the Hong Kong Stock Exchange marks the largest fundraising in the Hong Kong biopharmaceutical sector this year, highlighting the capital market's recognition of AI-driven drug development [1] - Insilico Medicine's partnership with MediXis (stock code: 688202.SH) has gained new attention and industry imagination, emphasizing the critical role of MediXis as a preclinical research service provider in the AI drug development wave [1] Group 1: AI and CRO Integration - The collaboration between Insilico Medicine and MediXis has transformed the drug development paradigm, with MediXis demonstrating efficient and stable delivery capabilities in various tumor projects, enabling rapid clinical progression of AI-discovered molecules [2] - This partnership represents a deep integration of service procurement and technical processes, with Insilico leveraging its Pharma.AI platform for breakthroughs in target discovery and molecular generation, while MediXis provides comprehensive preclinical services [2] Group 2: Expansion of Services and Capabilities - By mid-2025, MediXis has empowered approximately 588 IND approvals, with projects in collaboration with Insilico serving as successful examples of the "AI-driven development + professional CRO execution" model, enhancing both companies' efficiency and experience in AI drug development [3] - MediXis has expanded its AI drug discovery service platform, exploring new therapies such as PROTAC, ADC, nucleic acid drugs, and cell and gene therapies, showcasing its comprehensive strategic layout and capability evolution [4] Group 3: Industry Leadership and Global Strategy - MediXis has solidified its industry-leading position through systematic capability building, achieving breakthroughs in service granularity, technological foresight, compliance systems, and global expansion [4] - The company has successfully obtained various GLP qualifications and enhanced its competitiveness in international preclinical research, with a growing proportion of revenue from overseas clients and increased new order amounts [5] Group 4: Future Outlook - The successful listing of Insilico Medicine signifies a milestone in the capitalization and industrialization of AI drug development, positioning MediXis as an indispensable verification and efficiency engine within the AI drug development ecosystem [6] - As the demand for high-efficiency and high-reliability preclinical research services continues to grow, MediXis is well-positioned to strengthen its leading role as a preclinical research enabler by deepening collaborations with cutting-edge technology companies like Insilico [6]

江苏恒瑞医药股份有限公司 关于回购公司 A 股股份的进展公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2026-001 2025 年 12 月，公司通过上海证券交易所交易系统以集中竞价交易方式回购股 份 0 股。截至 2025 年 12 月 31 日，公司本次股份回购方案累计通过上海证券交易 所交易系统以集中竞价交易方式回购股份 889.87 万股，已回购股份占公司总股本 的比例为 0.13%，购买的最高价为人民币 70.00 元/股，最低价为人民币 59.32 元/ 股，已支付的总金额为人民币 59,521.63 万元（不含交易费用）。 上述回购符合相关法律法规的规定及公司既定的回购股份方案。 三、 其他事项 公司将严格按照《上市公司股份回购规则》《上海证券交易所上市公司自律监 管指引第 7 号——回购股份》等相关规定，在回购期限内根据市场情况择机做出 回购决策并予以实施，同时根据回购股份事项进展情况及时履行信息披露义务， 敬请广大投资者注意投资风险。 特此公 ...

Investment Rating - The report indicates a positive investment outlook for the innovative pharmaceutical and supply chain industry in China, highlighting a shift towards companies with core technological platforms and clear clinical value [5][9]. Core Insights - The year 2025 is identified as a pivotal moment for China's innovative pharmaceutical industry, characterized by a trend of "differentiation" where capital is increasingly directed towards companies with substantial technological capabilities and global potential [5][6]. - The policy environment has transitioned from merely encouraging innovation to providing systematic and precise guidance throughout the entire drug development lifecycle, enhancing the industry's overall efficiency and quality [9][20]. - The report emphasizes the importance of identifying true value in the industry amidst a backdrop of significant changes, with a focus on product strength, platform capabilities, and global operational abilities [6][11]. Summary by Sections 1. Industry Policy and Capital Market Trends - The Chinese innovative pharmaceutical policy system has entered a new phase of systematic guidance, covering all stages from research and clinical trials to market access and payment [17][25]. - Over 300 national and local policies have been issued in 2025, with a focus on enhancing clinical value and high-quality development [18][20]. - Capital is increasingly concentrated on late-stage projects and cutting-edge technologies, with a notable increase in BD transactions and a shift towards more complex collaboration models [9][26][28]. 2. Product and Technology Innovations - Significant breakthroughs in clinical and commercial value are expected in 2025, particularly in areas such as ADCs, bispecific antibodies, and cell therapies [10][11]. - The report highlights the emergence of new opportunities driven by existing pain points, particularly in CAR-T therapies and the development of universal CAR-T solutions [12][14]. - The report also notes the rapid iteration of technologies and the differentiation of product offerings, with a focus on platform-based approaches gaining international recognition [12][14]. 3. Future Trends and Predictions - The report predicts a shift in technological paradigms, with a focus on clinical and commercial value realization in innovative therapies [13][16]. - The competitive landscape is expected to evolve from single-point breakthroughs to a more integrated global capability competition [13][16]. - Changes in payment systems are anticipated, with a move towards making innovative drugs essential rather than optional in healthcare [13][16].

Group 1 - The core point of the article is the appointment of Zhou Yunshu, a former senior executive at Heng Rui Medicine, as the president of Xiansheng Pharmaceutical Group, although the company later clarified that this information is not entirely accurate and no formal internal appointment has been made yet [1][3] - Zhou Yunshu has a long history with Heng Rui Medicine, having joined the company in 1995 and serving in various leadership roles, including general manager and chairman [4] - Zhou resigned from his positions at Heng Rui Medicine in July 2021 due to health reasons, and he was later involved in an insider trading case, resulting in a fine from the China Securities Regulatory Commission [4] Group 2 - Xiansheng Pharmaceutical is a well-established domestic pharmaceutical company focusing on areas such as neuroscience, oncology, and autoimmune diseases, and is also undergoing a transformation towards innovation [4] - In the first half of 2025, Xiansheng Pharmaceutical reported revenues of 3.585 billion yuan and a net profit attributable to shareholders of 604 million yuan, representing year-on-year growth of 15.14% and 32.20%, respectively [4] - The company's innovative drug business generated revenue of 2.776 billion yuan, a year-on-year increase of 26%, accounting for 77.4% of total revenue [4] - In 2025, Xiansheng Pharmaceutical announced three business development transactions, including licensing agreements for several drug candidates with AbbVie and other companies [5]

Investment Rating - The report maintains an "Overweight" rating for the innovative pharmaceutical and medical device industry chain [4][8]. Core Viewpoints - The report continues to recommend the innovative pharmaceutical and medical device industry chain, highlighting a selection of A-share and H-share stocks with an "Overweight" rating [2][8][11]. - The performance of the pharmaceutical sector in December 2025 was weaker than the broader market, with the SW Pharmaceutical Biotechnology index declining by 4.1% compared to a 2.1% increase in the Shanghai Composite Index [18][30]. - The report notes that the premium level of the pharmaceutical sector relative to the entire A-share market is currently at a normal level, with a relative premium rate of 63.2% as of December 31, 2025 [29][32]. Summary by Sections A-Share Recommendations - The report lists the following A-share stocks with an "Overweight" rating: - 恒瑞医药 (Hengrui Medicine) - 科伦药业 (Kelun Pharmaceutical) - 华东医药 (East China Pharmaceutical) - 恩华药业 (Enhua Pharmaceutical) - 特宝生物 (Tebao Biological) - 京新药业 (Jingxin Pharmaceutical) - 益方生物 (Yifang Biological) - 药明康德 (WuXi AppTec) - 泰格医药 (Tigermed) - 乐普医疗 (Lepu Medical) - 联影医疗 (United Imaging) - 微电生理 (Microelectrophysiology) [8][9]. H-Share Recommendations - The report maintains an "Overweight" rating for the following H-share stocks: - 翰森制药 (Hansoh Pharmaceutical) - 三生制药 (3SBio) - 科伦博泰生物 (Kelun-Botai Biological) - 康方生物 (CanSino Biologics) - 映恩生物 (InnoCare Pharma) - 百济神州 (BeiGene) [11][12]. Performance Analysis - The report indicates that the 国泰海通医药 monthly portfolio outperformed the pharmaceutical index in December 2025, with an average decline of 1.8% compared to a 3.9% decline in the overall pharmaceutical index [14][15]. - The report highlights the best-performing stocks in December 2025, with 泰格医药 (Tigermed) increasing by 11.2%, 特宝生物 (Tebao Biological) by 7.5%, and 惠泰医疗 (Huitai Medical) by 3.9% [15][18].

Policy Guidance - The policy environment has shifted from encouraging innovation to systematic and precise guidance on "how to innovate," providing a supportive framework for projects with original innovation capabilities[9] - Over 300 national and local policies related to innovative drugs and supply chains were issued from January to October 2025, with a notable increase in policy density in October alone[18] - The National Medical Products Administration (NMPA) has published over 80 technical guidelines covering various stages from R&D to post-marketing monitoring, focusing on patient-centered approaches and unmet clinical needs[20] Capital Market Trends - The total financing amount in the innovative drug and supply chain sector reached $3.914 billion in the first ten months of 2025, slightly down from 2024 but over 60% of the total for 2023[28] - Capital is increasingly concentrated in later-stage projects (B round and beyond), with B, C, and D rounds collectively accounting for 39% of financing activities[30] - The number of IPOs in the innovative drug sector increased to 19 in the first ten months of 2025, indicating a recovery compared to the previous year[45] Pipeline Competitiveness - 2025 is marked by significant clinical and commercial breakthroughs in China's innovative drug sector, with domestic ADC and bispecific antibody products receiving approvals and showcasing leading clinical data at international conferences[10] - The emergence of new technologies such as CAR-T and TIL therapies is accelerating, with policies supporting their standardized development and addressing accessibility and cost challenges[2] M&A and BD Activities - Over 87 M&A activities occurred globally in the innovative drug sector in 2025, with multinational corporations focusing on acquiring cutting-edge technologies[54] - Domestic M&A activity has slowed compared to 2024, with a focus on internal integration and strategic enhancements by local companies[54]