Market Performance - After a six-day decline, the Hong Kong Stock Connect Innovation Drug ETF (520880) rebounded on January 23, rising over 2% at one point and closing up 1.53% with a trading volume of 348 million yuan [1][7] - Key constituent stocks such as Cloudtop New Drug led the gain with an 8.2% increase, while major stocks like Kangfang Biotech and CSPC Pharmaceutical rose by 3.5% [1][7] Policy Developments - On January 22, the Ministry of Commerce and nine other departments issued a document promoting high-quality development in the pharmaceutical retail industry, encouraging innovative drugs and reference preparations to enter retail pharmacy sales channels [3][9] - This policy is expected to provide a pathway for high-value innovative drugs, such as CAR-T, to fill the insurance coverage gap through commercial insurance directories [3][9] - The insurance industry association estimates that by 2025, the total compensation amount for innovative drugs and devices from commercial health insurance will reach approximately 14.7 billion yuan, with a compound annual growth rate of 70% over four consecutive years [3][9] Industry Insights - At the recent JPM conference, Chinese pharmaceutical companies showcased technological breakthroughs in areas such as ADC, IO dual antibodies, and GLP-1, moving towards global markets through licensing and collaborative development [3][9] - According to CITIC Securities, the Chinese pharmaceutical industry is at the starting point of a global value reassessment, with 2026 being a critical year for validating transformation effectiveness [3][9] Investment Opportunities - The Hong Kong Stock Connect Innovation Drug ETF (520880) is highlighted as a high-elasticity T+0 investment tool, with its index (Hang Seng Hong Kong Stock Connect Innovation Drug Select Index) offering three unique advantages: 1. Purely innovative drugs with 100% purity, covering companies focused on innovative drug R&D [5][11] 2. A significant concentration of leading companies, with the top ten innovative drug leaders accounting for over 73% of the index [5][11] 3. Enhanced risk control through forced de-weighting of less liquid constituent stocks [5][11] Constituent Stocks - The top ten constituent stocks of the Hong Kong Stock Connect Innovation Drug ETF (520880) have a combined weight of 73.41%, showcasing a strong representation of leading companies in the innovative drug sector [6][12] - Notable constituents include: - Kangfang Biotech: 10.49% weight, market cap of 110.9 billion HKD - BeiGene: 10.01% weight, market cap of 312 billion HKD - CSPC Pharmaceutical: 9.97% weight, market cap of 102.1 billion HKD [6][12]

Group 1 - The Hong Kong pharmaceutical sector is experiencing a strong rebound, with the Hong Kong Stock Connect Innovation Drug ETF (159570) rising nearly 2% and achieving a transaction volume exceeding 700 million yuan in a short period [1] - The ETF has seen a cumulative net inflow of over 430 million yuan in the past five days, with its latest scale surpassing 25.1 billion yuan, leading in its category [1] - The majority of the weighted stocks in the ETF's index have shown positive performance, including Kangfang Biopharma and Kelun-Botai, which both rose over 4% [3][4] Group 2 - Kangfang Biopharma announced that its new humanized anti-IL-17A monoclonal antibody, AK111, has received acceptance for a new drug application for treating active ankylosing spondylitis (AS) by the National Medical Products Administration (NMPA) [3] - This new drug is expected to provide a new treatment option for nearly 4 million AS patients in China [3] - The JPMorgan Healthcare Conference highlighted the achievements of Chinese innovative drug companies, with expectations for significant revenue growth and multiple drug approvals in the coming years [5][6] Group 3 - The domestic pharmaceutical industry is witnessing rapid technological advancements and an acceleration in globalization, with significant transactions exceeding 10 billion USD occurring [6][7] - The industry is entering a critical period of validation for innovative drug performance, with many companies expected to launch global registration studies and new product applications [6][7] - A domestic innovative drug company projected a revenue increase of 15.84% for 2025, with a substantial net profit growth of 102.65% [7]

1月23日早盘，港股通创新药板块强势反弹，高弹性港股通创新药ETF（520880）急速冲上2%！成份股 方面，云顶新耀、映恩生物-B领衔涨势，权重股康方生物涨超5%。 消息面，1月22日，商务部联合国家发展改革委、国家医保局等9部门印发《关于促进药品零售行业高质 量发展的意见》，明确提出鼓励创新药、参比制剂等进入零售药店销售渠道，并推动电子处方流转平台 建设，支持实体医疗机构与互联网医院与零售药店对接，优化购药体验。 分析人士指出，该政策旨在强化药品零售端的专业服务功能，提升创新药可及性，尤其为高值创新药 （如CAR-T）通过商保目录补充医保保障缺口提供落地路径。 二级市场资金提前埋伏，此前港股通创新药板块连阴6日，资金频频借道港股通创新药ETF（520880） 逢跌吸筹。数据显示，本周以来，520880累计获超2.3亿元资金净申购，最新份额升至45.38亿份，续创 历史新高！ 一键投资创新药，认准高弹性T+0利器——港股通创新药ETF（520880）及其场外联接基金 （025221），其跟踪的恒生港股通创新药精选指数具备三大独特优势，配置价值突出： 1、纯粹，全面。不含CXO，纯正创新药！全面覆盖创新药研发 ...

智通财经APP获悉，康方生物(09926)涨超5%，截至发稿，涨5.16%，报118.1港元，成交2.31亿港元。 据介绍，古莫奇单抗是康方生物继伊努西单抗(PCSK9)、依若奇单抗(IL-12/IL-23)之后，第三个进入上 市阶段的非肿瘤重磅产品。随着伊努西单抗、依若奇单抗相继上市并纳入国家医保目录，古莫奇单抗、 曼多奇单抗等产品逐步迈入商业化阶段，以及IL-4R/ST2双抗、神经退行性病变等非肿瘤创新靶点药物 针对多适应症深度开发的高效推进，公司产品组合力愈发强劲，非肿瘤板块的竞争力持续增强。 消息面上，据康方生物官微消息，近日，公司宣布，其自主研发的新型人源化抗IL-17A单克隆抗体古莫 奇单抗(AK111)用于治疗活动性强直性脊柱炎(AS)的新药上市申请(sNDA)，已获得国家药品监督管理局 药品审评中心(NMPA CDE)受理。这标志着该药有望为中国近400万AS患者带来新的治疗选择。 ...

是否活成一个NPC，是否不配有姓名？ 1月20日，历史上一个平淡的日子，唯一的热闹，可能是大寒之日上海飘雪。同日，另一场寒潮却无声 无息，恒生生物科技指数（HSHKBIO）成交额跌破100亿港币，与2025年最高点相比下降近80%，15家 港股18A公司日成交额不足100万港币。 创新药在研发主战场外，正在开辟争夺流动性的第二战场。 技术和资本，一体两面，是创新药企的两大属性。早期生物科技没有自我造血功能，全靠资本输血。成 熟创新药企在每一个重要节点，跃升到更高发展阶段，也靠资本支持。 当前，通过港股18A通道上市的生物科技企业已达85家(含摘B)，还有超过80家递表排队，而流动性却 在指缝间溜走。自研能力不够硬，又不做市值管理的公司，等于自动退出流动性争夺战，被边缘化，被 遗忘，直至丧失融资能力。 每家Biotech都曾经满怀绚丽的梦想，但时间会褪色一切，会否一不注意就成为创新药背景板上没有姓 名的NPC？ FDA敌意渐浓 进入2026年，FDA连续对多项生物制品上市申请（BLA）发出Complete Response Letter（CRL），拒绝 批准或要求补充关键临床与CMC（化学、生产与控制）证据，显 ...

Core Viewpoint - The Hong Kong Stock Connect innovative drug sector has experienced a continuous adjustment for six days, with the Hong Kong Stock Connect Innovative Drug ETF (520880) showing a decline of 0.75% and a trading volume of 200 million [1]. Group 1: Market Performance - The innovative drug ETF (520880) is fully invested in innovative drug R&D companies and has recently attracted significant capital inflows, indicating a potential opportunity for investment in innovative drugs [3][12]. - The leading pharmaceutical companies are expected to have promising earnings forecasts for 2025, which could lead to valuation recovery opportunities [3][12]. - The ETF has seen a recent increase in fund size to 2.348 billion, with the number of shares reaching 4.382 billion, both hitting new highs since its listing [4][10]. Group 2: Long-term Outlook - The core logic of the Hong Kong Stock Connect innovative drug sector remains solid, with expectations of a total overseas licensing amount for innovative drugs reaching 135.7 billion in 2025, reflecting global recognition of Chinese pharmaceutical R&D capabilities [3][12]. - The National Medical Products Administration (NMPA) is expected to approve 76 innovative drugs in 2025, leading the world in approvals, and will continue to optimize the review and approval process for innovative drugs [3][12]. - Investment strategies from Zhongtai International and Guosen Securities recommend continued focus on the innovative drug sector for 2026 [3][12]. Group 3: ETF Characteristics - The ETF exclusively covers innovative drug R&D companies, excluding CXO, and has a significant concentration in leading companies, with the top ten innovative drug companies accounting for over 73% of the weight [5][12]. - The ETF employs a strategy to reduce the weight of less liquid component stocks, effectively managing tail risks [6][12]. - The ETF's tracking index has a notable advantage with a high concentration of leading companies, enhancing its investment value [7][12].

大消费冲高回落，截止午盘下跌0.23%。其中安踏体验下跌5.75%，李宁下跌4%，申洲国际/蜜雪集团/ 康方生物等股跌幅均在3%上方；同程旅行/阿里健康/药明联合等涨幅均在2%上方。 恒生科技开盘后只需拉升，随后维持在中轴上方盘整，截止午盘上涨0.13%。其中百度集团上涨 3.29%，中芯国际上涨3.15%，比亚迪股份/阿里巴巴等股涨幅均在1%上方；网易逆势下跌3.43%，小米 集团下跌2.31%。 内容只是个人观点，仅供参考，不作为投资依据！欢迎关注交流，互相学习、共同探讨！ 冲高回落维持弱势，截止午盘，恒生指数小跌0.15%。银行跌幅居前，大消费/互联网等紧随其后；恒生 医疗和恒生科技等逆势小涨。 银行高开低走后一路回撤，截止午盘下跌0.29%。重庆农村商业银行下跌1.51%，大新集团下跌1.5%， 农业银行/光大银行/招商银行等股跌幅均在1%上方，青岛银行/招商银行/中国银行等股逆势小涨。 ...

数据来源：wind 进一步展望生物科技领域的投资前景。大家已经了解，港股为生物科技公司上市提供了得天独厚的条 件，那么当前为何要投资港股的生物科技公司？这可以从宏观背景层面进行分析。当前美联储正处于降 息周期，大家也清楚，在降息环境下，包括美国在内的境外资金更倾向于流出美股市场，转而寻找具有 成长价值的投资机会，而非停留在美股市场追求低息无风险收益，而港股很可能成为其优先选择。 在美联储新一轮防御式降息周期中，港股资产展现出比以往更优的收益弹性和流动性前景。这对于以港 股生物科技为代表的成长板块的估值修复和业绩增长，具有重要的指引意义。下方列出的时间序列图 表，重点标记了恒生生物科技指数与美联储降息周期时间节点的重要关联。可以看到，2019年7月至 2020年美联储降息期间，恒生生物科技指数就展现出了较好的业绩弹性。而从2024年至2025年年底，乃 至如今迈入2026年，在降息周期的大背景下，恒生生物科技指数很可能展现出更优的收益弹性表现。这 是我们从宏观政策角度分析得出的结论。 回归国内政策层面，未来境内尤其是港股上市的生物科技公司将获得哪些政策支持？我们能看到，行业 政策正全链条支持创新药发展。其中一个 ...

Core Viewpoint - The innovative drug sector is expected to experience a resurgence in 2025, transitioning from a broad market rally to a focus on select stocks driven by global clinical data, overseas commercialization, and domestic profitability turning points [1] Group 1: Market Performance - In 2025, the A-share innovative drug index saw an annual increase of nearly 20%, while the H-share index rose by 66.52%. The first half of the year recorded increases of approximately 17% for A-shares and 58% for H-shares, with the second half showing more modest gains of about 3% and 9% respectively [1] - The A-share billion-dollar club includes companies like BeiGene (市值4190.64亿元), Hengrui Medicine (市值3994.27亿元), and Baillie Gifford (市值1332.18亿元), while the H-share club includes Hengrui Medicine (市值4729.34亿元), BeiGene (市值3191亿元), and others [2] Group 2: Company Dynamics - Companies in the billion-dollar club are valued based on "pipeline value + BD monetization + global sales peak." Capital markets are comparing these firms to global leaders, elevating them from "First-in-class" to "Best-in-class" [3] - In 2025, domestic innovative drug license-out transactions totaled 83, amounting to $84.5 billion, surpassing the total of over $60 billion for 2024. Hengrui Medicine's international deals included partners like GSK and Merck, with upfront payments totaling $765 million [3] Group 3: Market Challenges - Some companies that previously entered the billion-dollar club, such as Kintor Pharmaceutical and China National Pharmaceutical Group, have fallen below the threshold due to systemic valuation corrections and stricter FDA approval standards [4] - The market has become desensitized to BD transactions, as evidenced by the stock price drop of Innovent Biologics following a $11.4 billion collaboration announcement, indicating a tightening of valuation expectations [4] Group 4: Capital Operations - As the innovative drug market heats up in 2025, companies are initiating new capital operations, including acquisitions and cross-border listings. For instance, China National Pharmaceutical Group acquired Lixian Pharmaceuticals for approximately $500 million [5] - Baillie Gifford raised 3.764 billion yuan through a private placement in the A-share market, while also applying for an IPO in Hong Kong [5] Group 5: Small-cap Stocks - The top three performing innovative drug stocks in A-shares for 2025 were Shuyou Pharmaceutical (涨幅488%), Yipinhong (涨幅370%), and Yifang Biotechnology (涨幅235%). In H-shares, the top performers were Beihai Kangcheng (涨幅1824%), Heber Pharmaceuticals (涨幅553%), and Sanofi (涨幅311.18%) [7] - These stocks have core products that received high recognition, with clinical pipelines achieving significant breakthroughs, such as Shuyou's STSP-0601 and Beihai Kangcheng's Selinexor [7] Group 6: Future Outlook - The innovative drug sector is expected to enter a "hardcore alpha" phase in 2026, focusing on companies that can deliver genuine clinical data, achieve overseas commercialization, and demonstrate domestic profitability [10] - The emphasis will shift from broad market rallies to specific companies that can prove their clinical trial results and secure sales milestones, with a focus on high-demand areas like dual antibodies and ADCs [11][12]

每经记者｜任飞 每经编辑｜赵云 继融通产业趋势臻选之后，1月21日，包括2025年股基冠军融通产业趋势在内，新生代基金经理李进管理的其余四只产品四季报全部发布。从季内持仓来 看，新进重仓华懋科技、源杰科技、嘉元科技等个股，A股剑桥科技、中际旭创则有所减持。 此外，李进也关注新能源、医药和消费行业的布局，并且在其他在管基金中新进重仓或加仓了相关个股。他在季报总结中表示，光模块和PCB龙头公司估值 处于合理偏低的水平，在后续频率和速率提升的背景下，PCB产品的层数和材料复杂性大幅提升，相关公司的业绩成长持续性能看到较长时间。 作为新生代的基金经理，融通基金李进在2025年打造出一只普通股票型基金的年度业绩"冠军"，即融通产业趋势，1月21日，该基金发布2025年第四季度报 告，新增了多只重仓股。 具体来看，华懋科技、源杰科技、港股剑桥科技以及嘉元科技是该基金四季度新进重仓的品种，与往期着重集中在人工智能算力方向上不同，此次季报展示 的重仓股已经有所扩散，在新能源、消费等行业均有涉及。 值得注意的是，李进管理的基金在季内仓位调整上也同永赢科技智选有相似之处。首先，在权益资产的配比上，融通产业趋势四季度末的股票持仓占 ...