21世纪经济报道记者 凌晨 西安报道 国内消费市场吹来寒意的同时，一纸来自瑞典的战略合作协议，摆在了巨子生物的案头。 近日，Nordberg Medical与巨子生物双方已正式签署战略合作协议，将基于巨子生物专有的合成生物学 技术平台，共同推进重组胶原蛋白在医美与生物医学领域的全球开发和商业化进程。 这家以重组胶原蛋白技术闻名的公司，正处于一个微妙的十字路口：主力品牌"可复美"线上流量红利渐 退，价格战硝烟四起。而财务报表的另一面，收入与利润增速仍浮动在20%左右。 表面的增长与掩盖深层的焦虑并存。转折的种子已然埋下——一张刚获批的三类医疗器械注册证，成了 破局的关键。这张"械字号"通行证，不仅意味着公司产品从护肤品货架正式迈入专业医疗机构的治疗 室，更标志着其商业逻辑的一次根本性跃迁。 于是，其与瑞典Nordberg Medical的合作，便超越了寻常的技术授权，成为一场精准的"借船出海"。 面对自建海外渠道的重重壁垒，巨子生物选择以核心技术为筹码，嫁接国际伙伴成熟的全球网络。在合 作协议签署现场，Nordberg Medical全球创新中心副总裁 Robert Braithwaite直言，在拓展注射类医美 ...

(作者：凌晨,陶力,视频编辑柳润瑛编辑：高梦阳) 近日，公司创始人严建亚罕见携担任董秘的女儿低调亮相，Nordberg Medical与巨子生物共同宣布，双 方已正式签署战略合作协议。与此同时，已有产品取得医疗器械注册证的巨子生物，正将目光投向更广 阔的B端专业市场与全球舞台，与瑞典企业的技术出海合作成为关键落子。这标志着公司从依赖单一消 费品牌增长，转向以核心技术驱动、B端与C端并重、国内与国际市场联动的全新发展阶段。 在国内医美市场竞争加剧、核心品牌增长承压的背景下，巨子生物并未放缓脚步，而是悄然开启了一场 深刻的战略转向。 ...

Group 1 - China Merchants Securities (Hong Kong) downgraded the rating of Giant Bio to neutral due to challenges such as a reputation crisis and a decline in sales during the Double Eleven shopping festival, indicating a potential strategic adjustment period in 2026 with no clear catalysts for rebound [1] Group 2 - CICC maintained a "outperform" rating for He Yu-B, setting a target price of 20 HKD, highlighting the approval of its first self-developed innovative drug, with an overall response rate (ORR) of 54%, which could provide new growth momentum for the company [2] Group 3 - CICC maintained a "outperform" rating for Mixue Group with a target price of 555 HKD, noting the brand's resilience in growth despite reduced delivery subsidies and the rapid expansion of its stores, indicating strong growth potential [3] Group 4 - CICC maintained a "outperform" rating for Tmall with a target price of 3.88 HKD, reporting that Q3 sales met expectations with healthy inventory and stable discounts, suggesting a potential stabilization in the channel [4] Group 5 - Huachuang Securities maintained a "strong buy" rating for Geely Automobile with a target price of 27.01 HKD, citing the completion of the Zeekr privatization significantly enhancing profits and brand synergy, with multiple flagship new models driving sales and average selling price (ASP) increases [5] Group 6 - Changjiang Securities maintained a "buy" rating for Aikang Medical, emphasizing its leading position in orthopedics and revenue surpassing pre-collection levels, with effective overseas expansion strategies [6] Group 7 - Changjiang Securities maintained a "buy" rating for Genscript Biotech, highlighting the establishment of a high-barrier pipeline in tumor vaccines and CAR-T therapies, with significant clinical trials expected to start soon [7] Group 8 - Shenwan Hongyuan maintained a "buy" rating for Tmall, noting improvements in channel efficiency and the end of a large-scale store closure phase, with a clear trend of recovery in the terminal market [8] Group 9 - Shenwan Hongyuan initiated coverage on China Railway with a "buy" rating, citing a substantial order backlog of 7.54 trillion, a high gross margin of 59.45% in its resource segment, and attractive valuation due to significant H-share discounts [9] Group 10 - Guosen Securities maintained an "outperform" rating for Zhongxin Innovation, reporting that the company's power battery installation volume ranked among the top three globally in October, with a year-on-year increase of over 75% in energy storage battery shipments [10]

Core Insights - The article highlights the significant innovation achieved by the Chinese biotechnology company, Juzhibio, in the field of recombinant collagen, particularly recombinant type IV collagen, overcoming technical bottlenecks through synthetic biology advantages [1][2][3]. Group 1: Technological Breakthroughs - Juzhibio has made substantial progress in the production of recombinant type IV collagen, achieving high activity and purity in large-scale production through advancements in expression systems, production processes, and efficacy validation [1][2]. - The company utilized Pichia pastoris as an expression host, achieving a secretion yield of approximately 25.1 g/L with a purity of over 90%, addressing the economic feasibility of large-scale production [3]. - Juzhibio conducted the first systematic scientific validation in China regarding the mechanism of recombinant type IV collagen's effect on skin basement membrane integrity, confirming its ability to promote the synthesis and expression of key substances in the basement membrane [4]. Group 2: Market Applications - The core technology in recombinant type IV collagen has been effectively applied to Juzhibio's consumer brand "Kefumei," resulting in successful market products such as the "Kefumei Collagen Stick 2.0," which addresses modern consumer skincare needs [6]. - Juzhibio has also developed a specialized product line, "Kefumei Frame Domain Repair Series," targeting post-aesthetic care, thus tapping into a high-growth market segment [7]. Group 3: Industry Leadership - Juzhibio has established a robust patent portfolio with 186 patents and applications, positioning itself as a leader in the global intellectual property landscape within the biotechnology sector [9]. - The company actively participates in the formulation of industry standards, having contributed to multiple standards related to recombinant collagen, thereby promoting scientific and transparent development in the industry [9]. - Juzhibio has expanded its global market presence, successfully entering markets in Canada, the USA, Japan, South Korea, Singapore, and Thailand, showcasing the capability of Chinese enterprises in the forefront of life sciences [10].

证券时报·数据宝统计，巨子生物在港交所公告显示，12月23日以每股35.740港元至36.480港元的价格回 购40.00万股，回购金额达1439.66万港元。该股当日收盘价35.740港元，下跌0.89%，全天成交额2.08亿 港元。 | 日期 | 回购股数（万股） | 回购最高价（港元） | 回购最低价（港元） | 回购金额（万港元） | | --- | --- | --- | --- | --- | | 2025.12.23 | 40.00 | 36.480 | 35.740 | 1439.66 | | 2025.12.22 | 40.00 | 36.340 | 35.860 | 1442.97 | | 2025.12.19 | 40.00 | 35.520 | 34.540 | 1405.36 | | 2025.12.18 | 40.00 | 35.040 | 34.420 | 1388.30 | | 2025.12.17 | 40.00 | 35.220 | 34.620 | 1397.13 | | 2025.12.16 | 40.00 | 35.400 | 34.680 | 1402.61 | | ...

格隆汇12月23日丨巨子生物(02367.HK)公告，12月23日耗资1439.66万港元回购40万股，每股回购价 35.74-36.48港元。 ...

智通财经APP讯，巨子生物(02367)发布公告，于2025年12月23日，该公司斥资1439.66万港元回购40万 股。 ...

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 巨子生物控股有限公司 呈交日期： 2025年12月23日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02367 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | 庫存股份變動 | | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | 佔有關事 ...

该行指，巨子生物的投资逻辑已由增长转向战略调整，该行认为当前尚缺乏明显的反弹催化剂。在企稳 迹象更加明朗之前，持观望态度。该行将2025-27年收入预测平均下调30%，以反映管理层最新指引及 该行对2026年更加审慎的展望。该行将销售费用率预测从36%上调至38%，以反映调整阶段下的执行挑 战。目标价基于由原来的2026年预测市盈率21.5倍降至16倍。 智通财经APP获悉，招商证券国际发布研报称，将巨子生物(02367)评级由"增持"下调至"中性"，将目标 价从64港元下调45%至35港元。报告指，公司正面临诸多挑战，包括一系列声誉危机，以及核心品牌可 复美在双11大促期间出现两位数下滑。虽然该行认为公司股价已基本消化相关问题及随后下调2025年销 售指引，但该行对2026年前景仍持谨慎态度。该行认为，当前市场一致预期可能过于乐观。 ...

招商证券国际发布研报称，将巨子生物(02367)评级由"增持"下调至"中性"，将目标价从64港元下调45% 至35港元。报告指，公司正面临诸多挑战，包括一系列声誉危机，以及核心品牌可复美在双11大促期间 出现两位数下滑。虽然该行认为公司股价已基本消化相关问题及随后下调2025年销售指引，但该行对 2026年前景仍持谨慎态度。该行认为，当前市场一致预期可能过于乐观。 该行指，巨子生物的投资逻辑已由增长转向战略调整，该行认为当前尚缺乏明显的反弹催化剂。在企稳 迹象更加明朗之前，持观望态度。该行将2025-27年收入预测平均下调30%，以反映管理层最新指引及 该行对2026年更加审慎的展望。该行将销售费用率预测从36%上调至38%，以反映调整阶段下的执行挑 战。目标价基于由原来的2026年预测市盈率21.5倍降至16倍。 ...