Core Points - The Shanghai Composite Index opened lower and the CSI 300 Pharmaceutical and Biotechnology Index reported 7479.61 points [1] - The CSI 300 Pharmaceutical and Biotechnology Index has decreased by 0.64% in the past month, increased by 3.66% over the last three months, and has risen by 0.48% year-to-date [1] Industry Composition - The CSI 300 Pharmaceutical and Biotechnology Index is composed of 11 primary industries, 35 secondary industries, over 90 tertiary industries, and more than 200 quaternary industries [1] - The index is based on the performance of all securities in the CSI 300 Index classified by industry, with a base date of December 31, 2004, and a base point of 1000.0 [1] Index Holdings - The top ten holdings in the CSI 300 Pharmaceutical and Biotechnology Index are: - Heng Rui Medicine (24.75%) - WuXi AppTec (15.82%) - Pian Zai Huang (6.85%) - Yunnan Baiyao (5.7%) - Kelun Pharmaceutical (4.68%) - New Horizon (3.79%) - East China Pharmaceutical (3.64%) - Shanghai Raist (3.44%) - Fosun Pharma (3.38%) - Changchun High-tech (3.17%) [1] Market Distribution - The market distribution of the CSI 300 Pharmaceutical and Biotechnology Index shows that the Shanghai Stock Exchange accounts for 63.33% and the Shenzhen Stock Exchange accounts for 36.67% [2] Sector Breakdown - The sector breakdown of the index holdings indicates that: - Chemical drugs account for 42.69% - Pharmaceutical and biotechnology services account for 21.06% - Traditional Chinese medicine accounts for 19.74% - Biological drugs account for 16.51% [2] Sample Adjustment - The index samples are adjusted every six months, with adjustments implemented on the next trading day after the second Friday of June and December each year [2] - Weight factors are adjusted in accordance with sample changes, and any special events affecting a sample company's industry classification will lead to corresponding adjustments in the index [2]

本文约 2 5 0 0 字，推荐阅读时长 1 5 分钟，欢迎关注新财富公众号。 1 引言 4月14日，美国商务部宣布启动对进口药品的国家安全调查。这一调查覆盖了所有进口药品，包括成 品仿制药、原研药以及用于生产这些药品的关键药用成分。此举属于特朗普政府根据1962年《贸易扩 展法》第232条对多个行业进行的关税调查的一部分。虽然调查尚未结束，预计结果将在270天内公 布，但业内普遍认为，这将赋予特朗普政府对进口药品和原料药征收关税的权力。特别是对中国等主 要药品出口国的影响，可能会带来严重的供应链中断及成本上升。 事实上，美国每年从中国进口药品总额约60亿美元，其中大量为抗生素、抗病毒及心血管药物等基础 药物。一旦关税进一步扩大实施，这些进口药品的成本预计将明显上升，对美国本土药品生产商带来 直接冲击。为应对这种风险，特朗普政府提出多项措施推动产业本土化。 分析师预计，如果对来自中国的API征收10%的关税，仿制药企业的利润将下跌2%-3%，创新药利润 下跌可能更严重。 2 美国关税筑墙， 中概股 跌宕 自2025年特朗普重新执政以来，美国政府出台了一系列针对生物医药产业的重要政策，核心目标是强 化美国医药产 ...

Investment Rating - The report does not explicitly state an investment rating for the industry, but it suggests a long-term focus on domestic innovative drugs in the oncology field and AI medical investment opportunities [3][4]. Core Insights - The pharmaceutical and biotechnology sector saw a weekly increase of 1.16%, outperforming the Wind All A index (1.15%) and the CSI 300 index (0.38%) [3][8]. - The upcoming ASCO conference is highlighted as a significant event for domestic innovative drug companies, with over 70 oral presentations and more than 10 major studies expected [3][4]. - The Ministry of Industry and Information Technology and six other departments issued a plan for the digital transformation of the pharmaceutical industry, aiming for significant advancements by 2027 and full coverage by 2030 [3][4]. Market Weekly Review - The pharmaceutical and biotechnology sector increased by 1.16% from April 21 to April 25, outperforming the Wind All A index and the CSI 300 index [3][8]. - Notable performers included medical research outsourcing (6.34%) and raw materials (4.72%), while blood products (-3.26%) and vaccines (-6.38%) continued to decline [3][9]. - Individual stock performances showed significant gains for Yong'an Pharmaceutical (31.4%), Shuyou Shen (28.4%), and Erkang Pharmaceutical (27.7%), while *ST Jiyuan (-43.2%), Nanhua Biological (-35.3%), and Shuangcheng Pharmaceutical (-27.7%) faced substantial losses [3][11]. Industry News and Key Company Announcements - On April 25, Kangfang Bio announced FDA approval for its drug Anike for the treatment of recurrent or metastatic nasopharyngeal carcinoma [12]. - The same day, Kangfang Bio also reported the approval of its PD-1/VEGF bispecific antibody for first-line treatment of specific lung cancer types [13]. - The digital transformation plan for the pharmaceutical industry aims to enhance competitiveness and quality management through AI and data integration by 2030 [3][4].

Core Viewpoint - 恒瑞医药 has successfully emerged from the shadow of centralized procurement, with its performance showing continuous improvement, particularly driven by its innovative drug business and international expansion efforts [2][3][5]. Financial Performance - In Q1 2025, 恒瑞医药 reported revenue of 7.206 billion yuan, a year-on-year increase of 20.14%, and a net profit of 1.874 billion yuan, up 36.9%, marking the highest net profit growth for the same period in nearly a decade [2][5]. - The company’s revenue and net profit for 2024 reached historical highs, with revenue of 27.985 billion yuan, a 22.63% increase, and net profit of 6.337 billion yuan, up 47.28% [3][4]. Innovation and Drug Development - 恒瑞医药's innovative drug sales reached 13.892 billion yuan in 2024, reflecting a 30.60% growth [4]. - The company has launched two Class 1 innovative drugs, contributing to its revenue growth [4]. International Expansion and Licensing Deals - Since 2018, 恒瑞医药 has engaged in 13 licensing transactions with global partners, with a potential total transaction value of approximately 14 billion USD [6]. - In 2025, the company signed two significant licensing agreements, including a 200 million USD upfront payment for a drug with Merck and a 15 million euro upfront payment for another drug with Merck Group [8]. Research and Development Investment - 恒瑞医药 has maintained high R&D investments, exceeding 6 billion yuan in 2022 and 2023, and increasing to 8.228 billion yuan in 2024 [10]. - The company has developed a leading and highly differentiated innovative product matrix, with 19 new molecular entity drugs approved in China and over 90 innovative products in clinical development [10].

江苏恒瑞医药股份有限公司 关于发行境外上市外资股（H 股） 获得中国证监会备案的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 江苏恒瑞医药股份有限公司（以下简称"公司"）于近日收到中国证券监督管 理委员会（以下简称"中国证监会"）出具的《关于江苏恒瑞医药股份有限公司境 外发行上市备案通知书》（国合函〔2025〕721 号）（以下简称"备案通知书"）。 备案通知书主要内容如下： 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-069 一、公司拟发行不超过 815,094,600 股境外上市普通股并在香港联合交易所上 市。 二、自备案通知书出具之日起至本次境外发行上市结束前，公司如发生重大事 项，应根据境内企业境外发行上市有关规定，通过中国证监会备案管理信息系统报 告。 三、公司完成境外发行上市后 15 个工作日内，应通过中国证监会备案管理信 息系统报告发行上市情况。公司在境外发行上市过程中应严格遵守境内外有关法律、 法规和规则。 特此公告。 江苏恒瑞医药股份有限公司董事会 2025 年 4 月 28 ...

证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-068 江苏恒瑞医药股份有限公司 关于获得药物临床试验批准通知书的公告 审批结论：根据《中华人民共和国药品管理法》及有关规定，经审查，2025 年2月11日受理的注射用卡瑞利珠单抗临床试验申请符合药品注册的有关要求， 同意本品开展临床试验。具体为：卡瑞利珠单抗联合甲磺酸阿帕替尼和注射用替 莫唑胺一线治疗晚期肢端黑色素瘤的一项多中心、随机、前瞻性、对照临床研究 及其子研究方案卡瑞利珠单抗对比达卡巴嗪一线治疗晚期肢端黑色素瘤随机、平 行研究。 二、药品的已获批适应症情况 注射用卡瑞利珠单抗已在国内获批九个适应症，分别为：2019 年 5 月获批 用于至少经过二线系统化疗的复发或难治性经典型霍奇金淋巴瘤的治疗；2020 年 3 月获批用于既往接受过索拉非尼治疗和/或含奥沙利铂系统化疗的晚期肝细 胞癌患者的治疗；2020 年 6 月获批联合培美曲塞和卡铂适用于表皮生长因子受 体（EGFR）基因突变阴性和间变性淋巴瘤激酶（ALK）阴性的、不可手术切除的 局部晚期或转移性非鳞状非小细胞肺癌（NSCLC）的一线治疗，和用于既往接受 过一线化疗后疾病进展或不 ...

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Views - The report highlights that the company's business development logic continues to deliver results, with multiple clinical trials set to be disclosed at the ASCO conference [1][5] - In Q1 2025, the company achieved operating revenue of 7.206 billion yuan, a year-on-year increase of 20.14%, and a net profit attributable to the parent company of 1.874 billion yuan, up 36.90% year-on-year [4][5] Financial Performance - The company is projected to have operating revenues of 31 billion, 34.9 billion, and 39.8 billion yuan for 2025, 2026, and 2027 respectively, with net profits of 7.07 billion, 8.04 billion, and 9.29 billion yuan for the same years [6][8] - The expected growth rates for operating revenue are 11%, 12%, and 14% for the years 2025, 2026, and 2027 respectively, while net profit growth rates are projected at 12%, 14%, and 16% [8][9] Market Performance - The company's stock has outperformed the CSI 300 index, with a 1-month performance of 12.0%, 3-month performance of 12.6%, and a 12-month performance of 14.0% [3] - As of April 25, 2025, the current stock price is 50.27 yuan, with a market capitalization of approximately 320.67 billion yuan [3][4] Strategic Developments - The company has engaged in 13 licensing transactions with global partners since 2018, involving 16 molecular entities, with a potential total transaction value of approximately 14 billion USD [5] - Recent licensing agreements include exclusive rights for the development and commercialization of specific drugs in various regions, with upfront payments totaling 200 million USD and 15 million euros [5] Upcoming Events - The company is set to present multiple academic studies at the 2025 ASCO conference, including data on various ADC-related studies and dual antibody products [5]

长按即可参与 风险提示：本文所提到的观点仅代表个人的意见，所涉及标的不作推荐，据此买卖，风险自负。 作者： KAIZEN投资之道 来源：雪球 今天我们谈谈牧原股份 、 恒瑞医药 、 爱尔眼科 。 在投资的世界里 ， 寻找那些拥有核心竞争 力 、 深筑护城河的企业 ， 就如同在茫茫大海中寻找珍贵的珍珠 。 它们不仅能在市场的风浪中 稳稳当当 ， 更能随着时间推移 ， 散发出愈发夺目的光彩 。 2025年一季报的发布 ， 让牧原股份 、 恒瑞医药和爱尔眼科再次成为大家关注的焦点 。 它们各 自代表了生猪养殖 、 创新药和眼科医疗领域的顶尖水平 ， 不仅展现了强劲的业绩 ， 更透露出 未来增长的无限可能 。 接下来的分析 ， 将带你深入探寻这些企业背后的核心竞争力与护城河 ， 以及它们在投资价值上的对比和未来的市场潜力 。 一 、 牧原股份 ： 周期上行+成本优势 ， 生猪养殖龙头护城河稳固 1.2025年一季报业绩 ： 营业总收入360.61亿元 ， 同比增37.26% ； 净利润46.19亿元 ， 同 比增287.87% ； 归母净利润44.91亿元 ， 上年同期亏损23.79亿元 。 2.核心竞争力与护城河 ...

证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-067 江苏恒瑞医药股份有限公司 关于获得药物临床试验批准通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 近日，江苏恒瑞医药股份有限公司（以下简称"公司"）子公司苏州盛迪亚 生物医药有限公司、上海恒瑞医药有限公司、上海盛迪医药有限公司收到国家药 品监督管理局（以下简称"国家药监局"）核准签发关于 SHR-4849 注射液、 SHR-8068 注射液、阿得贝利单抗注射液的《药物临床试验批准通知书》，将于 近期开展临床试验。现将相关情况公告如下： 二、药品的其他情况 江苏恒瑞医药股份有限公司董事会 2025 年 4 月 25 日 药品名称 SHR-4849 注射液 SHR-8068 注射液 阿得贝利单抗注射液 剂型 注射剂 申请事项 临床试验 受理号 CXSL2500111 CXSL2500110 CXSL2500109 审批结论 根据《中华人民共和国药品管理法》及有关规定，经审查， 2025 年 2 月 7 日受理的 SHR-4849 注射液、SH ...

Core Viewpoint - Heng Rui Medicine reported record high revenue and net profit for Q1 2025, but the market reaction was lukewarm, with a slight decline in stock price despite strong financial performance [1][2]. Financial Performance - For Q1 2025, Heng Rui Medicine achieved revenue of 7.206 billion yuan, a year-on-year increase of 20.14% [1] - The net profit attributable to shareholders was 1.874 billion yuan, up 36.90% year-on-year [1] - The net profit excluding non-recurring items was 1.863 billion yuan, reflecting a 29.35% increase year-on-year [1] Licensing and R&D Investments - The company recognized a $75 million upfront payment from IDEAYA Biosciences as revenue, contributing to profit growth [2] - Heng Rui Medicine licensed the global development rights (excluding Greater China) for the antibody-drug conjugate SHR-4849 to IDEAYA Biosciences [2] - Cumulative R&D investment reached 46 billion yuan, with R&D expenses for Q1 2025 amounting to 1.533 billion yuan [2] New Drug Approvals and Management Changes - Six innovative products have been approved in 2025, including a new generation JAK1 inhibitor and the first PCSK9 inhibitor in the cardiovascular field [3] - In Q1 2025, the company received 28 clinical trial approval notices [3] - A significant management change occurred with the appointment of Feng Ji as the new president and COO, seen as a move towards accelerating innovation and transformation [3]