Core Viewpoint - The current stock market focus is heavily on technology stocks, particularly driven by excitement around artificial intelligence (AI), creating a gap and opportunity for investment rotation into the healthcare sector [1] Technology Sector - The technology sector has attracted significant attention and capital, overshadowing other sectors, particularly healthcare [1] Healthcare Sector - The healthcare sector has seen many companies fall to valuation levels not seen in years, presenting potential investment opportunities [2] - Three companies stand out for potential benefits from a rotation from tech to healthcare: Eli Lilly Co. (NYSE: LLY), Pfizer Inc. (NYSE: PFE), and UnitedHealth Group Inc. (NYSE: UNH) [3] Eli Lilly - Eli Lilly is currently trading at $797.82, approximately 78% of its 52-week high of $972.53, with a P/E ratio of 64.92 and a price target of $1,012.56 [4] - Analysts expect Eli Lilly's earnings per share (EPS) to reach $6.77 by Q4 2025, nearly doubling from current levels, which could drive stock price growth [5] - Eli Lilly's high P/E ratio of 62.0x is justified by expected earnings growth, and the stock has room to trade back toward its highs if growth materializes [7] Pfizer - Pfizer is trading at $25.32, about 77% of its 52-week high of $31.54, with a P/E ratio of 18.35 and a price target of $28.55 [8] - Pfizer offers a dividend yield of 6.79%, which outperforms inflation and treasury rates, making it attractive in the current macroeconomic environment [8] - Institutional investor Robeco Institutional Asset Management increased its stake in Pfizer by 36.6%, indicating confidence in the stock's potential [9][10] UnitedHealth - UnitedHealth is trading at $292.40, only 45% of its 52-week high of $630.73, with a P/E ratio of 12.24 and a price target of $394.43 [13] - The stock's deep discount presents a potential opportunity for investors, especially as the company benefits from rising medical costs [14] - J.P. Morgan analyst Lisa Gill has set a new price target of $418 for UnitedHealth, suggesting a potential upside of 48% from current levels [15] - UnitedHealth's diverse business model positions it well to benefit from long-term trends in the healthcare sector [16]

Core Viewpoint - Morgan Stanley's strategy team highlights 15 stocks with short-term catalytic potential, indicating that S&P 500 index earnings growth in Q2 may exceed expectations [1] Earnings Expectations - The market anticipates a 5% year-over-year increase in S&P 500 Q2 earnings per share and over 4% revenue growth, but actual growth may be stronger [1] - The seven major tech companies are expected to see a 14% increase in net profit, while the remaining 493 constituents may experience a 3% decline [1] - Despite analysts lowering earnings expectations from April to May, the earnings revision has rebounded from -25% to approximately 1%, suggesting Q2 earnings will likely exceed expectations, aligning with the historical average of 4%-5% [1] Recommended Stocks - **argenx SE (ARGX.US)**: undervalued R&D pipeline, target price $700 [2] - **Atlassian (TEAM.US)**: continuous revenue growth potential over 20% and expected margin expansion, target price $320 [3] - **Chewy (CHWY.US)**: benefits from marketing and product optimization, expected revenue to maintain or exceed Q1 levels, target price $50 [4] - **CVS Health (CVS.US)**: advantages from competitor store closures and growth in pharmacy benefit management, target price $80 [4] - **DraftKings (DKNG.US)**: potential earnings inflection point in Q2, with actual licensing rates offsetting tax and regulatory pressures, target price $52 [4] - **Eaton Corporation (ETN.US)**: benefits from improved profit margins in U.S. electrical business, target price $375 [5] - **Eli Lilly (LLY.US)**: core products Mounjaro and Zepbound expected to contribute $8.2 billion in revenue, exceeding expectations may lead to 2025 guidance upgrades, target price $1,135 [5] - **F5 (FFIV.US)**: positive outlook due to demand growth in cloud and load balancing products, target price $305 [6] - **NVIDIA (NVDA.US)**: strong end-user demand and accelerated shipments of rack-level products supporting supply-side growth, target price $170 [7] - **Omada Health (OMDA.US)**: operational leverage through technology empowerment and multi-disease sales, target price $25 [8] - **Southwest Airlines (LUV.US)**: potential stock rebound if internal guidance is met and baggage fee impacts are confirmed as limited, target price $38 [9] - **Valley National Bank (VLY.US)**: expected net interest income growth of 3% quarter-over-quarter, target price $11 [10] - **Western Digital (WDC.US)**: undervalued gross margin expansion prospects, target price $85 [11] Cautious Outlook - **National Storage Affiliates Trust (NSA.US)**: cautious due to expected funds from operations (FFO) per share being below market and company guidance, target price $30 [12] - **Teradyne (TER.US)**: revenue and earnings per share forecasts for FY2026 are 7% and 14% below Wall Street expectations, target price $74 [13] Summary - Overall, Morgan Stanley's recommendations combine company fundamentals, industry trends, and market sentiment, providing diversified options for investors [14]

Group 1 - Zacks Premium offers various tools for investors, including daily updates on Zacks Rank and Industry Rank, access to the Zacks 1 Rank List, Equity Research reports, and Premium stock screens to enhance investment confidence [1][2] - The Zacks Style Scores rate stocks based on value, growth, and momentum characteristics, providing complementary indicators to the Zacks Rank [2][3] Group 2 - The Value Score identifies attractive and discounted stocks using ratios like P/E, PEG, and Price/Sales, appealing to value investors [3] - The Growth Score focuses on a company's financial strength and future outlook, analyzing projected and historic earnings, sales, and cash flow [4] - The Momentum Score helps investors capitalize on price trends by examining one-week price changes and monthly earnings estimate changes [5] Group 3 - The VGM Score combines all Style Scores, offering a comprehensive indicator for investors who utilize multiple investing styles [6] - The Zacks Rank employs earnings estimate revisions to simplify portfolio building, with 1 (Strong Buy) stocks achieving an average annual return of +23.62% since 1988, outperforming the S&P 500 [7][9] Group 4 - Eli Lilly and Company, a major pharmaceutical firm, has a diversified product profile and a strong pipeline in obesity, diabetes, and Alzheimer's [11] - Eli Lilly holds a Zacks Rank of 3 (Hold) with a VGM Score of A and a Growth Style Score of B, indicating a forecasted year-over-year earnings growth of 69.3% for the current fiscal year [11][12] - Recent upward revisions in earnings estimates and an average earnings surprise of +6.7% further enhance Eli Lilly's attractiveness to growth investors [12]

21世纪经济报道记者季媛媛 医院减重门诊前排起长队，商业广告中"越吃越瘦"的标语层出不穷，一场由GLP-1药物引领的全球体重 管理革命正席卷医疗与资本市场。 这一趋势在全球范围内形成了新的风向。7月22日，人民财讯报道称，世界卫生组织（WHO）正在制定 基于GLP-1疗法的成人肥胖症治疗新指南，计划于2025年9月正式发布。据悉，该指南由独立的指南开 发小组（GDG）负责制定，成员包括肥胖领域的专家、流行病学专家、临床管理专家、药理学家、卫 生经济学家、公共卫生项目专家及政策制定者，以确保指南符合世界卫生组织的严格标准。该指南旨在 明确GLP-1 RAs的临床适应症、应用及规划方面的考量，并有望成为世界卫生组织首次正式推荐使用减 肥药物治疗成人肥胖症。 有券商医药行业分析师对21世纪经济报道记者表示，该指南由肥胖专家、药理学家、卫生经济学家和政 策制定者组成的独立小组制定，标志着全球卫生权威对肥胖认知的根本转变——从生活管理问题转变为 需要系统性医疗干预的慢性代谢疾病。 "对于GLP-1产业链上的企业而言，这份指南绝非简单的诊疗规范更新，而是开启全球肥胖治疗市场的 政策钥匙，将重构数百亿美元市场的竞争规则与成 ...

Few things can jolt a pharmaceutical company's shares like positive results from highly anticipated clinical trials. Even so, long-term investors should have a balanced approach to potentially positive data readouts. Putting aside the fact that it's impossible to predict the outcome of a clinical trial beforehand, even when the results are up to Wall Street's standards, it's hardly worth investing in the company unless there are other good reasons to think it will perform well over long periods. That's why ...

Core Viewpoint - Novartis' stock price has increased by 32% since the beginning of the year, with a market capitalization exceeding $240 billion, reaching a historical high. However, the company has not participated in the PD-1 craze or engaged in fierce competition in popular fields like GLP-1 or ADC [2] Group 1: Market Position and Strategy - Novartis has conducted an in-depth evaluation regarding entering the obesity treatment market but believes that the current GLP-1, GIP, and GIPR drug market will continue to be dominated by Eli Lilly and Novo Nordisk, who are rapidly advancing new generation drug development [4] - The CEO of Novartis, Vas Narasimhan, stated that even with slightly differentiated new products, it would be challenging to break through in the current competitive landscape, as high rebate barriers and mature product portfolios will be established by the time follower drugs are launched [4] - Despite not fully abandoning the obesity treatment direction, Novartis is advancing early-stage research projects exploring truly differentiated new pathways, including evaluating longer-acting drug forms such as biologics or siRNA drugs [4] Group 2: Market Potential and Competitors - The obesity drug market is expected to reach $130 billion, with many pharmaceutical companies actively entering the field. Evaluate's latest report indicates that Novo Nordisk's CagriSema project is currently regarded as the most valuable R&D project in the industry [5] - Following closely is Eli Lilly's orforglipron, a new generation oral GLP-1 agonist. Although Novo Nordisk and Eli Lilly have first-mover advantages, Evaluate believes that new entrants with sufficient differentiation still have opportunities to establish a foothold in this field [5]

But finding these monster stocks isn't always easy. Most people try to find the next big thing when, often, the winners are already sitting in plain sight. Buy-and-hold investing only works if you choose the right companies. Here are some potential examples. The ultimate win for investors is finding a remarkable company that is not only highly productive, but also capable of growth over many years, resulting in substantial returns for long-term shareholders. After careful consideration, I've identified five ...

Summary of Key Points from the Conference Call Industry Overview - **Industry**: Biopharma in North America - **Market Analysis**: Comprehensive analysis of the US drug market conducted by IQVIA Rx Key Market Metrics - **Total Prescription Year-over-Year (YoY) Growth**: - Latest weekly growth (week ending July 11, 2025) was +4.0%, up from +3.4% the previous week and +2.5% over the past 12 weeks [1][6] - For the week ended July 11, the total market weekly TRx YoY change was +4.0%, compared to +1.8% a year ago [2] Prescription Trends - **Rolling 4-week TRx YoY**: +3.0% - **Rolling 12-week TRx YoY**: +2.5% - **Extended Unit (EUTRx) Weekly YoY Growth**: +3.3%, which is below the TRx YoY [2] - **Sequential Weekly TRx Growth**: +12.0%, a significant increase compared to -7.3% the week before [2] Company-Specific Insights - **Bristol Myers Squibb (BMY)**: - Cobenfy approved for schizophrenia on September 26, 2024, with scripts at ~2,040 for the week, up from ~1,820 the previous week [3] - To meet 2025 consensus expectations, Cobenfy TRx needs to track at ~2-3x the volumes from recent schizophrenia launches [3] - **Vertex Pharmaceuticals (VRTX)**: - Journavx approved for acute pain on January 30, 2025, with scripts at ~5,880 for the week, up from ~5,180 the previous week [4] - Hospital scripts, which are not captured by IQVIA, account for ~28% of total scripts [4] - **Gilead Sciences (GILD)**: - Yeztugo approved on June 18, 2025, with latest week TRx at ~70, up from ~20 the previous week [5] - Yeztugo's injectable formulation accounted for 54% of total TRx [5] Competitive Landscape - **Launch Comparisons**: - GILD's Yeztugo compared to Descovy and Apretude [5] - BMY's Sotyktu launch tracked against AMGN's Otezla [9] - LLY's Kisunla launched in July 2024 for Alzheimer's [9] Pricing and Sales Analysis - **Immunology Pricing**: Updated charts for 2Q25 for Stelara and Tremfya, analyzing how additional indications impact price per script [10] - **Biosimilar Adoption**: Comprehensive analysis of biosimilars across various branded drugs [12] Notable Trends - **Seasonal Respiratory Vaccine Tracking**: Exhibits tracking RSV and COVID vaccine weekly and monthly TRx launch trends [11] - **Key Products Performance**: Detailed tracking of TRx market share and performance for major pharmaceutical companies [48] Conclusion - The biopharma industry in North America is experiencing positive growth in total prescriptions, with significant contributions from new product launches and competitive dynamics among major players. The analysis indicates a robust market environment with potential investment opportunities in emerging therapies and established products.

Core Viewpoint - The article highlights the effectiveness and safety of GLP-1 receptor agonists, specifically Semaglutide and Tirzepatide, in treating obesity and improving health outcomes, as endorsed by public figures like Elon Musk [1][3][5]. Group 1: Efficacy of Semaglutide - Semaglutide has shown significant weight loss results in clinical trials, with an average weight reduction of 15% in obese patients, compared to only 2.4% in the placebo group [7][10]. - In the STEP 1 trial, 34% of participants lost over 20% of their body weight, while the average weight loss was 14.9% [7]. - The STEP 2 trial indicated a 10.6% average weight loss in type 2 diabetes patients, with improvements in cardiovascular risk factors and quality of life [8]. - The STEP 4 trial demonstrated that continuous use of Semaglutide led to an 18.2% weight reduction over time [9]. - Overall, Semaglutide has been approved by the FDA for long-term obesity management, marking it as a significant advancement in obesity treatment [10]. Group 2: Efficacy of Tirzepatide - Tirzepatide has shown promising results in the SURMOUNT trials, with weight reductions of 15.4% to 22.9% depending on the dosage, significantly outperforming the placebo group [11][12]. - The SURMOUNT-3 trial reported a weight loss of up to 26.6% after 12 weeks of lifestyle intervention combined with Tirzepatide treatment [13]. - In head-to-head trials, Tirzepatide demonstrated superior weight loss compared to Semaglutide, with an average reduction of 22.8 kg [13]. Group 3: Safety Profile - Semaglutide is generally well-tolerated, but gastrointestinal side effects such as nausea (17%), diarrhea (12.2%), and vomiting (6.4%) are common [15]. - Approximately 80% of Tirzepatide users reported at least one side effect, primarily gastrointestinal, with nausea reported in 33% of high-dose users [17]. - Experts suggest that Tirzepatide may have a lower frequency and milder symptoms of side effects compared to Semaglutide due to its dual action mechanism [19].

Core Viewpoint - President Trump's trade policies, particularly aggressive tariffs on imports, are impacting Wall Street and could increase costs for companies, affecting their margins and stock performance. However, certain healthcare companies like Eli Lilly and Novartis present investment opportunities despite these challenges [1][2]. Eli Lilly - Eli Lilly has committed to investing $50 billion in U.S.-based manufacturing since 2020, with half of this announced in the first quarter [4]. - The company aims to manufacture 100% of medicines for U.S. patients domestically, which will help mitigate the impact of tariffs [5]. - Eli Lilly has shown significant innovation in diabetes and obesity treatments, with new products like Mounjaro and Zepbound generating billions in revenue [5]. - In Q1, Eli Lilly's revenue rose 45% year over year to $12.7 billion, and net income increased by 23% to $2.8 billion [6]. - The company has a strong pipeline, including a promising oral GLP-1 candidate, orforglipron, which could attract patients seeking convenience [7]. - Eli Lilly has increased its dividend payout by 102.7% over the past five years, making it a solid choice for growth and income investors [8]. Novartis - Novartis plans to invest $23 billion over the next five years to enhance its U.S. manufacturing capabilities [9]. - Despite potential short-term impacts from tariffs, Novartis is expected to manage these challenges effectively [10]. - In Q1, Novartis reported a 12% increase in net sales to $13.2 billion and a 22% rise in net income to $4.5 billion [10]. - The company is facing a loss of U.S. patent exclusivity for its heart failure drug Entresto, which generated $2.3 billion in sales in Q1, a 20% increase year over year [11]. - Novartis has prepared for this loss with new medicines like Fabhalta and cancer drugs Scemblix and Pluvicto, which have shown promising sales [11][12]. - The company has increased its dividend for 28 consecutive years, currently offering a forward yield of 3.3%, which is significantly higher than the S&P 500 average [13].