Group 1 - Morgan Stanley's research report indicates that WuXi AppTec's valuation levels are attractive amid a stable fundamental backdrop, with a particular focus on WuXi Biologics [1] - The report highlights that WuXi Biologics has raised its earnings guidance and is undergoing significant capacity expansion, with high participation in the next-generation GLP-1 sector [1] - The firm has upgraded earnings forecasts for WuXi Biologics for 2025 to 2027 by 6% to 13%, and for WuXi AppTec by 3% to 4%, designating WuXi AppTec as a top pick [1] Group 2 - The compound annual growth rates for the three companies from 2024 to 2027 are projected at 24%, 23%, and 37% respectively [1] - Other major banks, including Oriental Securities and Goldman Sachs, have also maintained positive ratings on WuXi AppTec and WuXi Biologics, citing strong performance and robust customer demand [2] - Goldman Sachs set a target price of HKD 63.3 for WuXi AppTec, reflecting confidence in the company's order momentum and customer demand [2]

该行提到，药明康德(603259.SH)A股为投资者带来理想的买入机会，上调公司2025至27年盈测3至4%， 并列为首选股;将药明生物(02269)2025至27年盈测调升6至13%;升药明合联(02268)盈测7至8%。综合而 言，三间公司2024至27年的盈利复合年增长率分别为24%、23%及37%。 智通财经APP获悉，摩根士丹利发布研报称，中国医疗保健股自9月中旬起被持续抛售，投资者正在获 利了结，并等待明年业绩发展的讯号。该行指出，当中药明系在基本面持续稳健的背景下，估值水平更 具吸引力。大摩最看好药明康德(02359)，因此该公司不仅上调业绩指引，更进行大规模产能扩张，且 在下一代GLP-1领域参与度高。 ...

Group 1 - CRO concept stocks have collectively rebounded, with notable increases in share prices: Tigermed (300347) up 9.19% to HKD 39.92, WuXi AppTec (603259) up 4.43% to HKD 106, and others showing similar gains [1] - CMB International believes that the recovery of capital market financing activities, expansion of overseas transactions for innovative drugs, and a rebound in domestic R&D demand will lead to a recovery in CXO companies' performance in the second half of the year [1] - Morgan Stanley reports that healthcare stocks have been sold off since mid-September, with investors taking profits while awaiting signals for next year's performance [1] Group 2 - Morgan Stanley highlights that WuXi AppTec's fundamentals remain strong, making its valuation more attractive, especially as the company has raised its earnings guidance and is expanding capacity significantly [1] - The projected compound annual growth rates for earnings from WuXi AppTec, WuXi Biologics, and WuXi AppTec's subsidiaries from 2024 to 2027 are 24%, 23%, and 37% respectively [1]

Core Viewpoint - WuXi AppTec's stock price has shown significant growth this year, with a year-to-date increase of 75.56%, despite recent fluctuations in the short term [1][2]. Financial Performance - For the period from January to September 2025, WuXi AppTec achieved a revenue of 32.857 billion yuan, representing a year-on-year growth of 18.61% [2]. - The net profit attributable to shareholders for the same period was 12.076 billion yuan, marking an impressive year-on-year increase of 84.84% [2]. Stock Market Activity - As of November 24, WuXi AppTec's stock price was 93.68 yuan per share, with a trading volume of 1.071 billion yuan and a turnover rate of 0.47% [1]. - The company experienced a net inflow of main funds amounting to 46.0942 million yuan, with significant buying and selling activities from large orders [1]. Shareholder Information - As of September 30, 2025, the number of shareholders increased to 274,100, reflecting a growth of 16.39% [2]. - The average number of circulating shares per shareholder remained stable at 9,024 shares [2]. Dividend Distribution - WuXi AppTec has distributed a total of 14.06 billion yuan in dividends since its A-share listing, with 10.406 billion yuan distributed over the past three years [3]. Institutional Holdings - As of September 30, 2025, Hong Kong Central Clearing Limited was the second-largest circulating shareholder, holding 249 million shares, a decrease of 52.6071 million shares from the previous period [3]. - Other notable institutional shareholders, such as Huaxia SSE 50 ETF and Huatai-PB CSI 300 ETF, also reported reductions in their holdings [3].

Summary of Key Points from the Conference Call Industry Overview - **Industry**: China Healthcare, specifically focusing on Contract Development and Manufacturing Organizations (CDMOs) in the biopharma sector - **Outlook**: The industry is expected to benefit from robust biopharma out-licensing activity and a recovery in early-stage financing [1][5] Company-Specific Insights WuXi AppTec Co., Ltd (603259.SS) - **Upcoming Events**: - **Broker Healthcare Conference**: Scheduled for January 12, 2026, where management will discuss the 2026 outlook [8] - **US Biosecure Act**: Expected updates in Q4 2025, with no mention of Chinese companies in the amended version [8] - **Financial Advisory**: Morgan Stanley is advising WuXi AppTec on the acquisition of its site management and contract research organization businesses by Hillhouse Capital Group [2] WuXi XDC Cayman Inc (2268.HK) - **Reporting**: Anticipated positive profit alert in Q1 2026, with a high likelihood of beating market estimates [8] - **FDA Inspection**: First inspection expected in Q2 2026, which could lead to significant commercial contracts [8] WuXi Biologics Cayman Inc (2269.HK) - **Similar Events**: Participation in the Broker Healthcare Conference on January 12, 2026, and updates on the US Biosecure Act [8] Financial Metrics and Valuation - **WuXi XDC Cayman Inc**: - Valuation based on discounted cash flow (DCF) with a WACC of 10% and a terminal growth rate of 5% [9] - **WuXi Biologics Cayman Inc**: - Valuation also based on DCF with a WACC of 8.4% and a terminal growth rate of 4% [10] - **WuXi AppTec Co Ltd**: - Valuation using DCF with a WACC of 10% and a terminal growth rate of 4% [11] Risks and Opportunities Upside Risks - Increasing orders across all drug development stages - Successful launch of blockbuster products - Improved gross margins from new facilities [13] Downside Risks - Potential deceleration in biotech funding - Missed sales expectations for late-stage and commercial contracts - Geopolitical risks and IP protection issues [14] Analyst Ratings and Market Sentiment - **Overall Industry View**: Attractive, indicating positive expectations for the sector's performance over the next 12-18 months [5][39] - **Stock Ratings**: Various companies within the China healthcare sector have been rated, with a significant portion rated as Overweight [76] Conclusion - The China healthcare sector, particularly CDMOs, is poised for growth driven by favorable market conditions and strategic company developments. Key players like WuXi AppTec and its subsidiaries are expected to capitalize on upcoming catalysts, while also facing inherent risks that could impact their performance.

Summary of WuXi Group Conference Call Industry Overview - The healthcare sector, particularly the Contract Development and Manufacturing Organization (CDMO) industry in China, has experienced a sell-off since mid-September 2025 after a strong rally earlier in the year. Investors are now awaiting confirmatory signals for 2026 performance [1][2] - Leading indicators for China's top CDMOs suggest positive project momentum and earnings outlook for 2026 [1] Company Insights: WuXi AppTec - WuXi AppTec is identified as the best proxy for a global R&D spending boom, increased reliance on China for R&D, and strong out-licensing activity [3] - As China's largest CDMO by revenue, WuXi AppTec's capabilities extend beyond chemical drugs to new modalities, which accounted for 54% of global pipeline molecules in 2024 [3] - From 2022 to mid-2025, small molecules received 37% of venture capital funding, followed by biologics at 26% and cell/gene therapies at 17% [3] - WuXi AppTec produced 8 out of 40 novel small molecule drugs approved by the US FDA from 2024 to mid-2025, representing 20% of the total [3] - Approximately one-third of active customers in oncology, infectious disease, immunology, metabolic disease, and neuroscience utilize WuXi's discovery services [3] - WuXi AppTec was involved in 62 out of 213 global licensing and M&A deals for synthetic drugs from 2024 to mid-2025, accounting for 29% [3] Financial Projections - All three WuXi companies raised their full-year guidance, with WuXi AppTec projected to achieve 17-18% revenue growth and a forward P/E of 18x, making it an attractive entry point [4] - Earnings projections for WuXi AppTec for 2025-2027 have been raised by 3-4%, with a terminal growth rate increase from 3% to 4% [4] - Price targets for WuXi AppTec A have been raised from RMB 105.00 to RMB 128.00, while WuXi Biologics and WuXi XDC also saw increases in their price targets [6] Capacity and Investment - WuXi AppTec is expected to see a more than 40% increase in capex spending in 2025 compared to 2024, with small molecule capacity tracking at a 60% expansion for the full year [13] - WuXi Biologics plans a more than 60% increase in bioreactor capacity to 491,000L from 2024 levels [18] - WuXi XDC anticipates doubling its drug product capacity from 8 million to 19 million vials in 2025, with a new Singapore site expected to boost capacity further [23][24] R&D Spending Trends - R&D spending across biopharma categories has increased year-over-year, with ADCs showing the largest increase at 9%, followed by biologics at 7% and small molecules at 3% [26] - China's private financing for biopharma companies increased by 18% year-over-year from January to October, contrasting with a 34% decline in the US [32] Backlog and Revenue Growth - WuXi AppTec's backlog increased by 41% year-over-year to RMB 60 billion by Q3 2025, with management raising revenue growth guidance from 13-17% to 17-18% [37] - WuXi Biologics and WuXi XDC also raised their revenue growth guidance, with WuXi Biologics increasing its range from 12-15% to 14-16% [37] Geopolitical Context - Geopolitical tensions have eased, particularly regarding the US Biosecure Act, which no longer mentions Chinese companies in the biotech section [41] - WuXi companies have diversified their supply chains, making significant investments in Singapore and the US to mitigate risks associated with geopolitical tensions [41] Valuation and Investment Thesis - WuXi AppTec is viewed as having the best risk-reward profile among the three WuXi companies, with a forward P/E of 18x and strong growth indicators [42] - The investment thesis emphasizes WuXi's technological leadership, supply chain resilience, and a balanced project portfolio along the drug development cycle [45] Conclusion - WuXi AppTec is positioned as a top pick in the CDMO sector, with strong growth prospects driven by increased R&D spending, capacity expansions, and favorable geopolitical developments [48]

Investment Rating - The report indicates a neutral investment rating for the pharmaceutical industry, suggesting it is expected to perform in line with the overall market [24]. Core Insights - The pharmaceutical sector experienced a decline of 6.9% this week, underperforming compared to the Shanghai Composite Index, which fell by 3.9% [3][5]. - The overall valuation of the pharmaceutical sector stands at 28.9 times earnings, ranking it 10th among 31 primary sectors [5][12]. - Key events include the acceptance of a new drug application for 百利天恒's drug iza-bren, which showed promising results in clinical trials for nasopharyngeal cancer [9]. - 泽璟制药's ZG006 received FDA orphan drug designation for treating neuroendocrine cancer, demonstrating significant efficacy and safety in clinical trials [10]. - 盟科药业 decided to terminate its stock issuance plan due to disagreements among major shareholders, which may impact its operational stability [11]. Market Performance Summary - The pharmaceutical index ranked 26th among 31 sub-industries this week, with various segments showing declines, including raw materials (-8.6%) and chemical preparations (-6.8%) [3][5]. - The report highlights a focus on innovative drug sectors and medical devices, recommending specific companies for investment [2].

Group 1 - The pharmaceutical and biotechnology industry is facing pressure from multiple factors such as centralized procurement price reductions and medical insurance cost control, leading to overall performance challenges [1] - Despite the industry's downturn, WuXi AppTec and Mindray Medical have demonstrated strong profitability, allowing them to stand out in the market and rank among the top 100 companies by net profit attributable to shareholders in Q3 2025 [1] - WuXi AppTec ranked 55th with a net profit attributable to shareholders of 12.076 billion yuan, reflecting a year-on-year growth of 84.84%, although it dropped three places compared to the half-year report [3] Group 2 - The innovative drug and contract research organization (CXO) industry chain is one of the few high-growth sub-sectors amidst the overall industry slump, with WuXi AppTec benefiting directly from this trend [5] - Mindray Medical, operating in the medical device sector, is currently affected by tendering rhythms but has shown strong resilience through internationalization and technological upgrades [5]

- The China Securities Biotechnology Theme Index was launched on August 26, 2015, by China Securities Index Co., Ltd. The index selects listed company securities involved in gene diagnosis, biopharmaceuticals, blood products, and other human biotechnology as index samples to reflect the overall performance of biotechnology listed company securities[3][38] - The index sample space is the same as the China Securities All Index sample space, consisting of A-shares and depository receipts issued by red-chip companies that meet the following conditions: "(1) Non-ST, *ST securities; (2) Other securities: listed for more than one quarter, unless the average daily market value ranks in the top 30 since listing; (3) STAR Market and Beijing Stock Exchange securities: listed for more than one year and two years, respectively"[39] - The index sample selection method includes: (1) Ranking the securities in the sample space by average daily turnover over the past year and removing the bottom 20%; (2) Selecting biotechnology-related companies from the remaining securities as biotechnology theme candidates; (3) Ranking the candidates by average daily market value over the past year and selecting the top 50 securities as index samples[39] - The index's top ten constituent stocks are highly concentrated, focusing on the pharmaceutical industry. As of November 19, 2025, the top ten constituent stocks accounted for 55.26% of the total weight, forming a "CXO + innovative drugs + medical devices" golden triangle combination[40][41] - The index constituent stocks are evenly distributed across different market value ranges, with weights of 35.79% for stocks with a market value of over 100 billion, 44.24% for stocks with a market value between 200-1000 billion, and the rest distributed among other ranges[42][43] - The index constituent stocks are mainly concentrated in the biological medicine III, medical services, chemical preparations, and medical devices industries, with weights of 42.33%, 20.99%, 17.33%, and 11.97%, respectively[44][46] - The index constituent stocks have high exposure to concepts such as industry leaders, comprehensive private enterprises, main trading forces, dual circulation, fund heavy positions, and innovative drugs, with exposure rates of 70.56%, 64.78%, 64.58%, 62.60%, 62.48%, and 62.16%, respectively[47][48] - The index's current style is characterized by small market value, high liquidity, and high momentum. As of October 31, 2025, the index's market value style is significantly negatively exposed compared to the China Securities 800 Index, with higher liquidity and trading activity[48][51][52] - The index's PE valuation is near the historical average, and the PB valuation is near the historical -1 standard deviation, indicating a high safety margin and potential for upward valuation[53][54] - The index's profitability is outstanding, with expected revenue growth rates of 6.54%, 6.00%, and 13.76% for 2025, 2026, and 2027, respectively, and expected net profit growth rates of 52.09%, 18.58%, and 24.11% for the same years[55][56][57][58]

Market Overview - The medical services sector experienced a decline of 2.71% on November 21, with Baihua Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3834.89, down 2.45%, while the Shenzhen Component Index closed at 12538.07, down 3.41% [1] Stock Performance - Notable gainers included Yangguang Nuohua, which rose by 4.47% to a closing price of 61.21, with a trading volume of 86,300 shares and a transaction value of 530 million [1] - Baihua Pharmaceutical saw a significant decline of 9.67%, closing at 9.06, with a trading volume of 292,400 shares and a transaction value of 275 million [2] - Other notable decliners included Chengda Pharmaceutical (-9.58%), Berry Genomics (-8.67%), and Guangzheng Eye Hospital (-7.26%) [2] Capital Flow - The medical services sector experienced a net outflow of 1.325 billion in institutional funds, while retail investors saw a net inflow of 1.332 billion [2] - The table of capital flow indicates that major stocks like Yangguang Nuohua had a net inflow of 10.986 million from institutional investors, while retail investors had a net inflow of 1.374 million [3]