根据市场公开信息及8月21日披露的机构调研信息，知名私募大朴资产近期对4家上市公司进行了调研， 相关名单如下： 1）冰轮环境 （大朴资产参与公司业绩说明会） 调研纪要：2025年上半年公司实现营业收入31.2亿元，同比下滑7%，归母净利润2.66亿元，同比下降 20%，第二季度营收同比转增。总体上国内业务下游需求放缓，短期市场承压，实现营收21亿元；"向 海"战略顺利展开，海外业务显著增长30%，达到10.2亿元。公司提供压缩机和换热装置，覆 盖-271℃-200℃温度区间，产品广泛应用于多个领域，低温制冷板块营收17.3亿元，占比55%，暖通空 调板块营收12亿元，占比39%。顿汉布什公司和冰轮换热技术公司为数据中心提供冷却装备，服务国内 外多个数据中心项目，2024年7月推出升级版IDC专用新产品。公司研发核岛冷却、核能供热等技术， 服务多个核电站，拥有丰富的国内外案例，旗下顿汉布什公司是全球核岛制冷机服务商。公司贯彻双碳 战略，推出"工业全域热控综合解决方案"，实现余能高效收集与集约利用，拓展热泵应用场景。公司抽 调国内精干工程师增强海外技术力量，推进海外销售网络属地化建设，提升海外制造基地产能。 2） ...

Core Viewpoint - China Biopharmaceutical reported a 10.7% year-on-year revenue growth in 1H25, reaching 17.57 billion yuan, with adjusted net profit increasing by 101.1% to 3.09 billion yuan [1] Group 1: Financial Performance - 1H25 revenue and adjusted net profit accounted for 54.6% and 79.6% of the full-year forecast, respectively, with revenue proportion consistent with historical ranges [1] - The adjusted profit proportion significantly exceeded historical ranges due to the recognition of 1.35 billion yuan in dividends from Sinovac Biotech; excluding this, adjusted net profit would have grown approximately 13% year-on-year [1] - Revenue from innovative products grew robustly by 27.2% year-on-year to 7.80 billion yuan, representing 44.4% of total revenue, indicating sustained rapid growth in innovative products [1] Group 2: Innovation and R&D Pipeline - China Biopharmaceutical has built a rich innovation pipeline, with several candidates having global Top 3 or Best in Class potential; the acquisition of Lixin Pharmaceutical further strengthens its R&D capabilities [2] - TQB2868 (PD-1/TGF-β dual antibody) shows remarkable efficacy in first-line treatment of pancreatic cancer, with an ORR of 63.9%, significantly higher than first-line chemotherapy at 41.8% [2] - TQB6411 (EGFR/c-Met dual antibody ADC) has entered Phase I clinical trials, targeting the EGFR+ lung cancer market [2] Group 3: Overseas Licensing Potential - The company has multiple products with potential for overseas licensing collaborations, including TQC3721 (PDE3/4), TQB2868 (PD-1/TGF-β dual antibody), and others [3] - The recent acquisition of Verona Pharma by Merck for $10 billion highlights the significant market potential for PDE3/4 inhibitors, with TQC3721 being the second globally in development [3] Group 4: Upcoming Clinical Data - Several important clinical data readouts are expected in 2H25, including TQC3721 (PDE3/4) Phase II data for COPD and TQB2102 (HER2 dual antibody ADC) Phase Ib data for HER2+ breast cancer [4] - The company maintains a buy rating with a target price of 9.40 HKD, expecting revenue growth rates of +19.1% for 2025E and adjusted net profit growth of +81.3% for the same year [4]

Core Viewpoint - The core philosophy of the company is to meet unmet medical needs in the field of innovative drug development, as emphasized by the co-founder and CEO, Dr. Cui Jisong, during the company's tenth anniversary [2] Group 1: Company Background and Development - Dr. Cui Jisong has a solid research foundation, having obtained a PhD in molecular biology abroad and accumulated over a decade of experience in multinational pharmaceutical companies, which laid the groundwork for her entrepreneurial journey [3] - In 2015, the company was founded with a focus on differentiated paths in the innovative drug industry, particularly targeting hematological malignancies and autoimmune diseases, which have significant unmet needs [3] - The company's flagship product, Oubatinib (a BTK inhibitor), was initially designed for autoimmune diseases but showed great potential in treating hematological malignancies, thus enhancing research efficiency by covering two therapeutic areas [3][4] Group 2: Product Performance and Market Impact - Oubatinib has been approved for four hematological indications in China, with three of them included in the medical insurance system, marking it as the first BTK inhibitor approved for treating marginal zone lymphoma [4] - The sales revenue of Oubatinib reached 640 million yuan in the first half of the year, representing a year-on-year increase of 52.8%, contributing to a 74.3% increase in the company's total revenue, which reached 730 million yuan [4] - Oubatinib is also the first BTK inhibitor globally to show efficacy in phase II clinical trials for systemic lupus erythematosus (SLE) and has initiated global phase III studies for progressive multiple sclerosis [4] Group 3: Internationalization Strategy - The company aims for true internationalization, which involves strategically integrating global top resources and establishing its position in global competition, rather than merely selling products abroad [5] - The company has adopted a "dual-track" internationalization strategy, focusing on independently controlling global rights to core products while leveraging open cooperation to expand resources [6] - Successful business development (BD) is based on partnerships with leaders in relevant fields, ensuring efficient project execution, with a long-term focus on value rather than short-term gains [6] Group 4: Future Goals - The company is entering its "2.0 phase," aiming for a product harvest period with 5 to 6 competitive innovative drugs expected to be approved in the next 3 to 5 years, significantly boosting commercialization revenue [7][8] - The company plans to push 3 to 4 core products into global markets, with Oubatinib's advancements in autoimmune disease treatment being a key driver for this strategy [8] - The company will continue to ensure sustained innovation by focusing on developing drugs with significant clinical differentiation, particularly in urgent areas like solid tumors, to build a unique competitive advantage [8]

Core Viewpoint - The company reported a strong performance in H1 2025, with revenue of 7.434 billion yuan (+14% YoY) and net profit of 3.135 billion yuan (+15% YoY), driven by significant growth in innovative drug sales [1] Group 1: Financial Performance - In H1 2025, innovative drugs generated revenue of 6.145 billion yuan (+22% YoY), accounting for 83% of total revenue [1] - Excluding collaboration revenue, product sales growth is estimated at approximately 13%, with innovative drug sales growth exceeding 20% [1] Group 2: Treatment Areas Growth - Oncology revenue reached 4.531 billion yuan (+1% YoY), driven by Amivantamab, Furmonertinib, and GSK milestone payments, with product sales growth exceeding 20% when excluding collaboration revenue [1] - Anti-infection revenue was 735 million yuan (+5% YoY), primarily driven by Adefovir [1] - CNS revenue was 768 million yuan (+5% YoY), mainly driven by Inalizumab [1] - Metabolic and other diseases revenue surged to 1.4 billion yuan (+142% YoY), driven by milestone payments from MSD and Regeneron [1] Group 3: Innovation and Business Development - The company has 8+1 innovative drugs and 12+2 indications approved, with over 40 new molecular entities in development, expecting innovative drug sales to exceed 10 billion yuan in 2025 [1] - The company has achieved at least one high-quality external authorization annually for three consecutive years, totaling 7.3 billion USD across four projects [1] - The company maintains a strong cash position, allowing for continued licensing of competitive pipelines to expand its product matrix [1] Group 4: Pipeline Updates - Amivantamab is expected to achieve full coverage across multiple treatment lines by the end of 2025, with projected sales of around 6 billion yuan [2] - HS-20093 is in Phase III clinical trials for SCLC and osteosarcoma, with GSK expected to start overseas trials in Q4 [2] - HS-20089 has entered Phase III for ovarian cancer, with GSK planning to initiate key overseas trials in 2026 [2] - HS-20094 is in Phase IIb/III for diabetes and weight loss, with commercialization expected in 2027 [2] - HS-20117 is in Phase III for combination therapy with Amivantamab, and a subcutaneous formulation is entering clinical development [2] - The company is actively expanding into dermatological and renal autoimmune diseases, with HS-10374 and HS-20137 in Phase III trials for psoriasis [2] Group 5: Profit Forecast and Valuation - The company forecasts net profit for 2025-2027 at 5.202 billion, 5.480 billion, and 5.727 billion yuan, respectively, with EPS estimates of 0.88, 0.92, and 0.96 yuan [3] - The company’s SOTP valuation is estimated at 252.944 billion HKD, with innovative drug DCF valuation at 248.338 billion HKD [3] - The target price is set at 42.53 HKD, reflecting an adjustment based on more optimistic collaboration revenue expectations [3]

Core Viewpoint - The company, Hansoh Pharmaceutical, reported a 14.3% year-on-year revenue growth in the first half of 2025, reaching 7.43 billion yuan, with a net profit attributable to shareholders increasing by 15.0% to 3.14 billion yuan, exceeding expectations due to the strong sales of innovative drugs and BD collaboration income [1] Group 1: Financial Performance - In the first half of 2025, the company's comprehensive gross margin remained stable at 91.1% [1] - The sales expense ratio decreased by 2.0 percentage points to 24.5% year-on-year [1] - R&D expenses increased by 20.4% to 1.44 billion yuan, with the R&D expense ratio rising from 18.4% in the first half of 2024 to 19.4% [1] Group 2: Innovative Drug and Collaboration Revenue - The revenue from innovative drugs and collaboration increased by 22.1% year-on-year to 6.15 billion yuan, contributing 82.7% to total revenue, up from 77.3% in the first half of 2024 [2] - The sales of oncology products reached 4.53 billion yuan, accounting for 61% of total revenue, driven by the sales growth of Ameluz and Huasenxinfu [2] - Two new indications for Ameluz received NMPA approval, which are expected to further boost sales [2] Group 3: Innovation Pipeline - The company has over 40 innovative drugs in development and more than 70 clinical trials ongoing, covering both oncology and non-oncology areas [3] - Eight innovative drugs entered clinical stages for the first time in the first half of 2025, including HS-10561 (BTK inhibitor) and HS-20108 (ADC) [3] - Three new pivotal Phase III clinical trials were initiated, including HS-20093 (B7-H3 ADC for bone and soft tissue sarcoma) [3] Group 4: Licensing Agreements - In June 2025, the company granted global rights (excluding Greater China) for HS-20094 (GLP-1/GIP) to Regeneron, including an upfront payment of 80 million USD and milestone payments totaling 1.93 billion USD [4] - The company previously licensed two ADC drugs to GSK and HS-10535 to MSD [4] - Ongoing clinical trials for HS-20093 and HS-20089 are targeting various cancers, with HS-20094 and HS-10374 also in advanced clinical research stages [4] Group 5: Earnings Forecast and Target Price - The earnings per share forecast for 2025 was raised from 0.73 yuan to 0.88 yuan, with subsequent years also seeing upward adjustments [4] - The target price was increased from 25.1 HKD to 43.8 HKD, indicating a 22% upside potential, while maintaining a buy rating [4]

Group 1 - The latest stock price of Dize Pharmaceutical-U is 82.21 yuan, an increase of 0.24 yuan from the previous trading day, with a trading range of 80.23 to 83.00 yuan and a total transaction amount of 2.31 billion yuan [1] - Dize Pharmaceutical is part of the chemical pharmaceutical sector, focusing on the research and development of innovative drugs, including the globally first high-selective JAK1 inhibitor Golixitinib and LYN/BTK dual-target inhibitors [1] - Research reports indicate that there are significant investment opportunities in the field of hematological malignancies, suggesting attention to Dize Pharmaceutical and other innovative drug companies making progress in overcoming treatment bottlenecks [1] Group 2 - The report highlights a trend in hematological malignancy treatment towards chronic disease management, driven by emerging therapeutic methods such as targeted therapy, immunotherapy, and cell therapy [1] - In terms of capital flow, Dize Pharmaceutical-U experienced a net outflow of 9.2879 million yuan on the day, with a cumulative net outflow of 81.0427 million yuan over the past five days [1]

Core Viewpoint - The company Yipinhong reported a significant loss in the first half of the year, despite a substantial increase in stock price driven by the hype around its innovative gout drug AR882, which has recently completed patient enrollment for its global Phase III clinical trials [2][10]. Financial Performance - Yipinhong's revenue for the first half of 2025 was 584 million yuan, a decrease of 36% year-on-year [2][9]. - The net profit attributable to shareholders was a loss of 73.54 million yuan, compared to a profit of 46.46 million yuan in the same period last year. The loss would increase to 108 million yuan when excluding non-recurring items [2][9]. - The company's sales expenses for the first half of 2025 were 208 million yuan, accounting for 35.6% of revenue, which shows an upward trend compared to 34% in the first quarter of 2025 and 34.61% in the first half of 2024 [8][9]. Sales Expenses - From 2019 to 2022, Yipinhong's sales expenses consistently exceeded 50% of its revenue, with approximately 95% of these expenses categorized as "academic promotion fees" [7]. - Following a scandal involving the misappropriation of over 1.6 billion yuan in public relations expenses, the company had reduced its sales expenses, but there are signs of a resurgence in these costs [7][8]. Drug Development Progress - Yipinhong announced the completion of patient enrollment for its innovative gout drug AR882, developed in collaboration with Arthrosi, marking a significant milestone in its clinical trial process [10][12]. - AR882 is designed to lower serum uric acid levels by inhibiting the reabsorption of uric acid, and the global Phase III trials consist of two independent parallel studies, REDUCE 1 and REDUCE 2 [12]. - The company acknowledged the high investment, risk, and potential return associated with drug development, emphasizing the uncertainties in clinical trial progress, market competition, and the drug's acceptance post-approval [12]. Market Capitalization - As of August 21, Yipinhong's market capitalization exceeded 30 billion yuan, reaching 31.49 billion yuan [13].

Core Insights - The stock price of Zhongsheng Pharmaceutical closed at 22.56 yuan on August 21, 2025, down by 0.23 yuan, representing a decline of 1.01% [1] - The company is focused on the research and development of traditional Chinese medicine and innovative drugs, with a recent emphasis on the innovative drug RAY0221, which is intended for the treatment of diabetes, obesity, and non-alcoholic fatty liver disease [1] - RAY0221 is currently in the preclinical research stage, and the company plans to advance its development as scheduled [1] - On August 21, the net outflow of main funds was 61.98 million yuan, accounting for 0.36% of the circulating market value, while the cumulative net inflow over the past five trading days was 109 million yuan, representing 0.64% of the circulating market value [1] Financial Performance - The trading volume on August 21 was 848 million yuan, with a turnover rate of 4.92% [1]

营收、净利及经营性现金流净额均创往年同期新高，恒瑞医药（600276.SH，01276.HK）业绩大增。8 月21日，该公司股价上涨，涨幅为1.81%，收报63.99元/股。 8月20日晚间，恒瑞医药（600276.SH，01276.HK）发布2025年中报业绩，上半年实现营业收入157.61亿 元，同比增长15.88%；归母净利润44.50亿元，同比增长29.67%；经营性现金流净额达43.00亿元，同比 增长41.80%。 创新药成为业绩增长的主要推动力。上半年，该公司创新药销售及许可收入占营收占比超过六成，其中 创新药销售收入75.70亿元、授权许可收入2.75亿美元。即使不含对外许可收入，恒瑞医药上半年[PR1] 的创新药销售收入及公司药品销售收入也实现同比增长。 业绩增长的背后，该公司持续加大研发投入，创新成果不断涌现。上半年该公司研发投入38.71亿元， 其中费用化研发投入32.28亿元。今年以来，已有12项创新成果获批上市，实现3笔对外授权。 20日晚，恒瑞医药还公告，拟使用10亿元～20亿元回购公司股份，用于实行新的员工持股计划，2025年 激励规模不超过1400万股。 "未来，恒瑞医药将始终 ...

Core Insights - Yipinhong Pharmaceutical Group Co., Ltd. reported a steady development in the first half of 2025, focusing on children's medicine, chronic disease drugs, and innovative drugs [1] - The company achieved a revenue of 584 million yuan and a net profit attributable to shareholders of -73.54 million yuan in the first half of 2025 [1] - Total assets reached 4.981 billion yuan, reflecting a 13.1% increase compared to the beginning of the period [1] Financial Performance - Revenue for the first half of 2025 was 584 million yuan [1] - Net profit attributable to shareholders was -73.54 million yuan [1] - Total assets as of June 30, 2025, were 4.981 billion yuan, up 13.1% from the start of the year [1] R&D and Product Development - The company invested approximately 94.201 million yuan in R&D, accounting for 16.14% of total revenue [1] - A total of 10 new registration certificates were obtained, maintaining a leading position among pharmaceutical companies [1] - The company introduced 2 CMO projects and 1 equity investment project during the reporting period [1] Innovative Drug Progress - The innovative drug AR882 (Dezhuobote) is a selective URAT1 inhibitor with three indications: lowering blood uric acid for gout treatment, dissolving gout stones, and treating chronic kidney disease [2] - The global pivotal Phase III REDUCE 2 trial completed patient enrollment in March 2025, and the REDUCE 1 trial surpassed 50% enrollment by June 2025 [2] - The company acquired 15.25% of the equity in its subsidiary Guangzhou Ruianbo, increasing its ownership of AR882 in China to 100% [2]