Group 1 - The establishment of Guotou Biological Manufacturing Innovation Research Institute (Wuxi) Co., Ltd. has been announced, with a registered capital of 30 million yuan [1] - The company's business scope includes research and development of bio-based materials technology, production process of biomass liquid fuels, bio-chemical products technology, and artificial intelligence theory and algorithm software development [1] - The company is jointly held by the wholly-owned subsidiary of China National Development Investment Corporation and Wuxi Life Science Industry Development Co., Ltd. [1]

Core Insights - The Ministry of Industry and Information Technology has announced the first batch of typical applications of artificial intelligence (AI) in the field of biomanufacturing, with 16 companies' cases selected nationwide [1] - The selected cases cover various scenarios including intelligent control of bioreaction processes, construction and optimization of cell factories, design and construction of high-performance protein components, and design and optimization of metabolic pathways [1] - The cases are categorized into "excellent" and "typical" levels, with 5 cases rated as excellent and 11 as typical [1] Group 1: Excellent Cases - One of the excellent cases is from Beijing Chengyitong Control Technology Group Co., Ltd., which utilizes SemDB database technology for precise process control and AI big data analysis in large-scale biomanufacturing [1] - The company addresses challenges such as process black-boxing and data lag through big data analysis of process parameters, AI model predictions, and machine learning algorithms, leading to improved production stability and efficient raw material utilization [1] - The company aims to continue deepening the application of AI, big data, and industrial internet in the biomanufacturing sector, promoting digital, networked, and intelligent upgrades in the biomanufacturing process [1] Group 2: Typical Cases - A typical case from the Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, focuses on data-driven design and construction of aromatic compound cell factories, utilizing high-throughput microfluidic technology for efficient synthesis of aromatic chemicals [2]

Core Insights - The recent bio-manufacturing forum in Suzhou focuses on cutting-edge technologies and aims to facilitate technology transfer and industrial collaboration in the bio-manufacturing sector [1] - Bio-manufacturing is seen as a key driver of the "Fourth Industrial Revolution" and is crucial for developing new productive forces across various fields such as pharmaceuticals, agriculture, and food [1] - Suzhou Industrial Park is actively positioning itself in the bio-manufacturing sector, leveraging its strong industrial foundation and complete supply chain to seize development opportunities [1] Industry Development Plans - In March, Suzhou Industrial Park announced a three-year action plan to accelerate the development of the bio-manufacturing industry, focusing on synthetic biology, biopharmaceuticals, food, bio-based materials, and bio-manufacturing equipment [1][2] - The plan aims to enhance innovation capabilities, achieve scale effects, and improve the industrial ecosystem by 2027, with specific support in R&D, platform construction, innovation incubation, and collaborative development [2] Company Highlights - Suzhou has over 40 companies related to synthetic biology technology, accounting for nearly 60% of the total in the city [2] - Jinweizhi Biotechnology Co., Ltd. specializes in genomic research and technology applications, collaborating with 80% of the top 20 global pharmaceutical companies and serving multiple regions including China, North America, Europe, Southeast Asia, and Australia [2] - Jima Gene Co., Ltd. is a leading provider of RNA drug technology services in China, focusing on small nucleic acid technology and has established a pilot platform for nucleic acid drug research in collaboration with the National Biopharmaceutical Technology Innovation Center [3] Collaborative Models - The collaboration between national research centers and leading enterprises in Suzhou accelerates the overall industrial process of bio-manufacturing through a "national team + enterprise group" model [3] - The park plans to establish common technology platforms and resource libraries, including a microbial strain preservation library, to support high-throughput, intelligent, and automated pilot platforms [3]

Core Viewpoint - The integration of AI in the biomanufacturing industry is gaining significant attention, driven by national policies promoting automation and intelligence in the sector, alongside the introduction of AI by major biomanufacturing companies, with some even pursuing IPOs [2]. Group 1: AI Applications in Biomanufacturing - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the adaptability of AI in biomanufacturing scenarios, potential gains, and effective application methods [3]. - Key discussions will include the empowerment of synthetic biology through AI, with notable speakers from various institutions and companies addressing critical questions regarding AI's role in biomanufacturing [3][4]. Group 2: Conference Agenda - The conference will feature a macro forum on biomanufacturing, with sessions on AI's role in synthetic biology, authoritative interpretations of AI applications in biomanufacturing, and discussions on technological innovations driving growth [4][5]. - Specific sessions will cover topics such as data-driven programmable protein engineering, online metabolic analysis of E. coli cultivation processes, and the development of life science tools based on micro-nano chips and AI [6][10]. Group 3: Supporting Organizations - The event is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd., with support from various academic and research institutions, including Peking University Ningbo Institute of Ocean Medicine and the China Society of Biotechnology [11][12].

Core Viewpoint - The "Regulations on Promoting the Development of the Private Economy in Hainan Free Trade Port" (referred to as "Regulations") has been officially implemented, marking the first local legislation in China aimed at promoting the private economy following the promulgation of the Private Economy Promotion Law. This legislation provides legal support for private enterprises in Hainan to seize opportunities and respond to challenges in the context of trade liberalization [1][2]. Group 1: Fair Competition and Policy Support - The Regulations ensure fair competition by stipulating equal access to various production factors and public service resources, and by prohibiting entry barriers and restrictions against private economic organizations in public resource transactions [1]. - The Regulations empower private economic organizations to participate in the development of Hainan's four leading industries and key project construction, ensuring equal enjoyment of tax incentives and other benefits under the Hainan Free Trade Port policies [1]. Group 2: Financial Support Measures - The Regulations include multiple financial support measures, mandating the establishment of a government financing guarantee system and requiring banks to provide loans secured by accounts receivable, warehouse receipts, equity, and intellectual property [2]. - Financial institutions are required to treat private economic organizations equally in terms of guarantees, credit, and risk management, and are prohibited from imposing discriminatory thresholds or unreasonable credit conditions [2]. Group 3: Implementation and Future Measures - The Hainan Provincial Development and Reform Commission is focused on ensuring that policy benefits reach private economic organizations by addressing market access, government-enterprise communication, and supporting policies [3]. - Hainan is actively implementing 22 special measures to relax market access and is researching the introduction of a second batch of measures [3].

Summary of Key Points from Conference Call Records Industry Overview - The conference call discusses the performance of various industries, particularly focusing on industrial enterprises, public utilities, and manufacturing sectors in a low-interest-rate environment. The overall profit share of industrial enterprises is expected to remain above 15% in 2023-2024, with a slight decline to 12.5% in the first half of 2025, still higher than the pre-pandemic average of 5.9% [1][2]. Core Insights and Arguments - **Profit Recovery in Key Sectors**: Industrial enterprises' profit share has significantly rebounded, with public utilities also seeing an increase to 12.1% as of mid-2023, up from a pre-pandemic average of 6.9% [2]. - **Manufacturing Sector Decline**: Manufacturing profit share has decreased to approximately 75%, with export-oriented industries like computers and electronics maintaining stable profits due to overseas demand recovery [1][2]. - **Mining Sector Volatility**: The mining sector's profits have been affected by fluctuations in the Producer Price Index (PPI), with a notable decline in 2023 due to commodity price adjustments and insufficient demand [1][4]. - **Investment Returns**: High capital return rates are observed in public utilities, coal, and petrochemical sectors, while the real estate sector shows lower returns, particularly since 2021 [5]. Additional Important Insights - **Driving Factors for Profit Changes**: Key drivers include price fluctuations, overseas demand, policy support for equipment updates, and consumer recovery in sectors like beverages and metals [4]. - **Sector-Specific Performance**: High-performing sub-sectors include energy metals, coal, oil and gas extraction, aerospace, and electronics, with strong growth potential in smaller segments despite overall weaker performance in some primary categories [6]. - **Impact of PPI on Utilities**: A decrease in mining PPI has alleviated cost pressures for public utilities, leading to a recovery in profit margins, although this trend may reverse due to insufficient end-demand [7]. - **China's Export Dynamics**: China's export share has improved due to pandemic-related shifts, with a temporary recovery in 2023-2024 driven by inventory replenishment in Western manufacturing [8]. - **Outward Expansion of Chinese Enterprises**: The trend of Chinese companies expanding overseas has positively impacted profitability, particularly in home appliances, non-ferrous metals, and machinery sectors [9][10]. - **Policy Support for Emerging Industries**: Recent industrial policies emphasize the importance of maintaining industrial security and promoting new industrialization, benefiting sectors like energy metals and biomanufacturing [11]. - **Growth Potential in Service Consumption**: There is significant potential for growth in service consumption, with government initiatives aimed at enhancing domestic demand and expanding service sectors such as health care and home services [12].

Core Points - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI with bio-manufacturing, green chemicals, new materials, future food, and future agriculture [2][3] - The conference aims to explore the development trends of the bio-manufacturing industry during the 14th Five-Year Plan, innovations driven by AI, and the technologies and products that will sustain the vitality of the bio-manufacturing sector [2][3] - Various activities will take place during the conference, including a Youth Forum on Bio-Manufacturing, a high-level roundtable discussion, and a closed-door seminar on the "2025 AI Empowering Bio-Manufacturing Industry Innovation Development Blue Book" [2][3][20] Organizational Structure - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by several institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Meisai Bioengineering Co., Ltd. [3] - Supporting organizations include the Chinese Society of Biotechnology's Bio-based Materials Committee and various regional bio-manufacturing alliances [3] Conference Agenda - The agenda includes registration, high-level discussions, and thematic forums on topics such as green chemicals and new materials, AI-driven innovations in bio-manufacturing, and future food and agriculture [6][7][21] - Specific sessions will cover topics like enzyme molecular engineering, bio-based carboxylic acid conversion, and the design of humanized "4D" collagen proteins [11][12][17][25] Special Acknowledgments - Several companies and institutions have been acknowledged for their support, including Ningbo Meisai Bioengineering Co., Ltd., Peking University Ningbo Institute of Ocean Medicine, and various technology firms [4] Industry Insights - The conference will also feature the release of the "China Synthetic Biology Industry Distribution Map (2025 Edition)" and a list of over 500 representative bio-manufacturing enterprises in China [50][51] - The event aims to facilitate technology transfer, product scaling, and talent acquisition within the bio-manufacturing sector [2][3]

Core Viewpoint - The article discusses the construction project of a collagen production line by Shandong Furida Biotechnology Co., Ltd., highlighting its investment, production capacity, and timeline for completion [2]. Summary by Sections Project Progress - Shandong Furida Biotechnology Co., Ltd. is expanding its collagen production line, located in Linyi City, Shandong Province, with a total investment of 12 million yuan, including 500,000 yuan for environmental protection [2]. - The project will utilize existing facilities and is expected to produce 200 kg of collagen annually upon completion in June 2025 [2]. Existing Project Status - The company has several ongoing projects, including: - Sodium hyaluronate project with an annual output of 50 tons [4]. - Various fermentation projects with different production capacities, including: - Recombinant Type II collagen: 115.2 kg/a - Recombinant Type XVII collagen: 64 kg/a - Recombinant Type III transmembrane collagen: 20.8 kg/a - The total annual production capacity for collagen will reach 200 kg [3][4]. Industry Events - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang Province, focusing on AI and bio-manufacturing, green chemicals, new materials, future food, and agriculture [8][9].

Core Viewpoint - The article highlights the approval of the "Regulations on Promoting the Development of Synthetic Biology Manufacturing Industry in Changde City," marking a significant step in the local government's efforts to foster the synthetic biology sector and establish a national-level industrial cluster [2]. Group 1: Legislative Developments - The Changde City government has prioritized the development of the synthetic biology manufacturing industry, creating a multi-faceted industrial landscape across various regions such as Jinshi City, Anxiang County, and Changde Economic Development Zone [2]. - The "Regulations" represent the first local legislation in the synthetic biology manufacturing field in China, consisting of 19 articles covering objectives, scope, government responsibilities, innovation platform construction, and more [2]. Group 2: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on the intersection of AI and bio-manufacturing, as well as advancements in green chemicals, new materials, future food, and agriculture [4][5]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI-Enabled Bio-Manufacturing Industry Innovation Development" [5].

菌株是生物质炼制的 "芯片"，是以生物质为原材料的新型生物制造产业链和绿色低碳生物经济的核心。 用于生物制造的菌株细胞通常面临中间代谢产物积累、毒性产物抑制，导致反应效率低、终产物浓度低的问题，严重制约了绿色生物制造的发展。因 此，" 如何构建菌株细胞并强化反应过程合成生物基产品 "是该领域重要的研究课题。 以" 菌株细胞工厂构建及产物合成强化 "为核心，以" 人工细胞器创制、菌株细胞工厂构建、反应分离耦合调控 "从微观到宏观强化产物生物合成，可 以强化生物制造过程。 多 年来， 大连理工大学薛闯教授 团队创建了多酶自组装蛋白质笼的人工细胞器，该人工细胞器可实现化学诱导、光诱导提升细胞器的可调节性，揭 示了人工细胞器的时空调控机制；创建了"多枪-多靶"快速菌株构建方法，揭示了磷酸化激酶多维度协同调控菌株的新机制，阐明了梭状芽孢杆菌群体 感应系统中信号分子自诱导肽的合成途径和调控功能；制备了碳纳米管阵列复合膜，开发了反应分离耦合技术。实现了 以生物能源为主的产品生物合 成强化 ， 为解决工业生物技术领域催化效率低的瓶颈问题提供了新突破点与新思路 。 点击更多阅读 ： 祝贺！80后生物制造专家-薛闯教授获大奖，全 ...