2026.02. 04 本文字数：3072，阅读时长大约5分钟 作者 | 第一财经 缪琦 在今年的上海两会上，上海市市长龚正作政府工作报告时表示，2025年，上海市生产总值达到5.67万亿元、增长5.4%，好于预期。综合各方面因素，建 议2026年全市生产总值预期目标增长5%左右。 对于成绩单和目标，上海市人大代表们怎么看？又有何建议？ 不确定性与技术变革下，机遇与挑战并存 "上海过去一年的增长，离不开抓早、抓稳、抓实的谋划和部署。" 上海市人大代表、上海段和段律师事务所党支部书记吴坚对第一财经表示，首先，新 质生产力成为核心引擎，集成电路、生物医药、人工智能三大产业规模历史性突破2万亿元，成为经济增长的"压舱石"；其次，科技赋能显示了强大成 效，受益于人工智能和算力需求爆发，信息服务业增加值增长15.3%，软件和信息技术服务业营收大幅增长，成为服务业增长的最大亮点 ；第三，上海 经济的韧性更强了，在外向型经济面临国际经贸秩序不稳定的情况下，上海通过产业升级和内需挖潜，展现出经济韧性。 上海市人大代表、上海艾能电力工程有限公司副董事长朱柯丁告诉第一财经，今年的政府工作报告基调务实、判断理性，并抓住了关键变量。 ...

Core Viewpoint - Shanghai aims to achieve a GDP growth rate of around 5% for 2025, with a focus on enhancing its status as an international economic, financial, trade, shipping, and technological innovation center [3][5][12]. Group 1: Economic Goals and Projections - The main expected economic targets for Shanghai in 2025 include a GDP growth of approximately 5%, a 2% increase in local public budget revenue, and R&D expenditure reaching 4.6% of GDP [3][12]. - The "15th Five-Year Plan" outlines an average annual GDP growth target of around 5%, with potential growth levels estimated between 4.6% and 5.2% [3][12]. Group 2: Development of the "Five Centers" - The report emphasizes the continuous enhancement of the "Five Centers," which include international economic, financial, trade, shipping, and technological innovation centers [5][7]. - Specific initiatives include supporting industries such as smart connected vehicles, marine economy, low-altitude economy, aerospace, and satellite internet [5][11]. Group 3: New Quality Productivity - The focus is on integrating technological and industrial innovation to foster new quality productivity, including accelerating the application of major technological achievements and promoting intelligent, green, and integrated industrial development [9][10]. - Shanghai's R&D expenditure as a percentage of GDP reached approximately 4.5% in 2025, with significant growth in key industries like integrated circuits, biomedicine, and artificial intelligence [9][10]. Group 4: Modern Industrial System - The "2+3+6+6" modern industrial system aims to establish a world-class high-end industrial cluster, with a focus on traditional industry transformation and the development of three leading industries: integrated circuits, biomedicine, and artificial intelligence [10][13]. - By 2030, the plan targets that the total output value of strategic emerging industries will account for over 50% of the total industrial output value [12][13]. Group 5: Future Industry Layout - The report highlights the importance of forward-looking layouts in future industries, including quantum technology, brain-computer interfaces, and bio-manufacturing, to enhance Shanghai's competitive edge [14][12]. - The establishment of a reasonable investment mechanism for manufacturing and the promotion of collaboration between industry, academia, and research in emerging fields are emphasized [14][13].

在作用过程中，3种细胞因子像一支协同作战的"爆破小队"。干扰素γ负责"引路"，指引关键的打孔蛋白 前往胰腺癌细胞内的溶酶体；干扰素β提供"爆破工具"，激活打孔蛋白；转化生长因子β则是"稳定器"， 确保打孔蛋白保持维持激活状态。最终，打孔蛋白在溶酶体膜上打出孔洞，癌细胞随之从内部被彻 底"爆破"瓦解。 胰腺癌俗称"癌中之王"，恶性程度极高，治疗难度大，长期缺乏有效治疗手段。中国医学科学院基础医 学研究所教授黄波团队发现，胰腺癌细胞表面会形成一层黏液保护层，既能够逃避免疫细胞的攻击，也 能抵抗人体自身消化酶的清除，这是导致胰腺癌难以治疗的重要原因。3种细胞因子联合使用能够突破 这层屏障，激活胰腺癌细胞内部的死亡机制。 中国医学科学院团队近日发布一项研究成果，首次证实联合使用3种常见细胞因子，能够有效破坏胰腺 癌细胞内部结构，使癌细胞"炸裂"死亡，为胰腺癌治疗提供了新思路。 团队表示，该研究不仅揭示了3种细胞因子在胰腺癌治疗中的协同机制，也为临床转化提供了可行路 径，有望攻克胰腺癌治疗的医学难题。 来源：北京日报客户端 研究还提出，借助脂质纳米颗粒载体，可将这3种细胞因子的信使核糖核酸精准输送至肿瘤部位，既能 提高 ...

Core Viewpoint - The article emphasizes the importance of developing a professional talent system for "unaccompanied care services" in response to the aging population in Shanghai, highlighting the need for skilled nursing personnel and comprehensive care capabilities [2][5]. Unaccompanied Care Services - The average daily provision of "unaccompanied care services" at Zhongshan Hospital is between 1,300 to 1,400 patients, indicating a significant demand for this service [2]. - There is a shortage of qualified nursing staff with appropriate education and skills, which needs urgent attention [2]. - Recommendations include professional training for caregivers and establishing comprehensive fee standards for various levels of care, from "level II nursing" to post-stabilization care [5][6]. AI in Clinical Applications - The application of AI in clinical settings is increasingly prevalent, but many aspects are still in a "wild growth" phase, necessitating organized development and training of AI models [7]. - There is a call for administrative guidance in developing specialized AI models for specific diseases to enhance their applicability and effectiveness [7]. Innovation in Biomedicine - The article discusses the need for improved collaboration between scientific and clinical experts to drive innovation in biomedicine, particularly through AI-driven scientific discovery [9]. - The establishment of a "data factory" model is proposed to overcome data barriers and enhance drug development processes [10]. Global Access to Innovative Drugs and Devices - Suggestions include creating a "zero time difference" access channel for innovative drugs and devices in Shanghai, allowing for expedited approval processes for urgently needed clinical products [11]. - The exploration of cross-border data flow in healthcare is recommended to support international collaboration and digital therapy products [11].

Core Viewpoint - CAR-T cell therapy is a revolutionary cancer treatment that utilizes genetically modified T cells to target and kill cancer cells, and it has shown promise in treating autoimmune diseases as well [2]. Group 1: Challenges of Traditional CAR-T Therapy - The preparation of CAR-T therapy is complex and expensive, involving blood extraction, genetic modification, and expansion, which can take several weeks and incur high costs [3]. - A pre-treatment with chemotherapy is required to clear the patient's existing lymphocytes before reinfusion, leading to significant side effects [3]. Group 2: Innovations in CAR-T Therapy - Researchers have proposed in vivo CAR-T cell therapy, which allows for the direct generation of CAR-T cells in the body through injection, potentially simplifying and broadening access to CAR-T therapy [4]. - A study published on February 3, 2026, introduced a novel adeno-associated virus variant, AAV6-M2, which can specifically target human T cells and generate CAR-T cells effectively in a mouse model of systemic lupus erythematosus (SLE) [4][5]. Group 3: Mechanism and Efficacy - The AAV6-M2 variant was developed using AI-assisted design and high-throughput screening, allowing it to efficiently target resting T cells without prior activation, which is crucial for in vivo CAR-T cell generation [8]. - In tests on humanized mouse models, a single injection of AAV6-M2-CD19CAR led to a 77.5% conversion rate of CD8+ T cells to CAR-T cells, effectively eliminating B cells and improving symptoms of lupus [10]. Group 4: Safety and Advantages - AAV6-M2 demonstrated significantly reduced liver tropism compared to wild-type AAV, lowering the risk of liver toxicity and enhancing the cost-effectiveness of the treatment [13]. - The study indicates that AAV-mediated CAR delivery can generate functional human CAR-T cells in vivo, marking a shift from personalized treatments to more universal, off-the-shelf products [5][14]. Group 5: Future Prospects - This research signifies a platform innovation, proving that a single systemic injection of an AAV vector can generate durable, functional human CAR-T cells, paving the way for rapid clinical translation [14]. - The application of AAV-mediated gene therapy is expanding from genetic diseases to cancer and autoimmune diseases, opening new avenues for accessible cell and gene therapies [15].

对于成绩单和目标，上海市人大代表们怎么看？又有何建议？ 不确定性与技术变革下，机遇与挑战并存 在今年的上海两会上，上海市市长龚正作政府工作报告时表示，2025年，上海市生产总值达到5.67万亿 元、增长5.4%，好于预期。综合各方面因素，建议2026年全市生产总值预期目标增长5%左右。 然而，面对巨大的变化及严峻复杂的经济形势，各行各业的市场主体在实际经营中仍然不乏挑战，对于 现实的体感也不尽相同。 在吴坚看来，面对复杂的内外部环境，上海的外贸和外资不可避免地遭受到了冲击。内部转型方面，上 海作为超大城市，也正面临着产业结构深度调整的压力，如何在传统动能减弱的情况下，快速培育新动 能，是全年工作的核心突破口，也是值得持续关注的重点。 以朱柯丁所在的行业为例，他提出，一方面，需求增长很快，但系统建设的复杂度明显提高。算力相关 用电不是"多拉几条线"就能解决的，而是对电网结构、备用能力、调峰能力提出系统性要求。另一方 面，技术和工程标准提升，但项目回报周期偏长。大多数项目，前期投入大、专业门槛高，但回报更多 体现在长期运行效率和综合效益上，企业在资金和风险承受上压力不小。另外，在新业态的快速发展 中，规则体系却仍 ...

Core Viewpoint - The development of the Chengdu-Chongqing economic circle is a national strategy aimed at creating a high-quality growth hub in the western region of China, with significant progress made in the past six years, particularly during the 14th Five-Year Plan period [1]. Economic Growth Projections - By 2025, Chongqing's GDP is projected to reach 33,757.93 billion yuan, reflecting a growth rate of 5.3% compared to the previous year [1]. - Sichuan's GDP is expected to reach 67,700 billion yuan by 2025, with a growth rate of 5.5%, ranking fifth in both total and growth rate nationally [1]. Infrastructure and Project Development - A total of 555 key projects are being implemented in the Chengdu-Chongqing area over five years, including significant infrastructure like the Jiangbei International Airport T3B terminal and the Yukun high-speed railway [2]. - The region has successfully integrated into national technology innovation centers and has hosted two "Belt and Road" technology exchange conferences [2]. Urban and Regional Planning - The Chengdu-Chongqing economic circle's land spatial planning has been approved, with efforts to optimize urban green space and key area planning [3]. Cross-Regional Cooperation - The economic output of the Chengdu-Chongqing economic circle accounts for approximately 6.5% of the national total, with significant improvements in regional economic coordination and infrastructure connectivity [4]. - The region has established 28 inter-provincial railways, highways, and waterways, with various industrial clusters reaching trillion-yuan scales [4]. Future Development Strategies - In 2023, Chongqing aims to enhance the development level of the Chengdu-Chongqing economic circle by implementing seven major special actions and accelerating key engineering projects [6]. - The focus will be on strengthening regional collaboration, enhancing transportation networks, and promoting advanced manufacturing [6]. Comprehensive Cooperation Initiatives - The region will deepen reforms in market access and tax management, and promote cross-border financial cooperation [7]. - There will be a push for cultural tourism promotion and the establishment of high-standard international events [7].

Core Insights - Sequoia China has completed the global acquisition of the core product moxifloxacin (brand name: Avelox®) related to fluoroquinolone antibiotics on February 2, 2026, establishing Hangzhou Shanze Biological Pharmaceutical Co., Ltd. [1] - Shanze Biological and its parent company Ascenda Pte. Ltd. have acquired specific assets for Avelox® globally, including drug registration certificates, intellectual property, and business contracts, ensuring a solid foundation for the product's ongoing supply and future development [1] - Jin Xiaodong has recently been appointed as the CEO of Shanze Biological, bringing decades of experience in the pharmaceutical industry, previously serving as General Manager at Pfizer China [1]

人工智能的生命力和价值，只有落在具体场景里，才能赋能千行百业、造福社会。对此，钱塘先行 先试，在去年12月召开的人工智能产业新高地推进大会上，钱塘发布人工智能场景"机会清单"和"能力 清单"共40个具体场景，为人工智能企业搭建起从研发到产业化落地的"桥梁"，让人工智能成为创新钱 塘的核心支撑。 比如在"机会清单"中，杭州先欧生物医疗科技有限公司发现在针对宠物肿瘤治疗的传统穿刺和消融 操作中，人工误差难以有效控制，操作精准度不足甚至会给宠物带去二次伤害。"我们希望能寻求一家 有激光定位经验的科研单位，能实现对接微波消融、纳秒杀消融的消融针的精准定位。"公司相关负责 人说道。 杭州职业技术大学"科技副总"杨爱喜（杭州吉利汽车有限公司） 由浙江大学智能创新药物研究院和浙江大学药学院联合开发的XPert模型精准助力药物发现、研究 成果在国际权威期刊上发表，来自德睿智药的国内首款AI辅助设计新药进入III期临床，新型四足机器 人企业具微科技在手订单突破5亿元……新年伊始，科技创新活力在钱塘（新）区持续涌动。 "十四五"期间，钱塘研发投入强度从2020年的4.43%提升到2024年的4.91%、连续五年居全省第 二；环大 ...

2月3日，湖南省十四届人大四次会议开幕。湖南省政府工作报告透露，2025年湖南省地区生产总值达5.53万亿元、稳居全国前十强，增长4.8%。 在部署2026年的重点工作时，湖南省政府工作报告提出，强化区域协调联动发展。深度融入国家重大战略，统筹推动区域共进，加快推进新型城镇化，大 力发展县域经济，着力营造区域共赢互利、县域各擅其长的蓬勃发展态势。其中还特别明确，要"提高县域经济占全省经济比重"。 作为中部经济大省，县域经济是湖南经济发展的基石，也日益成为其发展的一大"软肋"。 数据显示，湖南86个县市县域面积占全省超九成、承载七成常住人口、贡献超五成经济总量。 2024年，20个经济大县以湖南全省约四分之一的土地与人口，贡献了超过一半的县域经济总量，撑起"半壁江山"。长沙县、浏阳市、宁乡市作为湖南县域 经济"龙头"，更多年稳居全国百强县前列。 不过，湖南近年也面临"原地踏步"的窘境—— 根据城市进化论此前研究，过去5年间，全国"千亿县"数量由2020年38个增至2025年至少74个，数量接近翻番；其中中西部贡献全国超三成增量，湖北五 年新增4个"千亿县"，成为中西部最大"赢家"。 相比之下，湖南"千亿县"出现 ...