以下文章来源于证券之星 ，作者刘凤茹 证券之星 . 证券之星始创于1996年，是国内领先的金融信息及综合服务平台。关注证券之星，即时获取有价值的财经资讯。 来源｜证券之星 作者｜刘凤茹 当前，全国正经历一个明显的流感高发季，活动水平陡升，南方地区尤为严重。作为预防流感最经济有效的手段，流感疫苗需求激增。这一公共卫生 事件迅速传导至市场，导致广州、西安、常州、济南等多地社区卫生服务中心出现流感疫苗"阶段性紧张"甚至缺货的现象。 需求旺盛下，行业龙头华兰疫苗(301207.SZ)因拥有年产1亿剂的产能，并在近期加快了批签发速度引发关注。市场也给予热烈回应，公司股价在一 个多月内区间涨幅超过30%。 证券之星注意到，供需两旺的表象之下，暗藏华兰疫苗业绩"寒意"：今年前三季度，公司营收与归母净利润双双大幅下滑，降幅分别达15.81%和 50.51%，呈现"越卖越亏"的尴尬局面。 这背后，始于2024年中的行业"价格战"。华兰疫苗曾期望"以价换量"稳住规模，但现实是"价"降"量"未足，毛利率和净利率显著下滑。当下需求高 峰中，华兰疫苗能否将短暂的市场需求转化为实实在在的业绩回暖，要打上一个问号。 01 流感疫苗出现阶段 ...

美洲地区的麻疹疫情此前就出现过反复。2018至2019年，委内瑞拉和巴西曾暴发大规模麻疹疫情，直到 2024年，美洲才重新成为"无麻疹地区"。泛美卫生组织主任巴博萨10日再次强调推广疫苗接种的重要 性，"去年美洲地区疫苗接种率为79%，尽管这个比例较前些年有所提升，但还是太低了"。（甄翔） 在泛美卫生组织官宣加拿大"麻疹消除国"地位丧失后，美国布朗大学传染病专家努佐直言："此事让人 感到失望和担忧，像加拿大这样资源雄厚的国家根本就不该丧失'麻疹消除国'地位。" 美联社根据近期麻疹疫情趋势判断，美国在未来极有可能丧失"麻疹消除国"地位。数据显示，今年美洲 地区共出现近1.26万个麻疹病例，较去年飙升30倍，疫情主要集中在加拿大、美国和墨西哥。美国疾控 中心统计，今年美国共出现44波麻疹疫情，共涉及1600多个麻疹确诊病例。目前全美只有9个州尚未出 现麻疹疫情。 【环球时报综合报道】加拿大公共卫生署10日发表声明确认，由于境内同一毒株的麻疹病毒持续传播超 过一年，美洲区域国际卫生机构——泛美卫生组织已正式通知加拿大，该国失去"麻疹消除国"地位。据 加拿大广播公司报道，该国已报告5100余起麻疹病例，并有两起死亡案 ...

Core Viewpoint - The inclusion of the HPV vaccine in China's national immunization program starting from November 10, 2025, will allow eligible residents to receive the vaccine for free, significantly enhancing public health efforts against cervical cancer and related diseases [1][2][4]. Group 1: Policy and Implementation - The HPV vaccine will be provided free of charge to girls born on or after November 10, 2011, who are 13 years old, with a recommended two-dose schedule [4][6]. - The addition of the HPV vaccine increases the total number of vaccines in the national immunization program to 15, which aims to improve vaccination rates and public health [2][4]. Group 2: Market Impact - The procurement price of the bivalent HPV vaccine has decreased significantly, with a reported price of 86 yuan per dose in March 2024 and a budgeted price of 27.5 yuan per dose for 2025 [5]. - The government’s centralized procurement is expected to drive a substantial increase in HPV vaccine sales and market penetration, benefiting companies like Watson Bio, which has sufficient production capacity to meet demand [5][6]. Group 3: Health Benefits and Efficacy - Vaccination can prevent over 70% of cervical cancer cases and reduce the incidence of other HPV-related diseases, as evidenced by experiences from other countries [4][6]. - Research indicates that girls aged 9-14 produce antibody levels more than twice that of those over 15 when vaccinated, making this age group a strategic target for vaccination [6][9]. Group 4: Vaccine Options and Recommendations - There are three types of HPV vaccines available: bivalent, quadrivalent, and nonavalent, with the nonavalent vaccine providing the broadest protection against various HPV strains [7][9]. - The guidelines suggest that women who have completed the bivalent or quadrivalent vaccination do not need to receive the nonavalent vaccine unless they choose to do so based on personal circumstances [9].

Core Points - The National Health Commission of China announced that the HPV vaccine will be included in the national immunization program starting November 10, 2025, allowing girls aged 13 and above to receive two doses of the bivalent HPV vaccine for free [1][3] - The decision comes in response to the rising incidence and mortality rates of cervical cancer in China, particularly among younger women, highlighting the importance of HPV vaccination in preventing high-risk HPV infections and related diseases [3][4] - The bivalent HPV vaccine, produced by two domestic manufacturers, Xiamen Wantai and Watson Biotech's Zairun Biotech, has received prequalification from the World Health Organization, confirming its safety and efficacy [3][4] Summary by Sections Vaccination Policy - The notification specifies that only girls born after November 10, 2011, will be eligible for free vaccination, without setting an upper age limit for vaccination [4] - The World Health Organization recommends that the optimal age for HPV vaccination is between 9 and 15 years, which corresponds to the upper grades of elementary school to junior high school in China [4][5] Implementation and Logistics - Local health departments are required to collaborate with education and health authorities to assess the target population and previous vaccination records, ensuring accurate vaccine demand statistics [4] - Training for vaccination personnel will be conducted to prepare for the implementation of the immunization program, including management and monitoring of vaccine usage [4][5] Future Implications - Achieving a 90% vaccination rate among girls is essential for the goal of eliminating cervical cancer, although specific guidelines on vaccination arrangements and targets have yet to be released [5][6] - The inclusion of the HPV vaccine in the national immunization program is seen as a significant step towards reducing cervical cancer cases in the future, with potential long-term public health benefits [6]

Core Viewpoint - The Chinese government has announced the inclusion of the HPV vaccine in the national immunization program, providing free vaccinations for girls born after November 10, 2011, starting from November 10, 2025 [1] Group 1 - The announcement was made by seven ministries, including the National Health Commission and the Ministry of Education [1] - The program will offer two doses of the bivalent HPV vaccine, with a six-month interval between doses [1] - The China Center for Disease Control and Prevention will be responsible for gathering vaccine demand information and conducting centralized procurement [1]

Core Viewpoint - A coalition of public health officials from major U.S. cities has issued a statement urging the public to get vaccinated against respiratory diseases as the high season approaches, criticizing federal officials for spreading misinformation about vaccines [1][2] Group 1: Vaccination Benefits - Vaccination has played a crucial role in eliminating deadly diseases, saving millions of lives, and ensuring the safe operation of schools, allowing children to socialize and participate in activities, while also enabling parents and caregivers to work with peace of mind [1] - Despite the significant benefits of vaccination, there is a decline in vaccination rates across many regions in the U.S., leading to an increase in outbreaks of serious diseases such as measles and polio [1] Group 2: Concerns Over Misinformation - Public health officials express deep concern over federal officials repeatedly spreading misinformation about vaccines, which they believe directly contributes to the decline in vaccination rates [1] - The recent changes made by the federal government regarding vaccination recommendations for children and adults are criticized as unnecessarily limiting public access to vaccinations [1] Group 3: Call to Action - The statement strongly urges the public to "filter out political noise" and consult trusted doctors, healthcare providers, or public health experts for appropriate vaccination plans [2] - The "Big City Health Alliance" is a forum mechanism involving public health officials from major U.S. cities, aimed at promoting communication and maintaining public health and safety [2]

Core Insights - Moderna's stock price increased by over 6.7%, reaching $29.17, following the CDC's announcement regarding new vaccination guidelines [1] Group 1: CDC Vaccination Guidelines - The CDC has introduced a new immunization plan for adults and children, incorporating COVID-19 vaccines into an "individualized decision-making" model [1] - The new guidelines recommend that young children receive the varicella (chickenpox) vaccine separately, rather than in combination with measles, mumps, and rubella vaccines [1] - Jim O'Neill, the acting director of the CDC, stated that the new policy restores informed consent to medical practice, allowing for better discussions between doctors and patients regarding vaccine risks and benefits [1] Group 2: Target Population for COVID-19 Vaccination - The updated guidelines emphasize that the benefits of COVID-19 vaccination are greater for high-risk individuals under 65, while low-risk individuals can decide with their doctors whether to get vaccinated [1]

Core Insights - Recent initiatives in various cities have launched promotional activities for shingles vaccines, offering significant discounts comparable to major sales events [1] - There is a growing concern among the public regarding the necessity of vaccinating older parents against shingles, especially considering the potential for reinfection after a previous episode [1][15] Group 1: Shingles Vaccine Promotion - Many cities have initiated shingles vaccine promotional activities, with prices slashed by half, making it more accessible to the public [1] - The promotional efforts are likened to major shopping events, indicating a strong push to increase vaccination rates [1] Group 2: Shingles Infection and Risks - Approximately one-third of individuals will experience shingles at least once in their lifetime, particularly those who had chickenpox in childhood [3] - The risk of developing shingles increases with age, especially for individuals over 50, due to declining immune function [10][13] - Chronic disease patients, such as those with diabetes or cardiovascular issues, face a significantly higher risk of severe shingles symptoms [8][10] Group 3: Vaccine Efficacy and Safety - The shingles vaccine is reported to provide at least 10 years of protection, with efficacy rates of 79-79% for adults over 50 during the 6th to 11th year post-vaccination [20] - Common side effects of the vaccine include localized redness and swelling, with most reactions being mild and self-resolving [17][18] - There are two types of shingles vaccines available in China, with different age recommendations and dosing schedules [24]

Group 1 - AI can assist in interpreting health check reports but should not be relied upon for authoritative diagnosis, as it may lack accuracy and context [1][2] - Anxiety disorders are real medical conditions that require proper treatment, rather than being dismissed as mere psychological weakness [2] - Vaccination schedules are scientifically determined and should not be delayed, as this can expose children to serious infectious diseases [3] Group 2 - Sunscreen is necessary even on cloudy days, as UV rays can penetrate clouds and cause skin damage [4] - The primary method to prevent heatstroke is adequate hydration, rather than consuming saltwater, which can lead to health risks if overdone [5] - The gender of a fetus is determined by the sperm's chromosomes and is not influenced by the mother's diet or body pH levels [6]

Core Insights - The vaccination rate for the pneumococcal conjugate vaccine (PCV) in China is significantly low at 7.3%, compared to the global average of 47.9% in 2019, leading to a high incidence of invasive pneumococcal disease (IPD) among children [1][4] - Pneumonia remains a major health threat, particularly for children under five, with China accounting for 12% of global cases, indicating a severe public health challenge [3][4] Vaccination and Disease Statistics - A national study indicated that from 2009 to 2019, pneumococcus accounted for 38.5% of acute respiratory infections in children under five in China [1] - Approximately 8,000 children under five die annually from pneumococcal diseases, with a mortality rate of 25% among those with pneumococcal meningitis [3] Challenges in Vaccination - The "six highs and one low" phenomenon describes the high rates of pneumococcal carriage, cases, complications, antibiotic resistance, and mortality, contrasted with the low vaccination rate [3] - Key challenges include inappropriate antibiotic use, high antibiotic resistance rates (46.1% multi-drug resistance among IPD patients), and the economic burden of treatment [3][4] Vaccine Hesitancy and Public Awareness - Vaccine hesitancy is identified as a significant barrier to increasing vaccination rates, stemming from a lack of scientific understanding regarding safety and efficacy [5][6] - Recommendations to address vaccine hesitancy include transparent communication, personalized education, and authoritative sources of information [6] Regional Disparities - There is a notable regional disparity in vaccination rates, with over 50% of PCV13 vaccinations reported from eastern regions, while central and western regions account for only 36.8% [7] - Improving vaccine accessibility in rural and remote areas is essential, with calls for enhanced public health infrastructure and education [7]