Core Viewpoint - The successful registration of bio-synthesized royal jelly acid by Furuida, a subsidiary of Lushang Group, marks a significant breakthrough in the Chinese cosmetics industry, enabling the large-scale application of this active ingredient and leading innovation in the sector [1][8]. Group 1: Royal Jelly and Its Applications - Royal jelly is a complex substance secreted by worker bees, consisting of water, proteins, sugars, lipids, and trace components, and is known for its strong biological activity with potential applications in food, medical materials, health products, and cosmetics [3][4]. - Historically, royal jelly has been used in skincare, with records dating back over 2000 years in ancient Egypt and China [3]. Group 2: Benefits of Royal Jelly Acid - Royal jelly exhibits multiple benefits in cosmetics, including anti-aging properties by promoting collagen production and inhibiting skin photoaging [4][5]. - It also has antibacterial properties, effectively inhibiting Staphylococcus aureus and other microbes [5]. - Additionally, royal jelly shows strong anti-inflammatory effects, enhancing skin barrier function and hydration [5]. Group 3: Challenges in Industrialization - The core component of royal jelly, 10-hydroxy-2-decenoic acid (royal jelly acid), is present in low concentrations (1.4%-2.4%), making extraction and application challenging [6][7]. - Despite China being the largest producer of royal jelly, the high cost and limited availability of royal jelly acid have hindered its widespread use in cosmetics [7][8]. Group 4: Industry Significance of Furuida's Breakthrough - Furuida's successful registration of royal jelly acid as a new cosmetic ingredient represents a significant advancement in the domestic cosmetics industry, breaking the research and application gap in this area [8][9]. - The innovative biosynthesis technology developed by Furuida enhances the efficiency and yield of royal jelly acid production, addressing the challenges of high costs and limited availability [9][10]. - The discovery of royal jelly acid's skin barrier protection and anti-aging effects further solidifies its potential as a key ingredient in cosmetics [10]. Group 5: Broader Implications for the Cosmetics Industry - The success of royal jelly acid is indicative of a broader trend in the Chinese cosmetics industry towards reducing reliance on foreign technology and increasing domestic innovation [11]. - The number of newly registered cosmetic ingredients in China is at a historical high, with over 40% being supported by synthetic biology, reflecting a strategic shift towards "domestic substitution" in response to global supply chain uncertainties [11].

（文章来源：每日经济新闻） 每经AI快讯，10月13日，港股巨子生物(02367.HK)跌超5%，截至发稿，跌5.33%，报50.6港元，成交额 6.28亿港元。 ...

消息面上，2025年双十一电商大促已经提前启动。华泰证券此前指出，在25Q2面临一定外部因素影响 的背景下，巨子生物上半年收入与利润仍能双增，且盈利能力维持相对稳定，彰显品牌定力与业绩韧 性。双11旺季临近，公司品牌宣传/达人推广等活动有望逐步恢复并带动公司H2增长提速。 巨子生物(02367)再跌超5%，截至发稿，跌5.33%，报50.6港元，成交额6.28亿港元。 值得注意的是，华熙生物9月底表示，已联合国家计量院等多家第三方检测机构对相关企业的相关产品 展开检测，结果几十份检测结果均显示，相关产品中的重组胶原蛋白添加量未达标。华熙生物表 示，"已将数十份检测报告提交国家药品监督管理局。"分析人士称，可复美在今年618电商大促中失 意，市场将重点关注双11期间可复美电商销售表现。 ...

值得注意的是，华熙生物9月底表示，已联合国家计量院等多家第三方检测机构对相关企业的相关产品 展开检测，结果几十份检测结果均显示，相关产品中的重组胶原蛋白添加量未达标。华熙生物表 示，"已将数十份检测报告提交国家药品监督管理局。"分析人士称，可复美在今年618电商大促中失 意，市场将重点关注双11期间可复美电商销售表现。 智通财经APP获悉，巨子生物(02367)再跌超5%，截至发稿，跌5.33%，报50.6港元，成交额6.28亿港 元。 消息面上，2025年双十一电商大促已经提前启动。华泰证券此前指出，在25Q2面临一定外部因素影响 的背景下，巨子生物上半年收入与利润仍能双增，且盈利能力维持相对稳定，彰显品牌定力与业绩韧 性。双11旺季临近，公司品牌宣传/达人推广等活动有望逐步恢复并带动公司H2增长提速。 ...

近日，自然堂向港交所递交了上市申请。 早在2023年，自然堂（未更名前的名称"伽蓝集团"）就有上市消息传出，而直到现在，这家拥有24年历 史的国货美妆巨头的上市之路才迎来实质性进展。 "攻占"下沉市场？ 海通证券分析师将中国化妆品零售渠道划成了四个阶段：2004年前的百货时代；2011年前的KA/CS （Key Account/Cosmetic Shop；大型卖场/化妆品专营店或连锁门店）；2011-2017年传统电商渠道； 2018年以来的社媒电商时代。 （文/霍东阳 编辑/张广凯） 不过，对于成立于2000年前后的国产美妆公司来说，零售渠道的阶段有所不同，它们身上最重要的标签 之一是"农村包围城市"。 在这批国产美妆品牌成立之初，国际大牌已凭借强大的品牌力和资金实力，牢牢占据了一二线城市的百 货商场渠道，它们只能选择下沉到国际品牌渗透率较低的三四线城镇及乡镇，通过成千上万的CS渠道 网点触达最广大的消费群体，完成最初的资本和品牌积累。 自然堂也是在这一阶段成立的。2001年，郑春颖在上海创立了自然堂，提出"打造中国人自己的世界级 品牌"的愿景。 自然堂的渠道策略经历了三个明显的阶段：在初期，自然堂一度占据 ...

Core Insights - Gu Yu has launched a new anti-aging ingredient, "Human-like Exosome HME," which is the third core ingredient developed through exclusive patented research, enhancing its competitive edge in the global life and health sector [1][3] - The company aims to establish a complete research and development ecosystem, focusing on original ingredient innovation and addressing the unique skin characteristics of Chinese consumers [1][8] - Gu Yu plans to invest 2 billion yuan in research and development over the next decade, demonstrating its commitment to technological advancement in the competitive beauty market [16] Research and Development Strategy - The newly developed "Human-like Exosome HME" utilizes proprietary artificial exosome technology to create a nanovesicle system that mimics natural human exosomes, delivering key genetic components for anti-aging effects [3][4] - The ingredient has shown significant efficacy in cell migration and collagen production, outperforming natural human exosomes in various tests [7][10] - Gu Yu has established a comprehensive R&D framework, including a 3,000 square meter research center and multiple production facilities, positioning itself as a leader in the industry [10][12] Collaboration and Innovation - The company collaborates with academic institutions, including the establishment of a joint research center with Xiamen University, focusing on the development of bioactive components and anti-aging research [13][14] - Gu Yu's research team consists of over 100 professionals, including 10 senior scientists and 15 PhDs, ensuring a robust talent pool for innovation [13] - The company has successfully developed other core ingredients, such as "Aurora Glycyrrhizin" and "Rare Ginseng Saponin CK," which have achieved high purity and efficacy through advanced biotechnological methods [8][10] Market Positioning - Gu Yu aims to enhance the global competitiveness of Chinese beauty brands by leveraging its proprietary technologies and research capabilities [1][16] - The company emphasizes the importance of safety, efficacy, compliance, and innovation in its product development, ensuring that its ingredients meet market standards [6][7] - With a focus on scientific rigor and consumer needs, Gu Yu is positioned to lead the domestic beauty market and expand its international presence [1][16]

Core Insights - Gu Yu Biotechnology Group has developed a proprietary anti-aging ingredient, "Human-like Extracellular Vesicle HME," addressing the challenge of applying human-derived exosomes in cosmetics [1][2] - The new ingredient is a significant innovation in the industry, enhancing Gu Yu's portfolio alongside existing key ingredients like Aurora Licorice and Rare Ginseng Saponin CK [1][2] Industry Context - Exosomes have become a focal point for major international cosmetic brands due to their proven anti-aging, antioxidant, and repair properties [2] - The aging process is linked to the inability of the body to maintain normal cell renewal and homeostasis, which is closely regulated by intercellular communication involving exosomes [2] Technological Breakthrough - The Human-like Extracellular Vesicle HME is synthesized using biomimetic methods, accurately simulating the structure of exosomes to encapsulate and deliver key active components like miRNA and siRNA [3] - Gu Yu's research has overcome traditional challenges associated with stem cell-derived exosomes, such as aging, mutation, and contamination risks [3] Scientific Validation - The exploration of exosomes has led to significant theoretical breakthroughs, including four Nobel Prizes in the last 20 years, validating their role as effective signaling molecules [4] AI Integration - Gu Yu leverages AI technology to accelerate the analysis and selection of high-activity target genes from thousands of candidates, ensuring the efficacy of the new ingredient [5][6] - The company has achieved stable and scalable production of the Human-like Extracellular Vesicle HME, ensuring consistency across batches [6] Competitive Advantage - Gu Yu's founder defines the Human-like Extracellular Vesicle HME as a groundbreaking "cell gene-level anti-aging" ingredient, positioning it as a leading solution in the next generation of anti-aging skincare [7] - The company has established a comprehensive self-research model, controlling the entire supply chain from raw material development to production [7][8] Future Outlook - With the introduction of the Human-like Extracellular Vesicle HME, Gu Yu has launched three core self-developed ingredients within its first decade, creating a competitive barrier that is difficult for others to replicate [9] - The company plans to invest 2 billion yuan in research and development over the next decade, reflecting its commitment to scientific innovation and market differentiation [9]

Core Insights - The 2025 Nobel Prize in Physiology or Medicine was awarded to immunologists Mary Brenk, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries related to "peripheral immune tolerance mechanisms," particularly focusing on regulatory T cells (Treg) [1][4][10] - The findings have significant implications for skin health and aging, suggesting that regulating Treg cell function could fundamentally maintain skin immune homeostasis, delay aging, and promote self-repair [3][4][8] Industry Implications - The skin, as the largest immune organ, has its health closely tied to the delicate balance of the immune system, which the Nobel findings could help elucidate [3][4] - Companies have begun integrating immunological principles into product development, but challenges remain in achieving effective ingredient penetration and balancing immune responses [3][10] - The cosmetic industry is shifting from traditional "anti-inflammatory" approaches to a more fundamental focus on "immune homeostasis regulation," recognizing that healthy skin is not just about the absence of inflammation but maintaining a precise immune balance [8][10] Research Directions - Current research on Treg cells in maintaining skin homeostasis is focused on three main areas: enhancing Treg cell function to suppress chronic inflammation, targeting the clearance of senescent cells, and strengthening the dialogue between the skin barrier and the immune system [9] - The understanding of Treg cells and peripheral immune tolerance mechanisms is reshaping the perception of skin health, emphasizing the dynamic balance between immune cells and tissues [10][12] Product Development - Shiseido has pioneered research in skin immunity, focusing on activating the skin's immune surveillance mechanisms rather than merely delaying cellular aging [12][14] - The use of PDRN (Polydeoxyribonucleotide) as a natural calibrator for skin immunity is gaining traction, demonstrating dual mechanisms to regulate immune balance and accelerate the repair of the immune microenvironment [15][16] - The challenge remains in translating complex immunological concepts into safe and effective skincare products, with a need for effective communication to consumers [16][17] Industry Evolution - The 2025 Nobel Prize recognition reflects a significant shift in the relationship between basic scientific research and industry application, with the cosmetic sector increasingly becoming a contributor to scientific advancements rather than merely an adopter [17][24] - Leading cosmetic companies are establishing strong research capabilities through collaborations with academic institutions and long-term investments in foundational research, moving towards a dual-driven innovation ecosystem [24][25] - The industry's focus is shifting from chasing trends to maintaining a commitment to core scientific principles, as exemplified by Shiseido's long-term dedication to skin immunology [25]

近日，据中华人民共和国黄埔海关官网公布一则行政处罚内容，广州逸仙电子商务有限公司（以下简称"逸仙电商"）因进口法定检验商品未报检，被太平 海关处以罚款15.63万元。 对此，有化妆品行业人士表示，"合规通关是最基本、也是最关键的一环。出现'未报检'这样的失误，无论是由于流程疏忽、人员操作失误，还是对法规 理解存在偏差，都清晰地指向了逸仙电商内部在进出口合规管理方面存在一定疏漏。" 因"未报检"被罚15.63万 据行政处罚决定书披露，太平海关在调查中发现，逸仙电商在进口业务中未对法定检验商品办理报检手续，该行为违反了《中华人民共和国进出口商品检 验法》第五条及《中华人民共和国进出口商品检验法实施条例》第十六条第一款的规定。 | 图行之 | | | | | | | | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | | | 行政处罚导入模板 | | | | | | | | | | | | 行政部到人名称 | (元政權対人 ...

Trade Relations - The U.S. plans to impose a 100% tariff on Chinese exports related to rare earths and key software, prompting a response from China's Ministry of Commerce urging dialogue to resolve trade concerns [1] - China announced countermeasures against U.S. port fees on Chinese vessels, asserting that the U.S. actions violate WTO rules and the principle of mutual benefit [2] E-commerce Trends - Adobe forecasts that U.S. online holiday sales will reach $253.4 billion in 2025, a 5.3% increase year-over-year, with mobile contributing 56.1% of sales [3] - OpenAI has launched an instant checkout feature on ChatGPT, allowing users to search, select, and purchase products directly within the platform [5] Transportation and Logistics - Didi reported a 14% increase in daily ride-hailing demand during the recent holiday period, with overseas travel demand more than doubling compared to summer [4] - Deppon Express has established logistics routes to six Middle Eastern countries, offering tailored solutions for various product categories [8] Consumer Brands - Xiaomi opened two flagship stores in Europe and plans to expand to ten stores by the end of 2025, aiming to sell electric vehicles by 2027 [9] - Natural堂 completed a new financing round with a valuation exceeding 7 billion RMB, and plans to go public in Hong Kong [11] - BYD's 14 millionth new energy vehicle rolled off the production line in Brazil, with the Brazilian president becoming a car owner [12] Social Media and E-commerce Integration - TikTok is testing a new shopping feature in the UK called "Trendy Beat," focusing on popular products driven by platform content [7] - Indonesia has reinstated TikTok's local operating license after a previous suspension due to data reporting issues [6]