8月20日，恒瑞医药（股票代码：600276.SH；01276.HK）发布2025年半年度报告。报告显示， 2025年上半年，公司实现营业收入157.61亿元，同比增长15.88%；归属于上市公司股东的净利润 44.50亿元，同比增长29.67%；经营性现金流净额达43.00亿元，同比增长41.80%。营收、净利及经 营性现金流净额均创往年同期新高，业绩进入爆发增长期。公司持续加大创新力度，维持较高的研 发投入，报告期内公司研发投入38.71亿元，其中费用化研发投入32.28亿元。 为了增强团队凝聚力及公司核心竞争力，充分发挥长效激励机制，恒瑞医药还同时公告将 回 购 1 0 亿 - 2 0 亿 元 的 股 份 ， 用 于 实 行 新 的 员 工 持 股 计 划 ， 2 0 2 5 年 激 励 规 模 不 超 过 1 4 0 0 万 股。 创新药销售引领业绩增长 对外许可成常态化业务 从业绩角度来看，持续的高强度研发投入加快公司转型升级步伐，公司迈入了创新药丰收 期，创新药收入持续提升。2 0 2 5年上半年公司创新药销售及许可收入9 5 . 6 1亿元，占公司 营业收入比重6 0 . 6 6%，其中创新药销 ...

智通财经APP获悉，中共中央政治局常委、国务院总理李强8月20日在北京调研生物医药产业发展情 况。他强调，要深入贯彻习近平总书记关于生物医药产业发展的重要指示精神，加大高质量科技供给和 政策支持，充分发挥企业创新主体作用，着力推动生物医药产业提质升级，研发生产更多优质高效的好 药新药，不断增进人民健康福祉。相关概念股：基石药业-B(02616)、和誉-B(02256)、和铂医药 (02142)、信达生物(01801)。 调研中，李强主持召开座谈会。听取有关企业和投资、研发、医疗机构负责人发言后，李强指出，生物 医药产业既是战略性新兴产业，也事关人民健康福祉。要加强原始创新和关键核心技术攻关，发挥政府 和市场两方面作用，充分调动各类资源，凝聚创新合力，尽快取得更大突破。要注重运用人工智能全面 赋能产业发展，提高药物研发、临床试验、诊断治疗、生产流通等环节智能化水平。要强化产品研发、 审评审批、管理使用等政策衔接和协同配合，优化药品集采和谈判议价机制，加大高水平创新药应用指 导力度。李强强调，要依靠创新促进中医药振兴发展，充分运用现代科学的理论、技术、材料等，深化 中医药基础理论、诊疗规律、作用机理的研究阐释，丰 ...

Core Viewpoint - Heng Rui Medicine reported strong financial performance for the first half of 2025, with significant growth in revenue and net profit, driven by innovative drug sales and licensing income [1][7]. Financial Performance - The company achieved operating revenue of 15.76 billion yuan, a year-on-year increase of 15.88% [2]. - Net profit attributable to shareholders reached 4.45 billion yuan, up 29.67% compared to the same period last year [3]. - Total profit amounted to 5.05 billion yuan, reflecting a growth of 34.63% [3]. - The net cash flow from operating activities was 4.30 billion yuan, an increase of 41.80% [3]. - The company's net assets at the end of the reporting period were 58.46 billion yuan, up 28.44% from the previous year [3]. Innovation and R&D - The company invested 3.87 billion yuan in R&D during the first half of 2025, with 3.23 billion yuan classified as expensed R&D [3]. - Six Class 1 innovative drugs were approved for market launch during the reporting period [8]. - The company has over 100 self-innovated products in clinical development and more than 400 clinical trials ongoing domestically and internationally [8]. Sales and Market Expansion - Innovative drug sales and licensing income totaled 9.56 billion yuan, accounting for 60.66% of total revenue, with innovative drug sales alone reaching 7.57 billion yuan [7]. - The company received significant licensing payments, including 200 million USD from Merck and 75 million USD from IDEAYA, contributing to revenue growth [7]. - The company has accelerated its internationalization efforts, with over 20 overseas clinical trials initiated in various countries [9]. Shareholder Activity - Despite the recent increase in stock price, three of the top ten shareholders reduced their holdings in the second quarter [4][6].

◎记者 何昕怡 8月20日，恒瑞医药发布2025年半年报。公司上半年实现营业收入157.61亿元，同比增长15.88%；实现 归母净利润44.50亿元，同比增长29.67%，营收、净利均创同期新高。 同日，恒瑞医药公告将回购10亿元至20亿元的股份，用于实行新的员工持股计划，2025年激励规模不超 过1400万股。 创新药硕果累累 上半年，恒瑞医药坚持自主研发与开放合作并重，创新药对外许可作为常态化业务，推动出海成为公司 业绩增长的第二引擎。报告期内，公司收到默沙东2亿美元及IDEAYA 7500万美元的对外许可首付款， 并确认为收入，进一步推动经营业绩指标增长。 今年3月，恒瑞医药将脂蛋白(a)[Lp（a）]的口服小分子药物HRS-5346的全球独家权益授权给默沙东， 获得2亿美元首付款、最高17.7亿美元里程碑付款、相应销售提成；4月，公司将口服GnRH受体拮抗剂 SHR7280（适应症涵盖医学辅助生殖及妇科领域）在中国的独家商业化权益及授权区域之外区域的优先 谈判权授予德国默克，获得1500万欧元首付款，并有权收取产品获批后一定的里程碑付款及达两位数百 分比的销售提成。 7月，恒瑞医药海外BD（业务拓展 ...

Group 1 - The stock price of Baiyang Pharmaceutical closed at 25.46 yuan on August 20, 2025, down by 0.50 yuan, a decrease of 1.93% from the previous trading day [1] - The trading volume on that day was 93,448 hands, with a total transaction amount of 238 million yuan [1] - Baiyang Pharmaceutical operates in the pharmaceutical commercial sector, with main business activities including wholesale and retail of pharmaceutical products, medical devices, and health products [1] Group 2 - Baiyang Pharmaceutical Group Co., Ltd., the controlling shareholder, has increased its registered capital by 400 million yuan, fully subscribed by the new shareholder Baiyang Huikang [1] - After the capital increase, Baiyang Huikang will indirectly control 72.03% of the company's shares [1] - In the first quarter of 2025, the company achieved operating revenue of 1.841 billion yuan and a net profit attributable to the parent company of 85.01 million yuan [1] Group 3 - On August 20, 2025, the net outflow of main funds was 1.5171 million yuan, with a cumulative net outflow of 63.2298 million yuan over the past five trading days [1]

Core Viewpoint - The retail pharmacy industry in China is entering a phase of negative growth by 2025, with a significant number of store closures and a shift in focus towards health services rather than just product sales [1][2][3] Industry Overview - The retail pharmacy sector has seen a 50% increase in store numbers over the past seven years, but the total number of pharmacies has now dropped below 700,000, marking the beginning of negative growth [2][3] - In Q1 2025, approximately 3,000 pharmacies closed, indicating a trend that may continue as the market contracts [2][3] Market Dynamics - The overall market size for pharmaceuticals in China is projected to decline for the first time, with a forecasted sales figure of 1.97 trillion yuan in 2024, reflecting a year-on-year decrease [2] - The competition among pharmacies has intensified due to a shrinking market, leading to a median revenue growth of only 4.7% among eight listed pharmacy companies, while median profit has decreased by 32.9% [2] Strategic Responses - Some retail pharmacies are slowing down their expansion plans, while others are increasing their franchise operations to boost market share [3] - The concentration of the top 100 pharmacy chains has risen to 53%, indicating a trend towards consolidation in the industry [3] Opportunities for Innovation - Despite declines in various product categories, the sales of biopharmaceuticals have surged by 17.7%, suggesting a potential growth area for the industry [3][4] - The DTP (Direct to Patient) market is expanding, with a projected sales growth of 17.2% in 2024, highlighting a shift towards more personalized patient care [4][5] Collaboration and Diversification - There is a growing interest from innovative pharmaceutical companies to collaborate with retail pharmacies, particularly in the DTP sector, to enhance patient services [5][6] - Retail pharmacies are exploring diversification into beauty and health products, with potential market opportunities reaching trillions [6][7] Future Outlook - The industry is expected to evolve from a product-centric model to a health-centric approach, driven by increasing health demands and innovations in drug supply [7][8] - The existing network of nearly 700,000 pharmacies provides a unique opportunity to enhance health service delivery across the country [7]

Core Viewpoint - Heng Rui Medicine (600276) reported strong financial performance in the first half of 2025, with significant growth in revenue and net profit driven by innovative drug sales and licensing [2][4]. Financial Performance - The company achieved operating revenue of 15.76 billion yuan, a year-on-year increase of 15.88% [2]. - The net profit attributable to shareholders reached 4.45 billion yuan, reflecting a year-on-year growth of 29.67% [2]. Innovative Drug Development - Innovative drug sales and licensing revenue amounted to 9.56 billion yuan, accounting for 60.66% of total revenue, with sales revenue from innovative drugs at 7.57 billion yuan [4]. - Key innovative drugs such as Rivoceranib, Darsylin, and Hengriletin continued to show rapid growth, while older drugs like Arixtra and Pyrrolidine contributed to revenue through new indications [4]. - The company invested 3.87 billion yuan in R&D during the first half of the year, with a total R&D investment exceeding 48 billion yuan as of June 30 [4]. International Expansion - Heng Rui Medicine accelerated its internationalization efforts, with innovative drug licensing becoming a key growth driver [6]. - The company received upfront payments of 200 million USD from Merck and 75 million USD from IDEAYA, contributing to revenue growth [6]. - Strategic partnerships were established, including a collaboration with GSK for the development of up to 12 innovative drugs, with an upfront payment of 500 million USD and potential total payments of around 12 billion USD [6]. Hong Kong Listing - Heng Rui Medicine successfully listed on the Hong Kong Stock Exchange on May 23, raising a total of 11.4 billion HKD (approximately 1.5 billion USD), marking the largest IPO in the Hong Kong pharmaceutical sector in the past five years [7].

Core Insights - The Chinese government emphasizes the need for high-quality technological supply and policy support to enhance the biopharmaceutical industry, aiming for the development of more effective new drugs to improve public health [2][3] Group 1: Government Initiatives - The government aims to accelerate the biopharmaceutical sector by increasing technological innovation and focusing on new targets, compounds, and mechanisms [2] - There is a significant market potential in the health industry, with a strong emphasis on identifying innovative drug projects with high clinical value and conversion potential [2][3] - The government encourages the cultivation of quality enterprises and provides policy support in areas such as talent and financing, while promoting international cooperation [2] Group 2: Research and Development Focus - The government stresses the importance of original innovation and tackling key core technologies, leveraging both government and market resources to foster innovation [3] - There is a call for the integration of artificial intelligence to enhance various stages of drug development, clinical trials, and production processes [3] - The government aims to modernize and industrialize traditional Chinese medicine by applying modern scientific theories and technologies [3]

Core Insights - Jiangsu Hengrui Medicine Co., Ltd. reported a revenue of 15.761 billion yuan for the first half of 2025, marking a year-on-year increase of 15.88% [1] - The net profit attributable to shareholders reached 4.45 billion yuan, reflecting a growth of 29.67% year-on-year [1] - Operating cash flow net amount was 4.3 billion yuan, up by 41.80% compared to the previous year [1] Revenue Breakdown - The sales and licensing income from innovative drugs amounted to 9.561 billion yuan, accounting for 60.66% of total revenue, with innovative drug sales alone contributing 7.570 billion yuan [1] - The company received upfront payments of 200 million USD from Merck and 75 million USD from IDEAYA for licensing agreements, which further boosted revenue [1] R&D Investment - Hengrui Medicine invested 3.871 billion yuan in R&D during the reporting period, with 3.228 billion yuan classified as expense-based R&D [2] - Cumulative R&D investment exceeded 48 billion yuan, supporting a surge in innovative outcomes [1][2] Product Approvals and Pipeline - Six Class 1 innovative drugs were approved for market launch, including injection of Ricacizumab and others [2] - The company has over 100 self-developed innovative products in clinical development and more than 400 clinical trials ongoing domestically and internationally [2] Strategic Collaborations - Hengrui Medicine has strengthened international cooperation, granting exclusive global rights for the oral small molecule drug HRS-5346 to Merck outside Greater China [2] - The company also entered into a collaboration agreement with GSK to co-develop up to 12 innovative drugs across various therapeutic areas [2] Employee Incentives - To enhance team cohesion and core competitiveness, Hengrui Medicine announced a share buyback plan of 1 to 2 billion yuan for a new employee stock ownership plan, with an incentive scale not exceeding 14 million shares in 2025 [3]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2025年8月20日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 江苏恒瑞医药股份有限公司 2025 年半年度报告 公司代码：600276 ...