在肥胖治疗领域，GLP-1（胰高血糖素样肽-1）靶点的价值已被广泛认可。作为重要的肠促胰素，GLP- 1通过激活GLP-1受体，既能调节血糖，又能作用于中枢抑制食欲、延缓胃排空以减少能量摄入。而 GCG（胰高血糖素）靶点的研究则为肥胖治疗打开了新视野。GCG由胰岛α细胞分泌，其受体 （GCGR）的激活可增强脂肪氧化、促进能量消耗，尤其在改善肝脏脂肪代谢方面具有独特潜力。GCG 与GLP-1靶点联用，可以通过"抑制食欲+加速代谢"的双重机制，更全面地解决肥胖患者内脏脂肪堆 积、胰岛素抵抗等复杂代谢问题，突破单一靶点的治疗局限。 "玛仕度肽（1BI362）是一种每周一次给药的GCG/GLP-1双受体激动剂。"纪立农介绍，在Ⅱ期临床试验 中，玛仕度肽6mg在中国超重或肥胖受试者和2型糖尿病受试者中均显示出显著的体重减轻效果，且其 耐受性和安全性与GLP-1受体激动剂及其联合激动剂相似。纪立农表示，此次入选《新英格兰医学杂 志》的研究，是首个在中国超重或肥胖受试者中评估玛仕度肽疗效和安全性的Ⅲ期临床试验（GLORY- 1）。该研究共入组610名受试者，结果显示各剂量玛仕度肽相较安慰剂均可显著降低体重。同时，患者 在血 ...

Core Viewpoint - The article highlights the successful Phase III clinical trial results of the obesity treatment drug Masitide (GCG/GLP-1 dual receptor agonist), which has been published in the prestigious New England Journal of Medicine (NEJM), marking a significant milestone for China's innovation in the field of endocrine metabolism and potentially transforming obesity treatment globally [1][5][10]. Group 1: Clinical Research and Results - The GLORY-1 study, which included 610 participants, demonstrated that Masitide significantly reduced body weight compared to placebo, with 73.9% and 82.0% of participants in the 4 mg and 6 mg groups, respectively, achieving a weight loss of ≥5% by week 32 [9]. - By week 48, 35.7% and 49.5% of participants in the 4 mg and 6 mg groups, respectively, achieved a weight loss of ≥15%, while only 2.0% in the placebo group did [9]. - The drug also showed significant improvements in various metabolic indicators, including blood lipids, blood pressure, and liver fat content [9]. Group 2: Significance and Implications - The publication of the study in NEJM signifies international recognition of China's innovative drug development in the field of obesity treatment, providing a new direction for global obesity management [3][6]. - The research results are expected to influence clinical guidelines and practices, contributing to the "Healthy China 2030" initiative by addressing the rising obesity rates in the country [6][10]. - The dual-target mechanism of Masitide, which combines appetite suppression and enhanced fat metabolism, represents a breakthrough in obesity treatment strategies [8][10]. Group 3: Broader Context and Public Health - The increasing prevalence of overweight and obesity in China poses significant public health challenges, with obesity-related deaths accounting for 11.1% of chronic non-communicable disease deaths in 2019 [4]. - The Chinese government has initiated a "Weight Management Year" campaign to address these issues, emphasizing the importance of weight management in improving national health [4][6]. - Experts suggest that obesity treatment should consider local population characteristics and implement differentiated strategies, particularly focusing on liver health and lipid management [6][10].

Core Viewpoint - The article emphasizes the importance of healthy eating and balanced diet in weight management, highlighting the need for a three-year action plan to address the rising obesity rates in China [9][11]. Group 1: Dietary Recommendations - The official dietary guidelines recommend daily intake of at least 300 grams of fresh vegetables, with dark vegetables making up over 50% of that amount, and 200 to 350 grams of fresh fruits [6]. - Adults are advised to consume 50 to 100 grams of whole grains daily, ensuring at least one meal per day includes whole grains [6]. - It is suggested to eat fish, shrimp, and shellfish 1 to 2 times a week, with a weekly intake of 300 to 500 grams for adults [8]. Group 2: Weight Management Strategies - The National Health Commission reports that the overweight and obesity rate among adults in China has reached 51.2%, potentially exceeding 70% by 2030 if not controlled [9]. - Maintaining an energy deficit is crucial, meaning calorie intake should be less than calorie expenditure, but this does not require extreme dietary restrictions [9][11]. - A diverse diet is essential, with a minimum of 12 different food types daily and over 25 weekly, alongside a balanced nutritional ratio [11]. Group 3: Nutritional Supplements - Nutritional supplements are becoming popular, but experts advise against replacing meals with them, as nutrients from food are generally better absorbed and have fewer side effects [12]. - Long-term excessive intake of certain nutrients may pose health risks, and it is not recommended for healthy adults to indiscriminately supplement vitamins and minerals [14].

Group 1 - The 2025 China International Sporting Goods Expo concluded in Nanchang, with an exhibition area of 163,700 square meters and over 1,800 participating companies [1] - Artificial intelligence emerged as a key theme at the expo, with products like AI-powered training equipment that provides personalized exercise prescriptions based on user data [2][3] - Weight management was highlighted, featuring a 3D intelligent body measurement mirror that uses AI to create a three-dimensional model for users to manage their weight and posture [3] Group 2 - The application of new materials and cross-disciplinary technologies is expanding the boundaries of sports equipment, with innovations like ultra-low temperature therapy chambers and carbon fiber products [3] - The expo attracted over 4,000 overseas buyers and 50,000 total attendees, with foreign VIP buyers expressing intent to purchase exceeding $90 million, showcasing China's shift towards intelligent manufacturing in sports [4]

Core Viewpoint - The Chinese government aims to establish comprehensive health weight management clinics by June 2025, addressing the rising obesity rates and related health issues among the population [1] Group 1: Current Situation and Demand - There is a significant demand for scientific weight loss solutions, with over 50% of adults in China classified as overweight or obese [2] - The obesity rate among children aged 6 to 17 is approximately 19%, highlighting a growing public health concern [2] - Many individuals have attempted extreme dieting or weight loss drugs, often leading to rapid weight regain and health risks [2] Group 2: Development of Weight Management Clinics - Since its establishment in 2016, the multidisciplinary weight management clinic at Peking University First Hospital has treated over 2,000 patients, with a 60% increase in visits in the first quarter of this year compared to the previous year [3] - Various hospitals across China are setting up weight management clinics, with 37 hospitals in Suzhou already offering such services [3] Group 3: Comprehensive Approach to Weight Management - Weight management clinics provide personalized plans that include medical assessments, nutritional guidance, exercise prescriptions, and behavioral interventions [4] - The collaboration of multiple medical disciplines ensures comprehensive health management for patients [4] Group 4: Role of Traditional Chinese Medicine - Traditional Chinese Medicine (TCM) plays a unique role in weight management by focusing on holistic approaches to restore metabolic balance [5] Group 5: Community-Based Initiatives - Community health centers are also piloting weight management services, offering affordable consultations and support for chronic disease management [5] Group 6: Challenges and Future Directions - Despite rapid development, challenges such as lack of policy support, insufficient training, and financial barriers for patients remain [6] - Experts suggest the need for national standards and the integration of weight management services into basic public health offerings [7]

大众的体重管理意识正在逐步提升。数据显示，约一半的人自认为存在超重风险，七成人已经具备体重管理意识并希望改善体重状况，超过六 成愿意为控制体重投入时间和精力，积极参与各类体重管理行动。 2025年5月10日，《成人健康体重管理白皮书（2025）》在第二届中国肥胖防控大会上正式发布。此次白皮书的推出，旨在推动社会更加重视 科学健康的减重方式。 据悉，这本白皮书由中华预防医学会联合暨南大学等机构，基于对公众体重管理实际情况的调研共同编写。内容涵盖了大众对体重管理的认知 与意识、实际行动举措以及未来的期望等多个方面。 国家卫生健康委发布的《体重管理指导原则（2024年版）》显示，目前我国成年人的超重率为34.3%，肥胖率为16.4%。如果不采取有效措施， 到2030年，成人超重和肥胖率预计将升至70.5%。与此同时，2030年因超重和肥胖带来的医疗费用预计高达610亿美元，占全国医疗卫生支出的 22%。 本更管理 国家卫生健康委员会 National Health Commission of the People's Republic of China 官方发布! 最新版25条"体重管理"措施来了, 文速查 中华预 ...

Core Insights - The life expectancy of Chinese residents has reached 79 years in 2024, an increase of 0.4 years from 2023, highlighting the importance of not just longevity but also health in later years [1] Group 1: Dietary Recommendations - Eating moderately, such as maintaining a 70-80% fullness, can reduce calorie intake and has been shown to slow aging by 2-3% and lower mortality risk by 10-15% [3][5] - A balanced diet should include whole grains, fruits, vegetables, legumes, and nuts while minimizing red and processed meats, alcohol, and high-sugar foods [9] Group 2: Health Metrics - Maintaining low levels of blood sugar, creatinine, and uric acid from the age of 60 is crucial for longevity, as evidenced by a study of 44,636 participants over 35 years [6][8] - Regular aerobic and resistance training can positively impact blood lipid levels and overall metabolic health [8] Group 3: Weight Management - Obesity is linked to over 200 diseases and can increase cancer risk; a "5+2 intermittent fasting" method is suggested for weight management, allowing for a structured eating pattern [10] Group 4: Muscle Health - Muscle strength is essential for metabolism and anti-aging; resistance training methods such as bodyweight exercises, resistance bands, and gym equipment are recommended for individuals over 40 [11][12][13][14]

Core Viewpoint - The Chinese government has initiated a national "Weight Management Year" action plan to combat the rising obesity rates, emphasizing that this is a public health issue rather than just a personal choice [3][4]. Group 1: Obesity Crisis - China's overweight and obesity rates have surged 12 times in the past 15 years, leading to significant health and economic consequences [4][6]. - As of 2021, nearly 2.6 billion people globally are overweight or obese, with a dramatic increase of 188% in adults and 149% in youth since 1990 [4][5]. - The direct medical costs associated with obesity in China exceed 240 billion yuan, highlighting the financial burden on the healthcare system [6]. Group 2: Global Responses - Various countries have implemented unique strategies to address obesity, such as the UK's sugar tax, which has led to a significant reduction in sugary drink sales [8]. - The Netherlands has adopted a dual approach of treatment and prevention for obesity, focusing on personalized care for different demographics [9]. - Spain's national strategy aims to reduce childhood obesity through increased physical activity and nutrition education [10]. Group 3: Economic Implications - Obesity is linked to economic disparities, with wealthier individuals often having better access to healthy food options, while lower-income communities face higher rates of obesity due to cheaper, unhealthy food choices [15][16]. - The healthcare costs associated with obesity are projected to strain China's medical insurance system, with over 70% of adults expected to be overweight by 2030 [6][15]. Group 4: Domestic Initiatives - The Chinese government is implementing localized measures to promote healthier eating habits, such as reducing oil and salt in popular dishes and encouraging lighter food options on delivery platforms [16][17]. - Schools are taking proactive steps to limit unhealthy snacks near campuses, aiming to combat childhood obesity from an early age [17].

Core Viewpoint - Obesity is defined as a chronic relapsing disease, and its diagnosis should not rely solely on weight but should include a comprehensive assessment of body fat distribution and health risks [1][2]. Group 1: Health Risks and Statistics - Over 70% of overweight individuals in China have at least one comorbidity, while nearly 90% of obese patients have at least one comorbidity, including diabetes, dyslipidemia, hypertension, cardiovascular diseases, chronic kidney diseases, depression, and anxiety [1]. - Obesity is associated with a reduced life expectancy [1]. Group 2: Diagnostic Tools and Guidelines - Common diagnostic tools for obesity include BMI, waist circumference, body fat percentage, and visceral fat area [1]. - The latest guidelines in China advocate for early intervention in overweight (BMI ≥ 24) and obese (BMI ≥ 28) individuals, emphasizing lifestyle changes as the primary method for weight management [2]. Group 3: Treatment Options - For individuals with obesity or overweight and comorbidities, pharmacological treatment may be initiated if lifestyle interventions are ineffective. GLP-1 receptor agonists can aid in weight loss while improving metabolic indicators such as blood sugar and blood pressure [2]. - Surgical options for severe obesity (BMI ≥ 37.5) or those with serious comorbidities include sleeve gastrectomy and gastric bypass, which can lead to long-term weight loss and improvement of comorbidities [2]. Group 4: Traditional Chinese Medicine (TCM) Approaches - TCM views obesity as an external manifestation of internal imbalance, focusing on restoring the normal function of organs such as the spleen, liver, and kidneys [3]. - Non-pharmacological therapies in TCM, such as acupuncture and dietary adjustments, are gaining popularity among the public for weight management [3]. Group 5: Community Health Initiatives - Shanghai encourages community health service centers to establish weight management clinics, creating an integrated service system for prevention, intervention, and maintenance of weight management [4]. - Experts emphasize that combating obesity requires scientific methods, sustained patience, and multi-dimensional support, viewing weight loss as a pursuit of quality of life rather than just a numerical goal [4].

Group 1: Industry Trends - The 2025 China International Sporting Goods Expo showcases a shift towards more intelligent, compact, and multifunctional fitness equipment, reflecting the integration of digital technology into fitness practices [1][2] - The concept of "multi-functional integration" and "space-friendly" development is emerging, with products designed to seamlessly fit into home environments while offering diverse functionalities [2][4] - The application of AI in fitness equipment is becoming prevalent, with systems that provide personalized training plans based on user data, enhancing the interaction between users and machines [4][5] Group 2: Technological Innovations - The SHOTLAB AI shooting system captures and analyzes shooting techniques in real-time, providing users with detailed feedback to improve their performance [3][4] - Smart training devices are being developed to cater to all age groups, featuring adjustable resistance and safety mechanisms to ensure user safety during workouts [7] - Modular construction systems for sports venues are being introduced, significantly reducing construction costs and time while enhancing operational efficiency through smart management [5][6] Group 3: Market Opportunities - The focus on "weight management" and personalized fitness solutions is gaining traction, with AI-driven devices creating tailored training plans for diverse demographics, including the elderly and youth [7][8] - The growth of the Chinese sports industry is linked to expanding the consumer base, emphasizing the need for increased awareness and engagement in sports activities among the general population [8]