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Company Overview - Guangzhou Bibetter Pharmaceutical Co., Ltd. is a biopharmaceutical company established in 2012, focusing on innovative drug research and development with a clinical value orientation [4] - The company specializes in major disease areas such as tumors and metabolic diseases, leveraging its core technology platform for continuous development of first-in-class drugs and innovative medicines addressing unmet clinical needs [4][11] Research and Development Pipeline - The company has established a diverse and differentiated R&D pipeline, having obtained over 30 clinical approvals, with one class 1 innovative drug already on the market and two others in phase III clinical trials [5][21] - The core product, BEBT-908, is a globally first-in-class HDAC/PI3Kα dual-target anti-tumor drug, approved for treating relapsed or refractory diffuse large B-cell lymphoma, with other indications in phase II clinical trials [5][25] - The company is also focusing on next-generation small nucleic acid (siRNA) drug development, having established three proprietary delivery systems with global intellectual property rights [6][22] Financials and Investment - The company has invested significantly in R&D, with expenditures of approximately 166.74 million yuan in 2022, 157.65 million yuan in 2023, and projected 120.29 million yuan in 2024 [17] - The funds raised from the IPO will primarily be used to accelerate the clinical progress of the R&D pipeline, enhance commercialization capabilities, and expand the product line [26][30] Market Position and Strategy - The company aims to become a globally influential innovative drug developer in major disease areas, focusing on deepening independent R&D, accelerating commercialization, and expanding into global markets [19] - The competitive advantages include innovation-driven development, strong R&D capabilities, a broad product pipeline, and significant market potential for approved and core products [20][25] Regulatory Environment - The implementation of the drug marketing authorization holder (MAH) system is seen as a favorable policy for the company, allowing it to focus resources on core R&D activities [25] - The company meets the listing standards for the Sci-Tech Innovation Board, having at least one core product approved for clinical trials and a projected market value of no less than 4 billion yuan [28][29]

Core Viewpoint - The acquisition of Jiangsu Langyan Life Science Technology Co., Ltd. by Sunshine Nuohuo aims to create a seamless integration of R&D and production, significantly enhancing the efficiency and success rate of drug development [1][2][3] Group 1: Acquisition Details - Sunshine Nuohuo plans to acquire 100% equity of Langyan Life for a transaction price of 1.2 billion yuan [1] - The acquisition will involve issuing shares and convertible bonds to 38 shareholders and raising up to 865 million yuan from no more than 35 specific investors [1][3] Group 2: Strategic Significance - The merger is expected to reduce R&D failure risks and conversion costs by integrating R&D services with manufacturing capabilities [1][2] - Sunshine Nuohuo aims to enhance its early involvement in new drug development, optimizing R&D strategies and increasing success rates [1][2] Group 3: Product Pipeline and Innovation - Langyan Life has over 30 products in development, including two innovative drugs in clinical trials, which will complement Sunshine Nuohuo's CRO services [2] - The company is also advancing in cutting-edge fields like small nucleic acid drugs, with products expected to enter clinical stages by 2026 [2] Group 4: Financial Projections - Langyan Life has profit commitments of at least 74.87 million yuan, 87.67 million yuan, 110.81 million yuan, and 131.11 million yuan from 2025 to 2028, contributing significantly to Sunshine Nuohuo's profitability [3] - The integration of CRO and pharmaceutical manufacturing is expected to diversify Sunshine Nuohuo's revenue structure, enhancing overall profitability and risk resilience [3] Group 5: Industry Impact - The acquisition represents a strategic industry integration rather than a simple asset purchase, setting a new benchmark for the pharmaceutical R&D industry [3] - As competition in the pharmaceutical R&D sector intensifies, industry integration is seen as a key path for companies to build core competitiveness [3]

Core Viewpoint - The siRNA drug sector is entering a rapid development phase, transitioning from rare diseases to common diseases, with significant commercial potential in large indications due to advancements in delivery systems and technology [1][2]. Group 1: Industry Trends - The siRNA drug market is evolving as a third wave of therapeutics following small molecules and antibody drugs, characterized by strong target expansion capabilities, extended research applicability, long-lasting effects, and reduced drug resistance [1]. - The GalNac delivery system has significantly improved the efficiency and specificity of siRNA drugs, leading to their validation in rare diseases and a gradual shift towards common disease applications, including cardiovascular diseases, chronic hepatitis B, weight loss, anticoagulation, and autoimmune diseases [1][3]. Group 2: Business Development and Collaborations - The market for small nucleic acid drugs is experiencing active business development (BD) transactions, with multinational corporations (MNCs) leveraging their understanding of indications to license pipelines or collaborate on technology platforms [2]. - The ongoing patent cliff faced by many pharmaceutical companies is driving them to seek new products to mitigate potential risks, making the acquisition of pipelines from companies specializing in small nucleic acid technology a rapid solution [2]. Group 3: Focus Areas and Future Opportunities - The commercialization of siRNA drugs is focused on common diseases with clear biological mechanisms, where early movers can achieve significant commercial benefits and collaboration opportunities [3]. - Future breakthroughs in the siRNA sector may depend on exploring new disease areas and overcoming challenges related to extrah hepatic delivery systems [3]. Group 4: Domestic Companies - Listed companies in the siRNA sector include Yuyuan Pharmaceutical, Hengrui Medicine, CSPC Pharmaceutical Group, Junshi Biosciences, Frontier Biotechnologies, Fuyuan Pharmaceutical, Chengdu Xian Dao, and Shengnuo Pharmaceutical [4]. - Unlisted companies include Bowang Pharmaceutical, Rebo Biotech, Jingyin Pharmaceutical, Shengyin Biotech, Dairui Biotech, and Weia Zhen Biotech [4].

Core Viewpoint - The A-share market continued its upward trend in September, driven by technology growth, with significant gains in the ChiNext and STAR Market indices, indicating a strong investor interest in tech stocks [2] Group 1: Market Performance - The Shanghai Composite Index rose approximately 0.64%, while the Shenzhen Component Index increased by about 6.54% in September [2] - The ChiNext Index surged over 12%, reaching a nearly three-year high, and the STAR Market Index rose about 11.48%, marking a nearly four-year high [2] - The average daily trading volume in the Shanghai and Shenzhen markets was 23,895.51 billion yuan, reflecting a year-on-year increase of 201% and a month-on-month increase of 5% [2] Group 2: Private Equity Research Activity - In September, 529 A-share companies were researched by private equity firms, with a total of nearly 2,800 research instances [3] - The six most favored industries by private equity firms included electronics, machinery, pharmaceuticals, power equipment, computers, and basic chemicals, each receiving over a hundred research instances [3][4] - The average performance of researched companies varied significantly, with electronics and power equipment sectors showing average gains of 10.89% and 11.74%, respectively, while pharmaceuticals and computers had average declines of -1.61% and -1.18% [3][4] Group 3: Individual Company Insights - The top three companies researched in September were Maiwei Biopharma, Lankai Technology, and Juguang Technology, with research instances of 88, 71, and 67, respectively [6][7] - Maiwei Biopharma, a company focused on innovative biopharmaceuticals, signed an exclusive licensing agreement for a dual-target small nucleic acid drug, indicating its strategic positioning in the market [8] - The average stock price increase for researched companies in September was 4.95%, with 65 companies receiving at least 10 research instances [6] Group 4: Private Equity Fund Performance - Among private equity firms, those with over 100 billion yuan in assets showed an average return of 30.04% year-to-date, outperforming smaller firms [11] - Panjing Investment was the most active among large private equity firms, conducting 34 research instances in September, with an average stock price increase of 15.62% for researched companies [13] - High Yi Asset, another significant player, conducted 23 research instances with an average stock price increase of 7.84% for the companies researched [13][14]

Investment Rating - The report rates the industry as "Overweight" [4] Core Insights - The siRNA drug industry is entering a new era with the maturation of technology platforms and the expansion of indications, focusing on the commercial value of siRNA drugs for common diseases [2][3] - siRNA drugs have transitioned from rare diseases to common diseases, showcasing strong target expansion capabilities, robust research and development extensibility, long-lasting effects, and low resistance [4][12] - The industry is witnessing a surge in business development (BD) transactions, particularly among multinational corporations (MNCs), indicating a vibrant market for siRNA technology [4][31] Summary by Sections 1. Dawn of a New Era for Small Nucleic Acid Drugs - Small nucleic acid drugs, including siRNA and ASO, are becoming a significant path for drug development, with a focus on their ability to regulate protein production [7] - The global approval of small nucleic acid drugs has reached 23, with siRNA drugs leading the way in rare disease applications [12][13] - Alnylam and other leading companies have demonstrated significant market capitalization differences due to their innovative drug development technologies [14][16] 2. Platform Characteristics and Focus on Indications - The siRNA drug industry is characterized by high barriers in modification and delivery, with a focus on breakthroughs in extrahepatic delivery systems [6][29] - The commercialization of siRNA drugs is accelerating, with multiple common diseases nearing market readiness [6][29] - The GalNAc delivery system has become the mainstream strategy for liver-targeted siRNA delivery, while breakthroughs in extrahepatic delivery are still needed [6][29] 3. Related Companies - Listed companies in the siRNA space include Yuyuan Pharmaceutical, Hengrui Medicine, and others, while unlisted companies include Bewang Pharmaceutical and others [4][12]

Core Insights - The report from Guotai Junan highlights that small nucleic acid drugs, particularly siRNA, are transitioning from rare diseases to common diseases due to technological advancements and product approvals [1][2] Group 1: Technological Advancements - The siRNA drugs are characterized by strong target expansion capabilities, extensive research adaptability, long-lasting effects, and low resistance [1] - Since 2016, the upgrade of the GalNac delivery system and the application of complete modification have propelled siRNA drugs into a rapid development phase, validating their value in rare diseases and now moving towards common diseases [1][3] Group 2: Market Dynamics - The market for small nucleic acid drugs is experiencing active business development (BD) transactions, with Chinese companies expected to shine due to their engineering advantages, particularly in chemical synthesis [2] - The ongoing patent cliff faced by many pharmaceutical companies necessitates new products to mitigate potential risks, making the acquisition of pipelines from companies specializing in small nucleic acid technology a quick solution [2] Group 3: Industry Characteristics - The commercialization of siRNA drugs is focused on common diseases with clear biological mechanisms, where early movers can achieve better commercial returns and collaboration opportunities [3] - The efficiency and specificity of the GalNac delivery system, along with potential patent breakthroughs, indicate high competition in diseases with clear pathogenic genes or mechanisms [3] Group 4: Domestic Companies - Listed companies in the small nucleic acid drug sector include Yuyuan Pharmaceutical, Hengrui Medicine, CSPC Pharmaceutical Group, Junshi Biosciences, Frontier Biotechnologies, Fuyuan Pharmaceutical, Chengdu Xian Dao, and Shengnuo Pharmaceutical [4] - Unlisted companies include Bowang Pharmaceutical, Rebo Biotech, Jingyin Pharmaceutical, Shengyin Biotech, Dairui Biotech, and Weia Zhen Biotech [4]

Group 1 - The report highlights a marginal recovery in China's manufacturing PMI in September, indicating a rebound in production activities, with new orders and export orders showing upward trends [1] - The report suggests three main investment directions based on economic recovery and market liquidity: breakthroughs in technology AI, resonance between domestic and international markets, and the continued rise of undervalued assets [1] - In the A-share market, major indices maintained upward momentum in September, with the ChiNext index rising over 12% and net inflows from southbound funds reaching 172.65 billion yuan [3] Group 2 - The global small nucleic acid drug market is projected to grow at a compound annual growth rate of 26.1%, reaching 46.7 billion USD by 2033, driven by technological advancements and increasing clinical approvals [10] - The report details the clinical progress of small nucleic acid drugs in various therapeutic areas, indicating significant potential for growth in this sector [10] - The report recommends focusing on both international and domestic companies involved in small nucleic acid drugs, highlighting key players in the market [10] Group 3 - The report on Lian Microelectronics indicates a stable revenue growth of 14.18% year-on-year for H1 2025, driven by technological innovation and an integrated supply chain [12] - Despite the revenue growth, the company reported a significant increase in net losses, indicating ongoing profitability challenges [12] - The report emphasizes the importance of capacity expansion and integrated industry chain advantages for the company's stable operations [12] Group 4 - The report on Solon Technology highlights the opportunities created by electrification and domestic substitution trends in the nylon pipeline sector, with potential revenue growth driven by increased demand from electric vehicles [18] - The company has established long-term partnerships with over 30 automotive manufacturers, positioning itself well in the market [18] - Revenue projections for 2025-2027 indicate a growth trajectory, with expected revenues of 1.57 billion, 1.96 billion, and 2.39 billion yuan respectively [18] Group 5 - The report on Yuheng Pharmaceutical shows a decline in revenue by 9.97% in H1 2025, while net profit increased by 7.56%, indicating effective cost management [37] - The company has signed promotional agreements for new drug products, enhancing its market presence and potential revenue streams [37] - The introduction of Pemabet tablets is expected to strengthen the company's product pipeline and competitive position in the cardiovascular sector [38]

Core Viewpoint - Sanofi Pharmaceutical has signed a subscription agreement with four investors, including Huaxi Biotechnology, to issue approximately 17.35 million new shares at a price of HKD 12 per share, raising around HKD 208 million, which is crucial for addressing its commercialization challenges and funding needs [2][6]. Group 1: Investment Details - The share placement represents about 16.50% of the current issued share capital and is expected to account for approximately 14.16% of the total share capital post-placement [2]. - The subscription price reflects a discount of approximately 19.84% compared to Sanofi Pharmaceutical's closing price of HKD 14.97 per share on September 5 [2]. - Huaxi Biotechnology will hold a 9.44% stake in Sanofi Pharmaceutical, becoming its second-largest shareholder after the transaction [2][6]. Group 2: Company Background and Challenges - Sanofi Pharmaceutical, established in 2007 and listed on the Hong Kong Stock Exchange in 2021, focuses on RNAi technology for drug development, with its lead candidate STP705 targeting two tumor indications [2][6]. - The company has not yet commercialized any products and has been operating at a loss, with net losses narrowing from USD 216 million in 2021 to USD 50 million in 2024, but still recording a loss of USD 3.49 million in the first half of 2025 [6]. - As of June 30, 2025, the company's current assets were only USD 14 million, highlighting the need for sufficient funding to support clinical pipelines and market preparations [6]. Group 3: Strategic Implications for Huaxi Biotechnology - Huaxi Biotechnology's investment is not merely financial but a strategic move to position itself in the small nucleic acid and RNAi technology sectors, with potential applications in targeted fat reduction [7][8]. - The investment aims to open new growth avenues for Huaxi Biotechnology, which has faced declining revenues, with a 19.57% year-on-year drop in the first half of 2025 [8]. - The collaboration is expected to enhance clinical progress for Sanofi Pharmaceutical's core pipeline while also allowing Huaxi Biotechnology to explore further investments and partnerships if market and technology validations are successful [7][8]. Group 4: Market Context and Future Outlook - The investment reflects Huaxi Biotechnology's response to increasing competition in the cosmetic market, particularly in traditional areas like hyaluronic acid, which has seen a decline in growth [8][10]. - The strategic partnership aims to leverage Sanofi Pharmaceutical's innovative technology to create synergies, although challenges remain in integrating the distinct business models and technologies of both companies [14]. - The success of this collaboration will depend on the clinical validation of Sanofi Pharmaceutical's technology and the ability to commercialize products effectively [7][14].

Core Viewpoint - Jingyin Pharmaceutical has officially filed for an IPO in Hong Kong, with its prospectus now publicly available, marking a significant step in its growth strategy [1]. Company Overview - Jingyin Pharmaceutical was established in 2021 and focuses on leveraging the clinical and commercial potential of siRNA therapies. The company has developed a diverse product pipeline with three main candidates: FXI siRNA, Lp(a) siRNA, and INHBE siRNA, targeting coagulation disorders, cardiovascular metabolic diseases, and obesity, respectively. The market potential for these therapies is substantial [4]. Product Pipeline - The FXI siRNA is currently in Phase II clinical trials in Europe and has a collaboration agreement with CRISPR Therapeutics for joint development, sharing global rights on a 50:50 basis. This partnership includes a cash infusion of $25 million and $70 million in equity, along with potential milestone payments totaling $800 million [4][6]. - The Lp(a) siRNA is in Phase I clinical trials, showing over 95% suppression after 43 days at doses of 300mg and 600mg, with a sustained effect lasting at least 12 weeks. There is potential for a dosing regimen of once every six months or even annually [9]. - The INHBE siRNA is also part of the pipeline, with ongoing development efforts [4]. Financial Background - Since its inception, Jingyin Pharmaceutical has completed three rounds of financing, with the latest being a $47.5 million Series B2 round in May 2025, resulting in a post-money valuation of $252.5 million [6][7]. Technology Platform - The company utilizes a proprietary PEPR technology platform that employs unique chemical modification techniques, enhancing the efficacy and durability of target protein knockdown. This platform positions Jingyin Pharmaceutical favorably within the siRNA landscape [11][14]. Market Position - The emergence of small nucleic acids as a significant drug modality, alongside antibodies and small molecules, is expanding treatment options for various diseases, including genetic disorders and cardiovascular diseases. Jingyin Pharmaceutical's established siRNA technology platform and differentiated product pipeline may position it as a new benchmark in the international market for small nucleic acids [14].