Core Insights - The Scripps Research Institute has developed a new imaging technology called vCATCH, which allows for precise localization of drug interactions at the single-cell level, aiding in the discovery of drug side effects [1][2] Group 1: Technology Overview - vCATCH technology illuminates the binding sites of drugs with single-cell precision, addressing the limitations of traditional methods that only show general organ distribution and overall drug concentration [1] - The technology is particularly applicable to covalent drugs that permanently bind to their targets [1] Group 2: Research Findings - In validation experiments, the team created binding maps for the cancer drugs ibrutinib and afatinib, revealing that ibrutinib binds not only to target cells in the blood but also to immune cells in the liver, heart tissue, and blood vessels, which may explain potential side effects like arrhythmia and bleeding [2] - The team is currently exploring whether vCATCH can enable cancer drugs to more selectively target tumor cells and is also studying the mechanisms of antidepressants in the brain [2] Group 3: Future Implications - The technology is expected to become a powerful tool for testing candidate drugs, ensuring strong binding to targets while minimizing adverse interactions in other organs, thereby reducing potential risks in early drug development [2]

Core Insights - A recent Stanford University report indicates that China's AI models, particularly open-weight large language models, are approaching or even surpassing international standards in capability and adoption [1][2] Group 1: Performance of Chinese Open-Weight Models - Open-weight models allow developers to download, use, and modify AI model parameters, enabling independent operation and customization [2] - The report highlights four representative Chinese large language models: Alibaba's Tongyi Qianwen, DeepSeek-R1, Kimi K2 from Moonlight, and GLM-4.5 from Z.ai [2] - Chinese open-weight models have surpassed OpenAI's open-source model GPT-oss in multiple benchmark tests, indicating a shift from follower to leader in the open-source large model field [2] Group 2: Global Adoption of Chinese AI Models - The usage rate of Chinese open-weight models globally surged from 1.2% at the end of 2024 to nearly 30% by August this year [3] - Chinese open-source models are praised for their affordability and performance, with some being free, leading to significant cost savings for companies [3] - Notable companies, including Airbnb, have adopted Tongyi Qianwen for its speed and cost-effectiveness compared to proprietary models like ChatGPT [3] Group 3: Rapid Development and Ecosystem Growth - The development of Chinese AI models is rapidly evolving, with many companies entering the AI agent development race [4] - By September, 63% of newly derived models on the Hugging Face platform were based on Chinese models, indicating a fast-growing application ecosystem [6] Group 4: Global AI Ecosystem and Governance - The rise of Chinese AI models is reshaping global technology adoption and dependency patterns, influencing AI governance and competition [6] - The release of DeepSeek-R1 has even impacted U.S. policy towards open-weight models, leading to a strategic emphasis on them [6] - The global leadership in AI is increasingly reliant on the coverage and adoption of open-weight models, not just proprietary systems [6]

Group 1 - The core issue with foldable screens is their vulnerability to low temperatures, which can cause the materials to become brittle and lead to screen damage [1][2] - Foldable screens are made of flexible OLED technology, which includes multiple layers of polymer materials, an organic light-emitting layer, and ultra-thin glass (UTG), all of which have a glass transition temperature that affects their performance in cold conditions [1][2] - The industry is actively working on improving foldable screen technology by focusing on material enhancements and structural optimizations, such as developing low glass transition temperature flexible substrates and more resilient low-temperature UTG [2] Group 2 - In low-temperature environments, foldable screens can experience three main issues: material brittleness, hinge stiffness due to solidified lubricants, and functional disruptions like touch sensitivity loss and battery performance decline [2][3] - Users are advised to take precautions to prevent foldable screens from freezing or cracking, including using insulated phone cases and keeping devices close to their body for warmth [2][3] - It is recommended that users minimize outdoor opening and closing of the device and allow the phone to acclimate to temperature changes before use to avoid potential damage [3]

Core Insights - The China Aviation Industry Corporation announced that its subsidiary, Xi'an Aircraft Industry Group, has delivered its 11,000th SR series aircraft, marking a significant milestone in the company's production history [1] Group 1: Aircraft Delivery and Features - The 11,000th SR series aircraft features a distinctive design with the number "11000" displayed on the fuselage, tail, and cabin, and is painted in a striking dark green color [1] - This aircraft is a new generation SR series G7+ model, which integrates the Safe Return emergency automatic landing system, allowing any passenger to initiate an emergency landing in case of pilot incapacitation [1] Group 2: Technological Innovations - In addition to the Safe Return system, the aircraft is equipped with the Cirrus Airframe Parachute System (CAPS) and the Perspective Touch+ avionics system, showcasing the company's commitment to enhancing industry safety standards [1] Group 3: Market Performance - The SR series, which includes models SR20, SR22, and SR22T, has been the best-selling high-performance single-engine piston aircraft for over 20 years since the first delivery in 1999 [1] - The total flight hours for Cirrus aircraft have reached 19 million hours, contributing significantly to the development of the global low-altitude economy [1]

26日，在重庆两江新区，46辆搭载L3级智能驾驶辅助系统的深蓝汽车正式驶入城市道路，这是我国首 批大规模L3级自动驾驶车辆正式上路通行，开启L3级自动驾驶汽车的规模化路测。 据了解，上路的46辆新能源汽车将会在试点路段上进行测试，深蓝汽车将重点检验L3级自动驾驶车辆 在加塞、急刹等极端动态环境下的预判与响应能力，评估人机共驾状态下的安全接管机制，通过长周 期、高密度的真实驾驶数据积累，持续提升L3级自动驾驶的可靠性与实用性。 "规模上路能积累海量运营数据，大幅提升我们的技术体系能力。"深蓝汽车董事长邓承浩表示，企业已 在规划下一代车型，未来每一款车都将搭载L3级甚至L4级自动驾驶功能，为全面走向消费市场做好准 备。 据悉，今年1—11月，深蓝汽车累计销量同比增长达45.7%，远超行业平均增速。目前，深蓝汽车全球 交付量已突破70万辆。 （文章来源：科技日报） ...

Core Viewpoint - The Chinese Academy of Sciences has showcased breakthroughs in precision breeding technology, particularly in the development of a new variety of fish that eliminates intermuscular bones, addressing consumer convenience in food preparation [1][2]. Group 1: Breakthroughs in Precision Breeding - The research teams have developed a new variety of fish, the "bone-free" silver crucian carp, which addresses the common issue of intermuscular bones in freshwater fish [2][3]. - The research identified the key regulatory gene runx2b responsible for the development of intermuscular bones in fish, leading to the creation of the world's first bone-free varieties of fish [3]. Group 2: Consumer Concerns and Testing - Concerns regarding the growth characteristics and flavor differences between bone-free and normal fish have been addressed through rigorous testing, showing no significant differences in growth performance and flavor under the same farming conditions [4]. - The research team conducted tests in various farming scenarios, including pond, cage, and indoor factory farming, to ensure the viability of the new fish varieties [4]. Group 3: Future of Production and Regulation - The promotion of these new fish varieties will require strict experimental evaluations and the establishment of national regulations regarding genetically modified organisms before they can be commercially produced [5]. - The advancement of molecular precision breeding technology is expected to enhance the economic traits of aquaculture, leading to increased production and income [5].

这8张博士学位证书的重量，远超纸张本身。这场改革不仅是给实干者的加冕，更是向全社会宣告—— 人才评价的最终标准，是解决真问题的能力。当更多"实践博士"能凭实绩脱颖而出，创新型国家建设将 会有更为坚实的人才根基。 改革的底气源于制度护航。2025年1月1日起施行的《中华人民共和国学位法》首次从法律层面明确"实 践成果"可作为申请学位的核心依据，为多元评价铺路。"实践博士"们的突围，恰恰填上了教育与产业 的鸿沟。 （文章来源：科技日报） 不久前，国内7所高校以不同方式公布了8名新晋的"实践博士"，越来越多的高校开始探索多元化的博士 学位授予方式。这场以实践成果替代学位论文的改革，不仅是对人才评价标准的校准，更是对教育科技 人才一体化的精准回应。 "实践博士"更深远的意义在于打通产学研的"最后一公里"。当高校认可车间里的创新，企业自然更愿接 纳校园里的研究，校企协同培养的良性循环由此激活。从2010年卓越工程师计划到如今"实践博士"落 地，如今的中国工科教育正逐步摆脱"学术化"倾向，转向更务实的轨道。 传统博士培养，常常陷入"为写论文而研究"的困境。长期以来，学位评价体系中的"唯论文"现象，催生 出教育与产业脱节、 ...

12月26日，由国家发展改革委、财政部推动设立的国家创业投资引导基金正式启动。启动仪式上，该引 导基金出资成立的3只区域基金与49只子基金和27个直投项目签订投资意向，涵盖集成电路、量子科 技、生物医药、脑机接口、航空航天等重点领域。 "科创企业成长壮大是一场旷日持久的'马拉松'，需要资本的耐心陪伴。"白京羽介绍，引导基金设置20 年存续期，其中10年投资期、10年退出期，通过更长久的投资期限，为企业提供长周期的资金供给；同 时通过更宽松的退出时限，为企业提供更多的发展空间，用耐心资本陪伴企业"长跑"，培育千行百业 的"小巨人"和"独角兽"。 不仅如此，国家创业投资引导基金还将坚持投硬科技。财政部经济建设司司长郭方明介绍，财政部门将 会同发展改革部门加强对基金投向的指导，聚焦"十五五"规划等国家规划明确的战略性新兴产业，鼓励 基金更多投向具有战略意义、有利于提高全要素生产率的项目以及外溢性强、社会效益高的领域，支撑 原创性、颠覆性技术创新和关键核心技术攻关，推动重大科技成果向现实生产力转化。 3只区域基金总规模均将超500亿元 为有效发挥中央资金"四两拨千斤"的杠杆效应，逐级吸引社会资本，实现万亿元的市场"造 ...

科技日报记者 刘侠 实习生 孔若溪 近日，东方电气集团所属东方电气长三角（杭州）创新研究院有限公司（以下简称"东长研究院"）与东方电气集团智慧光能有限公司（以下简称"东方光 能"）联合攻关打造的5千瓦钙钛矿—晶硅两端叠层光伏户外实证示范电站，在甘肃酒泉顺利完成调试并正式投运。 东长研究院与东方光能充分发挥"产研协同、优势互补"效能，与多家行业头部高校与企业组成联合攻关团队，依托自主搭建的钙钛矿叠层电池研发平台，攻 关核心技术，相继攻克宽带隙钙钛矿结晶调控、界面缺陷钝化等难题，成功研发出25毫米×25毫米规格的叠层电池，光电转换效率达到28.4%，为高效光伏 技术升级注入新动力。 当前，两端子钙钛矿—晶硅叠层电池技术的研发多集中于实验室，"实验室测试与户外实证脱节"成为制约技术产业化的突出瓶颈。此次建成的甘肃酒泉5千 瓦实证示范电站将有效破解这一瓶颈。该电站将全面监测叠层组件在西北典型干旱气候条件下的发电能力、温度响应特性、光谱利用效率以及长期衰减行 为，可为揭示该类新型电池在复杂自然环境中的老化机制与可靠性演化规律提供数据支撑。 作为我国首个千瓦级钙钛矿—晶硅两端叠层光伏示范电站平台，该项目的建成填补了我国在 ...

货物收运阶段，该货站引入RFID射频识别技术，实现货物与托盘信息秒级绑定赋码，全面推动受理全流程无纸化转型；安检环节搭载AI智能辅助判图系 统，通过X光机自动成像与AI算法精准识别，大幅提升违禁品判图效率与准确率；驳运环节大规模部署轻载AGV无人自动导引车，依托智能导航系统精准 对接货板，达成高精度、全天候定位搬运，同时通过重载集装器AGV及配套设备，实现从组板台至立体货架交接台的全流程无人化驳运；仓储环节采用 国内首台Lift&Run立体穿梭存储系统，通过多台升降机与穿梭车协同作业，在24米高立体货架中实现货物快速精准存取，并行作业效能实现倍数级增长。 整个智慧货站项目从收运、安检、储存到装机出港，实现了运营能力与技术水平的全方位迭代升级。 科技日报记者 于紫月 记者从航空工业规划总院获悉，近日，由该院参与设计的东航物流浦东西区智慧货站成功启动运营。 作为东航物流布局全球的首个智慧货站项目，该货站占地近3.6万平方米，以"智慧化、数字化、无人化"为核心建设理念，通过多项前沿物流技术的集成 创新应用，不仅填补了行业相关技术空白，更构建起覆盖货运全流程的智能化运营体系。其中，自主研发的核心物流数据平台，有效打破 ...