投资思路上，沿产业趋势方向寻找可能出海的标的，产业趋势与创新药几大主线有：1)新一代免疫疗 法：康方生物、三生制药、信达生物、华海药业、君实生物、宜明昂科等;2)ADC：科伦博泰、百利天 恒、复宏汉霖、映恩生物、迈威生物、恒瑞医药等;3)TCE双抗：泽璟制药等;4)慢病重大突破：GLP-1产 业链(信达生物、博瑞医药、华东医药、来凯医药、众生药业等)，信立泰、一品红、云顶新耀、益方生 物、舒泰神等。 创新及药品产业链 CXO板块经历投融资冰点和bio-secure事件后更加凸显竞争力，关注：1)药明生物、药明康德、药明合 联、康龙化成等龙头公司在手订单持续稳健增长;2)多肽、ADC、小核酸等第二、三增长曲线布局带来 机会;3)昭衍新药等基本面改善，后续有催化。原料药供给端出清仍在持续，下半年建议关注新产品、 新业务放量带动边际利润率改善的公司，如天宇股份、司太立、同和药业、国邦医药等;以及有创新药 催化的华海药业、博瑞医药等公司。上游产业链：仍看好上游出海趋势，国内市场价格竞争压力减缓， 国产替代趋势持续，业绩表现有望逐步回暖，关注百普赛斯、毕得医药等。 智通财经APP获悉，招商证券发布研报称，看好医药板块2 ...

Core Viewpoint - Recently, Maiwei Biotech announced two significant licensing agreements, potentially exceeding a total value of 4.7 billion RMB, which could enhance the company's operational strength and support its long-term development strategy [2][3][5]. Group 1: Licensing Agreements - Maiwei Biotech signed an exclusive licensing agreement with CALICO, a subsidiary of Alphabet, for the IL-11 targeted therapy, which includes the product 9MW3811. The agreement allows CALICO to develop, produce, and commercialize the product outside of China [3][4]. - The agreement with CALICO includes an upfront payment of 25 million USD (approximately 250 million RMB) and potential milestone payments totaling up to 571 million USD (approximately 4.095 billion RMB), along with royalties based on net sales [3][4]. - The second agreement with Qilu Pharmaceutical involves the product 8MW0511, which is an injectable drug for treating febrile neutropenia in cancer patients. This agreement includes an upfront payment of 3.8 billion RMB and potential sales milestone payments, as well as royalties based on net sales [4][6]. Group 2: Company Background and Financials - Founded in 2017, Maiwei Biotech focuses on the research, production, and sales of innovative drugs and biosimilars, primarily in oncology and other therapeutic areas [3][6]. - As of the end of 2024, the company has three products on the market but has not yet achieved profitability, with accumulated losses [3][6]. - In Q1 2025, the company reported revenue of 44.79 million RMB, a year-on-year decline of 33.7%, and a net loss of 292 million RMB, indicating an increase in losses due to high R&D expenditures [7]. - The company is preparing for an IPO on the Hong Kong Stock Exchange to alleviate financial pressures and enhance its international presence [7].

前些年，生物科技板块一度陷入寒冬;之中，相关概念股遭遇了持续暴跌，股价腰斩的不在少数，与此 同时生物科技企业还集体陷入融资困境之中，一级及二级市场的投融资环境异常严峻。 不过，进入2025年后，此前连遭暴击的生物科技板块迎来了反转;时刻，概念股普遍大涨，再度成为港 股市场的明星;板块，而趁着股价攀升，不少生物科技企业也开启了配股模式，融资困局也得到明显缓 解。 中国创新药崛起，生物科技概念大涨 数据显示，年初至6月25日，港股市场的生物医药B类股累涨逾92%，创新药概念也累涨逾49%。 生物科技内部，和铂医药-B（02142.HK）的股价自2024年末便拔地而起;，一路狂飙超350%，如下图 所示；此外，德琪医药-B（06996.HK）、三生制药（01530.HK）、信达生物（01801.HK）等多股实现 翻倍上涨；科伦博泰生物-B（06990.HK）、百济神州（06160.HK）等概念股亦有上佳表现。 生物科技板块的大涨有着基本面、消息面及资金面的配合。 近些年，随着管线深度和广度不断扩展，中国创新药出海（license-out）势头迅猛，提振了各方对生物 医药的信心。 数据显示，2025年前5个月，中国在 ...

Group 1 - The core viewpoint of the article highlights the significant rise of the innovative drug sector, with the Hang Seng Innovative Drug Index increasing by 55.61% year-to-date, outperforming the Hang Seng Index's 17.30% growth [1] - The innovative drug industry is transitioning from experience-based competition to technology-driven competition, positioning itself as a "tech-like" asset [1][2] - The trend of Chinese innovative drugs going global is irreversible and expected to strengthen, with a focus on whether Chinese companies can outperform their overseas counterparts in new target selection [2][6] Group 2 - The current price-to-sales (PS) valuation of innovative drugs is around 4 times, which is considered neutral in the context of asset scarcity, indicating potential for continued stock price increases as clinical data and business development improve [2][7] - The innovative drug market is characterized by high unmet medical needs, particularly in areas with few available treatment options, which presents opportunities for the development of blockbuster drugs [3][8] - The "double 10" rule in new drug development indicates an average development cycle of 10 years and costs exceeding $1 billion, highlighting the high-risk nature of the industry [4] Group 3 - China's innovative drug sector has made significant progress, with over 50% contribution to the top 20 global drug targets and surpassing Europe in original drug numbers as of 2021 [5][6] - The competition landscape is evolving into a scenario where both China and the U.S. are advancing in the innovative drug sector, with increased global competitiveness for Chinese companies [6] - The innovative drug sector is expected to continue its strong performance, driven by its alignment with current market trends and the recovery of valuations after years of pressure [7][8] Group 4 - Specific areas with strong potential for new drug development include antibody-drug conjugates (ADCs), GLP-1 metabolic disease drugs, and gene therapy for rare diseases [8] - For investors looking to enter the innovative drug market, a systematic investment approach through funds is recommended due to the high barriers and complexities involved in the sector [9]

Core Viewpoint - Rongchang Biologics announced the licensing of its product Taitasip to Vor Bio, granting exclusive rights for development and commercialization outside Greater China, which has led to a significant drop in its stock prices despite the potential financial benefits from the deal [1][2][3] Group 1: Licensing Deal Details - Rongchang Biologics will receive $125 million in cash and warrants from Vor Bio, including an upfront payment of $45 million and $80 million in warrants, representing approximately 23% equity stake [1] - Vor Bio is also obligated to pay up to $4.105 billion in milestone payments based on clinical registration and commercialization, along with high single to double-digit sales royalties [1] - The deal structure follows a Newco model, where specific pipelines are separated and developed through a newly established company, allowing Rongchang to leverage Vor Bio's resources for overseas commercialization [4] Group 2: Market Reaction and Stock Performance - Following the announcement, Rongchang Biologics' A and H shares experienced significant declines, with A shares hitting a 20% limit down and H shares dropping over 25% [1][2] - The stock had previously surged by 34.37% from June 20 to June 25, reaching a high of 70.1 yuan per share, indicating a stark contrast between market expectations and the actual deal terms [3] Group 3: Product Background and Clinical Development - Taitasip was conditionally approved for market entry in March 2021 and is the first dual-target biologic for treating systemic lupus erythematosus [5] - The product has received additional approvals for rheumatoid arthritis and adult generalized myasthenia gravis, with ongoing global Phase III clinical trials for various indications [6][7][9]

Core Viewpoint - Rongchang Biopharma has entered a global licensing agreement with Vor Bio for its innovative drug Taitasip, with a total deal value exceeding $4.23 billion, but the market reacted negatively to the announcement, leading to significant stock price declines for both A-shares and H-shares [1][3][17] Financial Summary - Rongchang Biopharma will receive $125 million in cash and warrants from Vor Bio, including a $45 million upfront payment and $80 million in warrants, which can be converted into 320 million shares of Vor Bio, representing approximately 23% of its expanded total share capital [1] - The deal includes potential milestone payments of up to $4.105 billion and high single to double-digit sales royalties [1][8] - Despite the promising revenue growth, with projected revenue of 1.717 billion yuan in 2024 (up 58.54% year-on-year), the company still faces a net loss of 1.468 billion yuan [14][15] Market Reaction - Following the announcement, Rongchang Biopharma's A-shares hit the daily limit down, falling over 17% to 61.25 yuan, while H-shares dropped over 16% to 55.85 HKD [3][4] - The market's negative response indicates dissatisfaction with the deal's structure, particularly the low upfront payment and the uncertainty surrounding milestone payments [7][8] Strategic Implications - The agreement is seen as a significant step in Rongchang Biopharma's global expansion strategy, potentially allowing access to mainstream markets in Europe and the U.S. [17] - However, concerns about Vor Bio's financial stability and operational capacity raise doubts about the realization of future milestone payments and sales royalties [10][12][17]

Core Viewpoint - The innovative pharmaceutical sector is experiencing a resurgence, driven by improved fundamentals, supportive policies, and increased market interest, particularly in the A-share and Hong Kong markets [1][3][12]. Group 1: Market Performance - The pharmaceutical sector has shown strong performance this year, with a notable rebound starting from April 9, despite recent pullbacks [1]. - The innovative drug segment in A-shares and Hong Kong stocks has continued to strengthen, indicating a recovery after four years of adjustment [1][3]. - The total amount of business development (BD) transactions for innovative drugs is projected to rise significantly, from $8.4 billion in 2020 to $51.9 billion in 2024 [4]. Group 2: Policy and Industry Trends - The policy environment has shifted from cost control to encouraging innovation, providing strong support for the development of innovative drugs [3]. - The number and quality of innovative drug products in China have significantly improved, leading to increased interest from foreign pharmaceutical companies [3][5]. - The penetration rate of innovative drugs in China is expected to rise, with current levels at around 20%, compared to 70%-80% in the U.S. [5]. Group 3: Investment Opportunities - Fund managers are optimistic about the future of innovative drugs, emphasizing the importance of technology and growth attributes in the sector [6]. - Investment strategies include focusing on high-quality companies, innovative drug leaders, and traditional pharmaceutical companies transitioning to innovative drugs [7][8][9]. - Investors can consider actively managed pharmaceutical funds or industry-themed ETFs to gain exposure to the innovative drug market [10][12]. Group 4: Fund Performance - Several funds managed by 工银瑞信 have demonstrated strong performance, ranking highly in their respective categories over various time frames [13][15]. - The 工银港股通创新药ETF has seen significant inflows, reflecting market preference for innovative drug companies [11].

和铂医药（上海）有限责任公司（简称"和铂医药"）再获一笔重磅交易。6月23日，和铂医药发布公告 称，公司与日本制药巨头大冢制药株式会社（简称"大冢制药"）达成全球战略合作，将其自主研发的、 治疗自身免疫性疾病的BCMA×CD3双特异性T细胞衔接器（TCE）HBM7020授权给大冢制药，交易总 金额达6.7亿美元。 年内第二笔跨国BD交易 不过，和铂医药在2023年成功转型并抓住了国产创新药出海的机遇 。2023年，和铂医药首次实现财务 盈利，实现营收8950.2万美元，同比增长119.9%，全年总盈利2276.3万美元，同比扭亏为盈。彼时，和 铂医药表示，其收入的增长主要是与辉瑞、Cullinan等的授权合作协议有关。 2023年2月，和铂医药与Cullinan签订授权及合作协议，根据该协议，Cullinan获得在美国及其领土和属 地（包括哥伦比亚地区和波多黎各）开发HBM7008的独家可转许可的授权，和铂医药获得2500万美元 预付款和最高达六亿美元的里程碑付款。2023年12月，和铂医药与辉瑞就HBM9033的全球临床开发及 商业化签订授权协议，并获得总额为5300万美元的预付款及近期付款和最高达约10. ...

Group 1 - The Hong Kong stock market experienced a collective rise, with the Hang Seng Index up by 0.83% and the Hang Seng Tech Index up by 1.15% [1] - The Hong Kong Innovative Drug ETF (159567) increased by 0.97%, with a turnover rate exceeding 30% and transaction volume quickly surpassing 700 million yuan, indicating active trading [1] - Major stocks within the ETF, such as Rongchang Biopharmaceuticals and Cloudtop New Medicine, saw significant gains, with Rongchang Biopharmaceuticals rising over 4% and Cloudtop New Medicine rising over 2% [1] Group 2 - Recent reports highlight substantial external licensing deals by Chinese innovative pharmaceutical companies, including a deal by 3SBio worth over 6 billion USD, with a record upfront payment of 1.25 billion USD [1] - Another significant deal was announced by CSPC Pharmaceutical Group in collaboration with AstraZeneca, totaling 5.33 billion USD, showcasing the increasing value of Chinese innovative drug products [1] - The narrative of "China R&D, overseas licensing" is gaining recognition, marking a transition for the Chinese innovative drug industry from a "follower" to a "contributor" in the global market [1] Group 3 - Aijian Securities suggests a focus on "hard technology" and "strong demand" in the domestic market, maintaining a bullish outlook on the Chinese innovative drug sector's international expansion [2] - The sector is viewed as having clear industrial trends and future growth potential, with innovative drugs expected to remain the main investment theme within the pharmaceutical sector [2] - Recommendations include focusing on high-quality innovative drug stocks and companies with business development (BD) or data catalysts, as well as monitoring AI healthcare and pharmaceutical companies showing positive changes [2]

分析师 杨松 SAC执业证书编号：S1110521020001 分析师 曹文清 SAC执业证书编号：S1110523120003 联系人 刘一伯 证券研究报告 2025年06月24日 医药生物 买全球最好的中国创新药 作者： 1 行业评级： 上次评级： 强于大市 强于大市 维持 （ 评级） 请务必阅读正文之后的信息披露和免责申明 行业报告： 行业专题研究 买全球最好的中国创新药：见证中国医药产业变迁，在部分领域先拔头筹 ◆ 突破性疗法梳理： （1）厚积薄发：创新药的发展离不开坚实的产业基础、政策扶持和资本支持。以2024年全球药物销售额计算，Keytruda和司美格鲁肽以 294.82亿美元和292.96亿美元分居前2位；ADC市场销售额也呈快速增长趋势。从主流产品来看，下一代国产免疫疗法（如PD-1/VEGF）、 减重药物、及ADC已经展露其锋芒。中国创新药的工程化改造持续突破，见证了中国医药产业变迁。回溯发展历程、CXO所带来的产业 基础、正确的政策扶持、大力的资本支持，为创新药高速发展提供了源源不断的活水。 （2）小有成就：中国的创新药到底发展到了哪一阶段？距离国际领先水平还有多远？针对以上问题，我们认 ...