人民财讯9月2日电，百济神州(688235)9月2日晚间发布股票交易异常波动公告，公司股票交易于连续三 个交易日内日收盘价格涨幅偏离值累计超过30%。由于生物医药行业具有研发周期长、投入大、风险高 的特点，公司的药物产品需完成药物早期发现、临床前研究等多个环节，容易受到一些不确定性因素的 影响。因此，公司未来的业务计划、实际业绩表现、财务状况或经营结果可能与公司预期情况有重大差 异。 ...

美股代码：ONC 百济神州有限公司 股票交易异常波动的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 1、百济神州有限公司（以下简称"公司"）股票交易于连续三个交易日内 （2025 年 8 月 28 日、2025 年 8 月 29 日和 2025 年 9 月 1 日）日收盘价格涨幅偏 离值累计超过 30%，根据《上海证券交易所交易规则》《上海证券交易所科创 板股票异常交易实时监控细则》的有关规定，属于股票交易异常波动情形。 2、经公司自查，截至本公告披露日，公司不存在应披露而未披露的重大事 项。公司目前生产经营正常，未发生重大变化。 3、公司股价短期波动幅度较大，敬请广大投资者注意投资风险，理性决策， 审慎投资。 A 股代码：688235 A 股简称：百济神州 公告编号：2025-035 港股代码：06160 港股简称：百济神州 （一）生产经营情况 经公司自查，公司目前生产经营活动正常，未发生重大变化。市场环境或 行业政策未发生重大调整，内部生产经营秩序正常。 一、股票交易异常波动的具体情况 公司股票 ...

百济神州9月2日晚间公告，公司股票交易于2025年8月28日至2025年9月1日连续三个交易日内收盘价格 涨幅偏离值累计超过30%，属于股票交易异常波动情形。经公司自查，目前生产经营活动正常，未发生 重大变化，也不存在应披露而未披露的重大信息。同时，公司股价短期波动幅度较大，提醒广大投资者 注意投资风险。 ...

Core Viewpoint - BeiGene has achieved a significant milestone with its stock price surging 9.84% on September 2, 2025, surpassing a market capitalization of 507.4 billion yuan, marking it as the leading pharmaceutical company in A-shares [1][17]. Financial Performance - In the first half of 2025, BeiGene reported total revenue of 17.518 billion yuan, a year-on-year increase of 46.03%, and a net profit of 450 million yuan, marking its first profit after four consecutive years of losses [3][5]. - The company's operating cash flow reached 1.631 billion yuan, up 152.6% year-on-year, indicating a strong turnaround in financial health [3][5]. Product Performance - BeiGene's flagship product, Brukinsa (Zebutinib), achieved global sales of 12.527 billion yuan, a 56.2% increase, maintaining the top market share in the U.S. BTK inhibitor market for two consecutive quarters [3][6]. - The PD-1 product, Tislelizumab, also performed well with sales of 2.643 billion yuan, reflecting a 20.6% growth due to new indications being included in medical insurance [6]. Market Contribution - The U.S. market contributed 8.958 billion yuan, a 51.7% increase, becoming the core growth driver, while the European market followed with a growth rate of 81.4% [6]. - Domestic market revenue grew by 36.5%, showcasing the company's strong foundation in the local market despite a slowdown [6]. Strategic Adjustments - Based on performance, BeiGene adjusted its revenue forecast for 2025 to a range of 35.8 billion to 38.1 billion yuan, with gross margin expectations revised to a higher range of 80% to 90% [9]. R&D Investment - In the first half of 2025, BeiGene invested 7.278 billion yuan in R&D, a 9.8% increase, reflecting its commitment to innovation and product development [10]. Pipeline and Collaborations - BeiGene has a robust pipeline with over 20 milestone advancements expected in the next 18 months, particularly in hematological malignancies and solid tumors [11][16]. - The company has established strategic partnerships with leading pharmaceutical firms, enhancing its global development capabilities and commercial reach [12][15]. Market Position - BeiGene's rise is attributed to its innovative product portfolio, global expansion strategy, and strong capital market support, positioning it as a leader in the rapidly evolving Chinese pharmaceutical industry [15][17].

百济神州公告，公司股票交易于2025年8月28日至2025年9月1日连续三个交易日内收盘价格涨幅偏离值 累计超过30%，属于股票交易异常波动情形。经公司自查，目前生产经营活动正常，未发生重大变化， 也不存在应披露而未披露的重大信息。同时，公司股价短期波动幅度较大，提醒广大投资者注意投资风 险，理性决策，审慎投资。 ...

南财智讯9月2日电，百济神州公告，公司股票交易于2025年8月28日至9月1日连续三个交易日内收盘价 格涨幅偏离值累计超过30%，构成股票交易异常波动。经公司自查，目前生产经营活动正常，市场环境 和行业政策未发生重大调整，不存在应披露而未披露的重大事项，也未发现对公司股价可能产生重大影 响的媒体报道及市场传闻。公司董事、高级管理人员在股票交易异常波动期间未买卖公司A股股票。公 司提醒投资者注意投资风险，理性决策，审慎投资。 ...

Summary of Key Points Core Viewpoint - On September 2, a total of 40 stocks were identified with institutional activity, with 19 stocks showing net buying and 21 stocks showing net selling by institutions [1]. Institutional Buying - The top three stocks with the highest net buying by institutions were: - Liao Co., with a net buying amount of 222 million [1] - Maiwei Bio, with a net buying amount of 109 million [1] - Yingweike, with a net buying amount of 93.3 million [1]. Institutional Selling - The top three stocks with the highest net selling by institutions were: - Baiji Shenzhou, with a net outflow amount of 1.261 billion [1] - Jingwang Electronics, with a net outflow amount of 290 million [1] - Chuangxin Medical, with a net outflow amount of 216 million [1].

Group 1 - Beijing-based innovative pharmaceutical company BeiGene announced an agreement with Royalty Pharma to sell the rights to receive royalties from the global sales of the drug Talazoparib outside of China, with a maximum transaction value of $950 million [1] - According to the agreement, BeiGene will receive an upfront payment of $885 million and has the option to sell the remaining royalty rights within 12 months for an additional payment of up to $65 million [1] - Talazoparib is a first-in-class immunotherapy that targets DLL3 protein on tumor cells and CD3 protein on T cells, activating T cells to kill DLL3-expressing tumor cells, and has been approved in the U.S. for treating extensive-stage small cell lung cancer [1] Group 2 - This year, Beijing's innovative pharmaceutical companies have been active in overseas licensing deals, generating significant revenue and enhancing self-sustainability [2] - Earlier this year, companies Innovent Biologics and Connaissance Therapeutics entered into a licensing agreement with Prolium Bioscience for the development and commercialization of a bispecific antibody, ICP-B02, with a total payment of up to $520 million [2] - The licensing fees from this agreement helped Innovent Biologics achieve its first quarterly profit in the first quarter of this year [2]

Core Insights - On September 2, a total of 40 stocks were involved in institutional trading, with 19 stocks showing net buying and 21 stocks showing net selling [1] Institutional Net Buying - The top three stocks with the highest net buying by institutions were: - Liou Co., Ltd. with a net buying amount of 222.5 million yuan [2] - Maiwei Bio with a net buying amount of 109.4 million yuan [2] - Yingweike with a net buying amount of 93.3 million yuan [2] Institutional Net Selling - The top three stocks with the highest net selling by institutions were: - Baiji Shenzhou with a net outflow of 1.26 billion yuan [4] - Jingwang Electronics with a net outflow of 290.3 million yuan [4] - Innovation Medical with a net outflow of 216.2 million yuan [4]

Core Viewpoint - The innovative drug sector has led the market this year, with the Hang Seng Innovative Drug ETF (159316) rising over 86% since April 9 [1][4]. Fund Inflows - In the last 60 days, the Hang Seng Innovative Drug ETF (159316) has seen a net inflow of 1.547 billion yuan, bringing its latest scale to 1.968 billion yuan [3]. Breakthroughs - The strong performance of the innovative drug sector is attributed to a series of favorable developments, particularly in international markets. A significant boost occurred on September 1 when Hengrui Medicine announced conditional approval from the National Medical Products Administration for its self-developed innovative drug, SHR2554, for treating relapsed or refractory peripheral T-cell lymphoma [4][5]. - SHR2554 represents a major breakthrough as China's first self-developed EZH2 inhibitor, indicating a shift from "Me-too" drugs to genuine innovation, showcasing China's capability to compete in global markets [5][6]. Incremental Growth - From January to July this year, Chinese innovative drug companies licensed out nearly 80 billion yuan, a year-on-year increase of over 160%. Several companies have announced large licensing agreements, indicating a growing trend in international collaborations [7][9]. - The innovative drug industry in China is characterized by increasing foundational innovation capabilities, expanding market size, and improving international market share. The number of self-developed innovative drugs surpassed that of the U.S. in 2020, with 592 drugs in development by 2021, accounting for 22% of the global total [9][11]. Qualitative Changes - The Hang Seng Innovative Drug Index has rebounded significantly after a steep decline, with a 73% drop from its peak in June 2021 to July 2024, followed by a doubling in value over the past year [13][14]. - Several companies have reported profitability for the first time, with notable net profits from companies like BeiGene and Innovent Biologics, indicating a shift towards sustainable revenue sources [15][16]. - The innovative drug sector is transitioning from a phase of heavy R&D investment to one of realizing results, supported by valuation recovery, earnings growth, accelerated international expansion, and favorable policies [18]. Conclusion - The innovative drug sector is expected to continue benefiting from multiple catalysts, including upcoming international conferences and potential interest rate cuts, which could enhance global liquidity and favorably impact the sector [18].