Summary of Key Points Core Viewpoint - The Hong Kong stock market experienced significant net selling from Northbound trading, with a total of HKD 30.47 billion in net sales on July 3, 2023, indicating a bearish sentiment among investors [1]. Group 1: Northbound Trading Activity - Northbound trading saw a net sell of HKD 30.47 billion, with HKD 18.66 billion from Shanghai Stock Connect and HKD 11.81 billion from Shenzhen Stock Connect [1]. - The most bought stocks included Meituan-W (03690), SMIC (00981), and Innovent Biologics (01801) [1]. - The most sold stocks were Alibaba-W (09988), Tencent (00700), and Guotai Junan International (01788) [1]. Group 2: Individual Stock Performance - Alibaba-W (09988) had a net sell of HKD 32.26 billion, with a total trading volume of HKD 71.91 billion, indicating a strong sell-off [2]. - Meituan-W (03690) received a net buy of HKD 9.87 billion, supported by the announcement of a new initiative to invest in 1,200 "Raccoon Canteens" over three years [4]. - SMIC (00981) saw a net buy of HKD 4.78 billion following the U.S. government's lifting of export restrictions on certain chip design software [5]. Group 3: Sector Insights - The healthcare sector, particularly innovative pharmaceuticals, is expected to benefit from new supportive policies from the National Healthcare Security Administration and the National Health Commission [5]. - The social services sector is projected to experience valuation recovery due to favorable government policies aimed at expanding domestic demand [4]. Group 4: Other Notable Stocks - Xiaomi Group-W (01810) had a net buy of HKD 22.71 million, with the CEO addressing order fulfillment priorities [6]. - Multi-point Smart (02586) received a net buy of HKD 61.61 million as it prepares to apply for a stablecoin license in Hong Kong [5].

Core Viewpoint - The short-term sentiment in the market has improved, with a significant number of stocks reaching their upper limit, indicating a potential recovery in investor confidence [1] Group 1: Market Performance - A total of 61 stocks hit the daily limit, with 14 stocks classified as consecutive limit-up stocks, and 5 of these achieved three consecutive limit-ups or more [1] - The upgrade rate for consecutive limit-up stocks was 41.67%, excluding ST and delisted stocks [1] - Over 3,200 stocks in the market experienced an increase, reflecting a broad-based rally [1] Group 2: Notable Stocks - Chengbang Co. achieved a limit-up, marking its sixth consecutive limit-up [1] - Dazhongnan showcased a "ground-to-sky" performance with 8 limit-ups in 6 days [1] - Haoshanghao reached a historical high with 5 limit-ups over 7 days [1] Group 3: Sector Performance - The innovative drug sector led the market gains, with notable performances from companies like Innovent Biologics, which saw a rise of over 9% in Hong Kong [1] - In the A-share market, Selin Medical achieved three consecutive limit-ups, while Chengyi Pharmaceutical and Weiming Pharmaceutical recorded two and three limit-ups, respectively [1] - The PCB sector also showed strength, with Shenghong Technology increasing over 6%, surpassing a market capitalization of 120 billion, and Pengding Holdings hitting the limit-up [1]

Group 1: Market Overview - The Hang Seng Index fell by 0.96%, down 232 points, closing at 23,989 points, while the Hang Seng Tech Index decreased by 1.20% [1] - The Hong Kong stock market saw a trading volume of HKD 130.6 billion in the morning session [1] Group 2: Pharmaceutical Sector - The National Healthcare Security Administration and the National Health Commission released measures to support the high-quality development of innovative drugs, indicating that innovative drugs remain a key investment theme [1] - The Hang Seng Biotechnology Index surged by 2.79% [1] - Ascentage Pharma-B (06855) rose by 8%, Kelun-Biotech (06990) increased by 7%, and Zai Lab (09688) gained 5.21% [1] - Kangfang Biotech (09926) saw a rise of over 11% as its first dual-antibody ADC drug AK146D1 entered clinical enrollment [2] - Innovent Biologics (01801) increased by over 6% following the approval of its drug Ma Shidu Peptide for commercialization [3] - CStone Pharmaceuticals-B (02616) rose by over 11% after disclosing two dual-specific antibody drug targets, CS2013 and CS2015 [4] - Sihuan Pharmaceutical (02096) gained 4.43% after its new generation anti-VEGF monoclonal antibody "Suvetizumab" was approved for market [5] Group 3: Other Sectors - Gaming stocks continued to rise, with Macau's June gaming revenue exceeding expectations, and Citigroup predicts growth momentum will continue in the second half of the year [5] - MGM China (02282) increased by 2.6%, and Melco International Development (00200) rose by 1.75% [5] - Wheelock Properties (01997) gained 7.32% as Hong Kong's retail sales value rebounded in May, leading Morgan Stanley to upgrade the company's rating [5] - Global New Material International (06616) rose by over 5% as the acquisition of Merck's surface solutions business is nearing completion [6] - Giant Star Legend (06683) increased by over 3% after its subsidiary invested USD 8 million in the Starlight New Economy Industry Fund [7] - Kingsoft (03888) fell nearly 7% as its new game "Unrestricted Machine" entered public testing, with market attention on its performance [8]

Core Viewpoint - The management of Innovent Biologics (信达生物) aims to become a leading global biopharmaceutical company by 2030, with significant advancements in product pipelines and international market presence [1] Group 1: Product Development and Clinical Trials - IBI363, a PD-1/IL-2α-bias dual antibody, is expected to show promising results in clinical trials, with Phase I focusing on understanding mechanisms of action and Phase II targeting representative tumors for proof of concept [2] - The management anticipates that Phase III trials will advance for indications with high certainty, with first-line indications for colorectal, gastric, and lung cancers expected to yield proof of concept data by 2026 [2] - Adverse reactions for IBI363 are manageable, with a reported rate of 43.9% for grade 3 or higher adverse reactions in the 3mg/kg Q3W group, but improvements are expected as clinical experience accumulates [3] Group 2: Product Launch and Market Strategy - The recently approved Marsduo peptide is expected to see rapid market penetration, targeting adults with a BMI of 28 or higher for long-term weight control [4] - The company plans to implement a multi-channel marketing strategy for Marsduo, including hospital-based, outpatient, retail, and e-commerce channels, with projected sales of 600 million yuan in 2025 and 1.8 billion yuan in 2026 [4] Group 3: Future Outlook - The domestic non-oncology business is projected to grow significantly, driven by the approval of Marsduo and other products, with expectations of reaching 20 billion yuan in revenue by 2027 [5] - The overseas business is also expected to see revenue growth from oncology products IBI363 and IBI343, with a focus on tumor indications initially and contributions from non-oncology later [5]

Investment Rating - The report rates Innovent shares as "Buy" with a target price raised to HK$90 from HK$60, indicating an expected share price return of 16.4% [5][18]. Core Insights - Innovent is leading the development of next-generation immuno-oncology (IO) and antibody-drug conjugate (ADC) combinations, which are expected to provide broader-spectrum, highly-potent, and less-toxic cancer treatments [9][18]. - The key product IBI363 has shown promising data in various cancers, including non-small cell lung cancer (NSCLC) and mucosal/acral melanoma, positioning it as a cornerstone for next-generation IO therapy [2][10]. - Innovent aims to achieve Rmb20 billion in product revenue by 2027 and advance five pipeline assets into global multi-regional clinical trials by 2030 [1][3]. Financial Projections - Revenue forecasts for 2025, 2026, and 2027 have been fine-tuned by 1%, 2%, and 2% respectively, with expected earnings per share (EPS) of Rmb0.05, Rmb0.53, and Rmb1.22 [3]. - Innovent's revenue is projected to grow from Rmb9.4 billion in 2024 to Rmb16.6 billion by 2027, reflecting a compound annual growth rate (CAGR) of approximately 23.1% [4][8]. Clinical Development - IBI363 is currently undergoing registrational trials for various indications, including head-to-head trials against pembrolizumab for melanoma and NSCLC, with enrollment expected to complete by the end of 2025 [2][12]. - Innovent is also developing multiple ADC platforms, including SyntecanE, SoloTx, and DuetTx, which are designed to enhance efficacy and reduce toxicity in cancer treatments [11][12]. Market Position - Innovent has transformed from a biotech start-up to a leading biopharma company with 15 launched commercial products, showcasing strong R&D and commercialization capabilities [17][18]. - The company is positioned to leverage its dedicated R&D platform, Innovent Academy, which employs over 500 scientists focused on developing innovative cancer therapies [9][18].

Core Viewpoint - The CESHKB index has shown significant growth, with a year-to-date increase of 64.30%, indicating a strong performance in the biotechnology sector listed in Hong Kong [1][2]. Group 1: Index Performance - The CESHKB index opened high and fluctuated, closing at 7388.22 points with a trading volume of 12.985 billion [1]. - Over the past month, the CESHKB index has risen by 14.05%, and over the last three months, it has increased by 17.80% [1]. Group 2: Index Composition - The CESHKB index is compiled by China Securities Index Co., Ltd. under the commission of China Securities Trading Service Co., Ltd., reflecting the overall performance of biotechnology companies listed in Hong Kong [1]. - The top ten holdings in the CESHKB index include: - CanSino Biologics (10.49%) - Innovent Biologics (9.9%) - WuXi Biologics (9.73%) - 3SBio (8.86%) - BeiGene (8.81%) - Zai Lab (5.86%) - WuXi AppTec (5.85%) - Kelun-Biotech (5.1%) - Genscript Biotech (4.42%) - Ascentage Pharma-B (4.15%) [1]. Group 3: Market and Industry Overview - The CESHKB index is entirely composed of companies listed on the Hong Kong Stock Exchange, with a 100% representation in the healthcare sector [2].

Market Overview - On July 2, the Hang Seng Index rose by 0.62%, closing at 24,221.41 points, with a net inflow of HKD 5.036 billion through the southbound trading channel [1] - The total trading volume for the southbound trading was HKD 128.967 billion, with a net buy of HKD 5.036 billion [1] Southbound Trading Details - The Shanghai Stock Exchange's southbound trading had a total transaction amount of HKD 81.984 billion, with a net buy of HKD 1.279 billion [1] - The Shenzhen Stock Exchange's southbound trading had a total transaction amount of HKD 46.983 billion, with a net buy of HKD 3.757 billion [1] Active Stocks - In the Shanghai Stock Exchange's southbound trading, Alibaba-W had the highest transaction amount at HKD 3.170 billion, followed by Chongqing Iron & Steel and Xiaomi Group-W with transaction amounts of HKD 2.929 billion and HKD 2.827 billion, respectively [1] - In terms of net buy amounts, the Yingfu Fund led with a net buy of HKD 1.674 billion, while Alibaba-W had the highest net sell amount at HKD 788 million, closing down by 0.36% [1] Shenzhen Stock Exchange Active Stocks - In the Shenzhen Stock Exchange's southbound trading, Alibaba-W also topped the transaction amount at HKD 2.407 billion, followed by Tencent Holdings and Xiaomi Group-W with transaction amounts of HKD 1.589 billion and HKD 1.582 billion, respectively [2] - The stock with the highest net buy was Innovent Biologics, with a net buy of HKD 651 million, closing up by 1.15%, while Alibaba-W had the highest net sell amount at HKD 945 million, also closing down by 0.36% [2]

Market Overview - On July 2, the Hang Seng Index rose by 0.62%, with southbound funds totaling HKD 128.97 billion in trading volume, including HKD 67.00 billion in buying and HKD 61.97 billion in selling, resulting in a net buying amount of HKD 5.04 billion [1] Southbound Trading Activity - The southbound trading through Stock Connect (Shenzhen) had a total trading volume of HKD 46.98 billion, with HKD 25.37 billion in buying and HKD 21.61 billion in selling, leading to a net buying amount of HKD 3.76 billion [1] - The southbound trading through Stock Connect (Shanghai) had a total trading volume of HKD 81.98 billion, with HKD 41.63 billion in buying and HKD 40.35 billion in selling, resulting in a net buying amount of HKD 1.29 billion [1] Active Stocks - Alibaba-W had the highest trading volume among southbound funds, totaling HKD 55.77 billion, followed by Xiaomi Group-W at HKD 44.08 billion and Chongqing Steel at HKD 37.21 billion [1] - The net buying stocks included 8 companies, with the largest net buying amount for Yingfu Fund at HKD 16.74 billion, followed by Innovent Biologics at HKD 6.51 billion and Meituan-W at HKD 3.38 billion [1] Continuous Net Buying and Selling - Two stocks, namely SMIC and Innovent Biologics, experienced continuous net buying for over three days, with SMIC leading at a total net buying of HKD 59.43 billion and Innovent Biologics at HKD 17.83 billion [2] - The stocks with the highest net selling included Tencent Holdings, Xiaomi Group-W, and Alibaba-W, with total net selling amounts of HKD 22.53 billion, HKD 3.74 billion, and HKD 3.08 billion respectively [2] Summary of Active Stocks on July 2 - The following table summarizes the active stocks with their trading amounts, net buying amounts, and daily price changes: - Yingfu Fund: Trading Amount HKD 1689.30 million, Net Buying HKD 1674.46 million, Daily Change 0.49% - Innovent Biologics: Trading Amount HKD 1079.97 million, Net Buying HKD 651.12 million, Daily Change 1.15% - Meituan-W: Trading Amount HKD 2976.06 million, Net Buying HKD 338.09 million, Daily Change 0.56% - SMIC: Trading Amount HKD 3274.27 million, Net Buying HKD 317.79 million, Daily Change -2.57% - Chongqing Steel: Trading Amount HKD 3720.82 million, Net Buying HKD 144.80 million, Daily Change 91.11% - Xiaomi Group-W: Trading Amount HKD 4408.50 million, Net Selling HKD 36.95 million, Daily Change 0.33% - Tencent Holdings: Trading Amount HKD 3438.30 million, Net Selling HKD 62.96 million, Daily Change -0.30% - Alibaba-W: Trading Amount HKD 5576.67 million, Net Selling HKD 173.65 million, Daily Change -0.36% [2]

Group 1 - On July 2, 2025, Alibaba-W (09988), Chongqing Steel (01053), and Xiaomi Group-W (01810) were the top three companies by trading volume in the Southbound Stock Connect, with trading amounts of 3.17 billion, 2.93 billion, and 2.83 billion respectively [1] - In the Southbound Stock Connect for the Shenzhen-Hong Kong Stock Connect, Alibaba-W (09988), Tencent Holdings (00700), and Xiaomi Group-W (01810) also ranked as the top three, with trading amounts of 2.41 billion, 1.59 billion, and 1.58 billion respectively [1] Group 2 - In the Southbound Stock Connect, the top ten active trading companies included Alibaba-W (09988) with a trading amount of 3.17 billion and a net buy of -788 million, Chongqing Steel (01053) with 2.93 billion and a net buy of 116 million, and Xiaomi Group-W (01810) with 2.83 billion and a net buy of -222 million [2] - The Southbound Stock Connect for Shenzhen-Hong Kong also featured Alibaba-W (09988) with a trading amount of 2.41 billion and a net buy of -945 million, Tencent Holdings (00700) with 1.59 billion and a net buy of -259 million, and Xiaomi Group-W (01810) with 1.58 billion and a net buy of -147 million [2]

Group 1: Core Insights - Recently, Innovent Biologics achieved two significant milestones: the approval of the new drug Ma Shidu Peptide Injection and the completion of a $550 million equity financing, equivalent to approximately 4 billion RMB, enhancing confidence in reaching the revenue target of 20 billion RMB by 2027 [1][5][6] - The Ma Shidu Peptide Injection, marketed as Xin Er Mei, is the world's first and only GCG/GLP-1 dual receptor agonist for weight loss, targeting the chronic metabolic disease market, which has a vast patient base in China [1][2][4] Group 2: Market Potential - The peak sales forecast for Ma Shidu Peptide is expected to exceed 5 billion RMB, driven by the large number of overweight and obese patients in China, estimated at around 500 million adults [2][4] - The drug has broad indications, including type 2 diabetes, metabolic-associated fatty liver disease, heart failure with preserved ejection fraction, and obstructive sleep apnea combined with obesity, supported by multiple ongoing Phase III clinical trials [2][3][4] Group 3: Competitive Landscape - Ma Shidu Peptide faces competition from established drugs like Novo Nordisk's Semaglutide and Eli Lilly's Tirzepatide, which have already been approved for diabetes and weight loss in China, with projected global sales of $29.3 billion and $16.4 billion respectively by 2024 [4][6] - Innovent is conducting head-to-head clinical trials against these competitors to establish a competitive edge in the market [4][6] Group 4: Global Expansion Strategy - Innovent completed a significant equity financing of approximately $550 million, the largest in the Hong Kong healthcare sector in the past four years, with 90% of the funds allocated for global R&D and facility expansion [5][6] - The company aims to leverage its innovative pipeline for global market penetration, similar to other biotech firms that have successfully expanded internationally [5][7] Group 5: Future Growth and R&D Strategy - Innovent's long-term strategy includes advancing at least five innovative pipelines to global multi-center Phase III registration studies by 2030, focusing on next-generation immunotherapy and antibody-drug conjugates (ADC) [9][12] - The dual upgrade strategy in oncology aims to address unmet needs in cancer treatment, with a systematic approach to tackle tumor heterogeneity and immune evasion [12][16] Group 6: Conclusion - The recent approvals and financing provide a strong impetus for Innovent Biologics to achieve its revenue target of 20 billion RMB by 2027, with a clear development path and potential for long-term growth driven by its innovative "IO+ADC" strategy [1][11][12]