Group 1 - China Shipbuilding Defense expects a net profit of 940 million to 1.12 billion yuan for 2025, an increase of 149.61% to 196.88% year-on-year [1] - China First Heavy Industries has only undertaken a small number of related accessory projects and has not generated revenue from them [2] - Huanyu Electronics plans to invest 30 million yuan in a private equity fund focused on AI and emerging industries [3] Group 2 - Zhixiang Jintai's GR1803 injection has been included in the priority review list by the National Medical Products Administration [4] - JianKai Technology's shareholder plans to reduce holdings by up to 3% of the company's shares [5] - Debon Holdings will continue to suspend trading from January 12 due to significant matters being planned [6] Group 3 - South Network Technology's shareholder intends to transfer 847.05 million shares, accounting for 1.50% of the total share capital [7] - Hengrui Medicine has received approval for clinical trials of four drugs [8] - Daotong Technology expects a net profit of 900 million to 930 million yuan for 2025, a year-on-year increase of 40.42% to 45.10% [10] Group 4 - Betta Pharmaceuticals has invested 50 million yuan to acquire a 20% stake in Hangzhou Zhixing Pharmaceutical [11] - Tianyu Biology reported a 10.38% year-on-year decline in cumulative sales revenue for 2025 [12] - Lifang Pharmaceutical's subsidiary has obtained a drug registration certificate for a pain relief product [13] Group 5 - R&F Properties reported a total sales revenue of approximately 14.21 billion yuan for 2025 [14] - Wanfu Biology expects a net profit decline of 87.71% to 91.81% for 2025 [15] - Dazhi expects a negative net profit for 2025 [16] Group 6 - Dongzhu Ecology is negotiating to terminate the acquisition of control over a satellite communication company [17] - Baotai has received a milestone payment of 10 million USD from Hikma Pharmaceuticals [18] - Huace Navigation expects a net profit of 670 million to 690 million yuan for 2025, a year-on-year increase of 14.84% to 18.27% [19] Group 7 - Shenzhen Gas reported a net profit decline of 3.45% for 2025 [20] - Baogang Co. plans to adjust the price of rare earth concentrate for Q1 2026 to 26,834 yuan per ton [21] - Jiuding Investment expects to report a loss for 2025 [22] Group 8 - Shanghai Pharmaceuticals has received a drug registration certificate for a treatment for myasthenia gravis [23] - Hualan Biological plans to acquire a 35% stake in Guangfeng Capsule [24] - Ruina Intelligent plans to invest 169.9 million yuan in a new R&D production base for heat pumps [25] Group 9 - Wantong Development expects to report a loss for 2025 [26] - Xianghe Industrial has completed the purchase of a 5% stake in Hezhixiang Technology [27] - Guangkang Biochemical received a warning letter from the Guangdong Securities Regulatory Commission [28] Group 10 - Xiaoming Co. reported a 37.07% year-on-year decline in chicken product sales revenue for December 2025 [29] - Luokai Co. won a procurement project from State Grid Fujian Power worth approximately 48.2 million yuan [30] - Minhe Co. reported a 65.22% year-on-year increase in the sales of commodity chick seedlings for December 2025 [31] Group 11 - Zhenghai Biological has obtained a registration certificate for calcium silicate bio-ceramic materials [32] - Three Gorges Energy reported a 5.99% year-on-year increase in cumulative total power generation for 2025 [33] - Huisheng Biological expects a net profit of 235 million to 271 million yuan for 2025 [34] Group 12 - Maihe Co. announced the release of the detention measures against its chairman [35] - Wandong's Alzheimer's project has been included in a national major special project for innovative drug development [36] - Kangxin New Materials plans to transfer forest land assets with a book value of 1.203 billion yuan [37] Group 13 - Greenland Holdings expects a net loss of 16 billion to 19 billion yuan for 2025 [39] - Zhongxin Fluorine Materials has obtained a pesticide production license [40]

Core Viewpoint - The company has received approval from the National Medical Products Administration for four drug clinical trials, focusing on prostate cancer-related multi-center, open-label Phase II clinical research [1] Drug Approval Summary - **SHR-4394 Injection**: - Indication: Prostate cancer - Cumulative R&D investment: 38.4 million yuan - No similar products approved domestically or internationally [1] - **HRS-5041 Tablets**: - A novel AR PROTAC small molecule for prostate cancer - Cumulative R&D investment: 92.66 million yuan - Potential to overcome drug resistance; no similar products available [1] - **Zemiglozole Tablets**: - EZH2 inhibitor, approved for market in 2025 - Cumulative R&D investment: 216.82 million yuan - Similar products expected to generate approximately 51 million USD in global sales by 2024 [1] - **Rivolumab Tablets**: - Second-generation AR inhibitor, approved in 2022 - Cumulative R&D investment: 696.72 million yuan - Similar products projected to achieve around 11.037 billion USD in global sales by 2024 [1]

证券代码：600276 证券简称：恒瑞医药 公告编号：临 2026-006 江苏恒瑞医药股份有限公司 关于药品上市许可申请获受理的提示性公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 近日，江苏恒瑞医药股份有限公司（以下简称"公司"）子公司成都盛迪医 药有限公司收到国家药品监督管理局（以下简称"国家药监局"）下发的《受理 通知书》，公司富马酸立康可泮（HRS-5965）胶囊的药品上市许可申请获国家药 监局受理。现将相关情况公告如下： 一、药品的基本情况 药品名称：富马酸立康可泮胶囊 剂型：胶囊剂 受理号：CXHS2600014 申报阶段：上市 申请人：成都盛迪医药有限公司 拟定适应症（或功能主治）：治疗既往未接受过补体抑制剂治疗的阵发性睡 眠性血红蛋白尿症（PNH）成人患者。 二、药品的临床试验情况 此次申报上市，是基于一项在既往未接受过补体抑制剂治疗的 PNH 患者中进 行的关键研究（HRS-5965-301）。该研究是一项评估 HRS-5965 胶囊对比依库珠 单抗用于治疗既往未接受过补体抑制剂治疗的 PNH 患者的 ...

证券代码：600276 证券简称：恒瑞医药 公告编号：临 2026-005 江苏恒瑞医药股份有限公司 关于获得药物临床试验批准通知书的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 近日，江苏恒瑞医药股份有限公司（以下简称"公司"）及子公司成都盛迪 医药有限公司、上海恒瑞医药有限公司收到国家药品监督管理局（以下简称"国 家药监局"）核准签发关于注射用 SHR-4394、HRS-5041 片、泽美妥司他片 （SHR-2554）、瑞维鲁胺片的《药物临床试验批准通知书》，将于近期开展临床 试验。现将相关情况公告如下： 二、药物的其他情况 注射用 SHR-4394 是公司自主研发的一款治疗用生物制品，拟用于治疗前列 腺癌。经查询，国内外尚无同类产品获批上市。截至目前，注射用 SHR-4394 相 关项目累计研发投入约为 3,840 万元。 HRS-5041 片是公司开发的新型、高效、选择性的 AR PROTAC（雄激素受体- 蛋白降解靶向嵌合体）小分子，拟用于治疗前列腺癌。HRS-5041 片对野生型及 药物名称 注射用 SHR ...

人民财讯1月9日电，恒瑞医药（600276）1月9日公告，近日，子公司成都盛迪医药有限公司收到国家药 品监督管理局(以下简称"国家药监局")下发的《受理通知书》，公司富马酸立康可泮(HRS-5965)胶囊的 药品上市许可申请获国家药监局受理。 ...

人民财讯1月9日电，恒瑞医药（600276）1月9日公告，近日，公司及子公司成都盛迪医药有限公司、上 海恒瑞医药有限公司收到国家药品监督管理局核准签发关于注射用SHR-4394、HRS-5041片、泽美妥司 他片(SHR-2554)、瑞维鲁胺片的《药物临床试验批准通知书》，将于近期开展临床试验。 ...

近日，国家药监局公布的2025年我国新药批准上市的数据振奋人心。 亮眼的成绩单表明，我国医药产业从"跟跑"向"并跑"乃至"领跑"迈进，也标志着中国在全球医药创新格局中正扮演越来越重要的角色。 我国新药创新的含金量在不断提升。 看数量。国家医保局数据显示，2018至2024年，我国一类新药获批上市数量明显增加，2024年获批48种，是2018年的5倍以上。其中，国产新药占比也在 不断提升。前些年，我国批准上市的新药，进口药"唱主角"；近年来，国产药占比不断提升。2025年批准的76个新药中，国产新药为65个，占比超85%， 真正实现了国产药"唱主角"。 转自：人民日报客户端 新药对外授权交易总金额超过1300亿美元，交易笔数突破150笔，双双创下历史新高！ 76个新药获批上市，大幅超过2024年的48个，创历史新高！ "这款药比金子还珍贵！"中南大学湘雅医院病房，患有Ⅰ型神经纤维瘤病的聪聪终于等来了有效药物——芦沃美替尼片，聪聪妈妈非常激动。Ⅰ型神经纤 维瘤病是一种罕见病，此前无药可医，肿瘤会不断生长，直至威胁患者生命。2025年5月，芦沃美替尼片获批上市。该药通过抑制相关蛋白活性来抑制肿 瘤细胞增殖并诱导其凋 ...

Group 1 - The core viewpoint of the report is that the CSI Technology Advantage Growth 50 Strategy Index (referred to as Technology 50 Strategy) utilizes multiple factors such as growth, innovation, value, low volatility, and quality to select and weight stocks from the technology sector, aiming to provide investors with a multi-factor strategy investment target based on the technology industry [1][7][11] - As of December 31, 2025, the top ten constituent stocks of the Technology 50 Strategy Index are primarily leading companies across various technology sub-sectors, with the top five stocks accounting for 17.63% and the top ten stocks accounting for 30.93% of the index's total weight [1][10][11] - The index is biased towards large-cap stocks, with 31 constituents having a market capitalization exceeding 100 billion yuan, while only 2 constituents have a market capitalization below 10 billion yuan [1][11] Group 2 - The report compares the Technology 50 Strategy Index with other representative technology and innovation indices, noting that the Technology 50 Strategy Index achieved an annualized return of 11.96% from January 1, 2020, to December 31, 2025, ranking third among six technology and innovation indices [1][57][60] - The Technology 50 Strategy Index shows lower volatility in revenue growth compared to other indices, with a projected revenue growth rate of 33.65% for 2026, which is higher than that of the other five technology and innovation indices [1][61][62] - The selection of constituent stocks for the Technology 50 Strategy Index incorporates 11 factors, providing a more comprehensive evaluation compared to other indices that focus on fewer factors [1][67][68]

Core Insights - The "2025 Extraordinary Investment Value Company" award recognizes companies with strong core barriers and growth resilience, highlighting their exceptional investment value [6] Group 1: Award Overview - The "2025 Golden Jubilee Award" is divided into three categories: company, institution, and comprehensive, continuing a tradition established over the past seven years [5] - The award is based on extensive data analysis and comparisons of thousands of companies, with final selections made by a panel of media reporters and research teams [4] Group 2: Award Winners - Inner Mongolia Yili Industrial Group Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd., and New China Life Insurance Co., Ltd. were awarded the "2025 Extraordinary Investment Value Company" title [5][6] - These companies represent key sectors: Yili in consumer goods, Hengrui in pharmaceuticals, and New China Life in finance, demonstrating strong profitability and value creation capabilities [6] Group 3: Company Performance Highlights - Yili's milk powder business leads nationally, with a 18.73% increase in net profit excluding non-recurring items in the first three quarters, benefiting from low raw milk prices and policy support [6] - Hengrui has made significant progress in innovation, launching 24 first-class innovative drugs and expanding through international collaborations [6] - New China Life has optimized its asset and liability structure, showcasing industry-leading investment capabilities [6]

对恒瑞医药而言，瑞拉芙普-α（SHR-1701）的成功上市，是一场从Fast Follow到FIC的"幸运逆袭"。 当PD-L1/TGF-β双抗赛道的领头羊默克四次折戟，让这一领域的未来充满变数时，恒瑞却凭借这款药物顺利突围，不 仅成为全球首个该靶点获批上市的企业，更充分展现了传统大药企在临床设计与注册沟通上的深厚功底。 1月7日，瑞拉芙普-α如期而至。据NMPA官网，恒瑞医药的抗PD-L1/TGF-βRII双功能融合蛋白瑞拉芙普-α正式获批上 市，其适应症为联合氟尿嘧啶类和铂类药物，用于局部晚期不可切除、复发或转移性胃及胃食管结合部腺癌的一线治 疗。 但争议也随之而来。瑞拉芙普-α的注册临床治疗组为瑞拉芙普-α联合化疗，对照组为安慰剂联合化疗——这一设计让 它的成功显得"似是而非"。 在当前胃癌一线治疗领域，免疫联合化疗已成为HER2阴性患者的标准方案，纳武利尤单抗、信迪利单抗等多款PD- （L）1抑制剂联合化疗的方案均已被全球指南推荐，且市场价格已降至"白菜价"水平。 尽管跨试验对比并不严谨，但从现有数据来看，瑞拉芙普-α并未展现出疗效和安全性优势。叠加PD-（L）1抑制剂成 熟的市场格局，让瑞拉芙普-α ...