Group 1 - The World Health Organization (WHO) is set to release new guidelines for GLP-1 therapies for treating adult obesity by September 2025, marking a significant policy shift in addressing the global obesity crisis [1] - The guidelines aim to clarify the clinical indications and applications of GLP-1 receptor agonists (RAs), which are expected to be the first officially recommended medications for adult obesity treatment by WHO [1] - In China, the diabetes prevalence has reached 11.9%, with a treatment rate of only 33%, indicating a substantial unmet medical need, particularly among the over 600 million overweight individuals [1] Group 2 - The GLP-1RA market in China grew from 9.62 billion yuan in 2020 to 10.74 billion yuan in 2023, with a compound annual growth rate (CAGR) of 3.7%. It is projected to reach 71.7 billion yuan by 2029, with a CAGR of 22.2% [2] - On June 26, 2024, a joint initiative by 16 departments in China to implement a "Weight Management Year" led to a significant stock price increase for Aorite, which rose by 9% and continued to rise thereafter [3] Group 3 - Currently listed companies with GLP-1 drugs include major pharmaceutical firms such as Novo Nordisk, Eli Lilly, and AstraZeneca, with various products targeting diabetes and weight management [5][6] - The GLP-1RA industry chain includes a range of companies involved in the development and commercialization of these therapies, highlighting the growing interest and investment in this sector [6]

高盛主要观点如下： 资金流向上 —— 高盛的交易平台买入呈现 1.2 倍净卖出状态。消费和科技板块是平台最活跃的主题(双 向交易并存，但消费股更适合卖出而科技股更宜买入)。消费板块呈现双向流动，餐饮类股遭遇部分抛 售，而普拉达等零售股则买卖交投活跃。科技板块中，持续在硬科技领域获得买单，但对腾讯音乐等冲 高个股转为卖出。网易也获得较大力度买入。医疗保健 / 制药板块更受青睐 —— 翰森制药虽呈双向交 易但买方更占优势。 香港股市创下自五月初以来的最佳单日表现。 从行业板块来看，医疗保健、科技和消费板块领涨 —— 在中国政府宣布对符合条件的个人消费贷款实 施贴息计划后，国内零售商与消费医疗企业的股价应声上扬。医疗板块中，信达生物(+9%)、药明康德 (+6.2%)、翰森制药(+5.4%)涨幅居前。科技板块以腾讯音乐(+15.6%)表现最为亮眼，其财报大幅超出预 期，多家投行同步上调目标价。其他涨幅显著的个股包括阿里巴巴(+6.1%)、哔哩哔哩(+7.4%)，华虹半 导体(+5.9%)等芯片股亦表现强势。能源与电信板块表现滞后，虽维持涨势但明显跑输大盘，部分资金 正轮动至成长股。 智通财经APP获悉，高盛发布研报 ...

Group 1 - The core viewpoint of the news is the performance and holdings of the Zhongyin Innovation Medical Mixed Fund C, which has shown significant growth in recent months and has a strong portfolio in the healthcare sector [1][3]. - As of August 13, 2025, the latest net value of Zhongyin Innovation Medical Mixed Fund C is 2.1969 yuan, reflecting a growth of 3.87% [1]. - The fund has achieved a return of 15.09% over the past month, ranking 1008 out of 4699 in its category [1]. - Over the last six months, the fund's return is 86.76%, ranking 26 out of 4543 [1]. - Year-to-date, the fund has returned 85.33%, ranking 30 out of 4501 [1]. - The top ten stock holdings of the fund account for a total of 62.83%, with significant positions in companies such as Innovent Biologics (8.33%), Kelun-Biotech (8.15%), and Hengrui Medicine (8.08%) [1]. Group 2 - The Zhongyin Innovation Medical Mixed Fund C was established on October 30, 2020, and as of June 30, 2025, it has a total scale of 2.686 billion yuan [1]. - The fund manager, Zheng Ning, has a background in asset management and has held various positions in the investment industry, including roles at Taikang Asset Management and Zhonggeng Fund Management [2]. - Zheng Ning has been managing the Zhongyin Innovation Medical Mixed Fund C since July 1, 2022, and has also taken on management roles for other funds within the healthcare sector [2].

Group 1 - The Hong Kong stock market showed strong performance on August 13, with the Hang Seng Index rising by 1.88% and the Hang Seng Tech Index increasing by 2.35%, particularly driven by the healthcare sector [1] - The Hong Kong Innovative Drug 50 ETF (513780) closed up by 3.38% with a turnover rate exceeding 18% and a transaction volume of over 400 million yuan, indicating strong investor interest [1] - Notably, the Hong Kong Innovative Drug 50 ETF (513780) experienced a net inflow of 1.07 billion yuan over the past 15 trading days, and it has gained over 92% year-to-date as of August 12 [1] Group 2 - The National Healthcare Security Administration announced the preliminary review results for the 2025 medical insurance directory and commercial insurance innovative drug directory, with 534 drugs passing the basic medical insurance directory review and 121 drugs passing the commercial insurance innovative drug directory review [2] - High-priced innovative drugs, including CAR-T therapies, are seeking inclusion in the commercial insurance innovative drug directory, indicating a push for diversified payment methods for innovative drugs [2] - Analysts suggest that the rise of innovative drugs is sustainable, recommending attention to companies with rich pipeline layouts, high-potential single innovative drugs, and leading technology platforms in the sector [2]

Group 1 - The Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index (HSSCPB) increased by 0.02%, with notable stock performances including Jingtai Holdings (02228) up 7.38% and Fosun Pharma (02196) up 6.00% [3] - The Hong Kong Innovative Drug Selection ETF (520690) rose by 0.52%, reaching a latest price of 0.97 yuan, with a trading volume of 240.45 million yuan and a turnover rate of 0.62% [3] - Jingtai Holdings announced an expected comprehensive income of no less than 500 million yuan for the six months ending June 30, 2025, representing an increase of at least 387% compared to the same period in 2024 [3] Group 2 - The Hong Kong Innovative Drug Selection ETF reached a new high in scale at 385 million yuan and a new high in shares at 399 million [4] - The ETF has seen continuous net inflows over the past three days, with a maximum single-day net inflow of 22.93 million yuan, totaling 42.28 million yuan [4] - The ETF's management fee is 0.50% and the custody fee is 0.10%, which are among the lowest in comparable funds [5] Group 3 - The HSSCPB index aims to reflect the performance of Hong Kong-listed companies involved in innovative drug research, development, and production [5] - The top ten weighted stocks in the HSSCPB index account for 78.05% of the total index weight, including companies like BeiGene (06160) and WuXi Biologics (02269) [5]

Core Insights - The latest net value of Zhongyin Innovation Medical Mixed A (007718) is 2.1723 yuan, reflecting a decline of 3.54%. The fund has shown a one-month return of 12.66%, a six-month return of 78.76%, and a year-to-date return of 80.53% [1]. Fund Performance - The fund ranks 684 out of 4457 in the one-month category, 23 out of 4316 in the six-month category, and 29 out of 4287 in the year-to-date category [1]. Holdings Overview - The top ten stock holdings of Zhongyin Innovation Medical Mixed A account for a total of 62.83%, with significant positions in companies such as: - Innovent Biologics (8.33%) - Kelun-Biotech (8.15%) - Heng Rui Medicine (8.08%) - CanSino Biologics (8.07%) - New Horizon Health (6.13%) - Bai Li Tianheng (5.99%) - BeiGene (5.97%) - Hansoh Pharmaceutical (4.15%) - Rongchang Biologics (4.05%) - CanSino Biologics-B (3.91%) [1]. Fund Manager Background - Zheng Ning, the fund manager, has a master's degree and has previously held positions at Taikang Asset Management and Zhonggeng Fund Management. He joined Zhongyin Fund Management in 2022 and has been managing the Zhongyin Innovation Medical Mixed Fund since July 1, 2022 [2].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 Hansoh Pharmaceutical Group Company Limited 翰森製藥集團有限公司 （於開曼群島註冊成立的有限公司） 董事會召開日期 翰森製藥集團有限公司（「本公司」）董事會（「董事會」）茲通告謹定於二零二五年 八月十八日（星期一）舉行董事會會議，藉以（其中包括）考慮及通過本公司及其附 屬公司截至二零二五年六月三十日止的六個月中期業績及建議中期股息（如有）以 及處理其他事項。 承董事會命 翰森製藥集團有限公司 主席 鍾慧娟 香港，二零二五年八月六日 於本公告日期，董事會成員包括主席兼執行董事鍾慧娟女士、執行董事孫遠女士 及呂愛鋒博士；及獨立非執行董事林國強先生、陳尚偉先生及楊東濤女士。 （股份代號：3692） ...

公告称，QX004N最近已进入III期临床试验，成为公司管线中第四个成功进入III期阶段的产品。 最近，公司已收到翰森制药根据授权协议支付的PsIII期里程碑及其他付款，共计人民币5800万元。 荃信生物-B(02509)公布，公司正在开发用于治疗银屑病(Ps)及克罗恩病(CD)的白介素23p19亚基 (IL23p19)抑制剂QX004N。于2024年4月，公司与翰森制药集团有限公司(03692.HK)的全资附属公司翰 森(上海)健康科技有限公司就QX004N在中国内地、中国台湾、中国香港及中国澳门的研发、生产及商 业化订立独家对外授权协议。 ...

Core Viewpoint - The company is developing an IL23p19 inhibitor, QX004N, for the treatment of psoriasis and Crohn's disease, and has entered into an exclusive licensing agreement with Hansoh Pharmaceutical for its development and commercialization in several regions [1] Group 1 - QX004N has recently entered Phase III clinical trials, marking it as the fourth product in the company's pipeline to reach this stage [1] - The company has received a total of RMB 58 million from Hansoh Pharmaceutical as milestone and other payments related to the Phase III trial [1]

Core Insights - The company is developing an IL23p19 inhibitor QX004N for the treatment of psoriasis (Ps) and Crohn's disease (CD) [1] - QX004N has recently entered Phase III clinical trials, marking it as the fourth product in the company's pipeline to reach this stage [1] - The company has signed an exclusive licensing agreement with Hansoh Pharmaceutical Group Co., Ltd. for the R&D, production, and commercialization of QX004N in mainland China, Taiwan, Hong Kong, and Macau [1] - The company received a total of RMB 58.0 million from Hansoh Pharmaceutical as milestone and other payments related to the Phase III trial of Ps [1]